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[Acute hemodynamic effects of adriamycin]. [阿霉素的急性血流动力学影响]。
Archiv fur Geschwulstforschung Pub Date : 1990-01-01
U Gerecke, B Katzberg
{"title":"[Acute hemodynamic effects of adriamycin].","authors":"U Gerecke,&nbsp;B Katzberg","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Several authors reported about acute haemodynamic effects of ADM years ago. We studied this problem in five patients in the invasive and noninvasive way and thus obtained the most important haemodynamic parameters. Acute haemodynamic effects in the meaning of a negative inotropy and vasodilatation are confirmed. The usual intravenous injection does not avoid the decrease of important haemodynamic parameters (SV, SWI, CI) even though injected over ten minutes. Possible infarction and complications during the injection may be the result of decrease of perfusion pressure in the meaning of a \"steal phenomenon\".</p>","PeriodicalId":8274,"journal":{"name":"Archiv fur Geschwulstforschung","volume":"60 2","pages":"125-8"},"PeriodicalIF":0.0,"publicationDate":"1990-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13489516","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Surface antigens and cytotoxic natural killer cell (NK) activity of blood lymphocytes in heavy cigarette smokers. 重度吸烟者血液淋巴细胞表面抗原和细胞毒性自然杀伤细胞活性的研究。
Archiv fur Geschwulstforschung Pub Date : 1990-01-01
E Jezewska, G Dworacki, A Skrzypczak, J Zeromski
{"title":"Surface antigens and cytotoxic natural killer cell (NK) activity of blood lymphocytes in heavy cigarette smokers.","authors":"E Jezewska,&nbsp;G Dworacki,&nbsp;A Skrzypczak,&nbsp;J Zeromski","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Surface phenotypes of lymphocytes and the assessment of cytotoxic NK activity were determined in peripheral blood leukocytes in a group of heavy smokers and respective non-smoking people control group. Cell phenotypes were evaluated by a panel of monoclonal antibodies by indirect immunofluorescence on cell sediments. Cytotoxic activity was assessed by single cell cytotoxic assay on target K 562 cells. There were no significant differences in T cell (CD 3+) as well as in CD 43+ ones (large sialoglycoprotein) per cent values. The cells possessing receptor for sheep red blood cell (CD 2+) were however more numerous in smokers as compared to non-smokers. Per cent value of B lymphocytes in the former group was significantly decreased vs control one. There was no difference in per cent values of activated and immature cells in both examined groups. Per cent values of NK cell activity were higher in non-smokers in relation to smokers. It was reflected by an increase of cytotoxicity of effector cells, while frequency of incidence of NK cells was comparable in both groups examined.</p>","PeriodicalId":8274,"journal":{"name":"Archiv fur Geschwulstforschung","volume":"60 3","pages":"187-92"},"PeriodicalIF":0.0,"publicationDate":"1990-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13517779","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Molecular mechanisms of cell transformation. 细胞转化的分子机制。
Archiv fur Geschwulstforschung Pub Date : 1990-01-01
C Altaner
{"title":"Molecular mechanisms of cell transformation.","authors":"C Altaner","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":8274,"journal":{"name":"Archiv fur Geschwulstforschung","volume":"60 2","pages":"134-40"},"PeriodicalIF":0.0,"publicationDate":"1990-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13340106","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Are mycotoxins risk factors for endemic nephropathy and associated urothelial cancers? 真菌毒素是地方性肾病和相关尿路上皮癌的危险因素吗?
