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Archiv fur Geschwulstforschung最新文献

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Evaluation of spin labeled TEPA and CCNU analogs against osteosarcoma and MNU-induced mammary carcinoma of the SD-rat. 自旋标记TEPA和CCNU类似物对sd大鼠骨肉瘤和mnu诱导的乳腺癌的作用。
Archiv fur Geschwulstforschung Pub Date : 1989-01-01
T Klenner, M R Berger, G Sosnovsky, N U Rao, F Wingen, D Schmähl
{"title":"Evaluation of spin labeled TEPA and CCNU analogs against osteosarcoma and MNU-induced mammary carcinoma of the SD-rat.","authors":"T Klenner,&nbsp;M R Berger,&nbsp;G Sosnovsky,&nbsp;N U Rao,&nbsp;F Wingen,&nbsp;D Schmähl","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The effectiveness to reduce tumor growth by 1-(2-chloroethyl)-3-(1-oxyl-2,2,6,6-tetramethylpiperidinyl)- 1-nitrosourea (SLCNU) and N,N,N,'N'- bis(1,2-ethanediyl)-N\"-(1-oxyl-2,2,6,6-tetramethyl- 2-piperidinylaminocarbonyl)-phosphoric triamide (SLDU) was studied in osteosarcoma and MNU-induced mammary carcinoma in the SD-rat. Both compounds elicited neither an inhibitory effect on these tumors nor an increase in the mean/median life span as compared to the control group.</p>","PeriodicalId":8274,"journal":{"name":"Archiv fur Geschwulstforschung","volume":"59 4","pages":"251-6"},"PeriodicalIF":0.0,"publicationDate":"1989-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13623177","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Immunohistochemical studies on pituitary adenomas in Wistar rats. 1. Demonstration of ACTH, LH, neurophysin, oxytocin and vasopressin in the pituitary of Ico:WIST rats from chronic toxicity studies]. Wistar大鼠垂体腺瘤的免疫组化研究。1. ACTH、LH、神经激素、催产素和加压素在Ico:WIST大鼠垂体中的表现[慢性毒性研究]。
Archiv fur Geschwulstforschung Pub Date : 1989-01-01
M Helminski, R Solecki, H Petter
{"title":"[Immunohistochemical studies on pituitary adenomas in Wistar rats. 1. Demonstration of ACTH, LH, neurophysin, oxytocin and vasopressin in the pituitary of Ico:WIST rats from chronic toxicity studies].","authors":"M Helminski,&nbsp;R Solecki,&nbsp;H Petter","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Spontaneous pituitary adenomas are common in certain strains of the laboratory rat. Investigations of Wistar rats of two years chronic toxicity studies revealed pituitary tumors in 50% of the females and 26% of the males. The morphology of the spontaneous changes in the pituitary gland was investigated with immunohistochemical and histological methods. The peroxidase-antiperoxidase (PAP) technique was used to localize different hormones (LH, ACTH) in cells of the pars intermedia and pars distalis as well as neurophysin, oxytocin and vasopressin the terminals of the classic neurosecretory system of the pars nervosa. The results show that most of the neoplasms were endocrinologically inactive chromophobe adenomas of the pars distalis.</p>","PeriodicalId":8274,"journal":{"name":"Archiv fur Geschwulstforschung","volume":"59 6","pages":"433-40"},"PeriodicalIF":0.0,"publicationDate":"1989-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13699972","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[The necessity for a stratification of patients with radically resected rectal cancer]. [直肠癌根治性切除患者分层的必要性]。
Archiv fur Geschwulstforschung Pub Date : 1989-01-01
W Slisow
{"title":"[The necessity for a stratification of patients with radically resected rectal cancer].","authors":"W Slisow","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>In contrast to the increasing incidence of rectal tumours the treatment results have reached a plateau. For their improvement it is necessary to exhaust all treatment modalities currently available. One approach might be centralized therapy at specialized hospitals (to use capacities and abilities located there) and another approach is the use of adjuvant treatments in certain patients. To secure optimal results of adjuvant treatments the patients should be stratified for some acknowledged prognostic factors.</p>","PeriodicalId":8274,"journal":{"name":"Archiv fur Geschwulstforschung","volume":"59 5","pages":"347-51"},"PeriodicalIF":0.0,"publicationDate":"1989-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13732820","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Organization of cancer care in Hungary. 匈牙利癌症护理组织。
