Archives of Disease in Childhood - Fetal and Neonatal Edition最新文献

{"title":"Effect of probiotic supplementation on the gut microbiota in very preterm infants: a systematic review.","authors":"Kayleigh Vievermanns, Thomas H Dierikx, Nathalie J Oldenburger, Faridi S Jamaludin, Hendrik J Niemarkt, Tim G J de Meij","doi":"10.1136/archdischild-2023-326691","DOIUrl":"10.1136/archdischild-2023-326691","url":null,"abstract":"<p><strong>Objective: </strong>There is increasing evidence that probiotic supplementation in very preterm infants decreases the risk of necrotising enterocolitis (NEC), sepsis and mortality. The underlying mechanisms, including effects on the gut microbiota, are largely unknown. We aimed to systematically review the available literature on the effects of probiotic supplementation in very preterm infants on gut microbiota development.</p><p><strong>Design: </strong>A systematic review in Medline, Embase, Cochrane Library, CINAHL and Web of Science.</p><p><strong>Setting: </strong>Neonatal intensive care unit.</p><p><strong>Patients: </strong>Premature infants.</p><p><strong>Intervention: </strong>Probiotic supplementation.</p><p><strong>Main outcome measures: </strong>Gut microbiota.</p><p><strong>Results: </strong>A total of 1046 articles were screened, of which 29 were included. There was a large heterogeneity in study design, dose and type of probiotic strains, timepoints of sample collection and analysing techniques. Bifidobacteria and lactobacilli were the most used probiotic strains. The effects of probiotics on alpha diversity were conflicting; however, beta diversity was significantly different between probiotic-supplemented infants and controls in the vast majority of studies. In most studies, probiotic supplementation led to increased relative abundance of the supplemented strains and decreased abundance of genera such as <i>Clostridium</i>, <i>Streptococcus</i>, <i>Klebsiella</i> and <i>Escherichia</i>.</p><p><strong>Conclusions: </strong>Probiotic supplementation to preterm infants seems to increase the relative abundance of the supplemented strains with a concurrent decrease of potentially pathogenic species. These probiotic-induced microbial alterations may contribute to the decreased risk of health complications such as NEC. Future trials, including omics technologies to analyse both microbiota composition and function linked to health outcomes, are warranted to identify the optimal mixture and dosing of probiotic strains.</p><p><strong>Prospero registration number: </strong>CRD42023385204.</p>","PeriodicalId":8177,"journal":{"name":"Archives of Disease in Childhood - Fetal and Neonatal Edition","volume":" ","pages":"57-67"},"PeriodicalIF":3.9,"publicationDate":"2024-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141454812","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of NICE clinical guidelines for prevention and treatment of neonatal infections on antibiotic use in very preterm infants in England and Wales: an interrupted time series analysis.","authors":"Mike Saunders, Shalini Ojha, Lisa Szatkowski","doi":"10.1136/archdischild-2024-326983","DOIUrl":"10.1136/archdischild-2024-326983","url":null,"abstract":"<p><strong>Objective: </strong>To assess the impact of publication of UK National Institute for Health and Care Excellence (NICE) guidelines on the prevention and treatment of early-onset infections (EOIs) in neonates (clinical guideline 149 (CG149), published in 2012, and its 2021 update (NG195) on antibiotic use in very preterm infants.</p><p><strong>Design: </strong>Interrupted time series analysis using data from the National Neonatal Research Database.</p><p><strong>Setting: </strong>Neonatal units in England and Wales.</p><p><strong>Participants: </strong>Infants born at 22-31 weeks' gestation from 1 January 2010 to 31 December 2022 and survived to discharge.</p><p><strong>Interventions: </strong>Publication of CG149 (August 2012) and NG195 (April 2021).</p><p><strong>Main outcome measures: </strong>Measures of antibiotic use, aggregated by month of birth: antibiotic use rate (AUR), the proportion of care days in receipt of at least one antibiotic; percentage of infants who received ≥1 day of antibiotics on days 1-3 for EOI and after day 3 for late-onset infection (LOI); percentage who received ≥1 prolonged antibiotic course ≥5 days for EOI and LOI.