Archives of ophthalmology最新文献

{"title":"Topical linezolid for refractory bilateral Mycobacterium chelonae post-laser-assisted in situ keratomileusis keratitis.","authors":"Rosa Dolz-Marco, Patricia Udaondo, Roberto Gallego-Pinazo, J Maria Millán, Manuel Díaz-Llopis","doi":"10.1001/archophthalmol.2012.1495","DOIUrl":"https://doi.org/10.1001/archophthalmol.2012.1495","url":null,"abstract":"diagnosis; (2) successful combination of topical, oral, and intraocular therapy with drugs that can reach therapeutic levels in aqueous and vitreous and are effective in vivo for other Acanthamoeba infections; and (3) guiding treatment by effective monitoring of the response by Acanthamoeba. We think oral and topical administration of voriconazole must have achieved a sustained therapeutic dose and frequent administration of intraocular voriconazole produced high peak levels, increasing effectiveness. Topical chlorhexidine was used before the PK but the keratitis worsened, raising the question of its effectiveness in our patient. It is unknown whether topical chlorhexidine can reach aqueous therapeutic levels; however, rabbit studies have shown that frequent instillation of chlorhexidine, 0.02%, in epithelialized corneas produces concentrations 10 to 40 times lower than voriconazole but, in our experience, a similar 90% inhibitory concentration. Moreover, in the other described cases, topical antiseptics such as chlorhexidine used after PK did not prevent endophthalmitis. Therefore, we believe chlorhexidine did not play a major role in our case. The susceptibility of Acanthamoeba to trimethoprim/sulfamethoxazole, also used in our patient, is based on a few reports; we have not tested the susceptibility of the patient’s strain and cannot be sure of its real contribution.","PeriodicalId":8303,"journal":{"name":"Archives of ophthalmology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2012-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1001/archophthalmol.2012.1495","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31042354","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"About this journal.","authors":"","doi":"10.1001/archopht.130.11.1371","DOIUrl":"https://doi.org/10.1001/archopht.130.11.1371","url":null,"abstract":"Universities struggle with alternate means of instructional delivery to meet the demands of distant student needs, the competition for enrollments, and restraints from limited physical building space. For many, fully online programs of study using internet-based instruction commonly named online instruction have become viable solutions. There has been significant growth in the number of on-line degree programs since many students want to take courses that will positively impact their future careers but not hinder family and work responsibilities. Shifting from a traditional program of study to an online format is not without challenges. There are three primary areas of focus when considering an online design format for course delivery: course design, instructor role, and student role. This paper will provide one instructor’s perspective of how to improve student engagement and interaction in master’s level Educational Leadership courses over a threeyear span utilizing available data from the university Student Perception of Teacher (SPOT) assessment available.","PeriodicalId":8303,"journal":{"name":"Archives of ophthalmology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2012-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31496271","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Scleral fistula closure at the time of glaucoma drainage device tube repositioning: a novel technique.","authors":"Joseph F Panarelli,&nbsp;Michael R Banitt,&nbsp;Paul A Sidoti","doi":"10.1001/archophthalmol.2012.2219","DOIUrl":"https://doi.org/10.1001/archophthalmol.2012.2219","url":null,"abstract":"<p><p>Repositioning a glaucoma drainage device tube from the anterior chamber to the ciliary sulcus or pars plana can be a challenging procedure owing to the difficulty in obtaining tight closure of the original limbal fistula. Failure to achieve watertight and airtight closure of the fistula can result in substantial difficulty in completing other key portions of the surgery and may lead to postoperative hypotony and associated complications. A novel technique using a Tutoplast scleral plug, polyglactin sutures, and, in certain cases, fibrin tissue sealant to close a limbal fistula at the time of glaucoma drainage device tube repositioning is described. This technique can be replicated with ease and provides a tight seal so that other concurrent surgical procedures can safely be completed and postoperative hypotony is avoided.</p>","PeriodicalId":8303,"journal":{"name":"Archives of ophthalmology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2012-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1001/archophthalmol.2012.2219","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31042345","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Swedish national register for retinopathy of prematurity (SWEDROP) and the evaluation of screening in Sweden.","authors":"Gerd E Holmström,&nbsp;Ann Hellström,&nbsp;Peter G Jakobsson,&nbsp;Pia Lundgren,&nbsp;Kristina Tornqvist,&nbsp;Agneta Wallin","doi":"10.1001/archophthalmol.2012.2357","DOIUrl":"https://doi.org/10.1001/archophthalmol.2012.2357","url":null,"abstract":"<p><strong>Objectives: </strong>To evaluate screening for retinopathy of prematurity (ROP) in Sweden and to investigate possible modifications of the present screening guidelines.