Insights into biological activities profile of gingerols and shogaols for potential pharmacological applications

IF 7.5 3区医学 Q1 CHEMISTRY, MEDICINAL

Archives of Pharmacal Research Pub Date : 2025-08-04 DOI:10.1007/s12272-025-01559-9

Anis Najwa Abdul Rani, Anand Gaurav, Vannajan Sanghiran Lee, Nadiah Mad Nasir, Sharifuddin Md Zain, Vaishali M. Patil, Ming Tatt Lee

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Abstract

Ginger (Zingiber officinale) rhizome has been widely used in traditional medicine for centuries to promote good health and well-being, treating conditions such as diarrhea, stomach discomfort, nausea, cholera, asthma, and respiratory diseases. Gingerol and shogaol are essential bioactive phenolic compounds abundantly found in fresh and dried ginger and have been extensively studied using modern technology to evaluate their therapeutic effects. These phenolic compounds demonstrate a wide range of properties, including antioxidant, anti-inflammatory, antidiabetic, and anticancer effects, which operate through various mechanisms. Furthermore, researchers have utilized the chemical structures of gingerol and shogaol as templates to develop novel, safer, and more effective drugs for treating multiple illnesses. This review article focuses on previous literature assessing the potential efficacy of these compounds as therapies based on their antioxidant, anti-inflammatory, antidiabetic, anticancer, and neuroprotective properties.

Abstract Image

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姜辣素和姜辣素的生物活性特征及其潜在药理应用。

几个世纪以来，生姜（Zingiber officinale）在传统医学中被广泛使用，以促进身体健康和幸福，治疗腹泻、胃部不适、恶心、霍乱、哮喘和呼吸系统疾病等疾病。姜辣素和姜酚是一种重要的生物活性酚类化合物，在鲜姜和干姜中都有大量发现，人们利用现代技术对其治疗效果进行了广泛的研究。这些酚类化合物表现出广泛的特性，包括抗氧化、抗炎、抗糖尿病和抗癌作用，它们通过各种机制起作用。此外，研究人员利用姜辣素和姜辣素的化学结构作为模板，开发出新的、更安全、更有效的治疗多种疾病的药物。本文主要综述了基于抗氧化、抗炎、抗糖尿病、抗癌和神经保护特性的这些化合物的潜在疗效。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Archives of Pharmacal Research 医学-药学

CiteScore

13.40

自引率

9.00%

发文量

审稿时长

3.3 months

期刊介绍： Archives of Pharmacal Research is the official journal of the Pharmaceutical Society of Korea and has been published since 1976. Archives of Pharmacal Research is an interdisciplinary journal devoted to the publication of original scientific research papers and reviews in the fields of drug discovery, drug development, and drug actions with a view to providing fundamental and novel information on drugs and drug candidates.