Archives of Disease in Childhood - Fetal and Neonatal Edition最新文献_第4页

Postnatal dexamethasone treatment for preterm infants at high risk for bronchopulmonary dysplasia is associated with improved regional brain volumes: a prospective cohort study. 一项前瞻性队列研究：产后地塞米松治疗支气管肺发育不良高风险早产儿可改善局部脑容量

IF 3.9 2区医学

Archives of Disease in Childhood - Fetal and Neonatal Edition Pub Date : 2025-05-28 DOI: 10.1136/archdischild-2024-328438

Rahul Chandwani, Julia Kline, Mekibib Altaye, Nehal Parikh

{"title":"Postnatal dexamethasone treatment for preterm infants at high risk for bronchopulmonary dysplasia is associated with improved regional brain volumes: a prospective cohort study.","authors":"Rahul Chandwani, Julia Kline, Mekibib Altaye, Nehal Parikh","doi":"10.1136/archdischild-2024-328438","DOIUrl":"10.1136/archdischild-2024-328438","url":null,"abstract":"Objective: To evaluate the effect of low-dose postnatal dexamethasone therapy for bronchopulmonary dysplasia (BPD) prevention/treatment on MRI-derived regional brain volumes at term-equivalent age (TEA) and neurodevelopmental outcomes in a regional cohort of preterm infants.Study design: We prospectively recruited 392 preterm infants (≤32 weeks gestational age (GA)), who underwent structural MRI (3T Philips Ingenia) at TEA. We automatically segmented T2-weighted MRI scans using the Developing Human Connectome Project pipeline to derive a priori selected, two primary outcomes of interest: volumes of the cerebellum and subcortical grey matter. We estimated propensity scores for subjects with a logistic regression model and used weighted linear regression to determine the independent effects of dexamethasone on primary and two secondary outcomes: cortical surface area at TEA and motor scores at 2 years corrected age.Results: Of 392 infants, 41 were treated with low cumulative dose dexamethasone (total 0.89 mg/kg) initiated at 36 days (median) of age for evolving BPD: 21 males; mean (SD) GA was 25.5 (1.6) weeks; postmenstrual age at MRI was 43.7 (1.2) weeks; and 33 had severe BPD. In multivariable linear regression, dexamethasone was significantly correlated with larger cerebellar (difference=0.510; 95% CI: 0.079 to 0.941) and subcortical grey matter volume (difference=0.138; 95% CI: 0.014 to 0.263). Dexamethasone was also positively correlated with motor scores (difference=5.220; 95% CI: 0.845 to 9.594).Conclusion: Low-dose dexamethasone therapy after the first postnatal week for evolving/established BPD did not result in adverse macrostructural effects and may have a protective effect on motor development in preterm infants.","PeriodicalId":8177,"journal":{"name":"Archives of Disease in Childhood - Fetal and Neonatal Edition","volume":" ","pages":""},"PeriodicalIF":3.9,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143966121","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Function over diagnoses: parents of extremely preterm infants give recommendations to clinicians about their information needs. 诊断功能：极度早产儿的父母向临床医生提供有关其信息需求的建议。

IF 3.9 2区医学

Archives of Disease in Childhood - Fetal and Neonatal Edition Pub Date : 2025-05-27 DOI: 10.1136/archdischild-2024-328249

Emilie Thivierge, Thuy Mai Luu, Claude Julie Bourque, Rebecca Pearce, Magdalena Jaworski, Keith J Barrington, Laurie-Anne Duquette, Annie Janvier

