Archives of Razi Institute最新文献

{"title":"Apoptosis Induction by New Coumarin Derivatives in a Mice Model of Breast Cancer.","authors":"Mesgari Abbasi Mehran, Khordadmehr Monireh, Shanehbandi Dariush, Jigari Asl Farinaz, Teimuri Mofrad Reza, Tahmasebi Shabnam, Shahab Asar Mohammad, Eskandari Vaezi Fateme, Panahi Yousef","doi":"10.22092/ARI.2023.78.5.1430","DOIUrl":"10.22092/ARI.2023.78.5.1430","url":null,"abstract":"<p><p>In the last decades, numerous studies have focused on the search for new agents to suppress the growth of cancer cells. In this study, we investigated the effect of two novel synthetic coumarin derivatives, namely <i>2-amino-4-(4-(2-hydroxyethoxy)-3-methoxyphenyl)-5-oxo-4H,5H-pyrano[3,2-c]coumarin-3-carbonitrile and 2-amino-4-(4-hydroxyphenyl)-5-oxo-4H,5H-pyrano[3,2-c]coumarin-3-carbonitrile</i>, on the induction of apoptosis in breast cancer in a mouse model. Breast cancer was induced in BALB/c mice, which were randomly divided into six groups and then underwent the experiment. The groups and treatments included A1: coumarin A with a low dose (10 µm), A2: coumarin A with a high dose (1 mM), B1: coumarin B with a low dose (10 µm), B2: coumarin B with a high dose (1 mM), D: doxorubicin, and C: cancer control/ treatment with normal saline. The samples underwent treatments for 5 weeks. Animals were euthanized, and tissue samples, including the lung, liver, and tumor mass, were collected for histopathological examination. In addition, quantitative real-time polymerase chain reaction (qRT-PCR) was performed to determine some apoptotic markers, such as BCL-2, caspase-9, COX-2, and <i>c-Myc</i>. The qRT-PCR presented that both coumarin compounds could significantly alter the expression levels of BCL-2, caspase-9, COX-2, and <i>c-Myc</i>. Consistent with these results, histopathological observations showed a significant reduction in pathological lesions and severity of malignancy of the tumor mass, as well as a decrease in microscopic metastases in the lung and liver. This suggests that the present new coumarin compounds may induce apoptosis in breast cancer cells by altering some apoptosis-related genes that may play a chemotherapeutic role in breast cancer therapy in the future.</p>","PeriodicalId":8311,"journal":{"name":"Archives of Razi Institute","volume":"78 5","pages":"1430-1440"},"PeriodicalIF":0.0,"publicationDate":"2023-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10998944/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140847394","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Broiler Heart Muscle Monoaminergic Receptors Alteration in Response to Chronic Heat Stress: Based on Transcription Analysis.","authors":"Badakhshan Yadollah, Arsalan Barazandeh Zahra Roudbari","doi":"10.22092/ARI.2023.78.5.1594","DOIUrl":"10.22092/ARI.2023.78.5.1594","url":null,"abstract":"<p><p>Chronic heat stress affects numerous physiological and behavioral mechanisms. Epigenetic changes following prolonged cyclic heat stress, creating new opportunities for molecular biology research. One of these changes involves monoamines, such as serotonin, epinephrine, norepinephrine, dopamine, and their transmission. Broiler chickens are highly susceptible to heat stress, and their hearts become insufficient during the growth phase, leading to hypertrophy of the left heart. RNA-seq data were obtained from NCBI with accession number SRP082125. The expression level of genes was determined with DESeq2 packages. Gene Ontology qualification, including biological processes, cellular components, and molecular role (MF), was performed from the Gene Ontology Resource. Cyclic heat stress in broilers significantly altered monoamine receptor expression. Twenty-nine genes of the monoamine pathway changed their expression in the left heart. Significant downregulation of expression was statistically associated with the <i>ADRB1</i>, <i>HTR2A</i>, and <i>PNMT</i> genes and upregulation of the <i>MAOA</i> gene (P<0.01). STRING database was used to construct the protein-protein interaction network; based on network analysis, the <i>HTR2C</i>, <i>HTR2A</i>, and <i>HTR5A</i> genes were identified as the major nodal genes in the network followed by <i>MAOA</i>, <i>DRD2</i>, <i>DRD5</i>, <i>HTR1B</i>, <i>DRD1</i>, <i>DRD3</i>, and <i>HTR2B</i> genes occupying the second important place in the network module. In conclusion, heat stress treatment prevented cardiac hypertrophy and altered the expression of monoamine genes. This would imply that monoamine transmission plays an important role in the development of cardiac hypertrophy, and that cyclic-chronic heat treatment modulates the cardiac monoaminergic system. These molecular biomarkers could be useful for screening, diagnosis, and treatment of cardiac hypertrophy.