Annali italiani di chirurgia最新文献

{"title":"The Impact of Early and Delayed Fat Transplantation on Scar Quality in Post-Traumatic Reconstruction.","authors":"Jing Liu, Chang Liu, Yangang Song, Ting Shang, Chen Yang, Hongyu Yin, Yanfu Han","doi":"10.62713/aic.3889","DOIUrl":"https://doi.org/10.62713/aic.3889","url":null,"abstract":"<p><strong>Aim: </strong>To evaluate the effects of early versus delayed fat transplantation on post-traumatic scars using adipose-derived stem cells (ADSCs) to enhance scar quality and address the aesthetic and psychological challenges in reconstructive surgery.</p><p><strong>Methods: </strong>This retrospective cohort study included 223 patients treated at Capital Medical University Beijing Shijitan Hospital between June 2022 and June 2023. Scar quality was evaluated using the Vancouver Scar Scale (VSS) and scar width measurements at 1, 3, and 4 months postoperatively. Complications were monitored during hospital stays and follow-up visits, while Quality of Life was assessed using the World Health Organization Quality of Life brief version (WHOQOL-BREF).</p><p><strong>Results: </strong>A retrospective cohort study of 223 patients with post-traumatic scars was conducted to compare the outcomes of early (n = 108) versus delayed (n = 115) fat grafting. Scar width reduction was significantly greater in the early group at 3 months (1.19 ± 0.30 cm) and 4 months (1.97 ± 0.58 cm) compared to the delayed group (1.31 ± 0.34 cm at 3 months and 2.15 ± 0.55 cm at 4 months; p < 0.05). The early group also demonstrated better VSS scores at 3 months (6.35 ± 1.26) and 4 months (2.16 ± 0.78) than the delayed group (6.81 ± 1.48 at 3 months and 2.37 ± 0.28 at 4 months; p < 0.05). However, the early group exhibited a higher complication rate (9.26% vs. 2.61%; p = 0.034). No significant difference was found in Quality of Life scores between the two groups.</p><p><strong>Conclusions: </strong>Early fat transplantation improves scar quality but is associated with a higher complication rate.</p>","PeriodicalId":8210,"journal":{"name":"Annali italiani di chirurgia","volume":"96 4","pages":"505-513"},"PeriodicalIF":0.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143961024","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Metastatic Lymph Node Ratio in Right-Sided Colon Cancers Associated With Decreased Overall Survival.","authors":"Kenan Buyukasık, Esin Kaplan, Mert Guler, Rozan Kaya, Aziz Ari, Omer Akay","doi":"10.62713/aic.3937","DOIUrl":"https://doi.org/10.62713/aic.3937","url":null,"abstract":"<p><strong>Aim: </strong>The aim of this study was to investigate the effect of metastatic lymph node ratio (mLNR) on overall survival after curative resection in patients with right-sided colon cancer.</p><p><strong>Methods: </strong>Patients diagnosed with right-sided colon cancer and treated at Istanbul Teaching and Research Hospital between 2012 and 2017 were retrospectively analyzed. Variables including age, sex, total number of lymph nodes removed, metastatic lymph node ratio, disease stage, tumor location, and patient morbidity were compared with overall survival. Kaplan-Meier survival analysis and Cox regression analysis were used to evaluate the impact of these variables on overall survival.</p><p><strong>Results: </strong>A total of 129 patients were included in this study. By the end of the follow-up period, 51 patients (39.5%) had died. Receiver operating characteristic (ROC) analysis identified a cut-off value for mLNR at 0.0801 (p < 0.001), with 39 patients (30.2%) having an mLNR greater than this threshold. Patients with a high mLNR exhibited significantly shorter overall survival (20.3 months, 95% confidence interval (CI): 12.0-28.6) compared to those with a lower mLNR (106.6 months, 95% CI: 98.4-114.8) (p < 0.001). Furthermore, overall survival was significantly lower in patients with advanced-stage tumors, highlighting the prognostic importance of tumor, node, and metastasis (TNM) staging system. In multivariate Cox regression analysis, TNM stage (hazard ratio (HR) = 50.229, 95% CI: 6.678-372.242, p < 0.001) and mLNR (HR = 3.136, 95% CI: 1.843-5.337, p < 0.001) were identified as independent prognostic factors for overall survival.