Archiv fur Geschwulstforschung Pub Date : 1990-01-01
M Castegnaro, I N Chernozemsky, E Hietanen, H Bartsch
{"title":"Are mycotoxins risk factors for endemic nephropathy and associated urothelial cancers?","authors":"M Castegnaro,&nbsp;I N Chernozemsky,&nbsp;E Hietanen,&nbsp;H Bartsch","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Evidence supporting a role of mycotoxin, in particular ochratoxin A (OA) and citrinin, in the etiology of Balkan endemic nephropathy (BEN) and associated urinary tract tumours (UTT) is reviewed. Both diseases occur in subjects born and/or living in certain rural areas where home-produced and home-stored stable foods were found to be more frequently contaminated by the OA and citrinin. OA levels in blood and urine from patients with BEN or UTT were higher than in controls. OA and possibly other mycotoxins cause endemic porcine nephropathy, a disease with morphology and clinical course similar to those of BEN. OA was carcinogenic in two rodent species with kidney as a major target organ. Animals and strains phenotype as fast metabolizers of debrisoquine were more susceptible to OA-induced carcinogenicity. Among BEN/UTT patients, a greater proportion of fast metabolizers was reported. Although no epidemiological proof of a direct causal role of mycotoxins in BEN/UTT etiology has been presented, the data accumulated so far indicate a need for prospective studies in which mycotoxins as well as other risk factors should be considered.</p>","PeriodicalId":8274,"journal":{"name":"Archiv fur Geschwulstforschung","volume":"60 4","pages":"295-303"},"PeriodicalIF":0.0,"publicationDate":"1990-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13354691","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cancer incidence rates in Turkey and two regions in the Federal Republic of Germany: a comparison. 土耳其和德意志联邦共和国两个地区的癌症发病率:比较。
Archiv fur Geschwulstforschung Pub Date : 1990-01-01
F Kaleagasioglu, M R Berger, D Schmähl
{"title":"Cancer incidence rates in Turkey and two regions in the Federal Republic of Germany: a comparison.","authors":"F Kaleagasioglu,&nbsp;M R Berger,&nbsp;D Schmähl","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Cancer incidence rates in Turkey are compared to those in two regions of West Germany, namely Hamburg and Saarland. Incidence rates of laryngeal, colorectal and prostatic cancer are significantly different in males of the two countries. Additionally, incidence rates of skin and trachea, bronchus, lung cancer show statistically significant differences in males of Turkey and Saarland. Between females, only the incidence of colorectal cancer is significantly different in both countries. These variations in cancer occurrence may be due to differences in tobacco and alcohol consumption, age distribution of the two populations and exposure to sunlight.</p>","PeriodicalId":8274,"journal":{"name":"Archiv fur Geschwulstforschung","volume":"60 3","pages":"201-7"},"PeriodicalIF":0.0,"publicationDate":"1990-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13517781","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[The pre- and postnatal carcinogenic effect of 3,3-diethyl-1-methyl-1-nitrosourea (DEMNU) in rats following intravenous application]. [3,3-二乙基-1-甲基-1-亚硝基脲(DEMNU)在大鼠静脉注射后的产前和产后致癌作用]。
Archiv fur Geschwulstforschung Pub Date : 1990-01-01
U Wagner, D Schreiber, R Thust, M Schneider
{"title":"[The pre- and postnatal carcinogenic effect of 3,3-diethyl-1-methyl-1-nitrosourea (DEMNU) in rats following intravenous application].","authors":"U Wagner,&nbsp;D Schreiber,&nbsp;R Thust,&nbsp;M Schneider","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The pre- and postnatal administration of DEMNU induces a high frequency of tumors when applied via the intravenous route, and the latency periods show a dose dependence (table I). Tumors of the brain, spinal cord and cranial nerves clearly predominate. Furthermore, a large number of neoplasms of kidney, heart and soft tissue was observed (table II). As DEMNU is per se a very stable compound, it is suggested that this agent is metabolized by monooxygenases. 3-Ethyl-1-methyl-1-nitrosourea should be formed as an intermediate product via this pathway, which is relatively stable and might explain the mainly neurotropic carcinogenicity of DEMNU. Species differences in the carcinogenicity of trialkyl-nitrosoureas and the mode of metabolic activation are discussed.</p>","PeriodicalId":8274,"journal":{"name":"Archiv fur Geschwulstforschung","volume":"60 3","pages":"179-86"},"PeriodicalIF":0.0,"publicationDate":"1990-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13517778","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Experimental metastasis inhibition by pretreatment of the host. 宿主预处理抑制肿瘤转移的实验研究。
Archiv fur Geschwulstforschung Pub Date : 1990-01-01
K Lapis, J Timár, J Pápay, S Paku, B Szende, A Ladányi
