Archives of ophthalmology最新文献

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BBS1 mutations in a wide spectrum of phenotypes ranging from nonsyndromic retinitis pigmentosa to Bardet-Biedl syndrome. 从非综合征性色素性视网膜炎到Bardet-Biedl综合征的广泛表型中的BBS1突变。
Archives of ophthalmology Pub Date : 2012-11-01 DOI: 10.1001/archophthalmol.2012.2434
Alejandro Estrada-Cuzcano, Robert K Koenekoop, Audrey Senechal, Elfride B W De Baere, Thomy de Ravel, Sandro Banfi, Susanne Kohl, Carmen Ayuso, Dror Sharon, Carel B Hoyng, Christian P Hamel, Bart P Leroy, Carmela Ziviello, Irma Lopez, Alexandre Bazinet, Bernd Wissinger, Ieva Sliesoraityte, Almudena Avila-Fernandez, Karin W Littink, Enzo M Vingolo, Sabrina Signorini, Eyal Banin, Liliana Mizrahi-Meissonnier, Eberhard Zrenner, Ulrich Kellner, Rob W J Collin, Anneke I den Hollander, Frans P M Cremers, B Jeroen Klevering
{"title":"BBS1 mutations in a wide spectrum of phenotypes ranging from nonsyndromic retinitis pigmentosa to Bardet-Biedl syndrome.","authors":"Alejandro Estrada-Cuzcano,&nbsp;Robert K Koenekoop,&nbsp;Audrey Senechal,&nbsp;Elfride B W De Baere,&nbsp;Thomy de Ravel,&nbsp;Sandro Banfi,&nbsp;Susanne Kohl,&nbsp;Carmen Ayuso,&nbsp;Dror Sharon,&nbsp;Carel B Hoyng,&nbsp;Christian P Hamel,&nbsp;Bart P Leroy,&nbsp;Carmela Ziviello,&nbsp;Irma Lopez,&nbsp;Alexandre Bazinet,&nbsp;Bernd Wissinger,&nbsp;Ieva Sliesoraityte,&nbsp;Almudena Avila-Fernandez,&nbsp;Karin W Littink,&nbsp;Enzo M Vingolo,&nbsp;Sabrina Signorini,&nbsp;Eyal Banin,&nbsp;Liliana Mizrahi-Meissonnier,&nbsp;Eberhard Zrenner,&nbsp;Ulrich Kellner,&nbsp;Rob W J Collin,&nbsp;Anneke I den Hollander,&nbsp;Frans P M Cremers,&nbsp;B Jeroen Klevering","doi":"10.1001/archophthalmol.2012.2434","DOIUrl":"https://doi.org/10.1001/archophthalmol.2012.2434","url":null,"abstract":"<p><strong>Objective: </strong>To investigate the involvement of the Bardet-Biedl syndrome (BBS) gene BBS1 p.M390R variant in nonsyndromic autosomal recessive retinitis pigmentosa (RP).</p><p><strong>Methods: </strong>Homozygosity mapping of a patient with isolated RP was followed by BBS1 sequence analysis. We performed restriction fragment length polymorphism analysis of the p.M390R allele in 2007 patients with isolated RP or autosomal recessive RP and in 1824 ethnically matched controls. Patients with 2 BBS1 variants underwent extensive clinical and ophthalmologic assessment.</p><p><strong>Results: </strong>In an RP proband who did not fulfill the clinical criteria for BBS, we identified a large homozygous region encompassing the BBS1 gene, which carried the p.M390R variant. In addition, this variant was detected homozygously in 10 RP patients and 1 control, compound heterozygously in 3 patients, and heterozygously in 5 patients and 6 controls. The 14 patients with 2 BBS1 variants showed the entire clinical spectrum, from nonsyndromic RP to full-blown BBS. In 8 of 14 patients, visual acuity was significantly reduced. In patients with electroretinographic responses, a rod-cone pattern of photoreceptor degeneration was observed.</p><p><strong>Conclusions: </strong>Variants in BBS1 are significantly associated with nonsyndromic autosomal recessive RP and relatively mild forms of BBS. As exemplified in this study by the identification of a homozygous p.M390R variant in a control individual and in unaffected parents of BBS patients in other studies, cis - or trans -acting modifiers may influence the disease phenotype.</p><p><strong>Clinical relevance: </strong>It is important to monitor patients with an early diagnosis of mild BBS phenotypes for possible life-threatening conditions.</p>","PeriodicalId":8303,"journal":{"name":"Archives of ophthalmology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2012-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1001/archophthalmol.2012.2434","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31042343","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 113
Live juvenile strobilate tapeworm in the anterior chamber of the human eye. 在人眼前房的活的幼虫。
Archives of ophthalmology Pub Date : 2012-11-01 DOI: 10.1001/archophthalmol.2012.553
