Annals of Surgical Oncology最新文献

{"title":"ASO Visual Abstract: Association Between Intraoperative Hypothermia and Postoperative Pancreatic Fistula.","authors":"Maho Takayama, Rebecca A Snyder, Heather G Lyu, Cassius K Mensah, Laura R Prakash, Jace P Landry, Edward Tsai, Zuhair A Siddiqui, Jessica E Maxwell, Michael P Kim, Ching-Wei D Tzeng, Jeffrey E Lee, Matthew H G Katz, Naruhiko Ikoma","doi":"10.1245/s10434-025-18487-z","DOIUrl":"https://doi.org/10.1245/s10434-025-18487-z","url":null,"abstract":"","PeriodicalId":8229,"journal":{"name":"Annals of Surgical Oncology","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145285505","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multimodal Management of Retroperitoneal Lymph Node Metastases in Colorectal Cancer: A Single-Center Retrospective Analysis.","authors":"Arthur Houbiers, Remy Barbe, Jerome Durand-Labrunie, Valerie Boige, Cristina Smolenschi, Antoine Hollebecque, Yves Menu, Marine Valery, Michel Ducreux, Alice Boileve, Elena Fernandez de Sevilla, Leonor Benhaim, Peggy Dartigues, Isabelle Sourrouille, Mohamed Amine Bani, Maximiliano Gelli","doi":"10.1245/s10434-025-18106-x","DOIUrl":"https://doi.org/10.1245/s10434-025-18106-x","url":null,"abstract":"<p><strong>Background: </strong>Retroperitoneal lymph node metastases (RLNMs) of colorectal cancer (CRC) have a low incidence, and the optimal treatment strategy remains unclear due to limited evidence. This study aimed to analyze morbidity and long-term oncologic outcomes associated with different multimodal approaches including systemic chemotherapy, surgery with or without preoperative radiotherapy.</p><p><strong>Methods: </strong>This retrospective, single-center study included consecutive patients treated from 2000 to 2023 for sub-renal RLNM from CRC. After induction chemotherapy, the patients were divided into two groups: those receiving radio(chemo)therapy (RCT) followed by surgery (RCT-surgery group; n = 30) and those undergoing upfront surgery (surgery-alone group; n = 24). The study analyzed treatment methods, perioperative data, morbidity, mortality, overall survival (OS), and recurrence-free survival (RFS).</p><p><strong>Results: </strong>The study included 54 patients (32 males, 22 females, age 51 years). Presentation of RLNM was synchronous in 48.1% (n = 25) of the patients, and 25.9% (n = 14) of the patients had previously treated extra-nodal metastases. Standardized retroperitoneal nodal dissection (RND) was performed for 40 (90.7%) patients. Operative time, blood loss, severe postoperative morbidity, and hospital length of stay were similar between the RCT-surgery and surgery-alone groups. Preoperative RCT was associated with a higher rate of complete response (18.2% vs 0%; p = 0.018). The median RFS was 13.1 months for the RCT-surgery group and 8.6 months for the surgery-alone group (p = 0.153). The median OS was 73.9 months for the surgery-alone group and not reached in the RCT-surgery group (p = 0.909).</p><p><strong>Conclusion: </strong>A multimodal curative strategy combining nodal dissection after systemic chemotherapy with or without preoperative RCT for RLNM from CRC is feasible, demonstrating low morbidity and promising oncologic outcomes in advanced metastatic disease.</p>","PeriodicalId":8229,"journal":{"name":"Annals of Surgical Oncology","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145290712","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ASO Visual Abstract: Clinicopathological Features and Management of Gastric Adenocarcinoma and Proximal Polyposis of the Stomach (GAPPS).","authors":"Shruthi R Perati, Amber F Gallanis, Disha Sharma, Gracia Viana Rodriguez, Grace-Ann Fasaye, Rachael Lopez, Cassidy Bowden, Sun A Kim, Andrew M Blakely, Jonathan M Hernandez, Louis Korman, Theo Heller, Jeremy L Davis","doi":"10.1245/s10434-025-18558-1","DOIUrl":"https://doi.org/10.1245/s10434-025-18558-1","url":null,"abstract":"","PeriodicalId":8229,"journal":{"name":"Annals of Surgical Oncology","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145290718","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of Perioperative Outcomes Between da Vinci XI and da Vinci SI/SP Robotic Radical Prostatectomies: A Meta-Analysis of Comparative Studies.","authors":"Si Ge, Zhiqiang Zeng, Lei Zheng, Jiakai Ma, Deyu Wang, Yuan Ren","doi":"10.1245/s10434-025-18498-w","DOIUrl":"https://doi.org/10.1245/s10434-025-18498-w","url":null,"abstract":"<p><strong>Background: </strong>This study aimed to compare perioperative outcomes between da Vinci XI and da Vinci SI or SP robotic radical prostatectomies.</p><p><strong>Methods: </strong>The study systematically searched four databases: Embase, PubMed, Cochrane Library, and Web of Science. The search time ranged from database creation to July 2025. Statistical analysis was performed using Stata17. Effect denoted a continuous variable, whereas OR/RR denoted a binary variable, and the 95 % confidence interval (CI) was calculated.