Archives of Pharmacal Research最新文献_第2页

Interplay between YAP/TAZ and metabolic dysfunction-associated steatotic liver disease progression. YAP/TAZ与代谢功能障碍相关脂肪性肝病进展之间的相互作用

IF 6.9 3区医学

Archives of Pharmacal Research Pub Date : 2024-06-01 Epub Date: 2024-06-14 DOI: 10.1007/s12272-024-01501-5

Na Young Lee, Myeung Gi Choi, Eui Jin Lee, Ja Hyun Koo

{"title":"Interplay between YAP/TAZ and metabolic dysfunction-associated steatotic liver disease progression.","authors":"Na Young Lee, Myeung Gi Choi, Eui Jin Lee, Ja Hyun Koo","doi":"10.1007/s12272-024-01501-5","DOIUrl":"10.1007/s12272-024-01501-5","url":null,"abstract":"Metabolic dysfunction-associated steatotic liver disease (MASLD) is becoming an increasingly pressing global health challenge, with increasing mortality rates showing an upward trend. Two million deaths occur annually from cirrhosis and liver cancer together each year. Yes-associated protein (YAP) and transcriptional coactivator with PDZ-binding motif (TAZ), key effectors of the Hippo signaling pathway, critically regulate tissue homeostasis and disease progression in the liver. While initial studies have shown that YAP expression is normally restricted to cholangiocytes in healthy livers, the activation of YAP/TAZ is observed in other hepatic cells during chronic liver disease. The disease-driven dysregulation of YAP/TAZ appears to be a critical element in the MASLD progression, contributing to hepatocyte dysfunction, inflammation, and fibrosis. In this study, we focused on the complex roles of YAP/TAZ in MASLD and explored how the YAP/TAZ dysregulation of YAP/TAZ drives steatosis, inflammation, fibrosis, and cirrhosis. Finally, the cell-type-specific functions of YAP/TAZ in different types of hepatic cells, such as hepatocytes, hepatic stellate cells, hepatic macrophages, and biliary epithelial cells are discussed, highlighting the multifaceted impact of YAP/TAZ on liver physiology and pathology.","PeriodicalId":8287,"journal":{"name":"Archives of Pharmacal Research","volume":null,"pages":null},"PeriodicalIF":6.9,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11217110/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141316670","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Challenges and opportunities of developing small-molecule therapies for age-related macular degeneration. 开发老年性黄斑变性小分子疗法的挑战与机遇。

IF 6.9 3区医学

Archives of Pharmacal Research Pub Date : 2024-06-01 Epub Date: 2024-06-20 DOI: 10.1007/s12272-024-01503-3

Xiang Fei, Sooyun Jung, Sangil Kwon, Jiweon Kim, Timothy W Corson, Seung-Yong Seo

{"title":"Challenges and opportunities of developing small-molecule therapies for age-related macular degeneration.","authors":"Xiang Fei, Sooyun Jung, Sangil Kwon, Jiweon Kim, Timothy W Corson, Seung-Yong Seo","doi":"10.1007/s12272-024-01503-3","DOIUrl":"10.1007/s12272-024-01503-3","url":null,"abstract":"Age-related macular degeneration (AMD) is the leading cause of vision loss in senior adults. The disease can be categorized into two types: wet AMD and dry AMD. Wet AMD, also known as exudative or neovascular AMD, is less common but more severe than dry AMD and is responsible for 90% of the visual impairment caused by AMD and affects 20 million people worldwide. Current treatment options mainly involve biologics that inhibit the vascular endothelial growth factor or complement pathways. However, these treatments have limitations such as high cost, injection-related risks, and limited efficacy. Therefore, new therapeutic targets and strategies have been explored to improve the outcomes of patients with AMD. A promising approach is the use of small-molecule drugs that modulate different factors involved in AMD pathogenesis, such as tyrosine kinases and integrins. Small-molecule drugs offer advantages, such as oral administration, low cost, good penetration, and increased specificity for the treatment of wet and dry AMD. This review summarizes the current status and prospects of small-molecule drugs for the treatment of wet AMD. These advances are expected to support the development of effective and targeted treatments for patients with AMD.","PeriodicalId":8287,"journal":{"name":"Archives of Pharmacal Research","volume":null,"pages":null},"PeriodicalIF":6.9,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141431232","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Antibacterial properties of natural products from marine fungi reported between 2012 and 2023: a review. 2012 年至 2023 年间报道的海洋真菌天然产品的抗菌特性：综述。

