Annali dell'Istituto superiore di sanita最新文献_第9页

Suicidal ideation among Italian medical students: prevalence and associated factors from a multicenter study. 意大利医学生的自杀意念:多中心研究的患病率及相关因素

IF 2.1 4区医学

Annali dell'Istituto superiore di sanita Pub Date : 2021-10-01 DOI: 10.4415/ANN_21_04_07

Paolo Leombruni, Giuseppina Lo Moro, Fabrizio Bert, Roberta Siliquini

{"title":"Suicidal ideation among Italian medical students: prevalence and associated factors from a multicenter study.","authors":"Paolo Leombruni, Giuseppina Lo Moro, Fabrizio Bert, Roberta Siliquini","doi":"10.4415/ANN_21_04_07","DOIUrl":"https://doi.org/10.4415/ANN_21_04_07","url":null,"abstract":"Objectives: To estimate Suicidal Ideation (SI) prevalence among Italian medical students and explore associated factors.Methods: Multicentre cross-sectional study (2018). Students were enrolled through convenience sampling (sample size=2513). Questionnaires included socio-demographic items and Beck Depression Inventory-II, which has an item on SI. A multivariable regression was performed (p-value<0.05 significant).Results: SI prevalence was 13.7%. Among students with and without depression SI prevalence was 36.0% and 4.3%. Being female, being in a relationship, good/excellent family cohesion, perceived good economic status were significantly associated with lower SI. Increasing age, bisexual/asexual orientation, psychiatric family history, negative judgment on medical school choice, competitive/hostile climate and unsatisfying friendships among classmates, being worried about not measuring up to the profession significantly increased SI.Conclusion: There was a high SI prevalence among Italian medical students, consistently with worldwide data. Demographic, relational, and motivational factors seem to influence SI. Determinants should be further investigated to plan university-level interventions.","PeriodicalId":8246,"journal":{"name":"Annali dell'Istituto superiore di sanita","volume":"57 4","pages":"324-329"},"PeriodicalIF":2.1,"publicationDate":"2021-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39734181","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Measurable residual disease in multiple myeloma and in acute myeloid leukemia, an evolving topic. 多发性骨髓瘤和急性髓性白血病中可测量的残留疾病，一个不断发展的话题。

IF 2.1 4区医学

Annali dell'Istituto superiore di sanita Pub Date : 2021-10-01 DOI: 10.4415/ANN_21_04_05

Germana Castelli, Elvira Pelosi, Ugo Testa

{"title":"Measurable residual disease in multiple myeloma and in acute myeloid leukemia, an evolving topic.","authors":"Germana Castelli, Elvira Pelosi, Ugo Testa","doi":"10.4415/ANN_21_04_05","DOIUrl":"https://doi.org/10.4415/ANN_21_04_05","url":null,"abstract":"Minimal or measurable residual disease (MRD) is a term that refers to the submicroscopic tumor disease persisting after therapy. Sensitive immunophenotypic and molecular techniques are used to detect the small amount of residual tumor cells, conferring a detection capacity clearly more sensitive of common cytomorphologic techniques. MRD evaluation now represents an important tool in the study of solid tumors and of hematological malignancies. Concerning hematological malignancies, MRD evaluation was particularly developed in the study of multiple myeloma and acute myeloid leukemia, representing in these diseases a precious biomarker to quantify response to treatment, to evaluate the chemosensitivity/chemoresistance of the disease and to have a prognostic prediction on disease outcome. The finding that MRD evaluation may have a prognostic value, predicting the risk of relapse, stimulated interest in the introduction of MRD in clinical trials, either as a clinical endpoint or as a tool to guide treatment decisions. However, the clinical use of MRD requires a standardization of the techniques used for its detection, the use of multiple techniques and the development of a consistent accuracy and reproducibility. Finally, prospective clinical trials are required to assess the real clinical benefit potentially deriving from the introduction of MRD evaluation into clinical studies.","PeriodicalId":8246,"journal":{"name":"Annali dell'Istituto superiore di sanita","volume":"57 4","pages":"300-313"},"PeriodicalIF":2.1,"publicationDate":"2021-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39734177","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Hepatitis B (HBV) reactivation in patients receiving biologic therapy for chronic inflammatory diseases in clinical practice. 慢性炎症性疾病生物治疗患者乙肝病毒再激活的临床研究

