Archives of Pharmacal Research最新文献_第10页

Non-alcoholic fatty liver disease and liver secretome 非酒精性脂肪性肝病与肝脏分泌组

IF 6.7 3区医学

Archives of Pharmacal Research Pub Date : 2022-11-28 DOI: 10.1007/s12272-022-01419-w

Muhammad Sohaib Khan, Choongho Lee, Sang Geon Kim

{"title":"Non-alcoholic fatty liver disease and liver secretome","authors":"Muhammad Sohaib Khan, Choongho Lee, Sang Geon Kim","doi":"10.1007/s12272-022-01419-w","DOIUrl":"10.1007/s12272-022-01419-w","url":null,"abstract":"<div><p>Metabolism of carbohydrates and lipids and protein degradation occurs in the liver and contributes to the body's homeostasis by secreting a variety of mediators. Any imbalance in this homeostasis due to excess fat consumption and the pathologic events accompanying lipotoxicity, autophagy dysregulation, endoplasmic reticulum stress, and insulin resistance may cause disturbances in the secretion of the proteins from the liver and their physiologic modifications and interactions with others. Since the liver secretome plays a role in the regulation of fuel metabolism and inflammation not only in the liver per se but also in other organs, the proteins belong to the utmost targets for treating metabolic and inflammatory diseases (e.g., COVID-19), depending on the available and feasible approaches to controlling their biological effects. However, in this era, we still come across new liver-derived proteins but are yet unable to entirely understand the pathologic basis underlying disease progression. This review aims to provide an updated overview of liver secretome biology with explanatory mechanisms with regard to the progression of metabolic and inflammatory liver diseases.</p></div>","PeriodicalId":8287,"journal":{"name":"Archives of Pharmacal Research","volume":null,"pages":null},"PeriodicalIF":6.7,"publicationDate":"2022-11-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s12272-022-01419-w.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10747603","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Neurological disorders of COVID-19: insights to applications of natural products from plants and microorganisms 2019冠状病毒病神经系统疾病:植物和微生物天然产物应用的见解

IF 6.7 3区医学

Archives of Pharmacal Research Pub Date : 2022-11-28 DOI: 10.1007/s12272-022-01420-3

Faezeh Almasi, Wen Dang, Fatemeh Mohammadipanah, Ning Li

{"title":"Neurological disorders of COVID-19: insights to applications of natural products from plants and microorganisms","authors":"Faezeh Almasi, Wen Dang, Fatemeh Mohammadipanah, Ning Li","doi":"10.1007/s12272-022-01420-3","DOIUrl":"10.1007/s12272-022-01420-3","url":null,"abstract":"<div><p>In addition to the typical respiratory manifestations, various disorders including involvement of the nerve system have been detected in COVID-19 ranging from 22 to 36%. Although growing records are focusing on neurological aspects of COVID-19, the pathophysiological mechanisms and related therapeutic methods remain obscure. Considering the increased concerns of SARS-CoV-2 potential for more serious neuroinvasion conditions, the present review attempts to focus on the neuroprotective effects of natural compounds as the principle source of therapeutics inhibiting multiple steps of the SARS-CoV-2 infection cycle. The great majority of the natural products with anti-SARS-CoV-2 activity mainly inhibit the attachment, entry and gene expression rather than the replication, assembly, or release. Although microbial-derived natural products comprise 38.5% of the known natural products with neuroprotective effects following viral infection, the neuroprotective potential of the majority of microorganisms is still undiscovered. Among natural products, chrysin, huperzine A, ginsenoside Rg1, pterostilbene, and terrein have shown potent in vitro neuroprotective activity and can be promising for new or repurpose drugs for neurological complications of SARS-CoV-2.</p></div>","PeriodicalId":8287,"journal":{"name":"Archives of Pharmacal Research","volume":null,"pages":null},"PeriodicalIF":6.7,"publicationDate":"2022-11-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s12272-022-01420-3.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10747604","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Effects of phytoestrogens on reproductive organ health 植物雌激素对生殖器官健康的影响

IF 6.7 3区医学

Archives of Pharmacal Research Pub Date : 2022-11-28 DOI: 10.1007/s12272-022-01417-y

S. Swathi Krishna, Beena Briget Kuriakose, P. K. Lakshmi

引用次数: 8

Scope and challenges of nanoparticle-based mRNA delivery in cancer treatment 基于纳米颗粒的mRNA递送在癌症治疗中的范围和挑战