</p><p><strong>Results: </strong>The seven included studies involved 2297 patients undergoing robotic radical prostatectomy. Compared with SP, XI had a longer hospital stay (effect, 0.91; 95 % CI 0.04-1.77; P < 0.05). Compared with SI, XI had a lower positive margin rate (odds ratio, 0.74; 95 % CI 0.57-0.97; P < 0.05). Operation time, estimated blood loss, overall complications, and major complications did not differ among XI, SI, and SP.</p><p><strong>Conclusion: </strong>Compared with SP, XI's hospital stay appeared to be longer. Compared with SI, XI seemed to have a lower positive surgical margin. However, more research is needed to determine differences in oncology outcomes and cost-effectiveness among several robotic surgical platforms.</p>","PeriodicalId":8229,"journal":{"name":"Annals of Surgical Oncology","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145290742","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Antibiotics and Surgical Site Infection in Expander-Based Breast Reconstruction Trial (ASSERT).","authors":"Surinder Kaur, Brian Gastman, Kristen P Broderick, Adeyiza O Momoh, Brett T Phillips, Graham Schwarz, Summer E Hanson, Geoffrey E Hespe, Carisa M Cooney, Katie Sommers, Cheng-Shiun Leu, Christine H Rohde","doi":"10.1245/s10434-025-18472-6","DOIUrl":"https://doi.org/10.1245/s10434-025-18472-6","url":null,"abstract":"<p><strong>Background: </strong>The use of prophylactic antibiotics following postmastectomy tissue expander breast reconstruction (TE-BR) varies widely. The Centers for Disease Control and Prevention (CDC) recommends a single preoperative antibiotic dose for clean and clean-contaminated procedures. This multi-institutional, prospective, randomized controlled trial (RCT) examined whether the CDC-recommended single preoperative dose (SPD) of antibiotics is not inferior to an additional week of postoperative (WPO) prophylactic antibiotics in preventing surgical site infection (SSI) in immediate TE-BR following mastectomy.</p><p><strong>Methods: </strong>Women aged ≥ 18 years undergoing immediate TE-BR were randomized to SPD or WPO groups. The primary outcome was SSI by CDC guidelines within 30 days of surgery. The study used a noninferiority trial design to examine whether the test product (single preoperative dose (SPD)) was not worse than the comparator (1 week of postoperative (WPO) prophylactic antibiotics) by more than a set noninferiority margin of 6%.</p><p><strong>Results: </strong>In total, five participating centers screened 499 women; 235 were enrolled. A total of 102 patients were randomized to the SPD arm and 112 to the WPO arm, with 21 patients withdrawn. The SSI rate in the SPD arm was 17% as compared with 11% in WPO arm, which is within the noninferiority margin set for this study but not significantly noninferior (p = 0.496). The rate of unplanned TE removal for infection, hospitalization rate, and return to OR rate within 30 days of surgery were comparable between the two groups.</p><p><strong>Conclusions: </strong>This multi-institutional RCT did not definitively demonstrate that a single preoperative dose of antibiotics is not inferior to a 7-day postoperative antibiotic regimen in preventing SSI in immediate TE-BR; there was also no evidence to support that the 7-day regimen was significantly better. As this represents one of the largest multi-institutional study of its kind, these results have practice-management considerations.</p>","PeriodicalId":8229,"journal":{"name":"Annals of Surgical Oncology","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145285434","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"International Survey on Evidence for Index Lymph Node Surgery After Neoadjuvant Systemic Therapy for Stage III Melanoma.","authors":"Elan Novis, Mervi Rautalin, Rodabe N Amaria, Paolo A Ascierto, Christian U Blank, Mark B Faries, Dirk J Grunhagen, David E Gyorki, Andrew J Hayes, Anke M J Kuijpers, Georgina V Long, Joshua M V Mammen, Alexander M Menzies, Merrick I Ross, Piotr Rutkowski, Hussein A Tawbi, Michael T Tetzlaff, Jonathan S Zager, Jennifer A Wargo, Tina J Hieken, Alexander C J van Akkooi","doi":"10.1245/s10434-025-18475-3","DOIUrl":"https://doi.org/10.1245/s10434-025-18475-3","url":null,"abstract":"<p><strong>Background: </strong>Neoadjuvant immunotherapy for resectable stage III melanoma has demonstrated promising outcomes in recent trials, prompting a change in clinical practice in many countries. Although therapeutic lymph node dissection (TLND) remains the standard of care after neoadjuvant treatment, a less invasive index lymph node (ILN)-guided approach has been proposed. The global melanoma community's acceptance of neoadjuvant immunotherapy and the need for TLND or ILN after this remains unclear.</p><p><strong>Methods: </strong>A two-stage international survey was conducted among melanoma experts between May 2023 and January 2025. Respondents were asked about their familiarity with neoadjuvant trials, current practices, and opinions on ILN versus TLND before and after publication of the NADINA trial.