IF 6.9 3区医学

Archives of Pharmacal Research Pub Date : 2024-06-01 Epub Date: 2024-06-08 DOI: 10.1007/s12272-024-01500-6

Ping Wang, Xiaomei Huang, Chenyuan Jiang, Rushuang Yang, Jialing Wu, Yinghui Liu, Shuangshuang Feng, Tingting Wang

{"title":"Antibacterial properties of natural products from marine fungi reported between 2012 and 2023: a review.","authors":"Ping Wang, Xiaomei Huang, Chenyuan Jiang, Rushuang Yang, Jialing Wu, Yinghui Liu, Shuangshuang Feng, Tingting Wang","doi":"10.1007/s12272-024-01500-6","DOIUrl":"10.1007/s12272-024-01500-6","url":null,"abstract":"The oceans are rich in diverse microorganisms, animals, and plants. This vast biological complexity is a major source of unique secondary metabolites. In particular, marine fungi are a promising source of compounds with unique structures and potent antibacterial properties. Over the last decade, substantial progress has been made to identify these valuable antibacterial agents. This review summarizes the chemical structures and antibacterial activities of 223 compounds identified between 2012 and 2023. These compounds, effective against various bacteria including drug-resistant strains such as methicillin-resistant Staphylococcus aureus, exhibit strong potential as antibacterial therapeutics. The review also highlights the relevant challenges in transitioning from drug discovery to product commercialization. Emerging technologies such as metagenomics and synthetic biology are proposed as viable solutions. This paper sets the stage for further research on antibacterial compounds derived from marine fungi and advocates a multidisciplinary approach to combat drug-resistant bacteria.","PeriodicalId":8287,"journal":{"name":"Archives of Pharmacal Research","volume":null,"pages":null},"PeriodicalIF":6.9,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141293095","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Continuous TNF-α exposure in mammary epithelial cells promotes cancer phenotype acquisition via EGFR/TNFR2 activation. 乳腺上皮细胞持续暴露于 TNF-α 可通过表皮生长因子受体/表皮生长因子受体 2 的激活促进癌症表型的获得。

IF 6.7 3区医学

Archives of Pharmacal Research Pub Date : 2024-05-01 Epub Date: 2024-05-11 DOI: 10.1007/s12272-024-01497-y