IF 6.7 3区医学

Archives of Pharmacal Research Pub Date : 2022-11-24 DOI: 10.1007/s12272-022-01418-x

Md. Emranul Karim, Sheikh Tanzina Haque, Hamed Al-Busaidi, Athirah Bakhtiar, Kyi Kyi Tha, Mark M. Banaszak Holl, Ezharul Hoque Chowdhury

{"title":"Scope and challenges of nanoparticle-based mRNA delivery in cancer treatment","authors":"Md. Emranul Karim, Sheikh Tanzina Haque, Hamed Al-Busaidi, Athirah Bakhtiar, Kyi Kyi Tha, Mark M. Banaszak Holl, Ezharul Hoque Chowdhury","doi":"10.1007/s12272-022-01418-x","DOIUrl":"10.1007/s12272-022-01418-x","url":null,"abstract":"<div><p>Messenger RNA (mRNA) recently emerged as an appealing alternative to treat and prevent diseases ranging from cancer and Alzheimer’s disease to COVID-19 with significant clinical outputs. The in vitro-transcribed mRNA has been engineered to mimic the structure of natural mRNA for vaccination, cancer immunotherapy and protein replacement therapy. In past decades, significant progress has been noticed in unveiling the molecular pathways of mRNA, controlling its translatability and stability, and its evolutionary defense mechanism. However, numerous unsolved structural, biological, and technical difficulties hamper the successful implementation of systemic delivery of mRNA for safer human consumption. Advances in designing and manufacturing mRNA and selecting innovative delivery vehicles are mandatory to address the unresolved issues and achieve the full potential of mRNA drugs. Despite the substantial efforts made to improve the intracellular delivery of mRNA drugs, challenges associated with diverse applications in different routes still exist. This study examines the current progress of mRNA therapeutics and advancements in designing biomaterials and delivery strategies, the existing translational challenges of clinical tractability and the prospects of overcoming any challenges related to mRNA.</p></div>","PeriodicalId":8287,"journal":{"name":"Archives of Pharmacal Research","volume":null,"pages":null},"PeriodicalIF":6.7,"publicationDate":"2022-11-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s12272-022-01418-x.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10402808","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 8

6′-Sialylactose abolished lipopolysaccharide-induced inflammation and hyper-permeability in endothelial cells 6′-唾液酰基乳糖可消除脂多糖诱导的内皮细胞炎症和高通透性

IF 6.7 3区医学

Archives of Pharmacal Research Pub Date : 2022-11-19 DOI: 10.1007/s12272-022-01415-0

Dung Van Nguyen, Thuy Le Lam Nguyen, Yujin Jin, Lila Kim, Chang-Seon Myung, Kyung-Sun Heo

{"title":"6′-Sialylactose abolished lipopolysaccharide-induced inflammation and hyper-permeability in endothelial cells","authors":"Dung Van Nguyen, Thuy Le Lam Nguyen, Yujin Jin, Lila Kim, Chang-Seon Myung, Kyung-Sun Heo","doi":"10.1007/s12272-022-01415-0","DOIUrl":"10.1007/s12272-022-01415-0","url":null,"abstract":"<div><p>\u0000Disruption of the endothelial barrier function and reduction in cell migration leads to endothelial dysfunction. One of the most abundant human milk oligosaccharides, 6′-sialylactose (6′-SL), is reported to exert various biological functions related to inflammatory responses. In this study, we evaluated the effects of 6′-SL on lipopolysaccharide (LPS)-induced inflammation caused by endothelial barrier damage. Our results showed that LPS at 500 ng/mL strongly not only abolished cell migration but also hyperactivated MAPK and NF-κB pathways. 6′-SL suppressed LPS-induced endothelial inflammation via ERK1/2, p38, and JNK MAPK pathways. 6′-SL supported endothelial junctions by upregulating PECAM-1 expression and mRNA levels of tight junctions, such as ZO-1 and occludin, which were downregulated by LPS stimulation. It significantly inhibited the nuclear translocation of NF-κB, along with the downregulation of inflammatory cytokines, including TNF-α, IL-1β, MCP-1, VCAM-1, and ICAM-1. Furthermore, 6′-SL abolished NF-κB-mediated STAT3 in controlling endothelial migration and hyperpermeability via downregulating STAT3 activation and nuclear translocation. Finally, LPS induced over-expression of VCAM-1 and ZO-1 disassembly in both atheroprone and atheroprotective areas of mouse aorta, which were reversed by 6′-SL treatment. Altogether, our findings suggest that 6′-SL is a potent therapeutic agent for modulating inflammatory responses and endothelial hyperpermeability.</p></div>","PeriodicalId":8287,"journal":{"name":"Archives of Pharmacal Research","volume":null,"pages":null},"PeriodicalIF":6.7,"publicationDate":"2022-11-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40695784","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Comparative evaluation of bioactive phytochemicals in Spinacia oleracea cultivated under greenhouse and open field conditions 温室栽培与露天栽培皂荚植物活性化学物质的比较评价