</p><p><strong>Methods: </strong>Infants in Sweden with a gestational age (GA) of 31 weeks + 6 days or less are screened for ROP. Data from the Swedish national register for ROP (SWEDROP) during 2008 and 2009 were extracted and compared with a national perinatal quality register.</p><p><strong>Results: </strong>In SWEDROP, there were 1791 infants born before a GA of 32 weeks from January 1, 2008, through December 31, 2009. Another 70 infants were registered in the perinatal quality register but not in SWEDROP (dropout rate, 3.8% [70 of 1861 infants]). Seven infants died before termination of screening. In the final study cohort (1784 infants), 15.6% had mild ROP and 8.5% had severe ROP. Treatment was performed in 4.4% of the infants, none of whom had a GA at birth of more than 28 weeks. Nine infants with a GA of more than 28 weeks at birth developed stage 3 ROP, which regressed spontaneously. The total number of examinations was 9286 (964 in infants with a GA of 31 weeks), and the mean (range) number of examinations of each infant was 5.2 (1-30).</p><p><strong>Conclusions: </strong>The SWEDROP, a quality register for ROP, has a national coverage (ie, participation) of 96%. Data from 2008 to 2009 show that it seems possible to reduce the upper limit for screening in Sweden by 1 week, including only infants with a GA of 30 weeks + 6 days or less. However, such a change should be combined with a strong recommendation to neonatologists to refer also severely ill and more \"mature\" infants.</p>","PeriodicalId":8303,"journal":{"name":"Archives of ophthalmology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2012-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1001/archophthalmol.2012.2357","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31042342","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ten years with detached descemet membrane.","authors":"George D Kymionis,&nbsp;Georgios A Kontadakis","doi":"10.1001/archophthalmol.2012.1684","DOIUrl":"https://doi.org/10.1001/archophthalmol.2012.1684","url":null,"abstract":"perience with the Ahmed Glaucoma Valve implant. Am J Ophthalmol. 1999;127(1):27-33. 6. Siegner SW, Netland PA, Urban RC Jr, et al. Clinical experience with the Baerveldt glaucoma drainage implant. Ophthalmology. 1995;102 (9):1298-1307. 7. Ainsworth G, Rotchford A, Dua HS, King AJ. A novel use of amniotic membrane in the management of tube exposure following glaucoma tube shunt surgery. Br J Ophthalmol. 2006;90(4): 417-419. 8. Godfrey DG, Merritt JH, Fellman RL, Starita RJ. Interpolated conjunctival pedicle flaps for the treatment of exposed glaucoma drainage devices. Arch Ophthalmol. 2003;121(12):1772-1775. 9. Lama PJ, Fechtner RD. Tube erosion following insertion of a glaucoma drainage device with a pericardial patch graft. Arch Ophthalmol. 1999;117 (9):1243-1244. 10. Tsai JC, Grajewski AL, Parrish RK II. Surgical revision of glaucoma shunt implants. Ophthalmic Surg Lasers. 1999;30(1):41-46. 11. Sibayan SA, Latina MA. The use of processed pericardium in the repair of corneo-scleral fistulas. Ophthalmic Surg Lasers. 1997;28(4):334-335. 12. Yoo C, Kwon SW, Kim YY. Pericardium plug in the repair of the corneoscleral fistula after Ahmed Glaucoma Va lve exp lan ta t ion . Korean J Ophthalmol. 2008;22(4):268-271.","PeriodicalId":8303,"journal":{"name":"Archives of ophthalmology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2012-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1001/archophthalmol.2012.1684","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31042346","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Carl B. Camras, MD: reflections on his contributions to glaucoma research and clinical practice.","authors":"Nancy L Camras","doi":"10.1001/archophthalmol.2012.1839","DOIUrl":"https://doi.org/10.1001/archophthalmol.2012.1839","url":null,"abstract":"<p><p>My husband, Carl B. Camras, MD (chairman of the Department of Ophthalmology and Visual Sciences, University of Nebraska Medical Center, Omaha), died at age 55 years in 2009. His dying wish was to be remembered for being the first to hypothesize that prostaglandins lower intraocular pressure and had potential as a medication to treat glaucoma. I reviewed the research he performed as an undergraduate at Yale University (New Haven, Connecticut), as a medical student at Columbia University (New York, New York), and on the faculty at Mount Sinai School of Medicine (New York, New York), which confirmed his hypothesis and led to the development of latanoprost. This article summarizes his contributions to glaucoma research, his role in the development of latanoprost, and the error of omission that prevented his recognition as its coinventor. Carl is best remembered as an ethical scientist, a gifted clinician, and a beloved teacher, who inspired the medical community and the next generation of ophthalmologists.