{"title":"Function over diagnoses: parents of extremely preterm infants give recommendations to clinicians about their information needs.","authors":"Emilie Thivierge, Thuy Mai Luu, Claude Julie Bourque, Rebecca Pearce, Magdalena Jaworski, Keith J Barrington, Laurie-Anne Duquette, Annie Janvier","doi":"10.1136/archdischild-2024-328249","DOIUrl":"https://doi.org/10.1136/archdischild-2024-328249","url":null,"abstract":"Objectives: Extremely preterm children may have a prolonged neonatal intensive care unit (NICU) stay. Their parents interact with clinicians both before and after birth. There is little information about parental satisfaction with the information received and what they would want to improve. The objective of this study was to explore parental perspectives regarding their information needs.Methods: Over 1 year, parents of children born at <29 weeks' gestational age (GA), who were aged between 18 months and 7 years old and came for their follow-up visit were invited to participate. They were asked to answer this question in their own words: \"Knowing what you know now, what do you wish doctors would have told you about prematurity before and/or after your child's birth?\" Mixed method analysis included thematic analysis performed by a multidisciplinary group, including parents, and logistic regression to compare parental responses.Results: Among parents (n=248, 98% of parents coming to follow-up), 45% were satisfied. When parents had recommendations, the main themes invoked improving communication about (1) preparing for discharge and life after the NICU in a stepwise, personalised and practical manner (40%), (2) more practical and functional information about being a parent in the NICU during the whole clinical trajectory (35%) and (3) more optimistic conversations with clinicians about the function of babies/families (as opposed to diagnoses) (26%).Conclusion: Although half the parents are satisfied with the information received, many recommended improvements in clinician-parent communication, mainly to make it more accessible, personalised, positive and practical.","PeriodicalId":8177,"journal":{"name":"Archives of Disease in Childhood - Fetal and Neonatal Edition","volume":" ","pages":""},"PeriodicalIF":3.9,"publicationDate":"2025-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144155913","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Prevention and treatment of autoimmune-mediated congenital heart block: practice provider survey from UK cardiac centres. 预防和治疗自身免疫介导的先天性心脏传导阻滞：来自英国心脏中心的实践提供者调查。

IF 3.9 2区医学

Archives of Disease in Childhood - Fetal and Neonatal Edition Pub Date : 2025-05-24 DOI: 10.1136/archdischild-2024-328428

Abhishek Agarwal, Sophia Khan, Melonie Johns, Colin J McMahon, Leila Rittey, Sophie Duignan, Peter John Lillitos, Nicola Boyd, David Black, Suhair Shebani, Abdulla Tarmahomed, Konta Laura, Olga Panagiotopoulou, Daniel Hawcutt

引用次数: 0

Treatment of Hypotension of Prematurity: a randomised trial. 早产儿低血压的治疗：一项随机试验。

IF 3.9 2区医学

Archives of Disease in Childhood - Fetal and Neonatal Edition Pub Date : 2025-05-24 DOI: 10.1136/archdischild-2024-328253

Thomas Alderliesten, Emad Arasteh, Anne van Alphen, Floris Groenendaal, Jeroen Dudink, Manon Jnl Benders, Frank van Bel, Pma Lemmers

{"title":"Treatment of Hypotension of Prematurity: a randomised trial.","authors":"Thomas Alderliesten, Emad Arasteh, Anne van Alphen, Floris Groenendaal, Jeroen Dudink, Manon Jnl Benders, Frank van Bel, Pma Lemmers","doi":"10.1136/archdischild-2024-328253","DOIUrl":"https://doi.org/10.1136/archdischild-2024-328253","url":null,"abstract":"Objective: To evaluate whether a perfusion-based approach (permissive hypotension, PH) for idiopathic low mean arterial blood pressure (MABP) during the first 72 hours after birth in preterm infants without overt sepsis affects neurodevelopmental outcome (NDO) at 24 months of age.Design: Randomised controlled trial. Outcome assessors were blinded.Setting: Single centre.Patients: Infants <30 weeks gestational age (GA) with MABP in mm Hg <GA in weeks during the first 72 hours after birth, without overt signs of sepsis.Intervention: Random assignment to PH, initiating treatment on signs of low perfusion and/or a MABP 5 mm Hg below their GA in weeks, or standard treatment (ST), initiating treatment when MABP was <GA in weeks.Main outcome measures: Death, NDO at 24 months, and composite adverse outcome (death or cognitive and/or motor NDO below -1 SD).Results: 86 infants were included, 57.3% of projected inclusions. Both cognitive NDO (PH-ST mean difference 0.8 (95% CI -5.6 to 7.3)) and motor NDO (mean difference 3.7 (-3.3 to 10.7)) were comparable. The relative risks for death (1.4 (0.6 to 3.7)) and composite adverse outcome (0.8 (0.5 to 1.3)) were comparable. The number of infants with inotropic support (n=19 (42.5%) vs 7 (15.2%), p=0.004) and duration of support (median 48.0 hours (IQR 26.8 to 77.5) vs 17.0 (14.0 to 37.0)) was lower in the PH group, with comparable MABPs.Conclusion: A PH approach in preterm infants is feasible. It leads to comparable blood pressures with less inotrope administration. Though underpowered, we did not detect a major negative impact of PH on short-term or long-term outcomes.Trial registration number: NCT01434251.","PeriodicalId":8177,"journal":{"name":"Archives of Disease in Childhood - Fetal and Neonatal Edition","volume":" ","pages":""},"PeriodicalIF":3.9,"publicationDate":"2025-05-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144141153","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Haemoglobin-oxygen affinity and the risk of bronchopulmonary dysplasia. 血红蛋白-氧亲和力与支气管肺发育不良的风险。