Gunjan Joshi, Swapnil Parchand, Mangat Ram Dogra, Puneet Kumar Gupta, Sumeeta Khurana, Vishali Gupta, Amod Gupta
{"title":"Live juvenile strobilate tapeworm in the anterior chamber of the human eye.","authors":"Gunjan Joshi,&nbsp;Swapnil Parchand,&nbsp;Mangat Ram Dogra,&nbsp;Puneet Kumar Gupta,&nbsp;Sumeeta Khurana,&nbsp;Vishali Gupta,&nbsp;Amod Gupta","doi":"10.1001/archophthalmol.2012.553","DOIUrl":"https://doi.org/10.1001/archophthalmol.2012.553","url":null,"abstract":"","PeriodicalId":8303,"journal":{"name":"Archives of ophthalmology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2012-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1001/archophthalmol.2012.553","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31042350","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 5
Successful monitoring and treatment of intraocular dissemination of acanthamoeba. 棘阿米巴眼内传播的成功监测和治疗。
Archives of ophthalmology Pub Date : 2012-11-01 DOI: 10.1001/archophthalmol.2012.2376
Francisco Arnalich-Montiel, Carmen M Martín-Navarro, Jorge L Alió, Rogelio López-Vélez, Enrique Martínez-Carretero, Basilio Valladares, José E Piñero, Jacob Lorenzo-Morales
{"title":"Successful monitoring and treatment of intraocular dissemination of acanthamoeba.","authors":"Francisco Arnalich-Montiel,&nbsp;Carmen M Martín-Navarro,&nbsp;Jorge L Alió,&nbsp;Rogelio López-Vélez,&nbsp;Enrique Martínez-Carretero,&nbsp;Basilio Valladares,&nbsp;José E Piñero,&nbsp;Jacob Lorenzo-Morales","doi":"10.1001/archophthalmol.2012.2376","DOIUrl":"https://doi.org/10.1001/archophthalmol.2012.2376","url":null,"abstract":"","PeriodicalId":8303,"journal":{"name":"Archives of ophthalmology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2012-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1001/archophthalmol.2012.2376","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31042353","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 36
Conjunctival pigmented epithelioid melanocytoma: a clinicopathological case report. 结膜色素上皮样黑色素细胞瘤1例临床病理报告。
Archives of ophthalmology Pub Date : 2012-11-01 DOI: 10.1001/archophthalmol.2012.1476
Alexandre Bissig, Alexandre Moulin, Barbara Spahn, Artur Zembowicz, Ann Schalenbourg
{"title":"Conjunctival pigmented epithelioid melanocytoma: a clinicopathological case report.","authors":"Alexandre Bissig,&nbsp;Alexandre Moulin,&nbsp;Barbara Spahn,&nbsp;Artur Zembowicz,&nbsp;Ann Schalenbourg","doi":"10.1001/archophthalmol.2012.1476","DOIUrl":"https://doi.org/10.1001/archophthalmol.2012.1476","url":null,"abstract":"118(1):209-218. 2. Shousha MA, Yoo SH, Kymionis GD, et al. Long-term results of femtosecond laser-assisted sutureless anterior lamellar keratoplasty. Ophthalmology. 2011; 118(2):315-323. 3. Shih CY, Ritterband DC, Rubino S, et al. Visually significant and nonsignificant complications arising from Descemet stripping automated endothelial keratoplasty. Am J Ophthalmol. 2009;148(6):837-843. 4. Fournié PR, Gordon GM, Dawson DG, Malecaze FJ, Edelhauser HF, Fini ME. Correlation between epithelial ingrowth and basement membrane remodeling in human corneas after laser-assisted in situ keratomileusis. Arch Ophthalmol. 2010;128(4):426-436. 5. Naumann GO, Rummelt V. Block excision of cystic and diffuse epithelial ingrowth of the anterior chamber: report on 32 consecutive patients. Arch Ophthalmol. 1992;110(2):223-227. 6. Haller JA, Stark WJ, Azab A, Thomsen RW, Gottsch JD. Surgical approaches to the management of epithelial cysts. Trans Am Ophthalmol Soc. 2002;100: 79-84.","PeriodicalId":8303,"journal":{"name":"Archives of ophthalmology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2012-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1001/archophthalmol.2012.1476","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31042813","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 12
Bilateral simultaneous-onset nongranulomatous acute anterior uveitis: clinical presentation and etiology. 双侧同时发病的非肉芽肿性急性葡萄膜炎:临床表现和病因学。
Archives of ophthalmology Pub Date : 2012-11-01 DOI: 10.1001/archophthalmol.2012.2006
Andrea D Birnbaum, Yi Jiang, Roshni Vasaiwala, Howard H Tessler, Debra A Goldstein