</p><p><strong>Results: </strong>96% of infants received an antibiotic during inpatient stay. AUR declined at publication of CG149, without further impact at NG195 publication. There was no impact of CG149 on the underlying trend in infants receiving ≥1 day antibiotics for EOI or LOI, but post-NG195 the monthly trend began to decline for EOI (-0.20%, -0.26 to -0.14) and LOI (-0.23%, -0.33 to -0.12). Use of prolonged antibiotic courses for EOI and LOI declined at publication of CG149 and for LOI this trend accelerated post-NG195.</p><p><strong>Conclusions: </strong>Publications of NICE guidance were associated with reductions in antibiotic use; however neonatal antibiotic exposure remains extremely high.</p>","PeriodicalId":8177,"journal":{"name":"Archives of Disease in Childhood - Fetal and Neonatal Edition","volume":" ","pages":"30-36"},"PeriodicalIF":3.9,"publicationDate":"2024-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11672067/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141157936","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Top 10 research priorities for congenital diaphragmatic hernia in Australia: James Lind Alliance Priority Setting Partnership.","authors":"Roberto Chiletti, Courtney Vodopic, Emiko Hunt, Jess Lawer, Monique Bertinetti, Stephanie Malarbi, Valerie Kyritsis, Scott Petersen, David Stewart, Jean Hellstern, Michael Stewart, Leah Hickey, David G Tingay, Trisha M Prentice","doi":"10.1136/archdischild-2024-327108","DOIUrl":"10.1136/archdischild-2024-327108","url":null,"abstract":"<p><strong>Objectives: </strong>The Gaps in the Congenital Diaphragmatic Hernia (CDH) Journey Priority Setting Partnership (PSP) was developed in collaboration with CDH Australia, James Lind Alliance (JLA) and the Murdoch Children's Research Institute to identify research priorities for people with CDH, their families and healthcare workers in Australasia.</p><p><strong>Design: </strong>Research PSP in accordance with the JLA standardised methodology.</p><p><strong>Setting: </strong>Australian community and institutions caring for patients with CDH and their families.</p><p><strong>Patients: </strong>CDH survivors, families of children born with CDH (including bereaved) and healthcare professionals including critical care physicians and nurses (neonatal and paediatric), obstetric, surgical, allied health professionals (physiotherapists, speech pathologists and speech therapists) and general practitioners.</p><p><strong>Main outcome measure: </strong>Top 10 research priorities for CDH.</p><p><strong>Results: </strong>377 questions, from a community-based online survey, were categorised and collated into 50 research questions. Through a further prioritisation process, 21 questions were then discussed at a prioritisation workshop where they were ranked by 21 participants (CDH survivors, parents of children born with CDH (bereaved and not) and 11 multidisciplinary healthcare professionals) into their top 10 research priorities.</p><p><strong>Conclusion: </strong>Stakeholders' involvement identified the top 10 CDH-related research questions, spanning from antenatal care to long-term functional outcomes, that should be prioritised for future research to maximise meaningful outcomes for people with CDH and their families.</p>","PeriodicalId":8177,"journal":{"name":"Archives of Disease in Childhood - Fetal and Neonatal Edition","volume":" ","pages":"23-29"},"PeriodicalIF":3.9,"publicationDate":"2024-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11672073/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141330289","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sebaceous naevus syndrome with multisystemic manifestations.","authors":"Eva Garcia Canto, Paula Soler López, Angela Martínez Bayo, Ana Fernández Bernal, Ismael Martín de Lara, Caridad Tapia Collado, Javier González de Dios","doi":"10.1136/archdischild-2024-327170","DOIUrl":"10.1136/archdischild-2024-327170","url":null,"abstract":"","PeriodicalId":8177,"journal":{"name":"Archives of Disease in Childhood - Fetal and Neonatal Edition","volume":" ","pages":"107-108"},"PeriodicalIF":3.9,"publicationDate":"2024-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141431182","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Randomised