IF 3.9 2区医学

Archives of Disease in Childhood - Fetal and Neonatal Edition Pub Date : 2025-05-23 DOI: 10.1136/archdischild-2025-328784

Chad Andersen, Danielle Nicole Bailey, Tara Marie Crawford, Michael Stark

引用次数: 0

Hole in one: factors associated with successful neonatal endotracheal intubation. 一孔：与新生儿气管插管成功相关的因素。

IF 3.9 2区医学

Archives of Disease in Childhood - Fetal and Neonatal Edition Pub Date : 2025-05-22 DOI: 10.1136/archdischild-2025-328493

Brett James Manley, Shiraz Badurdeen

引用次数: 0

Video versus direct laryngoscopy for urgent tracheal intubation in neonates: a systematic review and meta-analysis. 视频与直接喉镜在新生儿紧急气管插管中的比较：系统回顾和荟萃分析。

IF 3.9 2区医学

Archives of Disease in Childhood - Fetal and Neonatal Edition Pub Date : 2025-05-22 DOI: 10.1136/archdischild-2024-327555

Niall Donaldson, Colm Patrick Finbarr O'Donnell, Charles Christoph Roehr, Eleri Adams, David George Bartle, Lucy Elizabeth Geraghty, Robert Tinnion, Joyce E O'Shea

{"title":"Video versus direct laryngoscopy for urgent tracheal intubation in neonates: a systematic review and meta-analysis.","authors":"Niall Donaldson, Colm Patrick Finbarr O'Donnell, Charles Christoph Roehr, Eleri Adams, David George Bartle, Lucy Elizabeth Geraghty, Robert Tinnion, Joyce E O'Shea","doi":"10.1136/archdischild-2024-327555","DOIUrl":"https://doi.org/10.1136/archdischild-2024-327555","url":null,"abstract":"Introduction: Intubation is most often performed electively by anaesthetists in controlled conditions in operating theatres. In neonates, however, it is most often performed by neonatologists or paediatricians in urgent circumstances in the neonatal intensive care unit (NICU) or delivery room (DR). Neonatal intubation is a difficult skill to learn and maintain, and success rates are suboptimal both in the NICU and DR. Video laryngoscopy (VL) has the potential to increase intubation success and safety as it may offer a better view of the airway, which can be shared by the intubator and other clinicians.Objectives: To compare the efficacy and safety of using VL to direct laryngoscopy (DL) for intubation of neonates in the NICU and DR.Search methods: We searched the Cochrane Central Register of Controlled Trials, MEDLINE, Embase and CINAHL up to August 2024 without language restrictions.Selection criteria: Randomised controlled trials (RCTs), quasi-RCTs, cluster-RCTs or cross-over trials that compared VL to DL for intubation of neonates outside of the neonatal operating theatre.Main results: VL improves first attempt intubation success rates, 849 intubations (RR 1.46, 95% CI 1.21 to 1.75), with a number needed to treat (NNT) of 6.Conclusions: VL improves intubation success rates without increasing adverse events and should be the standard of care for neonatal intubations in the NICU and DR.","PeriodicalId":8177,"journal":{"name":"Archives of Disease in Childhood - Fetal and Neonatal Edition","volume":" ","pages":""},"PeriodicalIF":3.9,"publicationDate":"2025-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144126188","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Relationship between applied face mask force and mask leak during simulated neonatal ventilation: a randomised simulation study. 在模拟新生儿通气过程中应用面罩力与面罩泄漏的关系：一项随机模拟研究。

IF 3.9 2区医学

Archives of Disease in Childhood - Fetal and Neonatal Edition Pub Date : 2025-05-20 DOI: 10.1136/archdischild-2024-328378