{"title":"Bilateral simultaneous-onset nongranulomatous acute anterior uveitis: clinical presentation and etiology.","authors":"Andrea D Birnbaum,&nbsp;Yi Jiang,&nbsp;Roshni Vasaiwala,&nbsp;Howard H Tessler,&nbsp;Debra A Goldstein","doi":"10.1001/archophthalmol.2012.2006","DOIUrl":"https://doi.org/10.1001/archophthalmol.2012.2006","url":null,"abstract":"<p><p>OBJECTIVE To describe the etiology and outcome of patients with simultaneous-onset nongranulomatous bilateral acute anterior uveitis. METHODS The medical records of patients who presented to a single tertiary care center with simultaneous-onset nongranulomatous bilateral acute anterior uveitis between January 1990 and May 2010 were retrospectively reviewed; the clinical presentation, results of diagnostic testing, and outcome data are described. RESULTS A total of 4288 new patients with uveitis were evaluated by the Uveitis Service at the University of Illinois at Chicago Eye and Ear Infirmary between January 1990 and May 2010. Of these new patients, 44 (1%) presented with simultaneous-onset nongranulomatous bilateral acute anterior uveitis. The most common etiologies were postinfectious or drug-induced uveitis (23 of 44 patients [52%]) and idiopathic uveitis (15 patients [34%]). Tubulointerstitial nephritis and uveitis syndrome, HLA-B27-associated uveitis, inflammatory bowel disease, and Kawasaki disease each made up fewer than 5% of diagnoses. Overall, this group of patients was younger than the entire cohort of new patients with uveitis who were evaluated during the same time period (P = .002). For 14 of the 15 patients with at least a year of follow-up (93%), the disease duration was limited (&lt;3 months). Of these 14 patients, 7 (50%) developed recurrent disease, with an average time to first recurrence of 20 months (range, 7.5-40 months) after resolution of the initial inflammatory episode. CONCLUSIONS Simultaneous-onset nongranulomatous bilateral acute anterior uveitis is a rare clinical entity that is more common in younger patients and is most frequently associated with recent infection and/or systemic antibiotic use. Tubulointerstitial nephritis and uveitis syndrome should also be considered as a diagnosis. Diagnostic evaluation should include serum antistreptolysin-O titers, HLA-B27 antigen, and urine β2 microglobulin levels because these may reveal systemic disease that requires therapy.</p>","PeriodicalId":8303,"journal":{"name":"Archives of ophthalmology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2012-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1001/archophthalmol.2012.2006","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"30749273","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 18
Idiopathic pigmented vitreous cyst. 特发性色素玻璃体囊肿。
Archives of ophthalmology Pub Date : 2012-11-01 DOI: 10.1001/archophthalmol.2012.175
Shashank Rai Gupta, Nidhi Gupta, Raj Anand, Sanjay Dhawan
{"title":"Idiopathic pigmented vitreous cyst.","authors":"Shashank Rai Gupta,&nbsp;Nidhi Gupta,&nbsp;Raj Anand,&nbsp;Sanjay Dhawan","doi":"10.1001/archophthalmol.2012.175","DOIUrl":"https://doi.org/10.1001/archophthalmol.2012.175","url":null,"abstract":"","PeriodicalId":8303,"journal":{"name":"Archives of ophthalmology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2012-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1001/archophthalmol.2012.175","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31042820","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 4
Orbital bands in Gomez-Lopez-Hernandez syndrome. 戈麦斯-洛佩斯-埃尔南德斯综合征的眶带。
Archives of ophthalmology Pub Date : 2012-11-01 DOI: 10.1001/archophthalmol.2012.703
Michel J Belliveau, Brian W Arthur