Archiv fur Geschwulstforschung Pub Date : 1989-01-01
S Eckhardt
{"title":"Organization of cancer care in Hungary.","authors":"S Eckhardt","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":8274,"journal":{"name":"Archiv fur Geschwulstforschung","volume":"59 5","pages":"377-8"},"PeriodicalIF":0.0,"publicationDate":"1989-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13732824","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Applicability of the subrenal capsule assay (SRCA) in primary breast carcinoma]. 【肾下包膜试验(SRCA)在原发性乳腺癌中的适用性】。
Archiv fur Geschwulstforschung Pub Date : 1989-01-01
B Gerber, D Richter, E Rohde, H Wilken, K Rudolf, R Kasch
{"title":"[Applicability of the subrenal capsule assay (SRCA) in primary breast carcinoma].","authors":"B Gerber,&nbsp;D Richter,&nbsp;E Rohde,&nbsp;H Wilken,&nbsp;K Rudolf,&nbsp;R Kasch","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>We have examined the application of the subrenal capsule assay (SRCA) by use of normal immunocompetent (NIC) mice for chemosensitivity testing of primary breast cancers. In 18 out of 20 carcinomas an evaluation was possible. AB mice (10 breast cancers) and B6D2-F1 mice (10 breast cancers) were taken as recipients. Measurement of the size and the histological examination of all transplants were obligatory performed before and after finishing the assay on day 6. By use of AB mice as well as B6D2 mice in each group in 6 out of 9 evaluable cancers occurred a significant growth of the transplanted tissues after 6 days (p less than 0.05). It could be demonstrated by the histological examination that the enlargement was a consequence of the immunological reaction of the NIC mouse to the xenogeneic material. In most cases (76 of 97 used mice) the transplants consisted of inflammation cells only. Vital tumor cells were seen only in few cases (21 of 97 used mice). It is concluded, that the SRCA is not suitable for chemosensitivity testing of human breast cancer, if NIC mice as recipients are used.</p>","PeriodicalId":8274,"journal":{"name":"Archiv fur Geschwulstforschung","volume":"59 2","pages":"85-91"},"PeriodicalIF":0.0,"publicationDate":"1989-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13685055","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Experience in the treatment of metastatic breast carcinoma with norethisterone acetate in a clinical study]. 【临床研究中醋酸去甲睾酮治疗转移性乳腺癌的经验】。
Archiv fur Geschwulstforschung Pub Date : 1989-01-01
G Stier, R Gürtler, U M Schmidt
{"title":"[Experience in the treatment of metastatic breast carcinoma with norethisterone acetate in a clinical study].","authors":"G Stier,&nbsp;R Gürtler,&nbsp;U M Schmidt","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Twenty-nine patients with progressive advanced carcinoma of the breast were treated with 40 mg/day norethisterone acetate orally in this clinical trial. 27 of 29 patients were evaluable for response to the drug. One patient achieved a partial response (duration 2 months), 6 had a stable disease (median duration 7.6 months) and 20 developed a progressive disease on treatment. There was a high rate of liver toxicity in 23 patients [grade 3 and 4 according to WHO (1)]. The literature on norethisterone acetate is reviewed and compared with present results. The role of progestogenic agents in treatment of advanced mammary carcinoma is discussed.</p>","PeriodicalId":8274,"journal":{"name":"Archiv fur Geschwulstforschung","volume":"59 2","pages":"93-8"},"PeriodicalIF":0.0,"publicationDate":"1989-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13796220","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Experimental induction of embryo-derived teratomas and teratocarcinomas in mice. 小鼠胚胎源性畸胎瘤和畸胎癌的实验诱导。
Archiv fur Geschwulstforschung Pub Date : 1989-01-01
H Bauer, A Kaltschmidt, M Müller
