Annals of Dermatology最新文献

{"title":"Assessment of Disease Severity and Quality of Life in Patients with Atopic Dermatitis from South Korea.","authors":"Sang Wook Son,&nbsp;Ji Hyun Lee,&nbsp;Jiyoung Ahn,&nbsp;Sung Eun Chang,&nbsp;Eung Ho Choi,&nbsp;Tae Young Han,&nbsp;Yong Hyun Jang,&nbsp;Hye One Kim,&nbsp;Moon-Bum Kim,&nbsp;You Chan Kim,&nbsp;Hyun Chang Ko,&nbsp;Joo Yeon Ko,&nbsp;Sang Eun Lee,&nbsp;Yang Won Lee,&nbsp;Bark-Lynn Lew,&nbsp;Chan Ho Na,&nbsp;Chang Ook Park,&nbsp;Chun Wook Park,&nbsp;Kui Young Park,&nbsp;Kun Park,&nbsp;Young Lip Park,&nbsp;Joo Young Roh,&nbsp;Young-Joon Seo,&nbsp;Min Kyung Shin,&nbsp;Sujin Lee,&nbsp;Sang Hyun Cho","doi":"10.5021/ad.21.239","DOIUrl":"https://doi.org/10.5021/ad.21.239","url":null,"abstract":"<p><strong>Background: </strong>Data illustrating the impact of atopic dermatitis (AD) on lives of adults with AD in South Korea are limited.</p><p><strong>Objective: </strong>To assess the AD disease severity and its impact on quality of life (QoL) in patients with AD from South Korea.</p><p><strong>Methods: </strong>Patients with AD utilizing the specialist dermatology services of major hospitals in South Korea were assessed for disease severity using Eczema Area and Severity Index (EASI) score, for QoL using Dermatology Life Quality Index (DLQI) (for QoL), and for comorbidities and treatment experience via retrospective review of 12-month medical records. Clinical and sociodemographic characteristics were also measured.</p><p><strong>Results: </strong>Of the 1,163 patients, 695 (59.8%) were men (mean age [years]±standard deviation: 31.6±12.1). Overall, 52.9% (n=615) patients had moderate-to-severe disease (EASI>7). The QoL of 72.3% (n=840) patients was affected moderately-to-severely (DLQI score: 6~30). Systemic immunosuppressants were used ≥1 over past 12 months in 51.9% (n=603) patients, and the most commonly used were cyclosporines (45.7%, n=531) and systemic corticosteroids (40.5%, n=471). Approximately, 10.8% (n=126) patients consulted or received treatment for AD-related eye problem. Of these, 40% (n=50) patients reported poor, very poor, or completely blind status; approximately, 16.7% patients (n=192) reported having depression or anxiety; and 35.5% (n=410) reported suicidal ideation or suicidal attempt.</p><p><strong>Conclusion: </strong>A large proportion of patients had moderate-to-severe AD, a compromised QoL, and ocular or mental health comorbidities, indicating a high disease burden despite systemic treatment. These findings highlight the importance of a holistic approach for the evaluation and treatment of patients with AD.</p>","PeriodicalId":8233,"journal":{"name":"Annals of Dermatology","volume":"34 6","pages":"419-430"},"PeriodicalIF":1.6,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/f5/4e/ad-34-419.PMC9763909.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10658053","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Allergic Sensitization Pattern in the Korean Dermatologic Patients.","authors":"Yujin Han,&nbsp;Yu Ri Woo,&nbsp;Hei Sung Kim,&nbsp;Jeong Deuk Lee,&nbsp;Sookhee Choi,&nbsp;Jeesuk Yu,&nbsp;Sang Hyun Cho","doi":"10.5021/ad.21.260","DOIUrl":"https://doi.org/10.5021/ad.21.260","url":null,"abstract":"<p><strong>Background: </strong>Avoiding causative allergens is important for controlling the clinical course of allergic diseases. Allergen sensitization is influenced by many factors including the environment and lifestyle. The socioeconomic development, climate, and lifestyle changes have increased the prevalence of allergic diseases worldwide. However, there is little information about changes in the trend of the common allergens over time.</p><p><strong>Objective: </strong>This study was aimed at identifying the trends of the common allergens in Korea over a 10-year period based on the results of the multiple allergosorbent test chemiluminescent assay (MAST-CLA).</p><p><strong>Methods: </strong>We retrospectively reviewed the medical records of 5,760 patients aged ≥18 years who visited the Dermatology Department at a tertiary hospital over a period of 10 years. The serum total immunoglobulin (Ig) E and specific IgE levels to 41 allergens were determined using MAST-CLA, along with the clinical diagnosis, duration of illness, white blood cell count and eosinophil percentage.