cross-over study of thin catheters used for less invasive surfactant delivery in a newborn manikin.","authors":"Robert Thomas Joyce, Lucy Elizabeth Geraghty, Colm Patrick Finbarr O'Donnell","doi":"10.1136/archdischild-2024-327473","DOIUrl":"10.1136/archdischild-2024-327473","url":null,"abstract":"","PeriodicalId":8177,"journal":{"name":"Archives of Disease in Childhood - Fetal and Neonatal Edition","volume":" ","pages":"112-113"},"PeriodicalIF":3.9,"publicationDate":"2024-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141589513","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Survival and unique clinical practices of extremely preterm infants born at 22-23 weeks' gestation in Japan: a national survey.","authors":"Tetsuya Isayama, Kei Miyakoshi, Fumihiko Namba, Mariko Hida, Ichiro Morioka, Keisuke Ishii, Susumu Miyashita, Shuichiro Uehara, Yoshiaki Kinoshita, Sachie Suga, Katsutoshi Nakahata, Atsushi Uchiyama, Katsufumi Otsuki","doi":"10.1136/archdischild-2023-326355","DOIUrl":"10.1136/archdischild-2023-326355","url":null,"abstract":"<p><strong>Objectives: </strong>To investigate prognosis and clinical practices of infants born at 22-23 weeks' gestational age (wkGA) in Japan.</p><p><strong>Design: </strong>A national institutional-level electronic questionnaire surveys performed in September 2021.</p><p><strong>Setting: </strong>All perinatal centres across Japan.</p><p><strong>Patients: </strong>Infants born at 22-23 wkGA in 2018-2020.</p><p><strong>Main outcome measures: </strong>Proportion of active resuscitation and survival at neonatal intensive care unit (NICU) discharge, and various clinical practices.</p><p><strong>Results: </strong>In total, 255 of 295 NICUs (86%) responded. Among them, 145 took care of infants born at 22-23 wkGA and answered the questions regarding their outcomes and care. In most NICUs (129 of 145 (89%)), infants born at 22⁺⁰ wkGA can be actively resuscitated. In almost half of the NICUs (79 of 145 (54%)), infants born at ≥22⁺⁰ wkGA were always actively resuscitated. Among 341 and 757 infants born alive at 22 and 23 wkGA, respectively, 85% (291 of 341) and 98% (745 of 757) received active resuscitation after birth. Among infants actively resuscitated at birth, 63% (183 of 291) and 80% (594 of 745) of infants born at 22 and 23 wkGA survived, respectively. The survey revealed unique clinical management for these infants in Japan, including delivery with caul in caesarean section, cut-cord milking after clamping cord, immediate intubation at birth, hydrocortisone use for chronic lung disease, analgesia/sedation use for infants on mechanical ventilation, routine echocardiography and brain ultrasound, probiotics administration, routine glycerin enema and skin dressing to prevent pressure ulcers.</p><p><strong>Conclusions: </strong>Many 22-23 wkGA infants were actively resuscitated in Japan and had a high survival rate. Various unique clinical practices were highlighted.</p>","PeriodicalId":8177,"journal":{"name":"Archives of Disease in Childhood - Fetal and Neonatal Edition","volume":" ","pages":"17-22"},"PeriodicalIF":3.9,"publicationDate":"2024-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141079678","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"UK neonatal stoma practice: a population study.","authors":"Graciaa Singhal, Rema Ramakrishnan, Raph Goldacre, Cheryl Battersby, Nigel J Hall, Chris Gale, Marian Knight, Nick Lansdale","doi":"10.1136/archdischild-2024-327020","DOIUrl":"10.1136/archdischild-2024-327020","url":null,"abstract":"<p><strong>Objective: </strong>The optimal time for neonatal stoma closure is unclear and there have been calls for a trial to compare early and late surgery. The feasibility of such a trial will depend on the population of eligible infants and acceptability to families and health professionals. In this study, we aimed to determine current UK practice and characteristics of those undergoing stoma surgery.</p><p><strong>Design: </strong>A retrospective cohort study of neonates who had undergone stoma surgery (excluding anorectal malformations and Hirschsprung's disease) using three national databases: the National Neonatal Research Database (NNRD, 2012-2019), British Association of Paediatric Surgeons Congenital Anomalies Surveillance System (BAPS-CASS, 2013-2014) and Hospital Episode Statistics-Admitted Patient Care (HES-APC, 2011-2018).