{"title":"Experimental induction of embryo-derived teratomas and teratocarcinomas in mice.","authors":"H Bauer,&nbsp;A Kaltschmidt,&nbsp;M Müller","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The present study deals with the induction of teratomas and teratocarcinomas in two strains of mice (C3H/Bln and 129/terSv). 6 to 7 days old egg cylinders were transplanted beneath the kidney capsule of adult syngeneic male and female recipients. Out of 115 grafted embryos 32 gave rise to teratoid tumors. Both the overall tumor incidence (teratomas and teratocarcinomas) and the overall percentage of teratocarcinomas were approximately the same in the strains used. In strain C3H/Bln the gender of the recipient seemed to influence the outgrowth of malignant tumors. Two transplantable C3H-teratocarcinomas could be established (DTC-4, DTC-8). Up to date both have retained their pluripotent differentiation pattern which makes them useful for intended further investigations.</p>","PeriodicalId":8274,"journal":{"name":"Archiv fur Geschwulstforschung","volume":"59 5","pages":"333-40"},"PeriodicalIF":0.0,"publicationDate":"1989-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13732818","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cancer care in Greece. 希腊的癌症治疗。
Archiv fur Geschwulstforschung Pub Date : 1989-01-01
B Lissaios
{"title":"Cancer care in Greece.","authors":"B Lissaios","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":8274,"journal":{"name":"Archiv fur Geschwulstforschung","volume":"59 6","pages":"469"},"PeriodicalIF":0.0,"publicationDate":"1989-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13739674","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Enhancement of hepatic tumors induced by N-nitrosodimethylamine in female toads Bufo regularis by oestrone. 雌激素对n -亚硝基二甲胺诱导的雌性蟾蜍肝肿瘤的增强作用。
Archiv fur Geschwulstforschung Pub Date : 1989-01-01
S A Sakr, M M el-Mofty, A M Mohamed
{"title":"Enhancement of hepatic tumors induced by N-nitrosodimethylamine in female toads Bufo regularis by oestrone.","authors":"S A Sakr,&nbsp;M M el-Mofty,&nbsp;A M Mohamed","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The effect of oestrone on hepatic tumours induced in the female toads Bufo regularis by N-nitrosodimethylamine (DMNA) was evaluated. Injecting the toads with DMNA induced hepatocellular carcinomas in 17% comparable with 23% in toads injected with DMNA plus oestrone. These results show that oestrone insignificantly enhanced the tumour formation. Oestrone alone induced hepatic tumours in only 4 cases and was considered as a weak initiator.</p>","PeriodicalId":8274,"journal":{"name":"Archiv fur Geschwulstforschung","volume":"59 1","pages":"7-10"},"PeriodicalIF":0.0,"publicationDate":"1989-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14058629","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Temperature, pH value, acid load and filtrability of normal human erythrocytes: in vitro studies--possible significance for hyperthermic hyperacidotic tumor therapy]. 【正常人红细胞的温度、pH值、酸负荷和滤过性:体外研究——对高热高酸性肿瘤治疗的可能意义】。
Archiv fur Geschwulstforschung Pub Date : 1989-01-01
W K Barnikol
{"title":"[Temperature, pH value, acid load and filtrability of normal human erythrocytes: in vitro studies--possible significance for hyperthermic hyperacidotic tumor therapy].","authors":"W K Barnikol","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Normal human red blood cells, taken from healthy young men were separated from the other blood cells with the aid of a density centrifugation. The cells were titrated with acid to a defined minimal pH value and retitrated with sodium hydroxide to normal pH (7.4 +/- 0.1) two times. After each of the two acid loadings, which were done at 37 degrees C (normothermia) and 43 degrees C (hyperthermia) the so-called specific filtration time (FZsp) is determined with 5 microns Nuclepore membranes under 4% hematocrit. FZsp is a measure for the relative flow resistance of the red blood cells they have with the filtering membrane. FZsp was found to be irreversibly increased by the twofold acid load. The effect increases with decreasing pH and increasing temperature. Hydrochloric acid has a greater effect than lactic acid.</p>","PeriodicalId":8274,"journal":{"name":"Archiv fur Geschwulstforschung","volume":"59 1","pages":"11-7"},"PeriodicalIF":0.0,"publicationDate":"1989-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14058892","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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