{"title":"Orbital bands in Gomez-Lopez-Hernandez syndrome.","authors":"Michel J Belliveau,&nbsp;Brian W Arthur","doi":"10.1001/archophthalmol.2012.703","DOIUrl":"https://doi.org/10.1001/archophthalmol.2012.703","url":null,"abstract":"O rbital bands are anomalous muscle tissue connections between recti muscles or between a rectus muscle and the globe. Also known as supernumerary extraocular muscles, they have been identified by magnetic resonance imaging in 0.8% of orthotropic and 2.4% of strabismic patients. Gomez-LopezHernandez syndrome (OMIM 601853) is a rare sporadic syndrome reported in only 27 patients worldwide to date. This syndrome, also known as cerebellotrigeminal dermal dysplasia, has not received any attention in the ophthalmic literature. The characteristic triad is rhombencephalosynapsis, trigeminal anesthesia, and bilateral alopecia in the parietal or parieto-occipital regions. Additional features are listed in the Table.","PeriodicalId":8303,"journal":{"name":"Archives of ophthalmology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2012-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1001/archophthalmol.2012.703","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31042821","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Subjective quality of vision before and after cataract surgery. 白内障手术前后主观视力的变化。
Archives of ophthalmology Pub Date : 2012-11-01 DOI: 10.1001/archophthalmol.2012.1603
Eirini Skiadaresi, Colm McAlinden, Konrad Pesudovs, Silvio Polizzi, Jyoti Khadka, Giuseppe Ravalico
{"title":"Subjective quality of vision before and after cataract surgery.","authors":"Eirini Skiadaresi,&nbsp;Colm McAlinden,&nbsp;Konrad Pesudovs,&nbsp;Silvio Polizzi,&nbsp;Jyoti Khadka,&nbsp;Giuseppe Ravalico","doi":"10.1001/archophthalmol.2012.1603","DOIUrl":"https://doi.org/10.1001/archophthalmol.2012.1603","url":null,"abstract":"<p><strong>Objective: </strong>To investigate the effect of cataract surgery on subjective quality of vision.</p><p><strong>Methods: </strong>The Quality of Vision (QoV) questionnaire (Italian translation) was completed before and 3 months after cataract surgery in 4 groups of patients recruited from September through December 2010: first eye with ocular comorbidity, first eye without ocular comorbidity, second eye with ocular comorbidity, and second eye without ocular comorbidity. The questionnaire measures 3 aspects of quality of vision: frequency, severity, and bothersome nature of symptoms. The Lens Opacities Classification System (LOCS) III was used for cataract grading. Friedman and Kruskal-Wallis H tests were performed to compare QoV scores within and between groups. Spearman rank correlations (rs) were calculated to investigate the correlation between LOCS III and QoV symptoms.</p><p><strong>Results: </strong>Two hundred twelve patients (mean [SD] age, 74.2 [8.7] years) were recruited, and 212 eyes were included in the study. Improvements in QoV scores were found in all 4 groups (P < .05). There were no statistically significant (P > .05) differences among the 4 groups in the improvement in QoV scores or in the preoperative or postoperative scores. Blurred vision was correlated with posterior subcapsular cataract (rs = 0.420, P = .04).</p><p><strong>Conclusions: </strong>Cataract in one or both eyes causes a similar loss in subjective quality of vision, which is also irrespective of the presence of ocular comorbidity. Posterior subcapsular cataract causes the specific symptom \"blurred vision.\" Cataract surgery resulted in a large and comparable improvement in subjective quality of vision, regardless of ocular comorbidity and first or second eye surgery.</p>","PeriodicalId":8303,"journal":{"name":"Archives of ophthalmology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2012-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1001/archophthalmol.2012.1603","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31039331","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 54
Cataract blindness. 白内障失明。
Archives of ophthalmology Pub Date : 2012-11-01 DOI: 10.1001/jamaophthalmol.2013.765
Alan L Robin, Ravilla D Thulasiraj
{"title":"Cataract blindness.","authors":"Alan L Robin,&nbsp;Ravilla D Thulasiraj","doi":"10.1001/jamaophthalmol.2013.765","DOIUrl":"https://doi.org/10.1001/jamaophthalmol.2013.765","url":null,"abstract":"","PeriodicalId":8303,"journal":{"name":"Archives of ophthalmology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2012-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1001/jamaophthalmol.2013.765","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31042347","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 10
