Archives of ophthalmology最新文献_第4页

Eyebrow tissue expansion: an underappreciated entity in thyroid-associated orbitopathy. 眉组织扩张:甲状腺相关眼病中一个未被充分认识的实体。

Archives of ophthalmology Pub Date : 2012-12-01 DOI: 10.1001/archophthalmol.2012.2543

Louis M Savar, Ravi M Menghani, Kelvin K Chong, Helene Chokron Garneau, Robert A Goldberg

{"title":"Eyebrow tissue expansion: an underappreciated entity in thyroid-associated orbitopathy.","authors":"Louis M Savar, Ravi M Menghani, Kelvin K Chong, Helene Chokron Garneau, Robert A Goldberg","doi":"10.1001/archophthalmol.2012.2543","DOIUrl":"https://doi.org/10.1001/archophthalmol.2012.2543","url":null,"abstract":"Objectives: To report photographic evidence of eyebrow tissue expansion in patients with thyroid-associated orbitopathy (TAO) and to demonstrate consistency in grading through the use of standardized photographs.Methods: A retrospective cohort study of patients referred for evaluation of TAO in an orbitofacial tertiary care center between January 1, 2000, and December 31, 2010. A grading key was produced with representative views of each of 4 grades (0 [no expansion] to 3 [severe expansion]), corresponding to increasing severity of eyebrow tissue expansion. Photographs of each study patient, including both premorbid and morbid photographs, were retrieved from an electronic medical record system and graded by 6 independent, masked observers using this 4-point system.Results: Seventy-five patients with TAO were identified for inclusion. The average grade was 0.3 for premorbid eyes and 1.1 for morbid eyes. Intraclass correlation coefficients for the premorbid photographs were 0.705 and 0.632 for the right and left eyes, respectively. Intraclass correlation coefficients for the morbid photographs were 0.921 and 0.916 for the right and left eyes, respectively.Conclusions: Eyebrow tissue expansion is a common manifestation in TAO. Comparison of premorbid and morbid photographs is a useful means to identify and characterize the extent of brow involvement. The use of a grading key improves the consistency of identifying and grading eyebrow tissue expansion. Recognition of the eyebrow tissue as distinct anatomically in TAO may be crucial to rehabilitation of these patients, which may entail multiple surgical procedures.","PeriodicalId":8303,"journal":{"name":"Archives of ophthalmology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2012-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1001/archophthalmol.2012.2543","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31111171","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 10

Thrombophilia in patients with retinoblastoma receiving ophthalmic artery chemosurgery. 接受眼动脉化疗的视网膜母细胞瘤患者的血栓形成。

Archives of ophthalmology Pub Date : 2012-12-01 DOI: 10.1001/archophthalmol.2012.2284

Jasmine H Francis, Y Pierre Gobin, Aaron Nagiel, Ira J Dunkel, Nicole Kucine, Brian P Marr, Scott E Brodie, David H Abramson

{"title":"Thrombophilia in patients with retinoblastoma receiving ophthalmic artery chemosurgery.","authors":"Jasmine H Francis, Y Pierre Gobin, Aaron Nagiel, Ira J Dunkel, Nicole Kucine, Brian P Marr, Scott E Brodie, David H Abramson","doi":"10.1001/archophthalmol.2012.2284","DOIUrl":"https://doi.org/10.1001/archophthalmol.2012.2284","url":null,"abstract":"vea, as in cases 2 and 3 in our series. In addition, on SD-OCT images from case 1, the lesions highly scatter and block OCT signal from penetrating to deeper retinal layers. In cases 2 and 3, conversely, the lesions are finer, are located along a thin portion of the inner fovea, and span the entire foveola. In cases 2 and 3, there is some evidence of partial PVD with vitreofoveal attachment on OCT. Although this OCT appearance occurs as a normal stage of PVD progression, it is possible that the white granules may form secondary to mild, persistent vitreofoveal traction. This is speculation, however, and it remains unclear why the granular opacities form. In summary, we describe SDOCT findings in 3 patients with white dot fovea. In this condition, hyperreflective granular material is visualized in the inner retinal layers of the fovea both clinically as well as on OCT. Darkly pigmented fundi seem to enhance visualization of the white foveal granules. It is unknown what the granules are composed of or what structure of the retina they represent, and further studies are needed to elucidate the pathogenesis, prevalence, and potential risk associations of white dot fovea.","PeriodicalId":8303,"journal":{"name":"Archives of ophthalmology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2012-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1001/archophthalmol.2012.2284","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31111179","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 6

Epidermal growth factor receptor inhibitors for treatment of orbital squamous cell carcinoma. 表皮生长因子受体抑制剂治疗眼眶鳞状细胞癌。

Archives of ophthalmology Pub Date : 2012-12-01 DOI: 10.1001/archophthalmol.2012.2515

