Anticancer research最新文献

{"title":"Detection of Somatostatin Receptors by Ligand Derivative Staining in Breast Tumors.","authors":"Kento Iida, Erina Iwabuchi, Yasuhiro Miki, Koki Hasegawa, Yasuyo Ohi, Yoshiaki Rai, Yasuaki Sagara, Takanori Ishida, Hironobu Sasano, Takashi Suzuki","doi":"10.21873/anticanres.17684","DOIUrl":"https://doi.org/10.21873/anticanres.17684","url":null,"abstract":"<p><strong>Background/aim: </strong>Somatostatin receptors (SSTRs) are G protein-coupled receptors that inhibit tumor cell proliferation. SSTRs are also expressed in breast cancer cells, and examination of clinical breast cancer specimens has revealed that SSTRs are more prevalent in patients with lower malignancy rates. However, in clinical trials of breast cancer, no significant differences in survival rates were detected upon administration of somatostatin analogs, highlighting the importance of detecting SSTRs in tumor tissues. Herein, we determined the expression of SSTRs in breast tumors using immunohistochemistry and ligand derivative staining (LDS) and examined the relevance of SSTR expression.</p><p><strong>Patients and methods: </strong>Pathological tissues from breast tumors diagnosed as invasive ductal carcinomas (n=85) or breast neuroendocrine tumors (NETs) (n=20) were used. Immunohistochemistry and LDS using fluorescein isothiocyanate (FITC)-labeled octreotide were performed to detect SSTR expression.</p><p><strong>Results: </strong>Immunohistochemistry of SSTR2 in breast cancer tissues revealed a significant positive association with estrogen receptor (ER) (<i>p</i><0.001) status, a significant negative association with stage (<i>p</i>=0.023), and a negative association with pN (<i>p</i>=0.055), which did not reach statistical significance. LDS in breast cancer demonstrated a significant positive association (<i>p</i>=0.027) with SSTR2 immunohistochemistry, a positive tendency with ER (<i>p</i>=0.065), and a negative association with pN (<i>p</i>=0.061). LDS in breast NETs was not associated with SSTR2 expression.</p><p><strong>Conclusion: </strong>Our findings revealed that immunohistochemistry allows specific detection of SSTR isoforms, whereas LDS could comprehensively evaluate SSTR expression. To the best of our knowledge, this is the first study to detect SSTR expression in breast cancer tissues using LDS, and the results suggest LDS as a new mode of evaluating SSTR status in clinical specimens.</p>","PeriodicalId":8072,"journal":{"name":"Anticancer research","volume":"45 8","pages":"3221-3230"},"PeriodicalIF":1.7,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144764365","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Late-onset Colonic Graft and Overlying Skin Necrosis 15 Years After Esophagectomy and Gastrectomy: A Case Report.","authors":"Koki Fujiwara, Junko Mukohyama, Fumihiko Kato, Ayu Kato, Sojun Hoshimoto, Masahiro Shinoda, Yoshifumi Ikeda, Osamu Itano","doi":"10.21873/anticanres.17717","DOIUrl":"https://doi.org/10.21873/anticanres.17717","url":null,"abstract":"<p><strong>Background/aim: </strong><i>C</i>olonic interposition following esophagectomy for esophageal cancer is a relatively uncommon reconstructive procedure, primarily indicated in patients who have undergone or require gastrectomy. Graft loss predominantly results from compromised perfusion due to feeding vessel insufficiency, generally occurring within weeks after surgery. We present the first case of delayed necrosis of colonic graft and skin occurring 15 years after subtotal esophagectomy and total gastrectomy.</p><p><strong>Case report: </strong>A 67-year-old female patient had a history of subtotal esophagectomy and total gastrectomy 15 years ago for early-stage esophageal and gastric cancer. She presented with acute chest wall swelling and constipation. Contrast-enhanced computed tomography demonstrated marked distension of the colonic graft and poor contrast in the colonic graft wall under the necrotic skin. The patient underwent a two-stage surgical intervention, using a left colonic graft for reconstruction. After being discharged 83 days after her initial admission, the patient remained asymptomatic six months later.</p><p><strong>Conclusion: </strong>This report presents a case of delayed necrosis of a colonic graft that occurred 15 years after the primary surgery, which was successfully treated through drainage surgery and two-stage reconstruction using a left colonic graft. It should be kept in mind that colonic graft necrosis, a rare late complication of esophagectomy, can progress rapidly.