Archives of ophthalmology最新文献_第7页

Bilateral ophthalmic artery occlusions due to probable varicella-zoster virus vasculopathy. 可能是水痘-带状疱疹病毒引起的血管病变导致双侧眼动脉闭塞。

Archives of ophthalmology Pub Date : 2012-11-01 DOI: 10.1001/archophthalmol.2012.544

Hari Jayaram, Dinu Stanescu-Segal, Graham E Holder, Elizabeth M Graham

引用次数: 0

Cerebral damage may be the primary risk factor for visual impairment in preschool children born extremely premature. 脑损伤可能是早产儿视力受损的主要危险因素。

Archives of ophthalmology Pub Date : 2012-11-01 DOI: 10.1001/archophthalmol.2012.1393

Carina Slidsborg, Regitze Bangsgaard, Hans Callø Fledelius, Hanne Jensen, Gorm Greisen, Morten la Cour

{"title":"Cerebral damage may be the primary risk factor for visual impairment in preschool children born extremely premature.","authors":"Carina Slidsborg, Regitze Bangsgaard, Hans Callø Fledelius, Hanne Jensen, Gorm Greisen, Morten la Cour","doi":"10.1001/archophthalmol.2012.1393","DOIUrl":"https://doi.org/10.1001/archophthalmol.2012.1393","url":null,"abstract":"OBJECTIVES To investigate the importance of cerebral damage and retinopathy of prematurity (ROP) for visual impairment in preschool children born extremely premature and to determine the primary risk factor of the two. METHODS A clinical follow-up study of a Danish national cohort of children born extremely premature (gestational age, <28 weeks). The study sample consisted of 262 extremely preterm children born between February 13, 2004, and March 23, 2006, of whom 178 children (67.9%) participated. A matched control group consisted of 56 term-born children (gestational age, 37 to <42 weeks). All participants were identified through the National Birth Register and invited to participate in a clinical examination. The children were evaluated with regard to visual acuity, foveal sequelae, and maximum ROP stage and the presence of global developmental deficits (an indicator for cerebral damage) that was measured by the Ages and Stages Questionnaire. RESULTS Global developmental deficits and foveal sequelae occurred more often in extremely preterm children than in term-born control children and increased with ROP severity (χ2 test; P = .11 and P < .001, respectively). Global developmental deficits, moderate to severe foveal abnormality, and ROP treatment were independently associated with visual impairment (P < .05, for better and worse eyes). A stepwise multiple logistic regression for better-eye logarithmic visual acuities of 0.3 or greater (Snellen scale, ≤0.5) yielded an odds ratio of 8.7 (95% CI, 3.0-25.2; P < .001) for global developmental deficit and 6.3 (95% CI, 2.2-18.5; P < .001) for moderate to severe foveal sequelae. CONCLUSION Cerebral damage and ROP are independent risk factors for visual impairment in children born extremely premature, and cerebral damage may be the primary risk factor.","PeriodicalId":8303,"journal":{"name":"Archives of ophthalmology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2012-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1001/archophthalmol.2012.1393","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"30681682","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 22

Improved clinical assessment of a mouse model of retinopathy of prematurity. 改进早产儿视网膜病变小鼠模型的临床评估。

Archives of ophthalmology Pub Date : 2012-11-01 DOI: 10.1001/jamaophthalmol.2013.676

Marco Zarbin

引用次数: 0

Detection rate of pathogenic mutations in ABCA4 using direct sequencing: clinical and research implications. 直接测序ABCA4致病性突变的检出率:临床和研究意义

Archives of ophthalmology Pub Date : 2012-11-01 DOI: 10.1001/archophthalmol.2012.1697

Susan M Downes, Emily Packham, Treena Cranston, Penny Clouston, Anneke Seller, Andrea H Németh

引用次数: 11

Homozygous deletion in CDH3 and hypotrichosis with juvenile macular dystrophy. CDH3纯合子缺失与毛少症伴幼年黄斑营养不良。

Archives of ophthalmology Pub Date : 2012-11-01 DOI: 10.1001/archophthalmol.2012.708