IF 2.1 4区医学

Annali dell'Istituto superiore di sanita Pub Date : 2021-07-01 DOI: 10.4415/ANN_21_03_08

Lorenzo Ridola, Angelo Zullo, Bruno Laganà, Roberto Lorenzetti, Alberto Migliore, Roberta Pica, Andrea Picchianti Diamanti, Gianfranco Gigliucci, Palma Scolieri, Vincenzo Bruzzese

{"title":"Hepatitis B (HBV) reactivation in patients receiving biologic therapy for chronic inflammatory diseases in clinical practice.","authors":"Lorenzo Ridola, Angelo Zullo, Bruno Laganà, Roberto Lorenzetti, Alberto Migliore, Roberta Pica, Andrea Picchianti Diamanti, Gianfranco Gigliucci, Palma Scolieri, Vincenzo Bruzzese","doi":"10.4415/ANN_21_03_08","DOIUrl":"https://doi.org/10.4415/ANN_21_03_08","url":null,"abstract":"Introduction and aim: Biologic treatment - particularly with the anti-TNF molecules - is frequently used in clinical practice to treat the severe form for both chronic rheumatic diseases and inflammatory bowel diseases. The immunosuppression induced by biologic therapies increases the risk of infections, including tuberculosis, as well as hepatitis B virus (HBV) reactivation may occur in inactive carriers or occult HBV infection (OBI) subjects during biologic therapy. This study aimed to update data on HBV prevalence and reactivation in patients receiving biologic therapy for either chronic rheumatic diseases or IBD, and to describe their management in clinical practice.Materials and methods: This study was performed in 6 Italian centers (3 Rheumatology Units and 3 Gastroenterology Units). Clinical, biochemical and virological data, as well as follow up information, were recorded and analyzed.Results: 984 patients were considered, including 817 with rheumatic disease and 167 with IBD. A total of 43 showed HBV infection (38 OBI and 5 carriers) accounting for a prevalence of 4%. Among OBI patients, 1 (2.6%) case of HBV reactivation occurred in a male patient with Crohn disease. Among the 5 HBV carriers, two patients (1 with spondyloarthritis and 1 with rheumatoid arthritis) did not received HBV antiviral therapy, and both experienced flare of hepatitis at 47 and 49 months following biologic therapy starting.Discussion: Data of our study highlight that guidelines on management of HBV patients treated with biologic therapies should be still implemented in clinical practice when considering that, although infrequent, HBV reactivation could be potentially life-threatening.","PeriodicalId":8246,"journal":{"name":"Annali dell'Istituto superiore di sanita","volume":"57 3","pages":"244-248"},"PeriodicalIF":2.1,"publicationDate":"2021-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39444117","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Legionella pneumophila and SARS-COV-2 co-infection: the importance of laboratory diagnosis. Letter. 嗜肺军团菌与SARS-COV-2合并感染:实验室诊断的重要性。信。

IF 2.1 4区医学

Annali dell'Istituto superiore di sanita Pub Date : 2021-07-01 DOI: 10.4415/ANN_21_03_01

Maria Cristina Rota, Maria Grazia Caporali, Maria Scaturro, Antonietta Girolamo, Xanthi Andrianou, Maria Luisa Ricci

引用次数: 4

Dioxins and PCBs contamination in milk and dairy products from Province of Taranto (Puglia Region, Southern Italy): a six years spatio-temporal monitoring study. 塔兰托省(意大利南部普利亚地区)牛奶和乳制品中的二恶英和多氯联苯污染:六年时空监测研究。

