The Guthrie journal of the Donald Guthrie Foundation for Medical Research最新文献

{"title":"Guthrie Diabetes Center: The First Five Years","authors":"Mal R. Homan","doi":"10.3138/guthrie.72.1.001","DOIUrl":"https://doi.org/10.3138/guthrie.72.1.001","url":null,"abstract":"Because of the toll taken by diabetes and its complications, efforts are being made to improve care of diabetic patients. Although improved treatments and even a cure may be forthcoming, presently available interventions allow treatment to prevent complications. The team approach to diabetes care, proven to benefit individuals with diabetes, has been behind the development and philosophy of the Guthrie Diabetes Center, which has been successfully treating a large population of diabetic patients since its inception five years ago.","PeriodicalId":83043,"journal":{"name":"The Guthrie journal of the Donald Guthrie Foundation for Medical Research","volume":"16 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2003-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72543399","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diabetic Nephropathy 2003","authors":"Felix J. DeSio","doi":"10.3138/guthrie.72.1.010","DOIUrl":"https://doi.org/10.3138/guthrie.72.1.010","url":null,"abstract":"Nearly half of all patients on dialysis are diabetic. The incidence of diabetic nephropathy can be reduced by careful control of glucose, hypertension, and lipids, along with blockade of the renin-angiotension-aldosterone axis.","PeriodicalId":83043,"journal":{"name":"The Guthrie journal of the Donald Guthrie Foundation for Medical Research","volume":"17 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2003-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78808700","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Editors of the Guthrie Bulletin and Guthrie Journal","authors":"B. Cleary","doi":"10.3138/guthrie.72.1.041","DOIUrl":"https://doi.org/10.3138/guthrie.72.1.041","url":null,"abstract":"","PeriodicalId":83043,"journal":{"name":"The Guthrie journal of the Donald Guthrie Foundation for Medical Research","volume":"9 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2003-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81225402","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Small Cell Carcinoma of the Bladder-A Case Report and Literature Review","authors":"Arun Lakshmipathy, I. Wollak, W. Friedenberg","doi":"10.3138/guthrie.72.1.028","DOIUrl":"https://doi.org/10.3138/guthrie.72.1.028","url":null,"abstract":"Primary small cell carcinoma of the bladder is rare. The incidence varies between 0.5-1% of all primary bladder tumors. Fifty percent of small cell carcinomas of the bladder are mixed with other tumors of the bladder. Identifying small cell carcinoma of the bladder has both therapeutic and prognostic implications. They are much more aggressive than transitional cell carcinoma of the bladder and are biologically similar to small cell carcinoma of the lung.","PeriodicalId":83043,"journal":{"name":"The Guthrie journal of the Donald Guthrie Foundation for Medical Research","volume":"34 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2003-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76484257","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Treatment Algorithm for Type 2 Diabetes Mellitus","authors":"Ferrol J. Lee","doi":"10.3138/guthrie.72.1.004","DOIUrl":"https://doi.org/10.3138/guthrie.72.1.004","url":null,"abstract":"","PeriodicalId":83043,"journal":{"name":"The Guthrie journal of the Donald Guthrie Foundation for Medical Research","volume":"42 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2003-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88907518","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Genes Involved in Kidney Development, Differentiation and Tumor Progression","authors":"M. P. Quinlan","doi":"10.3138/guthrie.72.1.031","DOIUrl":"https://doi.org/10.3138/guthrie.72.1.031","url":null,"abstract":"Cancer is still the number two cause of death in highly developed countries. Epithelial cells represent the most important cell type in tumor formation and progression, because greater than 90% of human malignancies are carcinomas and thus of epithelial origin. Most, if not all, tumor cells show abnormalities in differentiation (i.e., anaplasia). A major cause of death from cancer in humans is the invasive and metastatic growth of malignant epithelial cells. For this to occur, epithelial cells must lose many of their differentiated properties and take on those of a mesenchymal cell type. Thus, tumor progression is a pathological epithelial-mesenchymal transition (EMT), a process that is a normal part of embryogenesis. Many embryonic genes are reexpressed in cancer cells, but unlike normal cells during embryonic development, tumor cells fail to differentiate and continue to proliferate. Being able to treat cancer through the induction of cellular differentiation is attractive, because the therapy would be more target cell specific and most likely be much less toxic then standard chemotherapeutic agents, which affect normal and tumor cells. However, greater knowledge about the molecular basis for the control of differentiation is necessary to lead to more accurate predictions, as well as the rational design of therapies for controlling tumor growth by manipulating the state of differentiation. To these ends, we employed representational difference analysis (RDA) to identify genes whose expression is altered during EMT and tumor progression. 