</p><p><strong>Results: </strong>1830 eligible neonates were identified from NNRD, 163 from BAPS-CASS, 2477 from HES-APC. Median (IQR) duration of stoma in days was 57 (36-80) in NNRD, 63 (41-130) in BAPS-CASS and 78 (55-122) for neonates identified from HES-APC. At the time of closure, there were low rates of invasive ventilation (13%), inotrope use (5%) and recent steroids use (4%). Infants who underwent earlier closure (<9 weeks) were less preterm (median 28 weeks vs 25 weeks), have higher birth weight (median 986 g vs 764 g) and more likely to have stoma complications (29% vs 5%).</p><p><strong>Conclusion: </strong>There are sufficient UK neonates undergoing stoma formation for a trial. Stoma closure is performed at around 2 months, with clinical stability, gestation, weight and stoma complications appearing to influence timing. The variation in practice we document indicates there is opportunity to optimise practice through a trial.</p>","PeriodicalId":8177,"journal":{"name":"Archives of Disease in Childhood - Fetal and Neonatal Edition","volume":" ","pages":"79-84"},"PeriodicalIF":3.9,"publicationDate":"2024-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11671890/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141426192","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between video laryngoscopy characteristics and successful neonatal tracheal intubation: a prospective study.","authors":"William Corder, Timothy Nelin, Anne M Ades, John Flibotte, Elizabeth Laverriere, Rodrigo Daly Guris, Leane Soorikian, Elizabeth E Foglia","doi":"10.1136/archdischild-2024-326992","DOIUrl":"10.1136/archdischild-2024-326992","url":null,"abstract":"<p><strong>Objective: </strong>To identify associations between procedural characteristics and success of neonatal tracheal intubation (NTI) using video laryngoscopy (VL).</p><p><strong>Design: </strong>Prospective single-centre observational study.</p><p><strong>Setting: </strong>Quaternary neonatal intensive care unit.</p><p><strong>Patients: </strong>Infants requiring NTI at the Children's Hospital of Philadelphia.</p><p><strong>Interventions: </strong>VL NTI recordings were evaluated to assess 11 observable procedural characteristics hypothesised to be associated with VL NTI success. These characteristics included measures of procedural time and performance, glottic exposure and position, and laryngoscope blade tip location.</p><p><strong>Main outcome measure: </strong>VL NTI attempt success.</p><p><strong>Results: </strong>A total of 109 patients underwent 109 intubation encounters with 164 intubation attempts. The first attempt success rate was 65%, and the overall encounter success rate was 100%. Successful VL NTI attempts were associated with shorter procedural duration (36 s vs 60 s, p<0.001) and improved Cormack-Lehane grade (63% grade I vs 49% grade II, p<0.001) compared with unsuccessful NTIs. Other factors more common in successful NTI attempts than unsuccessful attempts were laryngoscope blade placement to lift the epiglottis (45% vs 29%, p=0.002), fewer tracheal tube manoeuvres (3 vs 8, p<0.001) and a left-sided or non-visualised tongue location (76% vs 56%, p=0.009).</p><p><strong>Conclusion: </strong>We identified procedural characteristics visible on the VL screen that are associated with NTI procedural success. Study results may improve how VL is used to teach and perform neonatal intubation.</p>","PeriodicalId":8177,"journal":{"name":"Archives of Disease in Childhood - Fetal and Neonatal Edition","volume":" ","pages":"91-95"},"PeriodicalIF":3.9,"publicationDate":"2024-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141475772","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Case-control study of milk curd obstruction in newborn infants in a tertiary surgical neonatal intensive care unit.","authors":"Orla Walsh, Ross Anthony, Zeke Wang, Barbara Elizabeth Cormack, Frank Harry Bloomfield","doi":"10.1136/archdischild-2024-327565","DOIUrl":"10.1136/archdischild-2024-327565","url":null,"abstract":"<p><strong>Background: </strong>Milk curd obstruction (MCO), in which milk becomes inspissated, is a rare, serious, complication of preterm birth. Case reports implicate male sex and bovine-derived human milk fortifier (HMF) use as predisposing factors. We investigated this through a case-control study.