IF 2.1 4区医学

Annali dell'Istituto superiore di sanita Pub Date : 2021-07-01 DOI: 10.4415/ANN_21_03_06

Orazio Valerio Giannico, Grazia Rita Fragnelli, Simona Baldacci, Francesco Desiante, Angelo Pellegrino, Fabrizio Cosimo Basile, Ettore Franco, Gianfranco Diletti, Michele Conversano

{"title":"Dioxins and PCBs contamination in milk and dairy products from Province of Taranto (Puglia Region, Southern Italy): a six years spatio-temporal monitoring study.","authors":"Orazio Valerio Giannico, Grazia Rita Fragnelli, Simona Baldacci, Francesco Desiante, Angelo Pellegrino, Fabrizio Cosimo Basile, Ettore Franco, Gianfranco Diletti, Michele Conversano","doi":"10.4415/ANN_21_03_06","DOIUrl":"https://doi.org/10.4415/ANN_21_03_06","url":null,"abstract":"Introduction: Taranto Province (Puglia Region, Southern Italy) is of particular Public Health relevance due to the presence of industrial sources of dioxins and PCBs. The aim of this study was to analyze the spatio-temporal distribution of these pollutants in milk and cheese produced from 2013 to 2018.Materials and methods: Raw milk and dairy products were sampled in the farms located within 20 km from the industrial area.Results: 1005 milk samples were collected. Median (IQR) concentrations were: dioxins 0.21 (0.21) pg WHO-TEQ/g fat; dioxins+DL-PCBs 0.83 (0.71) pg WHO-TEQ/g fat; NDL-PCBs 1.92 (1.56) ng/g fat. Overall, only 6 (0.6%) samples were found to be non-compliant for at least one pollutants group. Temporal analysis showed a decreasing trend in dioxins and PCBs concentrations over the observed years and higher values in the first trimester. Spatial analysis showed higher levels of PCBs in areas closest to the industrial pole. 70 dairy products samples were collected. Median pollutants concentrations were far below the EU limits and no exceedances were observed.Conclusions: The extremely low number of exceedances appeared as an encouraging result and supported the validity of the Public Health measures adopted by the Department of Prevention of Taranto.","PeriodicalId":8246,"journal":{"name":"Annali dell'Istituto superiore di sanita","volume":"57 3","pages":"233-238"},"PeriodicalIF":2.1,"publicationDate":"2021-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39444115","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

The evaluation of capacity in dementia: ethical constraints and best practice. A systematic review. 痴呆症能力评估:伦理约束和最佳实践。系统回顾。

IF 2.1 4区医学

Annali dell'Istituto superiore di sanita Pub Date : 2021-07-01 DOI: 10.4415/ANN_21_03_04

Marina Gasparini, Valentina Moro, Stefania Amato, Nicola Vanacore, Giuseppe Gambina

引用次数: 0

Community waterborne outbreak linked to a firefighting response during the COVID-19 emergency. 与COVID-19紧急情况期间的消防反应有关的社区水传播疫情。

IF 2.1 4区医学

Annali dell'Istituto superiore di sanita Pub Date : 2021-07-01 DOI: 10.4415/ANN_21_03_05

Simona Nascetti, Luca Busani, Franco Bartoli, Riccardo Orioli, Alberta Stenico, Dagmar Regele

{"title":"Community waterborne outbreak linked to a firefighting response during the COVID-19 emergency.","authors":"Simona Nascetti, Luca Busani, Franco Bartoli, Riccardo Orioli, Alberta Stenico, Dagmar Regele","doi":"10.4415/ANN_21_03_05","DOIUrl":"https://doi.org/10.4415/ANN_21_03_05","url":null,"abstract":"Background: On 6 March 2020, a big fire in a village forced the firefighters to draw water simultaneously from many sources, including the Adige river. From 9 March, an increasing number of inhabitants reported gastrointestinal symptoms. We describe the outbreak and the challenges linked to the concurrent COVID-19 spread.Methods: Residents with enteric symptoms and their relatives were interviewed and samples from some of the patients and public water pipelines were tested for enteric pathogens with microbiological and molecular methods.Results: By 20 March, 182 people reported symptoms and 131 met the case definition. Norovirus GI/GII and other pathogens were found in human and water samples.Conclusions: Contamination of the public water network with sewage-contaminated river water through the firefighters pressurized water tank was the suspected source of the outbreak. The investigation was partly hampered due to the SARS-CoV-2 emergency. Control measures included avoiding tap water, alternative water supplies and chlorination of public water.","PeriodicalId":8246,"journal":{"name":"Annali dell'Istituto superiore di sanita","volume":"57 3","pages":"226-232"},"PeriodicalIF":2.1,"publicationDate":"2021-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39444113","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