Jacqueline Hannan, Gary Weiner, Leia Stirling

{"title":"Relationship between applied face mask force and mask leak during simulated neonatal ventilation: a randomised simulation study.","authors":"Jacqueline Hannan, Gary Weiner, Leia Stirling","doi":"10.1136/archdischild-2024-328378","DOIUrl":"https://doi.org/10.1136/archdischild-2024-328378","url":null,"abstract":"Objective: Assess the relationship between applied face mask force and leak during simulated ventilation using different ventilating devices and mask holds.Design: Randomised cross-over simulation study.Setting: Quiet, non-clinical room in children's hospital.Participants: Twenty-four experienced neonatal healthcare providers.Interventions: Ventilate a manikin for 2 min per trial, each with three trial conditions: self-inflating bag (SIB) with one-hand hold, T-piece with one-hand hold, T-piece with two-hand hold.Main outcome measures: Applied force (newtons (N)) measured under the head and at four locations on the manikin's face (nasal bridge, mentum, left and right zygomatic arches), force asymmetry applied to the mask rim, and mask leak.Results: Under-head force was greatest using the SIB with one-hand hold (mean (SD) 20.53 (5.87) N) and least using the T-piece with one-hand hold (mean (SD) 17.58 (6.11) N). While mask leak was reduced with increasing force, leak-free ventilation was achieved by some participants in all trial conditions with low (<10 N) under-head force. Force asymmetry on the manikin's face was similar using a one-hand hold compared with a two-hand hold. With both holds, forces were greater on the side of the face corresponding to the operator's non-dominant hand.Conclusion: Applied force and leak varied between devices and mask holds. Force asymmetry was present with both mask holds. Leak-free ventilation could be achieved with small forces using either an SIB or T-piece and either mask hold. Force feedback during training may improve the effectiveness and safety of neonatal ventilation.","PeriodicalId":8177,"journal":{"name":"Archives of Disease in Childhood - Fetal and Neonatal Edition","volume":" ","pages":""},"PeriodicalIF":3.9,"publicationDate":"2025-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144109465","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Automated tactile stimulation in response to cardiorespiratory events in preterm infants: a feasibility study. 自动触觉刺激对早产儿心肺事件的反应：可行性研究。

IF 3.9 2区医学

Archives of Disease in Childhood - Fetal and Neonatal Edition Pub Date : 2025-05-19 DOI: 10.1136/archdischild-2024-328123

Sophie J E Cramer, Stuart B Hooper, Hylke H Salverda, Ryanne Koster, Janneke Dekker, Arjan B Te Pas

{"title":"Automated tactile stimulation in response to cardiorespiratory events in preterm infants: a feasibility study.","authors":"Sophie J E Cramer, Stuart B Hooper, Hylke H Salverda, Ryanne Koster, Janneke Dekker, Arjan B Te Pas","doi":"10.1136/archdischild-2024-328123","DOIUrl":"https://doi.org/10.1136/archdischild-2024-328123","url":null,"abstract":"Objective: Assess the feasibility and safety of a purpose-built automated tactile stimulation device (ATSD) responding to cardiorespiratory events in preterm infants.Design: Randomised cross-over study.Setting: Level-III neonatal intensive care unit in the Netherlands.Patients: Infants born between 24 and 30 weeks gestational age, receiving non-invasive respiratory support and experiencing apnoea, bradycardia and/or hypoxia for>10 s.Interventions: Infants underwent two study periods of 24 hours. In the control period, the ATSD was attached but inactive. In the intervention period, ATSD was activated and used in addition to standard care, providing direct vibratory stimulation in response to clinical alarms.Main outcome measure: Feasibility of using ATSD, expressed by the number of infants completing the study, the ability to provide stimulation on the skin and the perceived feasibility by the nurses.Results: 16 infants were included, of which 14 (88%) completed both study periods. Two infants were withdrawn from the study prematurely: one infant required intubation for cyanotic spells and the other developed local non-blanching erythema consistent with a mild pressure ulcer, on which the device was removed. During the intervention period, ATSD correctly detected 84% of the cardiorespiratory events, with automatic stimulation following 100% of the events. Nurses found the ATSD easy to use and rated the clinical utility neutral to positive.Conclusion: Applying automated tactile stimulation in preterm infants using a purpose-built device is feasible, was well tolerated by infants and nurses considered our device useful and easy to use.Trial registration details: Dutch national trial register, NL9606.","PeriodicalId":8177,"journal":{"name":"Archives of Disease in Childhood - Fetal and Neonatal Edition","volume":" ","pages":""},"PeriodicalIF":3.9,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144109369","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Aicardi-Goutières syndrome as a rare cause of neonatal intracranial calcifications. aicardii - gouti<e:1>综合征是新生儿颅内钙化的罕见病因。

IF 3.9 2区医学

Archives of Disease in Childhood - Fetal and Neonatal Edition Pub Date : 2025-05-16 DOI: 10.1136/archdischild-2025-328751

Adriel Kwok Huang Chen, Laura Daniela Valderrama Penagos, Khadidja Belkhatir

引用次数: 0