{"title":"网络作为精准医疗的语言。","authors":"Lorenzo Farina","doi":"10.4415/ANN_21_04_08","DOIUrl":null,"url":null,"abstract":"<p><p>The article takes as a starting point the observation of a deep and long-standing gap between the views of biologists/physicians and that of physicists/data scientists when dealing with life sciences. This gap has been exacerbated by the advent of large-scale -omics technologies. Here, we focus on the impact of this gap in the field of precision medicine that impedes dialogue between omics data analysts and precision medicine physicians. To try to overcome this cultural divide, here we suggest a new possibility through the use of network science as a shared language composed of a vocabulary of words that have different meanings in each discipline but refer to the same biological entity. By doing so, one can move from biological concepts to network patterns and algorithms and backwards, thus generating a dialogue between \"life scientists\" and \"number scientists\". The article presents several simple network concepts with a straightforward biological interpretation as a starting point for such interdisciplinary dialogue.</p>","PeriodicalId":8246,"journal":{"name":"Annali dell'Istituto superiore di sanita","volume":"57 4","pages":"330-342"},"PeriodicalIF":1.1000,"publicationDate":"2021-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"4","resultStr":"{\"title\":\"Network as a language for precision medicine.\",\"authors\":\"Lorenzo Farina\",\"doi\":\"10.4415/ANN_21_04_08\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>The article takes as a starting point the observation of a deep and long-standing gap between the views of biologists/physicians and that of physicists/data scientists when dealing with life sciences. This gap has been exacerbated by the advent of large-scale -omics technologies. Here, we focus on the impact of this gap in the field of precision medicine that impedes dialogue between omics data analysts and precision medicine physicians. To try to overcome this cultural divide, here we suggest a new possibility through the use of network science as a shared language composed of a vocabulary of words that have different meanings in each discipline but refer to the same biological entity. By doing so, one can move from biological concepts to network patterns and algorithms and backwards, thus generating a dialogue between \\\"life scientists\\\" and \\\"number scientists\\\". The article presents several simple network concepts with a straightforward biological interpretation as a starting point for such interdisciplinary dialogue.</p>\",\"PeriodicalId\":8246,\"journal\":{\"name\":\"Annali dell'Istituto superiore di sanita\",\"volume\":\"57 4\",\"pages\":\"330-342\"},\"PeriodicalIF\":1.1000,\"publicationDate\":\"2021-10-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"4\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Annali dell'Istituto superiore di sanita\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.4415/ANN_21_04_08\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Annali dell'Istituto superiore di sanita","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.4415/ANN_21_04_08","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH","Score":null,"Total":0}
The article takes as a starting point the observation of a deep and long-standing gap between the views of biologists/physicians and that of physicists/data scientists when dealing with life sciences. This gap has been exacerbated by the advent of large-scale -omics technologies. Here, we focus on the impact of this gap in the field of precision medicine that impedes dialogue between omics data analysts and precision medicine physicians. To try to overcome this cultural divide, here we suggest a new possibility through the use of network science as a shared language composed of a vocabulary of words that have different meanings in each discipline but refer to the same biological entity. By doing so, one can move from biological concepts to network patterns and algorithms and backwards, thus generating a dialogue between "life scientists" and "number scientists". The article presents several simple network concepts with a straightforward biological interpretation as a starting point for such interdisciplinary dialogue.
期刊介绍:
Annali dell’Istituto Superiore di Sanità is a peer reviewed quarterly science journal which publishes research articles in biomedicine, translational research and in many other disciplines of the health sciences. The journal includes the following material: original articles, reviews, commentaries, editorials, brief and technical notes, book reviews.
The publication of Monographic Sections has been discontinued. In case you wish to present a small number of coordinated contributions on specific themes concerning priorities in public health, please contact the Editorial office.
The journal is in English.