The Italian National Faecal Microbiota Transplantation Program: a coordinated effort against Clostridioides difficile infection. 意大利国家粪便微生物群移植计划:一项针对艰难梭菌感染的协调努力。

IF 2.1 4区医学

Annali dell'Istituto superiore di sanita Pub Date : 2021-07-01 DOI: 10.4415/ANN_21_03_07

Maria Chiara de Stefano, Benedetta Mazzanti, Francesca Vespasiano, Giovanni Cammarota, Gianluca Ianiro, Luca Masucci, Maurizio Sanguinetti, Antonio Gasbarrini, Letizia Lombardini, Massimo Cardillo

{"title":"The Italian National Faecal Microbiota Transplantation Program: a coordinated effort against Clostridioides difficile infection.","authors":"Maria Chiara de Stefano, Benedetta Mazzanti, Francesca Vespasiano, Giovanni Cammarota, Gianluca Ianiro, Luca Masucci, Maurizio Sanguinetti, Antonio Gasbarrini, Letizia Lombardini, Massimo Cardillo","doi":"10.4415/ANN_21_03_07","DOIUrl":"https://doi.org/10.4415/ANN_21_03_07","url":null,"abstract":"Clostridioides (previously Clostridium) difficile infection (CDI) is a common cause of antibiotic-associated diarrhea, whose symptoms range from mild diarrhea to life-threatening pseudomembranous colitis. CDI is characterized by significant recurrence rate following initial resolution and recurrent C. difficile infection (rCDI) represents an onerous burden for the healthcare systems. Conventional antibiotic-based approaches are generally used for the treatment of rCDI but the effective therapy remains elusive. Recently, the faecal microbiota transplantation (FMT) has emerged as an alternative therapeutic strategy against rCDI, with high treatment success rate. In 2018, the Italian National FMT Program was launched, with the aim to provide high quality standards in FMT application to adults with rCDI not responding to antibiotic therapy. Here, we sketch out the key characteristics and the progress of the Italian National FMT Program during the COVID-19 pandemic.","PeriodicalId":8246,"journal":{"name":"Annali dell'Istituto superiore di sanita","volume":"57 3","pages":"239-243"},"PeriodicalIF":2.1,"publicationDate":"2021-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39444118","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Challenges on the achievement of World Health Organization goals for HCV elimination in Italy: need for a Regional programmatic approach on screening and linkage to care. Commentary. 意大利在实现世界卫生组织消除丙型肝炎病毒目标方面面临的挑战:需要在筛查和与护理联系方面采取区域规划办法。评论。

IF 2.1 4区医学

Annali dell'Istituto superiore di sanita Pub Date : 2021-07-01 DOI: 10.4415/ANN_21_03_02

Loreta A Kondili, Alessio Aghemo, Massimo Andreoni

引用次数: 3

Mortality risk in a population of patients treated for gambling disorders: results of a follow-up study. 赌博障碍治疗人群的死亡风险:一项随访研究的结果。

IF 2.1 4区医学

Annali dell'Istituto superiore di sanita Pub Date : 2021-07-01 DOI: 10.4415/ANN_21_03_03

Raimondo Maria Pavarin, Marco Domenicali, Silvia Marani, Elsa Turino, Fabio Caputo

引用次数: 0