Eales disease associated with serpiginous choroiditis. 与蛇形脉络膜炎相关的Eales病。
Archives of ophthalmology Pub Date : 2012-11-01 DOI: 10.1001/archophthalmol.2012.683
Adrian T Fung, Massimo Nicolò, Susanne Yzer, Carlo Enrico Traverso, Lawrence A Yannuzzi
{"title":"Eales disease associated with serpiginous choroiditis.","authors":"Adrian T Fung,&nbsp;Massimo Nicolò,&nbsp;Susanne Yzer,&nbsp;Carlo Enrico Traverso,&nbsp;Lawrence A Yannuzzi","doi":"10.1001/archophthalmol.2012.683","DOIUrl":"https://doi.org/10.1001/archophthalmol.2012.683","url":null,"abstract":"Report of a Case. A 49-year-old immunocompetent white man had gradual vision loss in his left eye. Visual acuity was 20/20 OD and 20/100 OS. Anterior segment examination of the left eye demonstrated small, white, central keratic precipitates but no cells or flare. Fundus examination revealed left temporal retinal vascular occlusive disease, arteriolar and venous sheathing, and peripheral retinal ischemia with neovascularization (Figure, A). The right eye was normal. Complete blood cell count, thrombophilia screen, antinuclear antibody, syphilis serology, and QuantiFERON results were normal. An anterior chamber paracentesis was negative for herpes simplex virus, varicella-zoster virus, and cytomegalovirus by polymerase chain reaction. Chest radiograph and tuberculin skin testing results were normal. Eales disease was diagnosed, scatter laser photocoagulation was applied to areas of ischemic retina, and systemic corticosteroids (60 mg/d) and mycophenolate mofetil (1.5 g/d) were prescribed. After 9 months, slowly progressive lobular peripapillary choroiditis (Figure, B), peripheral temporal retinal vascular occlusive disease with vitritis, and keratic precipitates developed in the right eye (Figure, C). Visual acuity remained 20/20. On fluorescein angiography, the area of peripapillary choroiditis revealed hyperfluorescent transmission defect and periphlebitis. Retinal neovascularization was detected at the edge of the capillary closure temporally. Bilateral Eales disease and right serpiginous choroiditis were diagnosed and the ischemic areas were photocoagulated. During the following 7 years, the capillary closure and retinal neovascularization progressed bilaterally, with development of cataract, rubeotic glaucoma, cystoid macular edema, and progressive serpiginous choroiditis with vitritis in the right eye (Figure, D-F). For this reason, bilateral intravitreal bevacizumab and triamcinolone acetonide injections and right intravitreal dexamethasone implants (Ozurdex), peribulbar triamcinolone injections, phacoemulsification with intraocular lens implantation, and pars plana vitrectomy were performed. Polymerase chain reaction results from the vitreous for Mycobacterium tuberculosis, herpes simplex virus, and varicella-zoster virus were negative. Comment. Although tuberculous infection and/or hypersensitivity has been associated with both Eales disease and serpiginous choroiditis, the evidence remains inconclusive. M tuberculosis has been detected by polymerase chain reaction from vitreous biopsies in patients with Eales disease, but the same biopsies were negative for mycobacterial cultures. In patients with systemic tuberculosis, the development of Eales disease is uncommon. A positive QuantiFERON result was detected in 11 of 21 patients with serpiginous-like choroiditis. Choroidal tuberculous lesions mimicking serpiginous choroiditis have been described and named tubercular serpiginous-like choroiditis. Previous authors believe that tubercular se","PeriodicalId":8303,"journal":{"name":"Archives of ophthalmology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2012-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1001/archophthalmol.2012.683","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31042816","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 4
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