IF 6.7 3区医学

Archives of Pharmacal Research Pub Date : 2022-11-19 DOI: 10.1007/s12272-022-01416-z

Bum Soo Lee, Hae Min So, Sil Kim, Jung Kyu Kim, Jin-Chul Kim, Dong-Min Kang, Mi-Jeong Ahn, Yoon-Joo Ko, Ki Hyun Kim

{"title":"Comparative evaluation of bioactive phytochemicals in Spinacia oleracea cultivated under greenhouse and open field conditions","authors":"Bum Soo Lee, Hae Min So, Sil Kim, Jung Kyu Kim, Jin-Chul Kim, Dong-Min Kang, Mi-Jeong Ahn, Yoon-Joo Ko, Ki Hyun Kim","doi":"10.1007/s12272-022-01416-z","DOIUrl":"10.1007/s12272-022-01416-z","url":null,"abstract":"<div><p>Various factors related to growing conditions can influence the nutritional quality of plants, including vegetable crops, especially the contents of health-promoting phytochemicals. In this study, the phytochemical contents of spinach (<i>Spinacia oleracea</i>) cultivated under greenhouse and open field conditions were comparatively analyzed using a metabolomic approach with Mass Profiler Professional (MPP) software. <i>S. oleracea</i>, which is one of the well-known leafy vegetables belonging to the family Chenopodiaceae, is cultivated worldwide. Although the nutritional value of spinach is high, the phytochemical contents of spinach cultivated under greenhouse and open field conditions have not been comparatively analyzed. Metabolomic analysis of the methanol (MeOH) extracts of greenhouse-cultivated spinach (GS) and open field-cultivated spinach (OFS) using ultra-high performance liquid chromatography-quadrupole time-of-flight mass spectrometry (UPLC-Q-TOF-MS), followed by principal component analysis (PCA) with MPP demonstrated the differential metabolite profiles of GS and OFS. The active compounds <b>1–3</b> were isolated and identified using LC-Q-TOF-MS-guided fractionation. Among these, 5,3',4'-trihydroxy-3-methoxy-6,7-methylenedioxyflavone 4'-glucuronide (2) exhibited growth-inhibitory activities against <i>Helicobacter pylori</i> 51. Distribution analysis of compound <b>2</b> revealed that the anti-<i>H. pylori</i> compound <b>2</b> is an OFS-specific bioactive phytochemical. This indicates that the phytochemical quality of OFS is better than that of GS. These findings will aid in providing vital data for vegetable processors, dieticians, nutritionists, and consumers to select optimal green leafy vegetables.</p></div>","PeriodicalId":8287,"journal":{"name":"Archives of Pharmacal Research","volume":null,"pages":null},"PeriodicalIF":6.7,"publicationDate":"2022-11-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40695785","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 12

New tricyclic systems as photosensitizers towards triple negative breast cancer cells 新的三环系统作为三阴性乳腺癌细胞的光敏剂

IF 6.7 3区医学

Archives of Pharmacal Research Pub Date : 2022-11-18 DOI: 10.1007/s12272-022-01414-1

Marilia Barreca, Angela Maria Ingarra, Maria Valeria Raimondi, Virginia Spanò, Antonio Palumbo Piccionello, Michele De Franco, Luca Menilli, Valentina Gandin, Giorgia Miolo, Paola Barraja, Alessandra Montalbano