Jin-Hee Lee, Steffanus Pranoto Hallis, Mi-Kyoung Kwak

{"title":"Continuous TNF-α exposure in mammary epithelial cells promotes cancer phenotype acquisition via EGFR/TNFR2 activation.","authors":"Jin-Hee Lee, Steffanus Pranoto Hallis, Mi-Kyoung Kwak","doi":"10.1007/s12272-024-01497-y","DOIUrl":"10.1007/s12272-024-01497-y","url":null,"abstract":"Tumor necrosis factor alpha (TNF-α), an abundant inflammatory cytokine in the tumor microenvironment (TME), is linked to breast cancer growth and metastasis. In this study, we established MCF10A cell lines incubated with TNF-α to investigate the effects of continuous TNF-α exposure on the phenotypic change of normal mammary epithelial cells. The established MCF10A-LE cell line, through long-term exposure to TNF-α, displayed cancer-like features, including increased proliferation, migration, and sustained survival signaling even in the absence of TNF-α stimulation. Unlike the short-term exposed cell line MCF10A-SE, MCF10A-LE exhibited elevated levels of epidermal growth factor receptor (EGFR) and subsequent TNF receptor 2 (TNFR2), and silencing of EGFR or TNFR2 suppressed the cancer-like phenotype of MCF10A-LE. Notably, we demonstrated that the elevated levels of NAD(P)H oxidase 4 (NOX4) and the resulting increase in reactive oxygen species (ROS) were associated with EGFR/TNFR2 elevation in MCF10A-LE. Furthermore, mammosphere-forming capacity and the expression of cancer stem cell (CSC) markers increased in MCF10A-LE. Silencing of EGFR reversed these effects, indicating the acquisition of CSC-like properties via EGFR signaling. In conclusion, our results reveal that continuous TNF-α exposure activates the EGFR/TNFR2 signaling pathway via the NOX4/ROS axis, promoting neoplastic changes in mammary epithelial cells within the inflammatory TME.","PeriodicalId":8287,"journal":{"name":"Archives of Pharmacal Research","volume":null,"pages":null},"PeriodicalIF":6.7,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140907907","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Potential of natural products in inflammation: biological activities, structure-activity relationships, and mechanistic targets. 天然产品在炎症中的潜力：生物活性、结构-活性关系和机理目标。

IF 6.9 3区医学

Archives of Pharmacal Research Pub Date : 2024-05-01 Epub Date: 2024-05-13 DOI: 10.1007/s12272-024-01496-z

Yajing Guo, Xuling Peng, Fanfei Liu, Qi Zhang, Liqin Ding, Gen Li, Feng Qiu

{"title":"Potential of natural products in inflammation: biological activities, structure-activity relationships, and mechanistic targets.","authors":"Yajing Guo, Xuling Peng, Fanfei Liu, Qi Zhang, Liqin Ding, Gen Li, Feng Qiu","doi":"10.1007/s12272-024-01496-z","DOIUrl":"10.1007/s12272-024-01496-z","url":null,"abstract":"A balance between the development and suppression of inflammation can always be found in the body. When this balance is disturbed, a strong inflammatory response can damage the body. It sometimes is necessary to use drugs with a significant anti-inflammatory effect, such as nonsteroidal anti-inflammatory drugs and steroid hormones, to control inflammation in the body. However, the existing anti-inflammatory drugs have many adverse effects, which can be deadly in severe cases, making research into new safer and more effective anti-inflammatory drugs necessary. Currently, numerous types of natural products with anti-inflammatory activity and distinct structural features are available, and these natural products have great potential for the development of novel anti-inflammatory drugs. This review summarizes 260 natural products and their derivatives with anti-inflammatory activities in the last two decades, classified by their active ingredients, and focuses on their structure-activity relationships in anti-inflammation to lay the foundation for subsequent new drug development. We also elucidate the mechanisms and pathways of natural products that exert anti-inflammatory effects via network pharmacology predictions, providing direction for identifying subsequent targets of anti-inflammatory natural products.","PeriodicalId":8287,"journal":{"name":"Archives of Pharmacal Research","volume":null,"pages":null},"PeriodicalIF":6.9,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140911371","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Phytochemical and pharmacological properties of the genus Tamarix: a comprehensive review. 柽柳属的植物化学和药理特性：全面综述。

IF 6.9 3区医学

Archives of Pharmacal Research Pub Date : 2024-05-01 Epub Date: 2024-05-15 DOI: 10.1007/s12272-024-01498-x