</p><p><strong>Conclusions: </strong>This study underscores that in right-sided colon cancer, the mLNR and TNM stage provide critical prognostic insights, independent of the total number of lymph nodes removed. These findings support the use of mLNR as a practical and reliable tool for refining prognostic assessments and guiding personalized treatment strategies, emphasizing its potential role in clinical decision-making.</p>","PeriodicalId":8210,"journal":{"name":"Annali italiani di chirurgia","volume":"96 6","pages":"783-789"},"PeriodicalIF":0.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144301091","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effectiveness of Perioperative Finger Sensory Rehabilitation in Patients Undergoing Fingertip Amputation and Reimplantation: A Retrospective Study.","authors":"Shibo Gao, Chao Yang","doi":"10.62713/aic.3755","DOIUrl":"10.62713/aic.3755","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Aim: &lt;/strong&gt;Finger reimplantation is an effective method for the treatment of amputated fingertips. However, there are several shortcomings in traditional postoperative rehabilitation programs, which may affect a patient's functional recovery after surgery. Finger sensory rehabilitation is a comprehensive program that helps patients restore sensory and motor function to their fingers through the use of specific training methods and equipment. Thus, this study aimed to analyze the effect of finger sensory rehabilitation on a group of patients who had undergone fingertip amputation and reimplantation.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;The medical records of 106 patients having undergone fingertip amputation and reimplantation from January 2022 to January 2024 were retrospectively analyzed. The patients were classified into experimental group (n = 52, receiving conventional rehabilitation training + finger sensory rehabilitation training) and the control group (n = 54, receiving only conventional rehabilitation training). Patients in both groups participated in a 20-week rehabilitation training, and the Semmes-Weinstein monofilament test was used to evaluate the finger touch pressure sensation after completing the rehabilitation training in both groups, and the Visual Analogue Scale (VAS) score, Generic Quality of Life Inventory-74 (GQOLI-74) score to evaluate their pain sensation and quality of life on the 2nd postoperative day and at the end of rehabilitation training.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;After completing rehabilitation, a specialized method for assessing the patient's tactile sensory deficits was used, showing that the number of cases with light tactile hypoesthesia to single-fiber sensation in the reimplanted fingertips was higher in the experimental group than in the control group (p &lt; 0.01), while there was no significant difference in the number of cases of protective hypoesthesia between the two groups (p &gt; 0.05), the number of cases of protective sensory loss was significantly lower in the experimental group than in the control group (p &lt; 0.01). There was no significant difference in the pain scores and comfort scores between the two groups before management (p &gt; 0.05). However, the pain level of the two groups after management was significantly lower than that before management (p &lt; 0.01), whereas the post-management comfort scores of both groups were significantly higher than that before management (p &lt; 0.001). The experimental group's degree of improvement was significantly higher than that of the control group (p &lt; 0.001). The pre-management GQOLI-74 scores were not significantly different between the groups (p &gt; 0.05), whereas after management, the experimental group outperformed the control group in all dimensions of the scores, except in thinking ability (p &lt; 0.01). Although not statistically significant (p &gt; 0.05), the total perioperative complication rate of the experimental group was lower than that of the c","PeriodicalId":8210,"journal":{"name":"Annali italiani di chirurgia","volume":"96 1","pages":"55-62"},"PeriodicalIF":0.