</p>","PeriodicalId":8303,"journal":{"name":"Archives of ophthalmology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2012-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1001/archophthalmol.2012.1839","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31042348","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Real-time polymerase chain reaction for diagnosing acyclovir-resistant herpetic keratitis based on changes in viral DNA copy number before and after treatment.","authors":"Tomoyuki Inoue,&nbsp;Rumi Kawashima,&nbsp;Takashi Suzuki,&nbsp;Yuichi Ohashi","doi":"10.1001/archophthalmol.2012.1176","DOIUrl":"https://doi.org/10.1001/archophthalmol.2012.1176","url":null,"abstract":"Acyclovir (ACV) is a specific anti– herpes simplex virus (HSV) and anti–varicella-zoster virus agent for herpetic infection; topical ACV ointment, 3%, has been the treatment of choice for HSV infection in Japan. Based on the widespread use of ACV, in some cases of recurrent herpetic keratitis, the disease was refractory to topical ACV treatment , which was previously reported as ACV-resistant herpetic kerat i t i s . 1 3 Convent ional ly , definitive diagnosis of an ACVresistant HSV keratitis requires a laboratory examination of viral cultures following in vitro drug sensitivity testing, which is generally difficult and complicated because of the low rates of replication of these viruses and the small number of ocular samples. A rapid, simple, and accurate method of diagnosing drug-resistant herpetic infection remains to be established. Realtime polymerase chain reaction (PCR) is a highly sensitive method for the detection and quantification of pathogens. We report 4 cases of ACV-resistant HSV keratitis using real-time PCR analysis; these cases were diagnosed based on changes in the viral DNA copy numbers before and after ACV treatment.","PeriodicalId":8303,"journal":{"name":"Archives of ophthalmology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2012-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1001/archophthalmol.2012.1176","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31042349","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cystic epithelial ingrowth in a case of deep anterior lamellar keratoplasty.","authors":"Jayangshu Sengupta,&nbsp;Archana Khetan","doi":"10.1001/archophthalmol.2012.509","DOIUrl":"https://doi.org/10.1001/archophthalmol.2012.509","url":null,"abstract":"","PeriodicalId":8303,"journal":{"name":"Archives of ophthalmology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2012-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1001/archophthalmol.2012.509","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31042812","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Novel etiological agent: molecular evidence for trematode-induced anterior uveitis in children.","authors":"Sivakumar R Rathinam,&nbsp;Lalan Kumar Arya,&nbsp;Kim R Usha,&nbsp;Lalitha Prajna,&nbsp;Veena Tandon","doi":"10.1001/archophthalmol.2012.729","DOIUrl":"https://doi.org/10.1001/archophthalmol.2012.729","url":null,"abstract":"","PeriodicalId":8303,"journal":{"name":"Archives of ophthalmology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2012-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1001/archophthalmol.2012.729","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31042815","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Improving preterm ophthalmologic care in the era of accountable care organizations.","authors":"C Jason Wang,&nbsp;Alison A Little,&nbsp;Karen Kamholz,&nbsp;Jaime Bruce Holliman,&nbsp;Marissa D Wise,&nbsp;Jonathan Davis,&nbsp;Steven Ringer,&nbsp;Cynthia Cole,&nbsp;Deborah K Vanderveen,&nbsp;Stephen P Christiansen,&nbsp;Howard Bauchner","doi":"10.1001/archophthalmol.2012.1890","DOIUrl":"https://doi.org/10.1001/archophthalmol.2012.1890","url":null,"abstract":"<p><p>OBJECTIVES To understand retinopathy of prematurity (ROP) follow-up care for preterm very low-birth-weight infants (VLBW; &lt;1500 g) in the context of the chronic care model and identify opportunities for improvement under accountable care organizations. METHODS We conducted focus groups and interviews with parents (N = 47) of VLBW infants and interviews with neonatal intensive care unit and ophthalmologic providers (N = 28) at 6 sites in Massachusetts and South Carolina. Themes are reported according to consolidated criteria for reporting qualitative research guidelines. RESULTS Respondents perceived that legal liability and low reimbursement contributed to shortages of ROP providers. Some neonatal intensive care units offered subsidies to attract ophthalmologic providers or delayed transfers to institutions that could not provide ROP examinations and/or treatment. Sites used variable practices for coordinating ROP care. Even at sites with a tracking database and a dedicated ROP coordinator, significant time was required to ensure that examinations and treatment occurred as scheduled. Parents' ability to manage their children's health care was limited by parental understanding of ROP, feeling overwhelmed by the infant's care, and unmet needs for resources to address social stressors. CONCLUSIONS Under accountable care organizations, hospitals and ophthalmology practices should share responsibility for ensuring coordinated ROP care to mitigate liability concerns. To promote integrated care, reimbursement for ROP care should be bundled to include screening, diagnosis, treatment, and appropriate follow-up. Clinical information systems should be enhanced to increase efficiency and limit lapses in care. Self-management tools and connections to community resources could help promote families' attendance of follow-up appointments.</p>","PeriodicalId":8303,"journal":{"name":"Archives of ophthalmology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2012-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1001/archophthalmol.2012.1890","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"30749140","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}