{"title":"New tricyclic systems as photosensitizers towards triple negative breast cancer cells","authors":"Marilia Barreca, Angela Maria Ingarra, Maria Valeria Raimondi, Virginia Spanò, Antonio Palumbo Piccionello, Michele De Franco, Luca Menilli, Valentina Gandin, Giorgia Miolo, Paola Barraja, Alessandra Montalbano","doi":"10.1007/s12272-022-01414-1","DOIUrl":"10.1007/s12272-022-01414-1","url":null,"abstract":"<div><p>Nineteen pyrrolo[1,2-<i>h</i>][1,7]naphthyridinones and pyrido[2,3-<i>c</i>]pyrrolo[1,2-<i>a</i>]azepinones were synthesized as new tricyclic systems in which the pyridine ring is annelated to the 6,7-dihydroindolizin-8(5<i>H</i>)-one and 5,6,7,8-tetrahydro-9<i>H</i>-pyrrole[1,2-<i>a</i>]azepine-9-one moieties to obtain potential photosensitizing agents. They were tested for their photoantiproliferative activity on a triple-negative breast cancer cell line, MDA-MB-231, in the dark and under UVA light (2.0 J/cm<sup>2</sup>). We demonstrated that their toxicity, only when exposed to light, was primarily due to the generation of reactive oxygen species while their photodegradation products were not responsible for their activity. The most active compounds exhibited photocytotoxicity with IC<sub>50</sub> values at low micromolar level inducing a decrease in the intracellular content of thiol, thus triggering cancer cell death through apoptosis. All the pyridone derivatives revealed to be pure photosensitizers with preferential photocytotoxic activity towards cancerous over healthy cells. Altogether, the results obtained confirm pyrrolo[1,2-<i>h</i>][1,7]naphthyridinones and pyrido[2,3-<i>c</i>]pyrrolo[1,2-<i>a</i>]azepinones as promising photosensitisers against triple-negative breast cancer.\u0000</p></div>","PeriodicalId":8287,"journal":{"name":"Archives of Pharmacal Research","volume":null,"pages":null},"PeriodicalIF":6.7,"publicationDate":"2022-11-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s12272-022-01414-1.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40696213","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 16

Mouse models of nonalcoholic steatohepatitis and their application to new drug development 非酒精性脂肪性肝炎小鼠模型及其在新药开发中的应用

IF 6.7 3区医学

Archives of Pharmacal Research Pub Date : 2022-11-01 DOI: 10.1007/s12272-022-01410-5

Hieu Huy Phung, Chang Hoon Lee

{"title":"Mouse models of nonalcoholic steatohepatitis and their application to new drug development","authors":"Hieu Huy Phung, Chang Hoon Lee","doi":"10.1007/s12272-022-01410-5","DOIUrl":"10.1007/s12272-022-01410-5","url":null,"abstract":"<div><p>Nonalcoholic steatohepatitis (NASH) is one of the important liver diseases currently attracting attention in liver research and drug development. Appropriate mouse models should be used to identify the mechanisms underlying the pathogenesis and progression of NASH in humans and to evaluate the efficacy of anti-NASH agents under development to treat this disease. In this review, we first summarised recent histopathology and pathogenesis of NASH in humans, including the concept of resolution of inflammation. We also examined whether these characteristics of NASH in humans are adequately reflected in mouse models. Through this review, we identified the usefulness and limitations of mouse models widely used in research on NASH. Mouse models can be divided into three main types: diet models, chemical models using toxic compounds, and genetic models using genetically transgenic mice. Genotype models are likely suitable for evaluating anti-NASH compounds because fibrosis, which is considered an important index to determine the drug efficacy of NASH inhibitors, is rapidly induced in genetic models. Using these models, we introduced some selected cases of NASH inhibitor development. This review aims to enhance the understanding of the pathogenesis of NASH and provide a basis for successfully selecting and utilising appropriate animal models of NASH in the development of effective inhibitors.</p></div>","PeriodicalId":8287,"journal":{"name":"Archives of Pharmacal Research","volume":null,"pages":null},"PeriodicalIF":6.7,"publicationDate":"2022-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40658999","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Enhancement of S(+)-zaltoprofen oral bioavailability using nanostructured lipid carrier system 纳米结构脂质载体系统增强S(+)-zaltoprofen口服生物利用度

IF 6.7 3区医学

Archives of Pharmacal Research Pub Date : 2022-10-28 DOI: 10.1007/s12272-022-01413-2