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142999006","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Electrochemotherapy for Cancers Affecting the Skin: Ten Years of Experience in a Tertiary Referral Hospital.","authors":"Piero Covarelli, Carlo Boselli, Francesco Barberini, Matteo Matteucci, Georgi Popivanov, Vincenzo De Giorgi, Gianmarco Tomassini, Mario Mandalà, Roberto Cirocchi","doi":"10.62713/aic.3718","DOIUrl":"10.62713/aic.3718","url":null,"abstract":"<p><strong>Aim: </strong>Electrochemotherapy (ECT) combines chemotherapy with an electric pulse to directly target tumor cells by increasing cell membrane permeability, facilitating the efficient uptake of chemotherapeutic agents by tumor cells and improving their therapeutic efficacy. It is widely used for treating skin metastatic nodules or metastases of subcutaneous tissue. Therefore, the aim of this study is to report the experience regarding the use of ECT in a tertiary referral hospital and explore its safety and efficacy in treating skin cancer.</p><p><strong>Methods: </strong>This study included 97 skin cancer patients treated with ECT at the Surgical Oncological Unit of the University of Perugia, Italy, between 2013 and 2024. ECT was performed using the Cliniporator® device (model EP02, IGEA, Carpi, Italy). The individuals with life expectancy greater than three months and American Society of Anesthesiologists physical status classification of I-III were included in this study, while those with arrhythmia and allergies to bleomycin were excluded.</p><p><strong>Results: </strong>In this study, melanoma was the most frequently observed malignancy, accounting for 47.4% of all cases. A total of 46 melanoma patients aged between 42 and 93 years underwent ECT treatment. Most of these patients presented with in-transit metastases (67.4%) and often had multiple lesions (71.74%). Furthermore, 21 patients received only one session, while 25 underwent multiple sessions. Almost all procedures were performed with intravenous administration of bleomycin. However, in two cases, intralesional cisplatin was used for a recurrence of melanoma localized in the scalp. Notably, no adverse events were observed during ECT procedure. Moreover, most of the patients (70.45%) were alive one year after the first ECT session. The 5-year probability of survival was 24% after the first ECT session.</p><p><strong>Conclusions: </strong>Electrochemotherapy represents a safe and effective therapeutic strategy for various malignancies, with significant potential for future clinical applications.</p>","PeriodicalId":8210,"journal":{"name":"Annali italiani di chirurgia","volume":"96 2","pages":"194-204"},"PeriodicalIF":0.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143432358","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Association of the Cancer Inflammation Prognostic Index with Microsatellite Instability, Tumor Budding and Prognosis in Colorectal Adenocarcinoma.","authors":"Uğur Topal, Sercan Yüksel, Mehmet Zişan Songür, Rabia Doğukan, Erdal Karaköse, Zafer Teke, Hasan Bektaş","doi":"10.62713/aic.3858","DOIUrl":"10.62713/aic.3858","url":null,"abstract":"<p><strong>Aim: </strong>This study aimed to investigate the relationship between the Cancer Inflammation Prognostic Index (CIPI) and microsatellite instability (MSI), tumor budding, and prognosis in colorectal cancer cases.</p><p><strong>Methods: </strong>Patients with stage 1-3 colorectal cancer who underwent curative surgical treatment between May 2020 and January 2022 were included. Serum CIPI was calculated, a cut-off point was established using Receiver Operating Characteristic (ROC) analysis and Patients were divided into two groups according to their CIPI scores: Group 1 (low CIPI) consisted of 94 patients, and Group 2 (high CIPI) consisted of 95 patients.</p><p><strong>Results: </strong>A CIPI score >8.54 predicted mortality with 82.2% sensitivity and 59.7% specificity (area under the curve (AUC): 0.712). There were differences in tumor localization (p = 0.01). Group 2 had higher C-reactive protein (CRP) levels (4.2 vs 11.7, p < 0.001), lower albumin levels (4.1 vs 4, p = 0.04), higher neutrophil counts (3.76 vs 4.83, p = 0.002), and higher levels of carcinoembryonic antigen (CEA) and carbohydrate antigen 19.9 (Ca 19.9) (2.08 vs 8.27, p < 0.001 and 8.85 vs 13.9, p = 0.014, respectively). Tumor diameter was larger in high CIPI group (3 vs 3.8 cm, p = 0.001) , disease-free survival (37.7 vs 27.6 months, p < 0.001) and overall survival (39.6 vs 30.6 months, p < 0.001) were lower in high CIPI group 2. In the multivariate Cox regression analysis, a high CIPI score remained a strong independent predictor of poor overall survival (hazard ratio (HR) = 3.383, 95% confidence interval (CI): 1.445-7.921, p = 0.005) disease-free survival, a high CIPI score again stood out as a critical prognostic factor (HR = 3.280, 95% CI: 1.695-6.347, p < 0.001).