Tarek El-Sawy, Anita L Sabichi, Jeffrey N Myers, Merrill S Kies, William N William, Bonnie S Glisson, Scott Lippman, Bita Esmaeli

{"title":"Epidermal growth factor receptor inhibitors for treatment of orbital squamous cell carcinoma.","authors":"Tarek El-Sawy, Anita L Sabichi, Jeffrey N Myers, Merrill S Kies, William N William, Bonnie S Glisson, Scott Lippman, Bita Esmaeli","doi":"10.1001/archophthalmol.2012.2515","DOIUrl":"https://doi.org/10.1001/archophthalmol.2012.2515","url":null,"abstract":"Orbitalandperiorbitalsquamouscell carcinomas (SCCs) are treated with surgicalresectionastheprimarymodality and radiation therapy as adjuvant treatment in patients with perineural invasion or concerns for microscopically positive margins. For advanced cases, extensive surgerysuchasorbitalexenterationmay be needed to fully extirpate the tumor. Orbital exenteration leads to loss of the eye and significant facial disfigurement but has the potential to produce long-term cure. The extensive surgical treatments required for advanced cases of orbital and periorbital SCC entail long periods of general anesthesia and inpatient hospitalization; thus, in patientswithpoorperformancestatus, advanced age, or multiple medical comorbidities, surgery may not be the best option. Several epidermal growth factor receptor(EGFR)inhibitorshaverecently been developed and have shownefficacyintreatmentofnon– small cell lung cancer, pancreatic cancer, colon cancer, and mucosal head and neck squamous cell carcinomas. 1-3 We herein report 2 elderly patients with recurrent advancedorbitalSCCwhoweretreated withEGFRinhibitors—erlotinib,an oral tyrosine kinase inhibitor, and cetuximab,amonoclonalantibody– and had striking initial responses to this treatment. Report of Cases.Case 1. A 90-yearold woman with a history of SCC of the left lateral canthus that had","PeriodicalId":8303,"journal":{"name":"Archives of ophthalmology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2012-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1001/archophthalmol.2012.2515","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31111180","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 37

Nasolacrimal duct obstruction resolution. 鼻泪管阻塞解决。

Archives of ophthalmology Pub Date : 2012-12-01 DOI: 10.1001/archophthalmol.2012.3067

Caroline J Macewen

引用次数: 0

Five-decade profile of women in leadership positions at ophthalmic publications. 五十年来在眼科刊物担任领导职务的女性概况。

Archives of ophthalmology Pub Date : 2012-11-01 DOI: 10.1001/archophthalmol.2012.2300

Ahmad M Mansour, Carol L Shields, Fadi C Maalouf, Vicky A Massoud, Lama Jurdy, Danny G P Mathysen, Dalida Jaafar, Wagih Aclimandos

{"title":"Five-decade profile of women in leadership positions at ophthalmic publications.","authors":"Ahmad M Mansour, Carol L Shields, Fadi C Maalouf, Vicky A Massoud, Lama Jurdy, Danny G P Mathysen, Dalida Jaafar, Wagih Aclimandos","doi":"10.1001/archophthalmol.2012.2300","DOIUrl":"https://doi.org/10.1001/archophthalmol.2012.2300","url":null,"abstract":"Objective: To evaluate the balance between the sexes of published ophthalmic material at the editorial, reviewer, and author levels.Design: Cross-sectional study of 3 journals, American Journal of Ophthalmology, Archives of Ophthalmology, and Ophthalmology, for 1969, 1979, 1989, 1999, and 2009. The data were compared with ophthalmologist-in-training and physician profile in major contributing states from North America and Europe during the same period.Results: Of the 3 major ophthalmology journals, none had a female editor-in-chief. For all journals, the proportion of editorial board members who were women increased from 3.3% in 1969 to 18.8% in 2009. For all journals and all years, women composed a higher proportion of first authors (29.2% in 2009) compared with senior authors (22.9% in 2009), reviewers (18.9% in 2009), or assistant editors (12.5% in 2009). There was an abrupt shift toward women after 1989 in first authorship in Ophthalmology (1969, 4.6%; 1979, 5.4%; 1989, 12.3%; and 1999, 20.2%), Archives of Ophthalmology (1969, 6.6%; 1979, 5.1%; 1989, 15.6%; and 1999, 28.6%), and American Journal of Ophthalmology (1969, 5.6%; 1979, 4.2%; 1989, 9.2%; and 1999, 23.9%). There was also an abrupt increase in female senior authorship for American Journal of Ophthalmology after 1989 (1979, 8.5%; 1989, 8.1%; and 1999, 18.3%). The increase in female first authorship during the 5 decades was parallel with the increase in US female physicians.Conclusions: Women ophthalmologists are authoring publications in increasing numbers that match their prevalence in the academic and overall workforce. However, all editors are men. This discrepancy relates to the relatively younger generation of female ophthalmologists or selection bias, a subject that requires further investigation.","PeriodicalId":8303,"journal":{"name":"Archives of ophthalmology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2012-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1001/archophthalmol.2012.2300","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31042344","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 41