Thi Mai Anh Pham, Dong Ho Lee, Young-Guk Na, Minki Jin, Minwoo Jung, Ha-Eun Kim, Hyelim Yoo, Jong-Hee Won, Jae-Young Lee, Jong-Suep Baek, Su-Cheol Han, Hong-Ki Lee, Cheong-Weon Cho

{"title":"Enhancement of S(+)-zaltoprofen oral bioavailability using nanostructured lipid carrier system","authors":"Thi Mai Anh Pham, Dong Ho Lee, Young-Guk Na, Minki Jin, Minwoo Jung, Ha-Eun Kim, Hyelim Yoo, Jong-Hee Won, Jae-Young Lee, Jong-Suep Baek, Su-Cheol Han, Hong-Ki Lee, Cheong-Weon Cho","doi":"10.1007/s12272-022-01413-2","DOIUrl":"10.1007/s12272-022-01413-2","url":null,"abstract":"<div><p>Zaltoprofen is a nonsteroidal anti-inflammatory drug with poor oral bioavailability. S(+)-zaltoprofen (SZPF)-loaded nanostructured lipid carriers (NLCs) were prepared to enhance oral bioavailability. SZPF-loaded NLCs (NLC-SZPF) were prepared using the hot-melting homogenization method and optimized using the Box-Behnken design. The characterization of optimized NLC-SZPF, in vitro release, cytotoxicity, cellular uptake, ex vivo permeability, and pharmacokinetic parameters were evaluated to confirm the advantages of NLC formulation. NLC-SZPF with a diameter of 105.5 ± 1.2 nm had a high encapsulation efficiency of 99.84 ± 0.01%. NLC-SZPF showed a sustained-release profile, high biocompatibility, and high permeability across the intestinal tract. The relative bioavailability of NLC-SZPF was 431.3% compared with that of SZPF after oral administration to experimental rats. NLC-SZPF was successfully optimized using experimental designs to enhance the oral bioavailability of SZPF. Hence, NLC-SZPF could be a promising approach to overcome the poor oral bioavailability of SZPF.</p></div>","PeriodicalId":8287,"journal":{"name":"Archives of Pharmacal Research","volume":null,"pages":null},"PeriodicalIF":6.7,"publicationDate":"2022-10-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40456045","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Cardiotoxicity linked to anticancer agents and cardioprotective strategy 与抗癌药物和心脏保护策略相关的心脏毒性

IF 6.7 3区医学

Archives of Pharmacal Research Pub Date : 2022-10-28 DOI: 10.1007/s12272-022-01411-4

Shraddha I. Khairnar, Yogesh A. Kulkarni, Kavita Singh

{"title":"Cardiotoxicity linked to anticancer agents and cardioprotective strategy","authors":"Shraddha I. Khairnar, Yogesh A. Kulkarni, Kavita Singh","doi":"10.1007/s12272-022-01411-4","DOIUrl":"10.1007/s12272-022-01411-4","url":null,"abstract":"<div><p>Chemotherapy is a main treatment for cancer, and it benefits patients by controlling cancer relapse and metastasis, thereby leading to an increase in the overall survival rate. However, this treatment is associated with mild to severe side effects, one of which is cardiotoxicity. The severity of cardiotoxicity, a leading cause of cardiovascular diseases, depends on the type of cancer therapy employed and the time required for its management. A chemotherapeutic agent is used either alone or in combination with other drugs for cancer treatment. The exact mechanism of chemotherapeutic agent-induced cardiotoxicity remains unclear, although it is likely to be multifactorial and to include oxidative stress, apoptosis, and inflammation. There are many approaches to avoid the untoward effects of chemotherapeutic agents. However, the available options for cardiac protection are minimal, and they include renin-angiotensin system blockers, beta-blockers, herbal drugs, or iron chelators such as dexrazoxane. The present review provides information on the molecular mechanism of chemotherapy-induced myocardial infarction and cardiotoxicity along with scientifically studied synthetic molecules, herbal extracts, and natural products to manage chemotherapy-induced cardiotoxicity.</p></div>","PeriodicalId":8287,"journal":{"name":"Archives of Pharmacal Research","volume":null,"pages":null},"PeriodicalIF":6.7,"publicationDate":"2022-10-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40668883","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4