Animal Nutrition最新文献

{"title":"Microencapsulated Lactobacillus plantarum promotes intestinal development through gut colonization of layer chicks","authors":"Yaoming Cui, Yanxia Liu, Jing Yang, Haitao Duan, Peng Wang, Linna Guo, Yanjiao Guo, Suying Li, Yating Zhao, Jinrong Wang, Guanghai Qi, Junjun Guan","doi":"10.1016/j.aninu.2024.03.016","DOIUrl":"https://doi.org/10.1016/j.aninu.2024.03.016","url":null,"abstract":"The effects of in microencapsulation (LPM) on intestinal development in layer chicks were investigated in this study, as well as the colonization of in the gut. A total of 480 healthy Hy-Line Brown layer chicks at 0 d old were randomly divided into 4 groups (8 replicates each treatment), and the diets of these birds were supplemented with nothing (control), (0.02 g/kg feed; 10 CFU/kg feed), LPM (1.0 g/kg feed; 10 CFU/kg feed) and wall material of LPM (WM; 0.98 g/kg feed), respectively. Compared to control, LPM improved growth performance and intestinal development of layer chicks, evidenced by significantly increased body weight, average daily gain, average daily feed intake, villus height, villus height/crypt depth, as well as weight and length of the duodenum, jejunum and ileum ( < 0.05). These results could be attributed to the increased colonization of in the gut, which was verified by significant increases in lactic acid content, viable counts in chyme and mucosa ( < 0.05), as well as a visible rise in number of strains labeled with fluorescein isothiocyanate. Meanwhile, the relative abundances of and significantly increased in response to microencapsulated supplementation ( < 0.05), accompanied by the significant up-regulation of colonization related genes ( < 0.05), encoding solute carrier family, monocarboxylate transporter, activin A receptor, succinate receptor and secretogranin II. To sum up, microencapsulated supplementation promoted intestinal development, which could be attributed to the enhancement of colonization in the intestine through the mutual assistance of and interactions with colonization related transmembrane proteins.","PeriodicalId":8184,"journal":{"name":"Animal Nutrition","volume":"73 1","pages":""},"PeriodicalIF":6.3,"publicationDate":"2024-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141509854","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multi-omics revealed the mechanism of feed efficiency in sheep by the combined action of the host and rumen microbiota","authors":"Guangchen Zhou, Junda Li, Xuhui Liang, Bohua Yang, Ximeng He, Hongyu Tang, Hongran Guo, Gongwei Liu, Wenyuan Cui, Yulin Chen, Yuxin Yang","doi":"10.1016/j.aninu.2024.04.009","DOIUrl":"https://doi.org/10.1016/j.aninu.2024.04.009","url":null,"abstract":"This study was conducted to investigate potential regulatory mechanisms of feed efficiency (FE) in sheep by linking rumen microbiota with its host by the multi-omics analysis. One hundred and ninety-eight hybrid female sheep (initial body weight = 30.88 ± 4.57 kg; 4-month-old) were selected as candidate sheep. Each test sheep was fed in an individual pen for 60 days, and the residual feed intake (RFI) was calculated. The ten candidate sheep with the highest RFI were divided into the Low-FE group, and the ten with the lowest RFI were divided into the High-FE group, all selected for sample collection. The RFI, average daily gain and average daily feed intake were highly significantly different between the two experimental groups ( < 0.05). Compared with Low-FE group, the insulin-like growth factor-1 and very low-density lipoprotein in serum and the propionate in rumen significantly increased in High-FE group ( < 0.01), but the acetate:propionate ratio in rumen significantly decreased in High-FE group ( = 0.034). Metagenomics revealed sp. and were key bacteria, and increased abundance of the genes encoding the enzymes for cellulose degradation and production of propionate in High-FE group. The results of proteomics and section showed the rumen papilla length ( < 0.001) and expression of carbonic anhydrase and Na/K-ATPase were significantly higher in High-FE group ( < 0.05). On the other hand, the acetyl-CoA content significantly increased in the liver of High-FE group ( = 0.002). The relative expression levels of insulin-like growth factor-1 and apolipoprotein A4 genes were significantly up-regulated in the liver of High-FE group ( < 0.01), but relative expression level of monoacylglycerol O-acyltransferase 3 gene was significantly down-regulated ( = 0.037). These findings provide the mechanism by which the collaborative interaction between rumen