</p><p><strong>Results: </strong><i>Dermatophagoides farinae</i>, <i>Dermatophagoides pteronyssinus</i>, and house dust were the most prevalent allergens during the 10 years period, but the percentage of higher class responses has decreased in recent years. The number of patients sensitized to house dust (<i>p</i><0.001), dogs (<i>p</i>=0.005), and cats (<i>p</i><0.001) increased while that of patients sensitized to cockroaches (<i>p</i><0.001) and storage mites (<i>p</i><0.001) decreased over time. There were no significant changes in the total number of sensitizing allergens over time.</p><p><strong>Conclusion: </strong>The common allergens have changed over time. Based on the findings of this study, physicians and patients should consider changing their strategies for disease prevention and management.</p>","PeriodicalId":8233,"journal":{"name":"Annals of Dermatology","volume":"34 6","pages":"431-441"},"PeriodicalIF":1.6,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/b4/cd/ad-34-431.PMC9763908.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10841276","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cutaneous Photorejuvenation of Light Emitting Diodes via the Melatonin Membrane Receptor Pathway.","authors":"Soo Hyeon Bae,&nbsp;Jun Hyeong Park,&nbsp;Soo-Hyun Kim,&nbsp;Sook Jung Yun,&nbsp;Jae Gwan Kim,&nbsp;Jee-Bum Lee","doi":"10.5021/ad.21.092","DOIUrl":"https://doi.org/10.5021/ad.21.092","url":null,"abstract":"<p><strong>Background: </strong>Melatonin receptors are present in the human skin and retina. These receptors can be stimulated by light emitting diodes (LEDs) at specific wavelengths, thereby inducing cutaneous photorejuvenation. However, the underlying mechanism remains unclear.</p><p><strong>Objective: </strong>To evaluate the influence of LEDs at specific wavelengths on melatonin membrane receptor (MT1) and cutaneous photorejuvenation via the MT1 pathway in vitro.</p><p><strong>Methods: </strong>Normal human dermal fibroblasts (HDFs) were irradiated using LEDs at different wavelengths (410~940 nm) at a dose of 1 J/cm². MT1 activity was evaluated after melatonin stimulation and LED irradiation. Thereafter, the expressions of collagen (COL) and matrix metalloproteinases (MMPs), with and without luzindole (MT1/2 receptor antagonist), were investigated via semi-quantitative reverse transcription polymerase chain reaction (PCR), real-time PCR, western blotting, and enzyme-linked immunosorbent assay.</p><p><strong>Results: </strong>In HDFs, the MT1 mRNA and protein levels increased significantly in response to melatonin (dose, 50 nM) (<i>p</i><0.01) and LED irradiation at 595, 630, 850, and 940 nm (<i>p</i><0.01). LED irradiation up-regulated COL type I and down-regulated MMP-1. Compared to LED irradiation without luzindole, LED irradiation with luzindole produced no significant increase in COL type I mRNA and protein levels (<i>p</i><0.01).</p><p><strong>Conclusion: </strong>We found that LED irradiation induces collagen synthesis and MMP-1 inhibition in HDFs via MT1 activation. Additionally, multiple LED wavelengths (595, 630, 850, and 940 nm) stimulated MT1 in HDFs, unlike in the eyes, where only blue light induced plasma melatonin suppression. This suggests the possibility of the melatoninergic pathway in photorejuvenation.</p>","PeriodicalId":8233,"journal":{"name":"Annals of Dermatology","volume":"34 6","pages":"401-411"},"PeriodicalIF":1.6,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/a5/ac/ad-34-401.PMC9763911.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10475496","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Case of Malignant Transformation of Solitary Recurrent Cylindroma on Scalp.","authors":"Ko Eun Kim,&nbsp;Jae Yeong Jeong,&nbsp;Tae Jun Park,&nbsp;Il-Hwan Kim","doi":"10.5021/ad.20.118","DOIUrl":"https://doi.org/10.5021/ad.20.118","url":null,"abstract":"<p><p>A 78-year-old male presented with an asymptomatic pinkish multi-nodular mass on his frontal scalp. The lesion had recurred twice after incomplete surgical excision. Initial punch biopsy was diagnosed with cylindroma. He revisited after one year with exophytic enlargement of the mass, and two staged Mohs micrographic surgery identified well-differentiated malignant cylindroma. Histopathology in the lower dermis and periosteal layer showed atypical cells with mitosis and hyperchromatic nucleoli with increased Ki-67 index of 10% to 30%. The postoperative wound was successfully treated with negative wound pressure therapy (NPWT) and secondary intentional healing. We report this case showing malignant transformation of solitary cylindroma, and good result for secondary intention healing using NPWT for postoperative defect.