</p><p><strong>Conclusions: </strong>A high CIPI score is associated with poor histopathological features and decreased survival. Closer monitoring or more aggressive treatment might improve prognosis for patients with high CIPI values.</p>","PeriodicalId":8210,"journal":{"name":"Annali italiani di chirurgia","volume":"96 3","pages":"362-370"},"PeriodicalIF":0.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143639424","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Acute Myocardial Infarction Due to Spontaneous Coronary Artery Dissection at 36 Weeks of Pregnancy: A Case Report.","authors":"Paolo Meloni, Paolo Izzo, Luciano Izzo, Manfredi Arioti, Terenzia Simari, Federico Ariel Sanchez, Cristian Cascione, Andrea Montevecchi, Chiara Boccherini, Fausta Orsi, Claudia De Intinis, Sara Izzo","doi":"10.62713/aic.3747","DOIUrl":"10.62713/aic.3747","url":null,"abstract":"<p><strong>Aim: </strong>Acute myocardial infarction in pregnancy (pAMI) is a rare event that is often caused by non-classical factors rather than atherosclerosis. The management of such complications requires a multidisciplinary team, and it is important to bring together the specialties involved to ensure that these teams are coordinated and ready to respond. The management of pAMI poses unique challenges because it requires consideration of both maternal and fetal well-being.</p><p><strong>Case presentation: </strong>We present the case of a 36-week pregnant woman who presented with anterolateral ST elevation myocardial infarction (STEMI) complicated by cardiogenic shock. To ensure comprehensive decision making, an emergency Pregnancy Heart Team meeting was convened, which comprised interventional cardiologists, gynecologists, and anesthesiologists. The team prioritized interventional treatment for pAMI, according to European Society of Cardiology (ESC) guidelines, and opted for primary percutaneous coronary intervention (PCI) due to the unstable maternal condition.</p><p><strong>Results: </strong>The patient underwent primary PCI as the chosen intervention for pAMI. A rapid response gynecology team closely monitored the procedure and was prepared to intervene in case of irreversible hemodynamic compromise leading to cardiac arrest. An emergency cesarean section was deemed necessary if cardiac activity was not restored within 4 minutes.</p><p><strong>Conclusions: </strong>Managing pAMI requires a multidisciplinary approach that balances the maternal and fetal well-being. In this particular case, the Pregnancy Heart Team decided to prioritize interventional treatment with primary PCI due to the unstable maternal condition. The presence of a closely monitored gynecology team ensured prompt action in case of complications.</p>","PeriodicalId":8210,"journal":{"name":"Annali italiani di chirurgia","volume":"96 3","pages":"309-314"},"PeriodicalIF":0.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143639390","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Application of Different Surgical Strategies in Helicobacter pylori-Associated Gastric Ulcers with Perforation: A Comparative Study of Short-Term and Long-Term Outcomes and Complication Risks.","authors":"Jianqiang Pan, Miao Shen, Su Peng","doi":"10.62713/aic.3812","DOIUrl":"10.62713/aic.3812","url":null,"abstract":"<p><strong>Aim: </strong>This study compared the short- and long-term efficacy of simple suture with omental patch repair (Graham patch) in open surgery versus laparoscopic omental patch repair (LOPR) in treating patients with Helicobacter pylori (H. pylori)-associated gastric ulcers with perforation, and analyzed the incidence of complications.</p><p><strong>Methods: </strong>The clinical information of patients who had stomach perforation repair surgery in Deqing People's Hospital between January 2021 and January 2022 was retrospectively analyzed. The patients were divided into a control group (n = 54), whose subjects underwent the Graham patch repair, and an observation group (n = 52), whose subjects underwent laparoscopic gastric perforation repair. The general characteristics, therapeutic outcomes, intraoperative and postoperative surgical indicators, 1-year postoperative recurrence, and incidence of various postoperative complications were recorded and compared between the two groups.