</p><p><strong>Results: </strong>The response rates were 50% (118/237) in the first survey and 62% (148/237) in the second survey. In the second survey, 74% of the respondents considered neoadjuvant therapy the standard of care, and support for ILN-guided surgery rose from 27 to 40% between the surveys. However, 54% still favored a phase 3 randomized controlled trial before changing the clinical practice guidelines, and only 27% believed the current data were sufficient for adoption of ILN as standard. Key barriers included concerns about oncologic safety, pathologic standardization, and patient selection.</p><p><strong>Conclusion: </strong>The current evidence supports the use of neoadjuvant immunotherapy as the standard of care for stage III melanoma. However, widespread clinical adoption of ILN-guided surgical de-escalation remains limited. A multicenter phase 3 trial (MSLT-3), launching in 2025, is expected to provide important data to guide future practice.</p>","PeriodicalId":8229,"journal":{"name":"Annals of Surgical Oncology","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145290764","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ASO Visual Abstract: Beyond the Scalpel-EGFR Mutation Predicts Intraoperative Blood Loss and Transfusion Needs During Lung Cancer-Derived Spinal Metastasis Surgery : Preoperative EGFR Profiling Guides Blood Conservation Strategies.","authors":"Guoqing Zhong, Yonghan Chen, Huahao Lai, Jingzhe He, Chongquan Huang, Yuan Yan, Shi Cheng, Yu Zhang","doi":"10.1245/s10434-025-18557-2","DOIUrl":"https://doi.org/10.1245/s10434-025-18557-2","url":null,"abstract":"","PeriodicalId":8229,"journal":{"name":"Annals of Surgical Oncology","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145290776","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Perioperative Expectations of Patients Undergoing Gastrointestinal Surgery for Cancer: A Systematic Review.","authors":"K E Kopecky, O Monton, S Koti, C Arbaugh, J Purchla, M Bodd, L Rosman, F M Johnston, J N Odom","doi":"10.1245/s10434-025-18439-7","DOIUrl":"https://doi.org/10.1245/s10434-025-18439-7","url":null,"abstract":"<p><strong>Background: </strong>Despite the prevalence of surgical intervention in patients with gastrointestinal cancers, little is known about patients' expectations regarding physical recovery, long-term prognosis, and quality of life following surgery.</p><p><strong>Methods: </strong>This systematic review followed the PRISMA reporting guidelines. Four electronic databases (MEDLINE, Embase, PsycINFO, and CINAHL) were searched. Studies were included if they reported the perioperative expectations of adult patients undergoing curative-intent GI cancer surgery. Data extracted included aims and study design, participant characteristics, disease and treatment characteristics, and findings related to patient expectations.</p><p><strong>Results: </strong>In total, 22 studies were included for analysis and provided data on 3605 patients. The majority of studies found that patients were uncertain about what to expect from surgery, which contributed to feelings of distress, anxiety, frustration, and isolation. Patients struggled to distinguish between normal postoperative symptoms and signs of potential complications and expressed a desire for more information about anticipated and unanticipated surgical outcomes. Expectations regarding the length of postoperative convalescence ranged from weeks to years, and most patients overestimated the ability of surgery to achieve cure. Only one study evaluated the impact of an intervention on preoperative expectation development.</p><p><strong>Conclusions: </strong>Patients undergoing surgery for resectable GI malignancies are frequently unprepared for the challenges of postoperative recovery and life after surgery. Many express a desire for more thorough and realistic information about what to expect. There is a clear need for the development and evaluation of supportive interventions.</p>","PeriodicalId":8229,"journal":{"name":"Annals of Surgical Oncology","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145290736","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Social Vulnerability and Surgical Delays for Patients with Lung Cancer.","authors":"Shamus R Carr","doi":"10.1245/s10434-025-18471-7","DOIUrl":"https://doi.org/10.1245/s10434-025-18471-7","url":null,"abstract":"","PeriodicalId":8229,"journal":{"name":"Annals of Surgical Oncology","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145290745","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ASO Visual Abstract: Association of Preoperative Gut Microbiota Disturbances with Postoperative Infectious Complications in Major Gastrointestinal Cancer Surgery-A Large-scale Exploratory Study.","authors":"Takuya Sugimoto, Yukihiro Yokoyama, Yukiko Kado, Shuta Yamamoto, Takashi Mizuno, Junpei Yamaguchi, Shunsuke Onoe, Tomoki Ebata, Takashi Asahara","doi":"10.1245/s10434-025-18493-1","DOIUrl":"https://doi.org/10.1245/s10434-025-18493-1","url":null,"abstract":"","PeriodicalId":8229,"journal":{"name":"Annals of Surgical Oncology","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145290766","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}