microbiota fermentation and host uptake and metabolism of fermentation products impacts feed efficiency traits in sheep.","PeriodicalId":8184,"journal":{"name":"Animal Nutrition","volume":"7 1","pages":""},"PeriodicalIF":6.3,"publicationDate":"2024-04-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142182332","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Combined intestinal microbiota and transcriptomic analysis to investigate the effect of different stocking densities on the ability of Pacific white shrimp (Litopenaeus vannamei) to utilize Chlorella sorokiniana","authors":"Hang Yuan, Minghua Xie, Jian Chen, Naijie Hu, Honming Wang, Beiping Tan, Lili Shi, Shuang Zhang","doi":"10.1016/j.aninu.2024.04.008","DOIUrl":"https://doi.org/10.1016/j.aninu.2024.04.008","url":null,"abstract":"Aiming to investigate the impact of different stocking densities on the ability of Pacific white shrimp () to utilize (CHL), a 3 × 2 factorial design stocking experiment was used in this study. Specifically, shrimp was fed with two dietary protein sources (fishmeal [FM] and CHL) at low (LSD; 100 per m), medium (MSD; 200 per m) and high (HSD; 300 per m) stocking densities for 8 weeks. The growth performance and resistance to (1.0 × 10 CFU/mL) of shrimp decreased with the increase of stocking density, but dietary CHL improved this result. Differences between the CHL and FM groups for . resistance were significant only under high-density conditions ( < 0.05). Significant interactions between stocking density and protein source were found on the activities of catalase (CAT), superoxide dismutase (SOD) and phenol oxidase (PO), and the contents of malondialdehyde (MDA) in the hepatopancreas and the activities of intestinal amylase, most of which were significantly different between CHL and FM groups only at high stocking density ( < 0.05). Analysis of 16S rDNA sequencing showed that dietary CHL increased the alpha diversity of intestinal microbiota, inhibited the colonization of pathogenic bacteria and enhanced the abundance of beneficial bacteria. Transcriptomic results showed that at high stocking densities, differentially expressed genes (DEGs) in the FM vs CHL group were mostly upregulated and primarily enriched in immune and metabolic related pathways including Toll, immune deficiency (Imd) and glycolysis–gluconeogenesis pathways. Pearson correlation analysis revealed significant correlation between the top ten intestinal bacteria at the genus level and markedly enriched DEGs, also more were detected under high density situations. In conclusion, CHL has great potential as a novel protein source in the intensive farming of shrimp.","PeriodicalId":8184,"journal":{"name":"Animal Nutrition","volume":"12 1","pages":""},"PeriodicalIF":6.3,"publicationDate":"2024-04-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142182333","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dietary supplementation with Neolamarckia cadamba leaf extract improves broiler meat quality by enhancing antioxidant capacity and regulating metabolites","authors":"Cheng Wang, Dandan Chen, Shou Wu, Wei Zhou, Xiaoyang Chen, Qing Zhang, Li Wang","doi":"10.1016/j.aninu.2024.01.011","DOIUrl":"https://doi.org/10.1016/j.aninu.2024.01.011","url":null,"abstract":"This study was to evaluate the effect of supplementing the diet of broilers with leaf extract (NCLE) on meat quality by evaluating antioxidant parameters and the expression of genes in the p38 mitogen-activated protein kinase/nuclear factor-erythroid 2-related factor 2/antioxidant responsive element (p38 MAPK/Nrf2/ARE) signaling pathway, coupled with LC–MS-based metabolomic analysis. A total of 480 one-day-old male broilers were randomly allocated to four treatment groups—a control (CON) group, which was fed a basal diet, and three NCLE treatment groups, which were fed the basal diet supplemented with 100, 200, or 400 mg/kg NCLE (N1, N2, and N3 groups, respectively) for 42 d. Compared with the CON group, meat quality was improved in the N2 and N3 groups, as evidenced by the higher pH ( < 0.05) and lower shear force ( < 0.05) in breast muscle (BM) and lower drip loss at 48 h ( < 0.05) in leg muscle (LM). Moreover, BM antioxidant capacity was significantly enhanced in the N3 group, characterized by an increase in the total antioxidant capacity (T-AOC), the concentrations of glutathione peroxidase (GSH-Px) and catalase (CAT), and the relative mRNA expression of , extracellular-signal regulated kinase (), c-Jun N-terminal kinase (), , , and ( < 0.05). Similarly, LM in the N3 group displayed higher