</p><p><strong>Results: </strong>A total of 106 patients' clinical data were included in the study, of which 52 (49.1%) underwent LOPR and 54 (50.9%) were treated with Graham patch. The general characteristics of the patients in both groups were comparable. The observation group demonstrated significantly better outcomes in terms of operative time, intraoperative blood loss, and postoperative recovery time compared to the control group (p < 0.05). Moreover, the observation group had lower rates of postoperative complications and recurrence compared to the control group (p < 0.05).</p><p><strong>Conclusions: </strong>LOPR is a potential therapeutic method for patients with H. pylori-associated gastric ulcers with perforations on grounds of its superior efficacy and decreased incidence of comorbidities.</p>","PeriodicalId":8210,"journal":{"name":"Annali italiani di chirurgia","volume":"96 1","pages":"63-68"},"PeriodicalIF":0.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142998953","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Surgical Priority for Echinococcal Cysts in the Lung and Liver: One or Two-Stage?","authors":"Turkan Dubus, Gokce Cangel, Kenan Büyükasik, Ibrahim Taskin Rakici, Aziz Ari","doi":"10.62713/aic.3793","DOIUrl":"10.62713/aic.3793","url":null,"abstract":"<p><strong>Aim: </strong>This study aimed to evaluate the surgical outcomes of liver and lung hydatid cysts treated either simultaneously or in separate stages. The main focus was to determine the impact of surgical timing on postoperative complications and overall patient recovery, with an emphasis on minimally invasive techniques.</p><p><strong>Methods: </strong>A retrospective analysis was conducted on 42 patients diagnosed with concomitant liver and lung hydatid cysts between March 2009 and July 2020. Surgical procedures included video-assisted thoracoscopic surgery (VATS), thoracotomy, laparoscopy, and laparotomy. Patient demographics, cyst characteristics, concomitant diseases, surgical procedures, postoperative complications, and recovery times were analyzed. The statistical significance of surgical outcomes between one-stage and two-stage procedures was assessed using appropriate statistical tests.</p><p><strong>Results: </strong>Demographic analysis revealed that 57.1% of the participants were female and 42.9% male, with an average age of 36 years. Comorbidities were present in 23.8% of patients, with chronic obstructive pulmonary disease (COPD) being the most common at 11.9% and asthma at 7.1%. The complication rate was 35.3% in patients who underwent lung hydatid cyst surgery and 30.8% in those who underwent liver and lung hydatid cyst surgery. Although there was no statistically significant difference among the three groups (p = 0.840), liver surgery was associated with a longer hospital stay (p = 0.013). Minimally invasive surgical techniques (VATS, laparoscopy) had a lower complication rate (20% versus 40.9%, p = 0.143). These results suggest that minimally invasive techniques can reduce the risk of complications.</p><p><strong>Conclusions: </strong>The timing of the surgical procedure, whether performed in one or two stages, had no significant effect on the complication rate. Minimally invasive techniques are recommended due to their lower complication rate and shorter recovery time.</p>","PeriodicalId":8210,"journal":{"name":"Annali italiani di chirurgia","volume":"96 2","pages":"168-178"},"PeriodicalIF":0.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143432320","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nomograms Predicting Long-Term Survival in Patients With De Novo Metastatic Colon Cancer: A Population-Based Analysis.","authors":"Rong Wang, Junchi Cheng, Wangyan Zhong, Xiaohong Wang","doi":"10.62713/aic.3345","DOIUrl":"https://doi.org/10.62713/aic.3345","url":null,"abstract":"<p><strong>Aim: </strong>Our study aims to evaluate the overall survival (OS) and cancer-specific survival (CSS) of patients with colon cancer who present with distant metastasis, and to construct a prognostic nomogram for forecasting long-term survival outcomes.</p><p><strong>Methods: </strong>This population-based cohort analysis involved patients identified with de novo metastatic colon cancer between 2010 and 2015, utilizing data from the Surveillance Epidemiology and End Results (SEER) database.