</p>","PeriodicalId":8233,"journal":{"name":"Annals of Dermatology","volume":"34 6","pages":"478-481"},"PeriodicalIF":1.6,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/5c/65/ad-34-478.PMC9763907.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10841275","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Myopericytoma of the Finger: A Case Report and Literature Review.","authors":"Ji-Hoon Lim,&nbsp;Soon-Hyo Kwon,&nbsp;Woo-Young Sim,&nbsp;Bark-Lynn Lew","doi":"10.5021/ad.20.326","DOIUrl":"https://doi.org/10.5021/ad.20.326","url":null,"abstract":"with mutations in KRT6A have more extensive disease compared with patients who have mutations in KRT16. Br J Dermatol 2012;166:875-878. 3. Samuelov L, Smith FJD, Hansen CD, Sprecher E. Revisiting pachyonychia congenita: a case-cohort study of 815 patients. Br J Dermatol 2020;182:738-746. 4. Goldberg I, Fruchter D, Meilick A, Schwartz ME, Sprecher E. Best treatment practices for pachyonychia congenita. J Eur Acad Dermatol Venereol 2014;28:279-285. 5. Gruber R, Edlinger M, Kaspar RL, Hansen CD, Leachman S, Milstone LM, et al. An appraisal of oral retinoids in the treatment of pachyonychia congenita. J Am Acad Dermatol 2012;66:e193-e199.","PeriodicalId":8233,"journal":{"name":"Annals of Dermatology","volume":"34 6","pages":"492-494"},"PeriodicalIF":1.6,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/f1/72/ad-34-492.PMC9763906.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10841282","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pigmented Onychomatricoma after Trauma: A Case Report and Review of Literature.","authors":"Su Jung Park,&nbsp;Jun Ki Hong,&nbsp;Soon Auck Hong,&nbsp;Kapsok Li","doi":"10.5021/ad.20.156","DOIUrl":"https://doi.org/10.5021/ad.20.156","url":null,"abstract":"clinical","PeriodicalId":8233,"journal":{"name":"Annals of Dermatology","volume":"34 6","pages":"482-484"},"PeriodicalIF":1.6,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/c5/f7/ad-34-482.PMC9763915.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10841273","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diagnosis of New Leprosy Patients through Various Histological Findings according to Biopsy Sites.","authors":"Shinyoung Song,&nbsp;Jaewoo Lim,&nbsp;Seha Park,&nbsp;Seulki Lee,&nbsp;Jinok Baek,&nbsp;Hyangjoon Park,&nbsp;Joo Young Roh,&nbsp;Hee Joo Kim","doi":"10.5021/ad.20.224","DOIUrl":"https://doi.org/10.5021/ad.20.224","url":null,"abstract":": An 81-year-old male had multiple erythematous to dusky patches on the trunk, arms, and legs for several years (Fig. 1A, B) and two violaceous nodules on the back with unknown onset (Fig. 1C). He had numbness of the hands and feet and edema of the hands and face during the previous six weeks. Punch biopsies were performed on the patch and nodule on the back. The nodule showed dense dermal infiltration by foamy histiocytes and lepra cells containing degenerated microbial components (Fig. 2A, B). The patch showed only superficial dermal perivascular and periappendageal lymphohistiocytic infiltration (Fig. 2C, D). Acid-fast bacillus (AFB) staining revealed that acid-fast bacilli was denser in the nodule than in the patch and some of the bacilli were clustered, forming globi (Fig. 2E, F). The patient was diagnosed as a new lepromatous leprosy patient based on clinical and histological findings. The patient was referred to the Hansen Welfare Association of Korea. Amplication of 154 bp Mycobacterium leprae-specific repetitive element (RLEP) was confirmed in PCR results of Hansen Welfare Association of Korea (Fig. 2G). The institution confirmed that the patient was","PeriodicalId":8233,"journal":{"name":"Annals of Dermatology","volume":"34 6","pages":"487-489"},"PeriodicalIF":1.6,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/0e/b6/ad-34-487.PMC9763914.