T-AOC, increased GSH-Px and CAT concentrations, reduced malonaldehyde contents ( < 0.05), and upregulation of the relative mRNA levels of , , heme oxygenase, , and superoxide dismutase () ( < 0.05). Metabolomics analysis revealed that D-arabinono-1,4-lactone and lyso-PAF C-16-d4 were negatively correlated with shear force and cooking loss ( < 0.05) and displayed increased abundance in BM of the N3 group. L-Serine levels were upregulated while D-fructose 1,6-diphosphate contents were downregulated in the three NCLE groups. Finally, the differential metabolites in both BM and LM were involved in amino acid metabolism pathways. Our results indicated that NCLE supplementation improved meat quality by enhancing antioxidant enzyme activities, promoting the expression of genes in the p38 MAPK/Nrf2/ARE signaling pathway, and regulating amino acid metabolism. The optimal NCLE concentration was found to be 400 mg/kg.","PeriodicalId":8184,"journal":{"name":"Animal Nutrition","volume":"47 1","pages":""},"PeriodicalIF":6.3,"publicationDate":"2024-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141153154","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advancements in animal nutrition: The interplay of feed enzymes, gut health, and nutrient supply in poultry and pig production – A tribute to Professor Mingan Choct's 30-year scientific legacy","authors":"Shu-Biao Wu","doi":"10.1016/j.aninu.2024.03.002","DOIUrl":"https://doi.org/10.1016/j.aninu.2024.03.002","url":null,"abstract":"","PeriodicalId":8184,"journal":{"name":"Animal Nutrition","volume":"47 1","pages":""},"PeriodicalIF":6.3,"publicationDate":"2024-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141153156","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fat deposition and partitioning for meat production in cattle and sheep","authors":"Shimin Liu, Yanyan Yang, Hailing Luo, Wenjie Pang, Graeme B. Martin","doi":"10.1016/j.aninu.2024.03.003","DOIUrl":"https://doi.org/10.1016/j.aninu.2024.03.003","url":null,"abstract":"In markets for beef and sheep meat, an appropriate level of intramuscular fat (IMF) is highly desirable for meat-eating quality, but strategies to improve it usually lead to an undesirable excess in carcase fat, presenting a major challenge to livestock producers. To solve this problem, we need to understand the partitioning of fat among the major fat depots: IMF, subcutaneous fat (SCF) and visceral fat (VF). In most genotypes of cattle and sheep, the rate of accretion is lower for IMF than for SCF and VF, so genetic selection for a high level of IMF, or the use of an increased dietary energy supply to promote IMF deposition, will increase overall fatness and feed costs. On the other hand, feeding postnatal calves with excessive concentrates promotes IMF deposition, so a nutritional strategy is feasible. With genetic strategies, several problems arise: 1) positive genetic correlations between IMF, SCF and VF differ among genotypes in both cattle and sheep; 2) genotypes appear to have specific, characteristic rates of accretion of IMF during periods of growth and fattening; 3) most breeds of cattle and sheep naturally produce meat with relatively low levels of IMF, but IMF does vary substantially among individuals and breeds so progress is possible through accurate measurement of IMF. Therefore, an essential prerequisite for selection will be knowledge of the genetic correlations and fat accretion rates for each genotype. Currently, selection for IMF is based on existing technology that directly measures IMF in the progeny or siblings, or estimates IMF in live animals. New technology is needed to permit the simultaneous measurement of SCF and IMF in the field, thus opening up the possibility of accurate selection, particularly for fat partitioning in live animals. Specifically, there would be great value in detecting individuals with an IMF advantage at an early age so the generation interval could be shortened and genetic gain accelerated. Genetic gain would also be greatly aided if we could select for genes that control adipogenesis and lipogenesis and are also differentially expressed in the various depots.","PeriodicalId":8184,"journal":{"name":"Animal Nutrition","volume":"61 1","pages":""},"PeriodicalIF":6.3,"publicationDate":"2024-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141153155","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rosemary leaf powder improves egg quality, antioxidant status, gut barrier function, and cecal microbiota and metabolites of late-phase laying hens","authors":"Lianhua Zhang, Junwei Ge, Fei