</p>","PeriodicalId":8311,"journal":{"name":"Archives of Razi Institute","volume":"78 5","pages":"1594-1602"},"PeriodicalIF":0.0,"publicationDate":"2023-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10998952/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140874480","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analysis and Identification of Putative Novel Peptides Purified from Iranian Endemic <i>Echis Carinatus</i> Sochureki Snake Venom by MALDI-TOF Mass Spectrometry.","authors":"Nasri Nasrabadi Nafiseh, Vatanpour Hossein, Mohammadpour Dounighi Nasser, Najafi Mojtaba, Ahmadinejad Minoo, Bayatzadeh Mohammad Ali, Pouyanmehr Giti","doi":"10.22092/ARI.2023.78.5.1503","DOIUrl":"10.22092/ARI.2023.78.5.1503","url":null,"abstract":"<p><p>The Iranian <i>Echis Carinatus</i> (IEC) venom is an exclusive natural source of bio-substances for a wide range of purposes in the blood coagulation cascade. The present study for the first time was aimed to assess novel pro-coagulant, anti-coagulant and anti-platelet proteins, named EC_{1.5 (a)}, EC_{5.1 (b)} and EC_{4 (a)} from Iranian <i>Echis Carinatus</i> (IEC) venom. These peptides were purified by multi-step chromatography methods. Hematological properties were measured using activated clotting tests, platelet aggregation studies, and hemorrhage assessment. Subsequently, these proteins were identified through both their intact molecular mass and peptide mass fingerprint (PMF) using matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS). Multiple sequence alignments were performed by ClustalW, Bioedit software. Molegro Data Modeller (MDM) 3.0 software was used to predict the putative tertiary structure of proteins.EC_{1.5 (a)}, a single-band protein with a molecular mass of 66 and 55 kDa, was observed by sodium dodecyl sulfate-polyacrylamide gel electrophoresis as a reduced and non-reduced state, respectively. Based on the Mascot results, we considered that EC_{1.5 (a)} is a metalloproteinase of group ΙΙ which exhibited potent pro-coagulant activity. It is predicted that the EC_{1.5 (a)} with hemorrhagic activity, potentially is a metalloproteinase/disintegrin region that constitutes the disintegrin-like domains. Our findings demonstrate that the disintegrin domain of EC_{1.5 (a)} lacks platelet aggregation inhibitory activity. On the contrary, this factor shows the property of a platelet aggregation inducer. Also, the EC_{5.1 (b)} was observed as a single-band protein with a molecular mass of 7.5 kDa. EC_{5.1 (b)} showed both anti-coagulant and anti-platelet properties. Additionally, the structure of the EC_{5.1 (b)} fraction is expected to be similar to that of phospholipase A₂, while EC_{4 (a)} structure is potentially very similar to that of Echistatin with 5 kDa molecular mass. We introduce the predicted structure of P-II snake venom metalloproteinase/ disintegrin domains, phospholipase A₂ and Echistatin-like fractions. Further research is therefore needed to determine the complete structure of these novel fractions and elucidate their mechanism of action and future therapeutic applications of cardiovascular and homeostasis disorders.</p>","PeriodicalId":8311,"journal":{"name":"Archives of Razi Institute","volume":"78 5","pages":"1503-1527"},"PeriodicalIF":0.0,"publicationDate":"2023-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10998951/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140851193","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Supplementation of Zinc on Antioxidant Activity, Blood Profile, Mineral Availability, Abdominal Fat, Digestive and Accessory Organs of Sikumbang Janti Duck.","authors":"R Kurniawan Rusli, R Amizar, Z Zurmiati, S Reski, A Darmawan, K Subekti, Kh Khalil","doi":"10.22092/ARI.2023.78.5.1586","DOIUrl":"10.22092/ARI.2023.78.5.1586","url":null,"abstract":"<p><p>The present research aimed to evaluate the addition of zinc (Zn) on antioxidant activity, blood profile, mineral availability, and abdominal fat of