</p><p><strong>Results: </strong>The analysis comprised 6857 individuals diagnosed with de novo metastatic colon cancer and divided evenly into training and validation sets. Results from multivariate Cox regression analysis revealed that both OS and CSS were independently influenced by histological grade, patient age, T and N stage, presence of distant metastasis, perineural invasion, levels of carcinoembryonic antigen (CEA), receipt of chemotherapy, and surgery. Additionally, race emerged as a predictive factor for CSS but not for OS. The investigation successfully crafted a predictive nomogram capable of estimating personalized long-term survival probabilities, with a concordance index (C-index) of approximately 0.72 in both training and validation cohorts. By incorporating various clinicopathological characteristics, this nomogram effectively stratifies patients into distinct risk groups, each with a unique prognostic outlook.</p><p><strong>Conclusions: </strong>This investigation sheds light on prognostic factors that impact the survival of patients with newly diagnosed metastatic colon cancer. Nomograms also enable accurate prediction of individual long-term survival for patients with de novo metastatic colon cancer.</p>","PeriodicalId":8210,"journal":{"name":"Annali italiani di chirurgia","volume":"96 5","pages":"695-702"},"PeriodicalIF":0.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144075388","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impacts of Average Real Variability Parameters of Blood Pressure on Recovery Following Posterior Fixation Surgery for Thoracolumbar Vertebral Fractures.","authors":"Guanyi He, Nan Yu, Rui Huang, Yingzhe Jin, Ming Yao, Shuo Wang, Huibin Zhang","doi":"10.62713/aic.3929","DOIUrl":"https://doi.org/10.62713/aic.3929","url":null,"abstract":"<p><strong>Aim: </strong>This study aimed to investigate the influence of average real variability (ARV) parameters of blood pressure on the recovery following posterior fixation surgery for thoracolumbar vertebral fractures.</p><p><strong>Methods: </strong>A retrospective analysis was conducted on 190 patients who underwent posterior fixation surgery for thoracolumbar vertebral fractures at Ningbo Medical Center Lihuili Hospital between January 2021 and December 2023. Patients were divided into two groups based on their postoperative recovery: the good recovery group (n = 140) and the poor recovery group (n = 50). Univariate and binary logistic regression analyses were performed to identify factors influencing postoperative recovery. Pearson correlation analysis was used to assess the relationships between ARV and other variables, while receiver operating characteristic (ROC) curve analysis was conducted to evaluate the predictive value of ARV in postoperative recovery.</p><p><strong>Results: </strong>No statistically significant differences were observed between the two groups in terms of age, body mass index (BMI), gender, place of residence, monthly family income, occupation, education level, surgery duration, intraoperative blood loss, fracture type, fracture location, or fracture stage (p > 0.05). However, significant differences were noted in complication rates, ARV levels, and self-efficacy scores (p < 0.05). Pearson linear correlation analysis revealed that ARV was positively correlated with the presence of complications (r = 0.151, p < 0.05). Binary logistic regression analysis identified complications, ARV, and self-efficacy as significant factors influencing postoperative recovery (p < 0.05). Patients were divided into four groups based on ARV quartiles: Group 1 (ARV < 0.79), Group 2 (0.79 ≤ ARV < 0.89), Group 3 (0.89 ≤ ARV < 0.98), and Group 4 (ARV ≥ 0.98). A statistically significant difference in complication rates was observed across the groups (p < 0.05). ROC analysis showed that the area under the curve (AUC) for ARV in predicting postoperative recovery was 0.724 (95% confidence interval (CI): 0.612-0.836, p < 0.001).</p><p><strong>Conclusions: </strong>ARV is a significant factor influencing recovery following posterior fixation surgery for thoracolumbar vertebral fractures. Higher ARV levels are associated with increased postoperative complications, leading to poorer recovery outcomes.</p>","PeriodicalId":8210,"journal":{"name":"Annali italiani di chirurgia","volume":"96 4","pages":"470-477"},"PeriodicalIF":0.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143959741","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}