Gao, Min Yang, Hui Li, Fei Xia, Hongtong Bai, Xiangshu Piao, Zhiying Sun, Lei Shi","doi":"10.1016/j.aninu.2024.02.003","DOIUrl":"https://doi.org/10.1016/j.aninu.2024.02.003","url":null,"abstract":"This study sought to determine the effects of rosemary leaf powder (RP) on laying performance, egg quality, serum indices, gut barrier function, and cecal microbiota and metabolites of late-phase laying hens. A total of 84 “Jing Tint 6” laying hens at 65-week old were randomly divided into 2 groups and fed either a basal diet (CON) or a basal diet supplemented with 0.3% RP. Our study revealed that RP improved the Haugh unit and decreased yolk n-6/n-3 polyunsaturated fatty acid (PUFA) ratio of laying hens, increased serum superoxide dismutase (SOD), jejunal activities of SOD and catalase (CAT), and jejunal zonula occludens-1 () expression, as well as decreased serum tumor necrosis factor-α (TNF-α) level and jejunal mRNA expression. RP markedly enhanced ( < 0.05) cecal abundances of Rikenellaceae, , and , tended to promote ( = 0.076) butyrate concentration, and reduced ( < 0.05) cecal abundances of Erysipelatoclostridiaceae, Sutterellaceae, Fusobacteriaceae, Campylobacteraceae, , , and , which were closely linked with Haugh unit, yolk n-6/n-3 PUFA ratio, serum SOD and TNF-α. In addition, RP altered the metabolic functions of cecal microbiota and enhanced the abundances of butyrate-synthesizing enzymes, including lysine 2,3-aminomutase, β-lysine 5,6-aminomutase, and 3-oxoacid CoA-transferase. Together, 0.3% RP has the potential to enhance egg quality by partially modulating serum antioxidant status, jejunal barrier function, and cecal microbiota structure and metabolites, indicating that RP could be considered a promising feed additive to promote the production performance of late-phase laying hens.","PeriodicalId":8184,"journal":{"name":"Animal Nutrition","volume":"25 1","pages":""},"PeriodicalIF":6.3,"publicationDate":"2024-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140182521","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Influence of previous plane of nutrition on molecular mechanisms regulating the expression of urea and water metabolism related genes in the rumen and kidney of finishing crossbred Angus steers","authors":"Aghata E. Moreira da Silva, Arturo Macias Franco, Bradley S. Ferguson, Mozart A. Fonseca","doi":"10.1016/j.aninu.2023.12.011","DOIUrl":"https://doi.org/10.1016/j.aninu.2023.12.011","url":null,"abstract":"This study aimed to understand how molecular mechanisms controlling water and urea metabolism at the finishing phase can be affected by previous plane of nutrition of crossbred Angus beef steers. Twenty-four ( 24) animals were randomly distributed into either a moderate (MP) or high plane of nutrition during the background phase for 85 d. Animals were then blocked by their previous plane and were moved onto a 105-d finishing phase in a 2 × 2 factorial arrangement. The forage-finished group received only high-quality alfalfa hay, whereas the grain-fed group received a high grain diet (80% whole corn and 20% alfalfa hay). By the end of the finishing phase, animals were harvested and tissue samples from the rumen and kidney were collected. Changes in gene expression of aquaporins () -, -, -, -, , (kidney and rumen), (kidney only) and (rumen only), were assayed via real-time qPCR; rRNA was used as an endogenous control. One-way ANOVA followed by Tukey’s post hoc analysis was conducted. When animals were from MP, forage-finishing increased the relative abundance of ( < 0.05) ( < 0.05) ( < 0.05) and ( < 0.05) in the kidney when compared to grain-fed animals. In the rumen, for the MP group, was differentially expressed in both treatments at the finishing phase ( < 0.01), with forage-finished steers having the highest expression of . For the MP group, had a tendency of presenting a higher expression on grain-fed animals ( = 0.075). Overall, these results suggest that previous plane can impact expression of genes associated with water and urea metabolism during the finishing phase, namely and in the kidney, and and in the rumen. The greatest impact observed on gene expression changes of investigated genes at the finishing phase was reflective of animals backgrounded on the moderate previous plane.","PeriodicalId":8184,"journal":{"name":"Animal Nutrition","volume":"17 1","pages":""},"PeriodicalIF":6.3,"publicationDate":"2024-03-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140182514","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessment of four different dietary amino acid profiles