Fangjie Li, Wenli Xie, Xianrui Ding, Kuo Xu, Xianjun Fu

{"title":"Phytochemical and pharmacological properties of the genus Tamarix: a comprehensive review.","authors":"Fangjie Li, Wenli Xie, Xianrui Ding, Kuo Xu, Xianjun Fu","doi":"10.1007/s12272-024-01498-x","DOIUrl":"10.1007/s12272-024-01498-x","url":null,"abstract":"The genus Tamarix in the Tamaricaceae family consists of more than 100 species of halophyte plants worldwide that are mainly used to improve saline-alkali land and for coastal windbreaks, sand fixation, and afforestation in arid areas. A considerable number of species in this genus are also used as traditional medicines to treat various human diseases, especially in Asian and African countries. This review presents a comprehensive summary of 655 naturally occurring compounds derived from the genus Tamarix, categorized into flavonoids (18.0%), phenols (13.9%), tannins (9.3%), terpenoids (10.5%), essential oils (31.0%), and others (17.3%). The investigation revealed that the crude extracts and phytochemicals of this genus exhibited significant therapeutic potential, including anti-inflammatory, anti-Alzheimer, anticancer, antidiabetic, antibacterial, and antifungal activities. Six species of Tamarix have anticancer effects by causing cancer cell death, inducing autophagy, and stopping cell division. Seven species from the same genus have the potential for treating diabetes by inhibiting α-glycosidase activity, suppressing human islet amyloid polypeptide, regulating blood glucose levels, and modulating autophagy or inflammation. The focus on antibacterial and antidiabetic effects is due to the presence of volatile oil and flavonoid components. Extensive research has been conducted on the biological activity of 30 constituents, including 15 flavonoids, 5 phenols, 3 terpenoids, 1 tannin, and 6 others. Therefore, future research should thoroughly study the mechanisms of action of these and similar compounds. This is the most comprehensive review of the phytochemistry and pharmacological properties of Tamarix species, with a critical assessment of the current state of knowledge.","PeriodicalId":8287,"journal":{"name":"Archives of Pharmacal Research","volume":null,"pages":null},"PeriodicalIF":6.9,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140943971","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

PBPK modeling to predict the pharmacokinetics of venlafaxine and its active metabolite in different CYP2D6 genotypes and drug-drug interactions with clarithromycin and paroxetine. 通过 PBPK 模型预测文拉法辛及其活性代谢物在不同 CYP2D6 基因型中的药代动力学，以及与克拉霉素和帕罗西汀的药物相互作用。

IF 6.7 3区医学

Archives of Pharmacal Research Pub Date : 2024-04-25 DOI: 10.1007/s12272-024-01495-0

Chang-Keun Cho, Pureum Kang, C. Jang, Seok-Yong Lee, Yun Jeong Lee, Jung-Woo Bae, Chang-ik Choi

引用次数: 0

Combination therapy involving HSP90 inhibitors for combating cancer: an overview of clinical and preclinical progress 涉及 HSP90 抑制剂的抗癌联合疗法：临床和临床前进展综述

IF 6.7 3区医学

Archives of Pharmacal Research Pub Date : 2024-04-17 DOI: 10.1007/s12272-024-01494-1

Yajun Liu, Chenyao Li, Hongwei Liu, Shutao Tan

{"title":"Combination therapy involving HSP90 inhibitors for combating cancer: an overview of clinical and preclinical progress","authors":"Yajun Liu, Chenyao Li, Hongwei Liu, Shutao Tan","doi":"10.1007/s12272-024-01494-1","DOIUrl":"https://doi.org/10.1007/s12272-024-01494-1","url":null,"abstract":"The molecular chaperone heat shock protein 90 (HSP90) regulates multiple crucial signalling pathways in cancer by driving the maturation of key signalling components, thereby playing a crucial role in tumorigenesis and drug resistance in cancer. Inhibition of HSP90 results in metastable conformational collapse of its client proteins and their proteasomal degradation. Considerable efforts have been devoted to the development of small-molecule inhibitors targeting HSP90, and more than 20 inhibitors have been evaluated in clinical trials for cancer therapy. However, owing to disadvantages such as organ toxicity and drug resistance, only one HSP90 inhibitor has been approved for use in clinical settings. In recent years, HSP90 inhibitors used in combination with other anti-cancer therapies have shown remarkable potential in the treatment of cancer. HSP90 inhibitors work synergistically with various anti-cancer therapies, including chemotherapy, targeted therapy, radiation therapy and immunotherapy. HSP90 inhibitors can improve the pharmacological effects of the above-mentioned therapies and reduce treatment resistance. This review provides an overview of the use of combination therapy with HSP90 inhibitors and other anti-cancer therapies in clinical and preclinical studies reported in the past decade and summarises design strategies and prospects for these combination therapies. Altogether, this review provides a theoretical basis for further research and application of these combination therapies in the treatment of cancer.","PeriodicalId":8287,"journal":{"name":"Archives of Pharmacal Research","volume":null,"pages":null},"PeriodicalIF":6.7,"publicationDate":"2024-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140611385","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Advances in sarcopenia: mechanisms, therapeutic targets, and intervention strategies 肌肉疏松症的研究进展：机制、治疗目标和干预策略