{"title":"Experimental metastasis inhibition by pretreatment of the host.","authors":"K Lapis,&nbsp;J Timár,&nbsp;J Pápay,&nbsp;S Paku,&nbsp;B Szende,&nbsp;A Ladányi","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>In an experimental murine metastasis model host pretreatment protocol (HPP) was tested to abrogate lung colonization of tumor cells. The stimulation of the host defense by lentinan or TP4, and the PGI2 administration was effective in the case of the immunosensitive low metastatic tumor. The modulation of the host cells and/or the extracellular matrix by the glycosaminoglycan biosynthesis blocking agent KL-103--but not by the degradation inhibitor suramin--inhibited the lung colonization of the highly metastatic immunoresistant tumor variant. In combination with the cytotoxic antiproliferative agents these non-toxic drugs could be useful in new protocols to prevent tumor dissemination.</p>","PeriodicalId":8274,"journal":{"name":"Archiv fur Geschwulstforschung","volume":"60 2","pages":"97-102"},"PeriodicalIF":0.0,"publicationDate":"1990-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13266187","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Laser-induced fluorescence diagnosis of tumors exemplified by solid Ehrlich carcinoma]. [以实体型埃利希癌为例的激光诱导荧光诊断]。
Archiv fur Geschwulstforschung Pub Date : 1990-01-01
K König, W Dietel
{"title":"[Laser-induced fluorescence diagnosis of tumors exemplified by solid Ehrlich carcinoma].","authors":"K König,&nbsp;W Dietel","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The laser-induced fluorescence of hematoporphyrin derivative (HpD) sensitized experimental Ehrlich carcinoma on mice is investigated. The fluorescence is excited with the 364-nm argon laser line. The tumor fluorescence spectra are recorded in the red spectral region. The HpD induced fluorescence of the tumors is superimposed on the autofluorescence of tissue. The tumor fluorescence shows a maximum 4 h after i.p. application of HpD. The fluorescence intensity is reduced by strong excitation causing bleaching of the HpD absorption. The fluorescence spectrum is also changing and the generation of a fluorescent photoproduct is observed.</p>","PeriodicalId":8274,"journal":{"name":"Archiv fur Geschwulstforschung","volume":"60 1","pages":"1-9"},"PeriodicalIF":0.0,"publicationDate":"1990-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13293014","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[The current value of classical (conventional) x-ray diagnosis within the scope of complex tumor diagnosis]. 【经典(常规)x线诊断在复杂肿瘤诊断范围内的应用价值】。
Archiv fur Geschwulstforschung Pub Date : 1990-01-01
E Baudisch
{"title":"[The current value of classical (conventional) x-ray diagnosis within the scope of complex tumor diagnosis].","authors":"E Baudisch","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Conventional X-ray methods and ultrasound tomography are the general basic imaging modalities in oncology. These methods are important for tumor detection as well as for further diagnostic decision making. In the diagnosis of thoracic and bone tumors the conventional X-ray methods still are of high diagnostic value. CT and MRI are complementary methods for extension diagnosis. In the diagnostics of gastrointestinal tumors the complementary endoscopic-radiologic examinations are the initial procedures. Tumors of the liver, pancreas and bile ducts require the application of ultrasound tomography and US-guided fine needle biopsy. In these cases CT provides additional information. Tumors of the kidney can be detected by sonography. Primary diagnostic methods in tumors of the urinary bladder are the cystoscopy, delayed cystography and sonography. CT and MRI are the predominant procedures in the diagnosis of brain and spinal cord tumors. Conventional X-ray methods represent the basic imaging procedures, and, combined with digital radiography, conclusive ultrasound tomography a necessary part of the complex tumor diagnosis.</p>","PeriodicalId":8274,"journal":{"name":"Archiv fur Geschwulstforschung","volume":"60 1","pages":"41-9"},"PeriodicalIF":0.0,"publicationDate":"1990-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13332409","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Influence of age on antileukemic action, subacute toxicity and tissue distribution of ambazone in B6D2F1 mice. 年龄对B6D2F1小鼠抗白血病作用、亚急性毒性及组织分布的影响。
Archiv fur Geschwulstforschung Pub Date : 1990-01-01
R Amlacher, J Baumgart, A Härtl, H Weber, H J Kühnel, W Schulze, H Hoffmann
{"title":"Influence of age on antileukemic action, subacute toxicity and tissue distribution of ambazone in B6D2F1 mice.","authors":"R Amlacher,&nbsp;J Baumgart,&nbsp;A Härtl,&nbsp;H Weber,&nbsp;H J Kühnel,&nbsp;W Schulze,&nbsp;H Hoffmann","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The influence of age of experimental animals on the antileukemic activity, toxicity and distribution of ambazone, a new potential antineoplastic agent, was studied in 2- and 12-month-old B6D2F1 mice. The predominant effect observed was a significant reduction of the antileukemic action of this compound in old-aged mice. Together with a slight increase in several toxicity parameters this caused a marked reduction of the therapeutic index in 12-month-old mice compared to younger individuals. Furthermore, a general tendency to increased ambazone levels in liver, kidneys and thymus of old-aged mice was observed. Our data therefore provide further evidence that age has to be taken into consideration as one factor that may account for the variety of drug response frequently observed during clinical therapy with anticancer agents.</p>","PeriodicalId":8274,"journal":{"name":"Archiv fur Geschwulstforschung","volume":"60 1","pages":"11-8"},"PeriodicalIF":0.0,"publicationDate":"1990-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13459961","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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