Inhibition of neovascularization but not fibrosis with the fluocinolone acetonide implant in autosomal dominant neovascular inflammatory vitreoretinopathy. 醋酸氟西诺酮在常染色体显性遗传的新血管炎性玻璃体视网膜病变中的抑制新生血管形成而非纤维化作用

Archives of ophthalmology Pub Date : 2012-11-01 DOI: 10.1001/archophthalmol.2012.1971

Paul S Tlucek, James C Folk, Jason A Orien, Edwin M Stone, Vinit B Mahajan

{"title":"Inhibition of neovascularization but not fibrosis with the fluocinolone acetonide implant in autosomal dominant neovascular inflammatory vitreoretinopathy.","authors":"Paul S Tlucek, James C Folk, Jason A Orien, Edwin M Stone, Vinit B Mahajan","doi":"10.1001/archophthalmol.2012.1971","DOIUrl":"https://doi.org/10.1001/archophthalmol.2012.1971","url":null,"abstract":"OBJECTIVE To review the effect of the fluocinolone acetonide implant in subjects with autosomal dominant neovascular inflammatory vitreoretinopathy (ADNIV), an inherited autoimmune uveitis. METHODS A retrospective case series was assembled from patients with ADNIV who received fluocinolone acetonide implants. Visual acuity and features of ADNIV, including inflammatory cells, neovascularization, fibrosis, and cystoid macular edema, were reviewed. RESULTS Nine eyes of 5 related patients with ADNIV with uncontrolled inflammation were reviewed. Follow-up ranged from 21.7 to 56.7 months. Visual acuity at implantation ranged from 20/40 to hand motion. Preoperatively, 8 eyes had vitreous cells (a ninth had diffuse vitreous hemorrhage). Eight eyes had cystoid macular edema, 7 had an epiretinal membrane, and 3 had retinal neovascularization. Following implantation, vitreous cells resolved in all eyes and neovascularization regressed or failed to develop. Central macular thickness improved in 4 eyes. During the postoperative course, however, visual acuity continued to deteriorate, with visual acuity at the most recent examination ranging from 20/60 to no light perception. There was also progressive intraocular fibrosis and phthisis in 1 case. Four eyes underwent cataract surgery. Six of the 7 eyes without previous glaucoma surgery had elevated intraocular pressure at some point, and 3 of these required glaucoma surgery. CONCLUSIONS The fluocinolone acetonide implant may inhibit specific features of ADNIV such as inflammatory cells and neovascularization but does not stabilize long-term vision, retinal thickening, or fibrosis. All eyes in this series required cataract extraction, and more than half required surgical intervention for glaucoma. Further studies may identify additional therapies and any benefit of earlier implantation.","PeriodicalId":8303,"journal":{"name":"Archives of ophthalmology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2012-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1001/archophthalmol.2012.1971","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"30748996","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 17

Projecting the growth of cataract surgery during the next 25 years. 预测未来25年白内障手术的发展。

Archives of ophthalmology Pub Date : 2012-11-01 DOI: 10.1001/archophthalmol.2012.838

Wendy V Hatch, Erica de L Campbell, Chaim M Bell, Sherif R El-Defrawy, Robert J Campbell

引用次数: 45

Error in Author's Name in: Intravitreal Bevacizumab for Peripapillary Choroidal Neovascular Membranes. 作者姓名错误:玻璃体内贝伐单抗治疗乳头周围脉络膜新生血管膜。

Archives of ophthalmology Pub Date : 2012-11-01 DOI: 10.1001/2013.jamaophthalmol.450

引用次数: 0

Chlorpromazine-induced corneal toxicity. 氯丙嗪引起的角膜毒性。

Archives of ophthalmology Pub Date : 2012-11-01 DOI: 10.1001/archophthalmol.2012.475

Victor Koh, Wei-Boon Khor, Li Lim

引用次数: 3

Response to ranibizumab following tachyphylaxis to bevacizumab in a patient with radiation maculopathy following stereotactic fractionated radiotherapy for optic nerve meningioma. 视神经脑膜瘤立体定向分割放疗后放射黄斑病变患者对贝伐单抗快速反应后对雷尼单抗的反应。

Archives of ophthalmology Pub Date : 2012-11-01 DOI: 10.1001/archophthalmol.2012.1542

Gurjeet Jutley, Olajumoke A Shona, Richard Cheong Leen, Nicholas Lee, Jane M Olver, Sheena M George

引用次数: 10