Sikumbang Janti duck. A total of 96 female Sikumbang Janti ducks aged 8 weeks were used in this research. This study used a completely random design with four treatments and four replications (6 duck/replications). The treatments were as follows control diet (Z0), the addition of 30 mg Zn/kg (Z1), 60 mg Zn/kg (Z2), and 90 mg Zn/kg(Z3). Variables observed were antioxidant activity, blood profile, mineral content in the tibia, and abdominal fat. The results showed that Zn addition on feed significantly increased antioxidant activity (DPPH), Zn concentration in thigh, leukocytes, mineral availability (Ca, P, and Zn) (<i>P</i><0.01), and decreased weight of abdominal fat in Sikumbang Janti duck (<i>P</i><0.01). Blood profiles (except leukocytes) were not affected by the addition of Zn in the diet (<i>P</i>>0.05). It is concluded that the Z2 (60 mg Zn/kg) addition improves antioxidant activity, blood leukocytes, zinc content in thigh meat, mineral availability, and decreases abdominal fat weight of Sikumbang Janti duck.</p>","PeriodicalId":8311,"journal":{"name":"Archives of Razi Institute","volume":"78 5","pages":"1586-1593"},"PeriodicalIF":0.0,"publicationDate":"2023-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10998943/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140850217","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Membrane Trafficking Mechanisms and Their Biological Relevance.","authors":"O Adeoye Akinwunmi","doi":"10.22092/ARI.2023.78.5.1397","DOIUrl":"10.22092/ARI.2023.78.5.1397","url":null,"abstract":"<p><p>Most chemicals expressed in mammalian cells have complex delivery and transport mechanisms to get to the right intracellular sites. One of these mechanisms transports most transmembrane proteins, as well as almost all secreted proteins, from the endoplasmic reticulum, where they are formed, to their final location. Nearly all eukaryotic cells have a membrane trafficking mechanism that is both a prominent and critical component. This system, which consists of dynamically coupled compartments, supports the export and uptake of extracellular material, remodeling and signaling at the cellular interface, intracellular alignment, and maintenance of internal compartmentalization (organelles). In animal cells, this system enables both regular cellular activities and specialized tasks, such as neuronal transmission and hormone control. Human diseases, including neurodegenerative diseases, such as Alzheimer's disease, heart disease, and cancer, are associated with the dysfunction or dysregulation of the membrane trafficking system. Treatment and cure of human diseases depends on understanding the cellular and molecular principles underlying membrane trafficking pathways. A single gene mutation or mutations that result in impaired membrane trafficking cause a range of clinical disorders that are the result of changes in cellular homeostasis. Other eukaryotic organisms with significant economic and agricultural value, such as plants and fungi, also depend on the membrane trafficking system for their survival. In this review, we focused on the major human diseases associated with the process of membrane trafficking, providing a broad overview of membrane trafficking.</p>","PeriodicalId":8311,"journal":{"name":"Archives of Razi Institute","volume":"78 5","pages":"1397-1412"},"PeriodicalIF":0.0,"publicationDate":"2023-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10998955/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140848861","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence of Epstein-barr Virus (EBV) among Patients with Oral Squamous Cell Carcinoma from Ahvaz, Iran: A Case-Control Study.","authors":"Mirzaei Habibollah, Azaran Azarakhsh, Mahmoudvand Shahab, Shokri Somayeh, Bagheri Shahram, Ramezani Ali, Jalilian Shahram","doi":"10.22092/ARI.2023.78.5.1495","DOIUrl":"10.22092/ARI.2023.78.5.1495","url":null,"abstract":"<p><p>Epstein-Barr virus (EBV), one of the most significant causes of lymphoid and epithelial cancers, has been linked to oral carcinogenesis; however, this etiological association remains controversial. To investigate this association, the present study aimed to determine the prevalence of EBV in cancerous and non-cancerous oral tissues from Ahvaz, Iran. In total, 164 blocks of formalin-fixed paraffin-embedded tissues from oral squamous cell carcinoma (OSCC), including 76 tongue squamous cell carcinomas and 88 non-cancerous tongue tissues, were collected from Ahvaz Imam Khomeini Hospital, Ahvaz, Iran, from December 2014 to March 2019, for this case-control study. The tissues were cut into 15-μm-thick sections, and DNA was extracted using a solution of Phenol, Chloroform, and Isoamyl Alcohol. The EBV detection and typing were performed using nested polymerase chain reaction. The EBV was detected in 9 (5.48%) out of the 164 samples studied, including 4 (5.26%) of the 76 SCC cases and 5 (5.68%) of the 88 samples in the control group (P>0.05). The EBV was positive in 2.40% of the 83 male and 8.6% of the 81 female samples (P>0.05). In terms of the histological grades of the case group, 3 (3/57) and 1 (1/13) of the EBV-positive samples were well and moderately differentiated, respectively (P>0.05). For EBV typing, the 9 EBV-positive samples were tested, and it was found that 2 and 7 of the cases were EBV type I and II, respectively. Results of the current study demonstrated the low frequency of EBV in Iranian patients with OSCC, with EBV type II predominating. Further studies are required to clarify the association between EBV and OSCC.</p>","PeriodicalId":8311,"journal":{"name":"Archives of Razi Institute","volume":"78 5","pages":"1495-1502"},"PeriodicalIF":0.0,"publicationDate":"2023-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10998940/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140849531","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Morphological Study of <i>Hemiscorpius</i> Peters, 1861 (Scorpiones: Hemiscorpiidae) in Hormozgan Province, Southern Iran.","authors":"Shahi Mehran, Barahoei Hossein","doi":"10.22092/ARI.2023.78.5.1542","DOIUrl":"10.22092/ARI.2023.78.5.1542","url":null,"abstract":"<p><p><i>Hemiscorpius</i> species are distributed in Africa and Asia. Seven species of this genus have been identified in Iran of which six species have been reported from Hormozgan province. Members of this genus are the most dangerous scorpions in Iran. corpions were collected by moving stones during the day and searching at night using portable UV lights from 2011 to 2022 from different areas in Hormozgan province. Three species were identified from Hormozgan province including <i>Hemiscorpius acanthocercus</i>, <i>H.enischnocela</i> and <i>H. shahii</i> which are endemic to Iran. These species have limited distribution and were reported only from the south of Iran. The number of trichobothria are 3, 10-12 and 15-17 in <i>H. acanthocercus</i>, <i>H. enischnochela</i> and <i>H. shahii</i>, respectively. The measured values showed that <i>H. Shahii</i> is larger than <i>H. enischnochela</i> and <i>H. acanthocercus</i>. Specimens of <i>H. acanthocercus</i> are brown to dark brown samples with dark metasomal segment V. There have been reports of death from biting this species. Members of <i>H. enischnochela</i> are light brown to yellow samples. Members of <i>H. Shahii</i> are large brown samples. All three species have sexual dimorphism. Although these three species can be distinguished based on their morphological characters, the molecular investigation is needed to confirm the validity of all species of this genus. Identifying species and determining their distribution range is very useful in facilitating education and treatment management.</p>","PeriodicalId":8311,"journal":{"name":"Archives of Razi Institute","volume":"78 5","pages":"1542-1554"},"PeriodicalIF":0.0,"publicationDate":"2023-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10998954/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140849389","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"CrossMark Policy","authors":"","doi":"10.32592/ari.crossmarkpolicy","DOIUrl":"https://doi.org/10.32592/ari.crossmarkpolicy","url":null,"abstract":"Crossmark Policy Archives of Razi Institute(ARI) is a member of Crossref, which provides the Crossmark scheme. So all articles published through ARI are permanent. We assign DOIs to all published articles to make them forever accessible on our journal portal. If an author aims to modify or revise the paper, s/he might return us the revised version of the article. But, the authors should be cautious that all the former versions will be accessible with the current version as a reference for readers. CrossMark is a service from CrossRef