35 differentially expressed mRNAs were identified and classified into several functional categories, including 9 novel cDNAs. Among the 26 known cDNAs, extracellular matrix and related proteins made up the largest group of differentially expressed genes, followed by growth factors and receptors and transcription factors. Some of the known genes have previously been associated with EMT and/or tumor progression and thus served to validate the system to obtain the desired target genes, while other cDNAs are newly linked with dedifferentiation/malignancy. Array analyses indicated that the cDNAs were specifically upregulated in invasive or metastatic tumors, especially of breast, uterus and lung, suggesting their involvement in the progression of these tumors.","PeriodicalId":83043,"journal":{"name":"The Guthrie journal of the Donald Guthrie Foundation for Medical Research","volume":"105 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2003-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86966492","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diabetes Self-Management Education: Promoting Healthy Behaviors and Reducing Long-Term Costs","authors":"J. Riley","doi":"10.3138/guthrie.72.1.007","DOIUrl":"https://doi.org/10.3138/guthrie.72.1.007","url":null,"abstract":"Diabetes self-management education has been considered an integral component of clinical management since the 1930’s.1 Through the years, it has evolved from a didactic learning process to one of an empowerment approach.2 It is no longer considered simply “survival skill” education but is geared as an ongoing process of learning the knowledge and skills necessary to promote behavior change and positive health outcomes. Goals of diabetes education include optimizing metabolic control, prevention of acute and chronic complications, and optimizing quality of life while controlling costs.3 Provision of this education process is ideally met through a diabetes educator: a health care professional who has mastered the core of knowledge and skills of diabetes management and who has met the experiential requirements to become a CDE.4","PeriodicalId":83043,"journal":{"name":"The Guthrie journal of the Donald Guthrie Foundation for Medical Research","volume":"38 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2003-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89344448","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diabetic Eye Care at Guthrie: Past, Present, and Future","authors":"Michael J Hudock","doi":"10.3138/guthrie.72.1.018","DOIUrl":"https://doi.org/10.3138/guthrie.72.1.018","url":null,"abstract":"Treatment of macular edema, proliferative and non-proliferative diabetic retinopathy has developed over the past eighteen years through carefully controlled, multicenter studies. The results of those studies, their implementation within the Guthrie system, and anticipated future directions, are described along with the pathophysiology of the underlying disease processes. Laser treatment of retinopathy can arrest vision loss but the most effective intervention is prevention through careful glycemic control.","PeriodicalId":83043,"journal":{"name":"The Guthrie journal of the Donald Guthrie Foundation for Medical Research","volume":"16 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2003-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85894281","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hairy Cell Leukemia","authors":"P. Bergevin","doi":"10.3138/guthrie.71.4.122","DOIUrl":"https://doi.org/10.3138/guthrie.71.4.122","url":null,"abstract":"Hairy cell leukemia (HCL) is a chronic lymphoproliferative disorder characterized by splenomegaly, pancytopenia, and bone marrow infiltration. HCL is quite responsive to new purine analogs and long-lasting remissions may be achieved.","PeriodicalId":83043,"journal":{"name":"The Guthrie journal of the Donald Guthrie Foundation for Medical Research","volume":"46 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2002-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80007991","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advances in the Treatment of Multiple Myeloma","authors":"W. Friedenberg, Laurie Warzyniak","doi":"10.3138/guthrie.71.4.129","DOIUrl":"https://doi.org/10.3138/guthrie.71.4.129","url":null,"abstract":"There have been dramatic advances in the palliative treatment of multiple myeloma, although cure remains elusive. Accurate diagnosis is essential to effective therapy, because there are many disorders associated with a monoclonal gammopathy. Standard treatment with melphalan and predisone has been superceded by nonalkylating therapy followed by high dose therapy and autologous stem cell transplantation in appropiate patients. Seven patients with multiple myeloma have received stem cell transplants at Guthrie and six continue in either complete or near complete remission, with one patient receiving a second transplant, and one patient relapsing with resistant disease and dying. Bisophosphonates have contributed to less pain and musculoskeletal complications. Thalidomide and dexamethasone have markedly improved the response to initial or salvage treatments. PS-341, a protease inhibitor, has recently been shown to be effective in heavily pre-treated patients. New treatments with the prospect of cure are needed.","PeriodicalId":83043,"journal":{"name":"The Guthrie journal of the Donald Guthrie Foundation for Medical Research","volume":"38 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2002-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88090681","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}