Stephanie Halford, Richard Holt, Andrea H Németh, Susan M Downes

{"title":"Homozygous deletion in CDH3 and hypotrichosis with juvenile macular dystrophy.","authors":"Stephanie Halford, Richard Holt, Andrea H Németh, Susan M Downes","doi":"10.1001/archophthalmol.2012.708","DOIUrl":"https://doi.org/10.1001/archophthalmol.2012.708","url":null,"abstract":"H ypotrichosis associated with juvenile macular dystrophy (HJMD; OMIM 601553) is a rare autosomal recessive disorder characterized by short scalp hair from birth and progressive macular degeneration. Loss of central vision usually occurs between the second and fourth decades of life. Mutations in the P-cadherin gene (CDH3; GenBank NM_001793) were first reported to underlie HJMD by Sprecher et al; splice, missense, and nonsense mutations have since been described. Report of a Case. A 48-year-old man had a 21-year history of deterioration of central vision. The original diagnosis was Stargardt disease. Initial symptoms at age 17 years included photosensitivity, abnormal color vision, and central scotomata. His sister has the same phenotype and the parents were likely to be related. The proband and his sister both gave a history of having very fine, sparse hair that never thickened, with a persistently visible scalp (Figure 1A). Funduscopy in the proband revealed bilateral symmetrical macular degeneration with sparing of the peripheral retina (Figure 1B and C). Visual acuities were 6/760 OD and 6/96 OS. Goldmann visual field testing showed bilateral central scotomata (Figure 1D). Electrophysiology showed extinguished pattern electroretinograms, normal scotopic responses, and significant reduction in amplitudes of both a and b waves in the standard flash electroretinogram and photopic responses. The electro-oculogram light rise was normal in both eyes.","PeriodicalId":8303,"journal":{"name":"Archives of ophthalmology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2012-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1001/archophthalmol.2012.708","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31042818","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 19

Bietti crystalline retinopathy: report of retinal crystal deposition in male adolescent siblings. Bietti晶体视网膜病变:报告视网膜晶体沉积的男性青少年兄弟姐妹。

Archives of ophthalmology Pub Date : 2012-11-01 DOI: 10.1001/archophthalmol.2012.1567

Bita Manzouri, Panagiotis I Sergouniotis, Anthony G Robson, Andrew R Webster, Anthony Moore

引用次数: 18

Relationship Between Fuchs Endothelial Corneal Dystrophy Severity and Glaucoma and/or Ocular Hypertension. 角膜内皮营养不良严重程度与青光眼和/或高眼压的关系

Archives of ophthalmology Pub Date : 2012-11-01 DOI: 10.1001/archophthalmol.2012.1969

Mehul Nagarsheth, Annapurna Singh, Brian Schmotzer, Denise C Babineau, Joel Sugar, W Barry Lee, Sudha K Iyengar, Jonathan H Lass

{"title":"Relationship Between Fuchs Endothelial Corneal Dystrophy Severity and Glaucoma and/or Ocular Hypertension.","authors":"Mehul Nagarsheth, Annapurna Singh, Brian Schmotzer, Denise C Babineau, Joel Sugar, W Barry Lee, Sudha K Iyengar, Jonathan H Lass","doi":"10.1001/archophthalmol.2012.1969","DOIUrl":"https://doi.org/10.1001/archophthalmol.2012.1969","url":null,"abstract":"OBJECTIVE To investigate whether Fuchs endothelial corneal dystrophy (FECD) severity is associated with glaucoma and/or ocular hypertension (G/OHTN). METHODS A subset of eyes (n = 1610) from the FECD Genetics Multi-Center Study were examined to estimate the association between FECD severity (grades 0-6 based on guttae confluence) and G/OHTN. Logistic regression models that accounted for the correlation between eyes and adjusted for age, sex, central corneal thickness, intraocular pressure, presence of diabetes, and time of day of the initial evaluation were fit. RESULTS A total of 107 eyes (6.6%) had G/OHTN based on the study definition. The prevalence of G/OHTN in the control group was 6.0%. The prevalence was lower in index cases with an FECD grade of 1 through 3 and family members with a grade of 0 or 1 through 3 (0.0% and 2.1%, respectively) but higher in index cases and family members with a grade of 4 through 6 (11.2% and 8.5%, respectively). Adjusting for covariates, eyes with a grade of 4 through 6 were more likely to have concurrent G/OHTN than eyes with no FECD (index cases vs controls: odds ratio [OR] = 2.10, P = .04; affected vs unaffected family members: OR = 7.06, P = .07). Age (OR = 1.06 per 1-year increase, P < .001) and intraocular pressure (OR = 1.15 per 1-mm Hg increase, P < .001) were also associated with an increased prevalence of G/OHTN. Sex, diabetes, time of day of evaluation, and central corneal thickness were not associated with the prevalence of G/OHTN (P ≥ .15). CONCLUSIONS Glaucoma and/or ocular hypertension occurs more often in eyes with severe FECD compared with unaffected eyes. Therefore, it may be beneficial to monitor for the development of glaucoma in these patients.","PeriodicalId":8303,"journal":{"name":"Archives of ophthalmology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2012-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1001/archophthalmol.2012.1969","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"30749198","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 16