</p><p><strong>Methods: </strong>MCO cases in the Starship Child Health neonatal database between 2008 and 2020 were matched with controls in a 1:2 ratio based on gestational age (±1 week), birth weight (±200 g) and date of birth (±1 month). Data were analysed using the Student's t-test, Mann-Whitney U-test or χ² test as appropriate. Data are median (IQR) or n (%).</p><p><strong>Results: </strong>Of 20 MCO cases, gestation was 26.1 (24.5-28.1) weeks, birth weight was 822 (713-961) g, 15 (75%) were male. 40 controls were well-matched for gestation (26.1 (24.8-27.9) weeks) and birth weight (849 (690-1066) g) but only 18 (45%) were male (p=0.05). MCO occurred at 21 (15-33) days; 6 (30%) cases died compared with 3 (7.5%) controls (p=0.06). HMF was commenced at 243 (150-309) hours in cases and 224 (172-321) hours in controls (p=0.95); full-fortification (manufacturer's recommended dose) was achieved in 8 (40%) cases and 27 (68%) controls (p=0.08). In cases, MCO occurred 10 (7-17) days after commencing HMF. Medically/surgically-managed gut pathology occurred in 7 (35%) cases prior to MCO but in no controls (p<0.001).</p><p><strong>Conclusions: </strong>Our data support male sex but not HMF use as a predisposition to MCO. Evidence of prior medical/surgical gut pathology may be a premonition for MCO; however, further research is required to confirm this.</p>","PeriodicalId":8177,"journal":{"name":"Archives of Disease in Childhood - Fetal and Neonatal Edition","volume":" ","pages":"102-106"},"PeriodicalIF":3.9,"publicationDate":"2024-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11672052/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142456717","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sensorineural hearing impairment among preterm children: a Norwegian population-based study.","authors":"Dagny Hemmingsen, Dag Moster, Bo Lars Engdahl, Claus Klingenberg","doi":"10.1136/archdischild-2024-326870","DOIUrl":"10.1136/archdischild-2024-326870","url":null,"abstract":"<p><strong>Objective: </strong>To investigate the risk for sensorineural hearing impairment (SNHI) in preterm infants, and to what extent the risk is attributed to perinatal morbidities and therapies.</p><p><strong>Design: </strong>Population-based cohort study using data from several nationwide registries.</p><p><strong>Setting: </strong>Norwegian birth cohort 1999-2014, with data on SNHI until 2019.</p><p><strong>Participants: </strong>60 023 live-born preterm infants, divided in moderate-late preterm (MLP) infants (32-36 weeks), very preterm (VP) infants (28-31 weeks) and extremely preterm (EP) infants (22-27 weeks), and a reference group with all 869 797 term-born infants from the study period.</p><p><strong>Main outcome measures: </strong>SNHI defined by selected ICD-10 codes, recorded during minimum 5-year observation period after birth.</p><p><strong>Results: </strong>The overall SNHI prevalence in the preterm cohort was 1.4% compared with 0.7% in the reference group. The adjusted risk ratios (95% CIs) for SNHI were 1.7 (1.5-1.8) in MLP infants, 3.3 (2.8-3.9) in VP infants and 7.6 (6.3-9.1) in EP infants. Among EP infants, decreasing gestational age was associated with a steep increase in the risk ratio of SNHI reaching 14.8 (7.7-28.7) if born at 22-23 weeks gestation. Among the VP and MLP infants, mechanical ventilation and antibiotic therapy had strongest association with increased risk of SNHI, but infants not receiving these therapies remained at increased risk. Among EP infants intracranial haemorrhage increased the already high risk for SNHI. We found no signs of delayed or late-onset SNHI in preterm infants.</p><p><strong>Conclusion: </strong>Preterm birth is an independent risk factor for SNHI. Invasive therapies and comorbidities increase the risk, predominantly in infants born after 28 weeks gestation.</p>","PeriodicalId":8177,"journal":{"name":"Archives of Disease in Childhood - Fetal and Neonatal Edition","volume":" ","pages":"68-74"},"PeriodicalIF":3.9,"publicationDate":"2024-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141261116","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}