that provides an advanced system to present the current version of a research report. This system, ARI, ensures its readers present the latest version of the academic papers and commitment to present any modifications made to that research article. A reader can be informed about the current status of an article and, moreover, might check for supplementary information about that article by looking at the Crossmark logo on the article's first page.","PeriodicalId":8311,"journal":{"name":"Archives of Razi Institute","volume":"174 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136308556","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Designing of Multi-Epitope Peptide Vaccine Based on Outer Membrane Proteins OmpF, OmpC, and PgtE of Salmonella enterica Typhi","authors":"","doi":"10.32592/ari.2023.78.5.1440","DOIUrl":"https://doi.org/10.32592/ari.2023.78.5.1440","url":null,"abstract":"Consumption of contaminated water and foods by Salmonella Typhi cause the most common enteric disease known as Typhoid fever in both humans and animals. Despite the existence of various vaccines but infectious diseases remain a major cause of mortality worldwide. Nowadays, in-silico tools design a reliable and stable vaccine to combat such infections. The study aimed to design and evaluate a multi-epitope vaccine based on the outer-membrane proteins of Salmonella Typhi. B-cells and T-cells epitopes were predicted. Predicted epitopes were connected by AAY, KK, and GPGPG linkers. Heparin-Binding Hemagglutinin Adhesin (HBHA) has been attached to the N-terminal of the final vaccine as a potent immune adjuvant. Epitope’s antigenicity, allergenicity, immunogenicity, and physicochemical characteristics were defined using in-silico tools. Molecular docking of vaccine-TLR4 was done. ∆G of vaccine-TLR4 is -3.91×104 Kcal mol-1 with 1.93 RMSD. The results indicated protein was stable and non-allergen. In conclusion, the multi-epitope vaccine base on outer membrane proteins of the Salmonella Typhi bacterium might be considered to combat typhoid fever.","PeriodicalId":8311,"journal":{"name":"Archives of Razi Institute","volume":"62 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139339090","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Membrane Trafficking Mechanisms and Their Biological Relevance","authors":"","doi":"10.32592/ari.2023.78.5.1397","DOIUrl":"https://doi.org/10.32592/ari.2023.78.5.1397","url":null,"abstract":"Most chemicals expressed in mammalian cells have complex delivery and transport mechanisms to get to the right intracellular sites. One of these mechanisms transports most transmembrane proteins, as well as almost all secreted proteins, from the endoplasmic reticulum, where they are formed, to their final location. Nearly all eukaryotic cells have a membrane trafficking mechanism that is both a prominent and critical component. This system, which consists of dynamically coupled compartments, supports the export and uptake of extracellular material, remodeling and signaling at the cellular interface, intracellular alignment, and maintenance of internal compartmentalization (organelles). In animal cells, this system enables both regular cellular activities and specialized tasks, such as neuronal transmission and hormone control. Human diseases, including neurodegenerative diseases, such as Alzheimer's disease, heart disease, and cancer, are associated with the dysfunction or dysregulation of the membrane trafficking system. Treatment and cure of human diseases depends on understanding the cellular and molecular principles underlying membrane trafficking pathways. A single gene mutation or mutations that result in impaired membrane trafficking cause a range of clinical disorders that are the result of changes in cellular homeostasis. Other eukaryotic organisms with significant economic and agricultural value, such as plants and fungi, also depend on the membrane trafficking system for their survival. In this review, we focused on the major human diseases associated with the process of membrane trafficking, providing a broad overview of membrane trafficking.","PeriodicalId":8311,"journal":{"name":"Archives of Razi Institute","volume":"56 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-09-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139339987","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}