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10841280","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pachyonychia Congenita with a Novel Variant in the <i>KRT16</i> Gene, c.348_379delinsAA.","authors":"Keunyoung Hur,&nbsp;Jung Min Ko,&nbsp;Je-Ho Mun","doi":"10.5021/ad.20.248","DOIUrl":"https://doi.org/10.5021/ad.20.248","url":null,"abstract":"Corresponding Author Je-Ho Mun Department of Dermatology, Seoul National University College of Medicine, 103 Daehak-ro, Jongno-gu, Seoul 03080, Korea Tel: +82-2-2072-3274, Fax: +82-2-742-7344, E-mail: jehomun@gmail.com https://orcid.org/0000-0002-0734-2850 *These authors have equally contributed to the article. Dear Editor: Pachyonychia congenita (PC) is a rare autosomal dominant keratinization disorder primarily affecting the skin and nails. PC is caused by dominant-negative mutations in one of five different keratin genes: KRT6A, KRT6B, KRT6C, KRT16, or KRT17. A Korean adolescent in his late 10s presented with painful plantar hyperkeratosis and nail changes. Due to plantar pain, he had difficulty in walking. His mother and sister had similar lesions. Physical examination revealed plantar keratoderma and dystrophic hyperkeratotic yellowish nails. Leukokeratosis of the oral mucosa was also observed (Fig. 1). A punch biopsy was obtained from his left sole (Fig. 2A). Microscopic examination of the sample showed marked acanthosis with hyperkeratosis, suggestive of palmoplantar keratoderma. We received the patient’s consent form about publishing all photographic materials. Blood sample was obtained to perform target gene sequencing using a next-generation sequencing panel. A novel likely pathogenic variant (PM1+PM2+PM4+PP1+PP3) in the KRT16 gene (NM_005557.3:c.348_379delinsAA) was","PeriodicalId":8233,"journal":{"name":"Annals of Dermatology","volume":"34 6","pages":"490-492"},"PeriodicalIF":1.6,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/a9/19/ad-34-490.PMC9763913.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10478214","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Secondary Intracranial Hypertension Associated with Alitretinoin Treatment for Twenty-Nail Dystrophy.","authors":"Uri Shon,&nbsp;Dea Kwan Yun,&nbsp;Mi Soo Choi,&nbsp;Byung Cheol Park,&nbsp;Myung Hwa Kim","doi":"10.5021/ad.20.293","DOIUrl":"https://doi.org/10.5021/ad.20.293","url":null,"abstract":"Intracranial hypertension (ICH) is a condition with increased intracranial pressure without structural cause. It is charac-terized by severe headaches, nausea, vomiting","PeriodicalId":8233,"journal":{"name":"Annals of Dermatology","volume":"34 6","pages":"485-486"},"PeriodicalIF":1.6,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/2d/3f/ad-34-485.PMC9763903.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10841278","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analysis of the Microbiome of the Ear Canal in Normal Individuals and Patients with Chronic Otitis Externa.","authors":"Ji Su Lee,&nbsp;Seon Mi Lee,&nbsp;Hyung Seok Son,&nbsp;Yi Na Yoon,&nbsp;Jung Eun Shin,&nbsp;Woo Jun Sul,&nbsp;Da Ae Yu,&nbsp;Yong Beom Choe,&nbsp;Yang Won Lee","doi":"10.5021/ad.22.153","DOIUrl":"https://doi.org/10.5021/ad.22.153","url":null,"abstract":"<p><strong>Background: </strong>Recently, microbiome research has been actively conducted for various skin areas. However, no study has yet compared the microbiome of bacteria and fungi in the ear canal of healthy individuals and patients with chronic otitis externa in Korea.</p><p><strong>Objective: </strong>This study aimed to investigate the difference in the distribution of fungal and bacterial microbial communities in ear canal samples of healthy individuals and patients with chronic otitis externa.</p><p><strong>Methods: </strong>In 24 patients with bilateral chronic otitis externa and 24 healthy controls, cotton swabs were used to obtain samples from the bilateral ear canal. To characterize the fungal and bacterial communities, we sequenced and analyzed the 16S rRNA V4-V5 and ITS1 regions using Quantitative Insights into Microbial Ecology 2, respectively.</p><p><strong>Results: </strong>The alpha diversity analysis for bacteria and fungi confirmed that both richness and evenness decreased in the patient group. The beta diversity analysis for bacteria confirmed that these parameters differed between the control and patient groups. The beta diversity analysis for fungi showed no difference between the groups.</p><p><strong>Conclusion: </strong>We observed different skin microbiomes in the patients with chronic otitis externa compared with those in the healthy individuals.</p>","PeriodicalId":8233,"journal":{"name":"Annals of Dermatology","volume":"34 6","pages":"461-471"},"PeriodicalIF":1.6,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/c1/63/ad-34-461.PMC9763917.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10841279","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}