recommended for ISA Brown layer hens: a validation study","authors":"Mehdi Toghyani, Shemil Macelline, Juliano C. de Paula Dorigam, Peter V. Chrystal, Peter H. Selle, Sonia Y. Liu","doi":"10.1016/j.aninu.2024.01.009","DOIUrl":"https://doi.org/10.1016/j.aninu.2024.01.009","url":null,"abstract":"The current feeding study was designed to validate the two dietary essential amino acid profiles (EAAP) established based on linear broken-line (LBL) and quadratic broken-line (QBL) models, in a previous study, against Evonik (AMINOHen) and breeder recommendations for ISA Brown layers for peak production (PP, 20 to 44 weeks), and post peak production (post PP, 44 to 75 weeks). The EAAP based on LBL models on average had 19.5% and 26.0% lower digestible AA (Lys, Met + Cys, Thr, Trp, Ile and Val), than the EAAP based on QBL models for PP and post PP, respectively. The EAAP based on AMINOHen and breeder recommendation had lower digestible AA than QBL, and higher EAAP than LBL models for both production phases. At 20 weeks of age 224 ISA Brown layer hens were weighed and randomly allocated to individual battery cages. Each of the four diets was replicated 8 times with 7 birds per replicate. Egg production was recorded daily, and egg weights were measured at the end of each week. Feed consumption was measured at the end of each period. The egg production rate was not significantly affected by the diets and remained at around 98.0% (PP) and 95.0% (post PP). Birds fed diets based on LBL recommendation consistently laid smaller eggs, resulting in a lower egg mass (59.8 vs. 62.0 g egg/hen per day during PP, and 60.3 vs. 63.0 g egg/hen per day during post PP; < 0.05). Diets had no significant effect on feed intake and body weight ( > 0.05). The highest FCR during PP ( = 0.067) and post PP ( < 0.05) was recorded for the birds offered diets based on LBL recommendation. In conclusion, all four EAAP tested in this study support an above average egg production rate. However, the EAAP based on LBL models may potentially decrease the input feed cost per kilogram of eggs but are not set to optimise FCR and maximise egg mass.","PeriodicalId":8184,"journal":{"name":"Animal Nutrition","volume":"127 1","pages":""},"PeriodicalIF":6.3,"publicationDate":"2024-03-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140182538","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nutrition, gastrointestinal microorganisms and metabolites in mastitis occurrence and control","authors":"Yue Wang, Yiguang Zhao, Xiangfang Tang, Xuemei Nan, Linshu Jiang, Hui Wang, Jun Liu, Liang Yang, Junhu Yao, Benhai Xiong","doi":"10.1016/j.aninu.2024.01.010","DOIUrl":"https://doi.org/10.1016/j.aninu.2024.01.010","url":null,"abstract":"Mastitis affects almost all mammals including humans and dairy cows. In the dairy industry, bovine mastitis is a disease with a persistently high incidence, causing serious losses to the health of cows, the quality of dairy products, and the economy of dairy farms. Although local udder infection caused by the invasion of exogenous pathogens into the mammary gland was considered the main cause of mastitis, evidence has been established and continues to grow, showing that nutrition factors and gastrointestinal microbiome (GM) as well as their metabolites are also involved in the development of mammary inflammatory response. Suboptimal nutrition is recognized as a risk factor for increased susceptibility to mastitis in cattle, in particular the negative energy balance (NEB). The majority of data regarding nutrition and bovine mastitis involves micronutrients. In addition, the dysbiotic GM can directly trigger or aggravate mastitis through entero-mammary gland pathway. The decreased beneficial commensal bacteria, lowered bacterial diversity, and increased pathogens as well as proinflammatory metabolites are found in both the milk and gastrointestinal tract (GIT) of mastitic dairy cows. This review discussed the relationship between the nutrition (energy and micronutrient levels) and mastitis, summarized the role of GM and metabolites in regulating mastitis. Meanwhile, several non-antibiotics strategies were provided for the prevention and alleviation of mastitis, including micronutrients, probiotics, short-chain fatty acids (SCFA), high-fiber diet, inulin, and aryl hydrocarbon receptor (AhR).","PeriodicalId":8184,"journal":{"name":"Animal Nutrition","volume":"45 1","pages":""},"PeriodicalIF":6.3,"publicationDate":"2024-03-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140182504","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}