Relationship Among CFH and ARMS2 Genotypes, Macular Pigment Optical Density, and Neuroretinal Function in Persons Without Age-Related Macular Degeneration. 无年龄相关性黄斑变性者CFH和ARMS2基因型、黄斑色素光密度和神经视网膜功能的关系

Archives of ophthalmology Pub Date : 2012-11-01 DOI: 10.1001/archophthalmol.2012.1940

Beatrix Feigl, C Phillip Morris, Brian Brown, Andrew J Zele

{"title":"Relationship Among CFH and ARMS2 Genotypes, Macular Pigment Optical Density, and Neuroretinal Function in Persons Without Age-Related Macular Degeneration.","authors":"Beatrix Feigl, C Phillip Morris, Brian Brown, Andrew J Zele","doi":"10.1001/archophthalmol.2012.1940","DOIUrl":"https://doi.org/10.1001/archophthalmol.2012.1940","url":null,"abstract":"OBJECTIVES To determine whether there is a difference in neuroretinal function and in macular pigment optical density between persons with high- and low-risk gene variants for age-related macular degeneration (AMD) and no ophthalmoscopic signs of AMD, and to compare the results on neuroretinal function to patients with manifest early AMD. METHODS Neuroretinal function was assessed with the multifocal electroretinogram for 32 participants (22 healthy persons with no AMD and 10 patients with early AMD). The 22 healthy participants with no AMD had either high- or low-risk genotypes for CFH (rs380390) and/or ARMS2 (rs10490924). Trough-to-peak response densities and peak-implicit times were analyzed in 5 concentric rings. Macular pigment optical density was assessed by use of customized heterochromatic flicker photometry. RESULTS Trough-to-peak response densities for concentric rings 1 to 3 were, on average, significantly greater in participants with high-risk genotypes than in participants with low-risk genotypes and in persons with early AMD after correction for age and smoking (P < .05). The group peak-implicit times for ring 1 were, on average, delayed in the patients with early AMD compared with the participants with high- or low-risk genotypes, although these differences were not significant. There was no significant correlation between genotypes and macular pigment optical density. CONCLUSIONS Increased neuroretinal activity in persons who carry high-risk AMD genotypes may be due to genetically determined subclinical inflammatory and/or histological changes in the retina. Neuroretinal function in healthy persons genetically susceptible to AMD may be a useful additional early biomarker (in combination with genetics) of AMD before there is a clinical manifestation.","PeriodicalId":8303,"journal":{"name":"Archives of ophthalmology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2012-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1001/archophthalmol.2012.1940","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"30749453","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 6

Traumatic sinolacrimocutaneous fistula managed with endonasal dacryocystorhinostomy and anterior ethmoidectomy. 外伤性鼻泪口皮瘘经鼻内泪囊鼻腔造口术及前筛切除术治疗。

Archives of ophthalmology Pub Date : 2012-10-01 DOI: 10.1001/archophthalmol.2012.2452

Pari N Shams, Dinesh Selva

引用次数: 2

Iris ring melanoma with extrascleral extension. 虹膜环黑色素瘤伴巩膜外延伸。

Archives of ophthalmology Pub Date : 2012-10-01 DOI: 10.1001/archophthalmol.2012.822

Sherif Khedr, David Lewis, Daniel Albert, Mark Lucarelli, Heather Potter

引用次数: 2