IF 6.7 3区医学

Archives of Pharmacal Research Pub Date : 2024-04-09 DOI: 10.1007/s12272-024-01493-2

Youle Zheng, Jin Feng, Yixin Yu, Min Ling, Xu Wang

引用次数: 0

TNF receptor 2 knockout mouse had reduced lung cancer growth and schizophrenia-like behavior through a decrease in TrkB-dependent BDNF level TNF 受体 2 基因敲除小鼠通过降低 TrkB 依赖性 BDNF 水平，减少了肺癌生长和类似精神分裂症的行为

IF 6.7 3区医学

Archives of Pharmacal Research Pub Date : 2024-04-09 DOI: 10.1007/s12272-024-01487-0

In Jun Yeo, Ji Eun Yu, Sung-Hyun Kim, Dae Hwan Kim, Miran Jo, Dong Ju Son, Jaesuk Yun, Sang-Bae Han, Jin Tae Hong

{"title":"TNF receptor 2 knockout mouse had reduced lung cancer growth and schizophrenia-like behavior through a decrease in TrkB-dependent BDNF level","authors":"In Jun Yeo, Ji Eun Yu, Sung-Hyun Kim, Dae Hwan Kim, Miran Jo, Dong Ju Son, Jaesuk Yun, Sang-Bae Han, Jin Tae Hong","doi":"10.1007/s12272-024-01487-0","DOIUrl":"https://doi.org/10.1007/s12272-024-01487-0","url":null,"abstract":"The relationship between schizophrenia (SCZ) and cancer development remains controversial. Based on the disease-gene association platform, it has been revealed that tumor necrosis factor receptor (TNFR) could be an important mediatory factor in both cancer and SCZ development. TNF-α also increases the expression of brain-derived neurotrophic factor (BDNF) and tropomyosin receptor kinase B (TrkB) in the development of SCZ and tumor, but the role of TNFR in mediating the association between the two diseases remains unclear. We studied the vital roles of TNFR2 in the progression of tumor and SCZ-like behavior using A549 lung cancer cell xenografted TNFR2 knockout mice. TNFR2 knockout mice showed significantly decreased tumor size and weight as well as schizophrenia-like behaviors compared to wild-type mice. Consistent with the reduced tumor growth and SCZ-like behaviors, the levels of TrkB and BDNF expression were significantly decreased in the lung tumor tissues and pre-frontal cortex of TNFR2 knockout mice. However, intravenous injection of BDNF (160 μg/kg) to TNFR2 knockout mice for 4 weeks increased tumor growth and SCZ-like behaviors as well as TrkB expression. In in vitro study, significantly decreased cell growth and expression of TrkB and BDNF by siTNFR2 transfection were found in A549 lung cancer cells. However, the addition of BDNF (100 ng/ml) into TNFR2 siRNA transfected A549 lung cancer cells recovered cell growth and the expression of TrkB. These results suggest that TNFR2 could be an important factor in mediating the comorbidity between lung tumor growth and SCZ development through increased TrkB-dependent BDNF levels.","PeriodicalId":8287,"journal":{"name":"Archives of Pharmacal Research","volume":null,"pages":null},"PeriodicalIF":6.7,"publicationDate":"2024-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140572464","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0