</p>","PeriodicalId":8072,"journal":{"name":"Anticancer research","volume":"45 8","pages":"3561-3566"},"PeriodicalIF":1.7,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144764312","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nuclear Localization of Chitinase 3-like 1 Is a Novel Biomarker for Detecting the Early Stage of Inflammation-associated Dysplasia in the Oral Cavity.","authors":"Yui Teratani, Takayuki Sadanaga, Siyuan Wang, Jingo Kusukawa, Emiko Mizoguchi","doi":"10.21873/anticanres.17708","DOIUrl":"https://doi.org/10.21873/anticanres.17708","url":null,"abstract":"<p><strong>Background/aim: </strong>Although the oral cavity is a site that can be seen directly, early detection of oral cancer remains challenging, with a cumulative 5-year survival rate of approximately 55% across all stages of the cancer, leading to poor treatment outcomes. Chitinase 3-like 1 (CHI3L1/YKL-40), is a chitinase-like protein that binds to chitin (a polymer of N-acetylglucosamine) despite lacking enzymatic activity. CHI3L1 is strongly expressed in colonic epithelial cells (CECs) under inflammatory conditions. Although CHI3L1 has been implicated in the carcinogenic transformation of CECs, the precise underlying mechanisms remain unclear.</p><p><strong>Materials and methods: </strong>CHI3L1 expression in oral epithelial cells was evaluated by immunofluorescence staining and quantitative-PCR. Immunostaining for CHI3L1 was conducted on paraffin-embedded tissue specimens, including oral squamous cell carcinoma (n=4) and carcinoma in situ (CIS; n=6) as malignant cases, and oral leukoplakia (n=29) as a precancerous condition. The nuclear-to-cytoplasmic ratio of the immunofluorescence signal was analyzed in each group.</p><p><strong>Results: </strong>CHI3L1 was found to be strongly expressed in the nucleus among patients with oral leukoplakia developing dysplasia (85.7%) or CIS (100%), whereas CHI3L1 exhibited weak and diffuse cytoplasmic expression in advanced cancer patients. These results suggest that CHI3L1 may temporarily translocate into the nucleus under chronic inflammatory conditions, leading to a transition to a precancerous stage.</p><p><strong>Conclusion: </strong>Nuclear translocation of CHI3L1 from cytoplasm seems to be a reliable biomarker for detecting the precancerous stage of oral epithelium under chronic inflammatory conditions.</p>","PeriodicalId":8072,"journal":{"name":"Anticancer research","volume":"45 8","pages":"3469-3478"},"PeriodicalIF":1.7,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144764353","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development and External Validation of Machine Learning-based Models for Predicting Survival Outcomes in Endometrial Cancer: A Population-based Study.","authors":"Munetoshi Akazawa, Kazunori Hashimoto, Hiroaki Nagano","doi":"10.21873/anticanres.17715","DOIUrl":"https://doi.org/10.21873/anticanres.17715","url":null,"abstract":"<p><strong>Background/aim: </strong>Most endometrial cancers are early-stage cancers with a good prognosis, but the prognosis for recurrent endometrial cancer is poor. Accurate prognostication is essential for the management of patients with cancer. This study aimed to assess the survival outcome of endometrial cancer using machine learning.</p><p><strong>Materials and methods: </strong>We used data from the Surveillance, Epidemiology, and End Results (SEER) database, constructing machine learning models to predict the 5-year overall survival (OS) and cancer-specific survival (CSS). The variables included patient demographics, pathological factors, and therapeutic factors.</p><p><strong>Results: </strong>The OS rates of 71,506 patients and the CSS rates of 66,368 patients were included. For the prediction of OS, the best machine learning model achieved a class accuracy of 0.86 (95% CI=0.85-0.87) and an area under the curve (AUC) of 0.83 (95% CI=0.82-0.84) in the internal validation set (SEER dataset). In the external validation set of 149 patients, the best model achieved a class accuracy of 0.85 (95% CI=0.86-0.86) and an AUC of 0.85 (95% CI=0.85-0.86). The model predicted CSS more accurately than OS.</p><p><strong>Conclusion: </strong>Using machine learning, we were able to predict the prognosis of patients with endometrial cancer.</p>","PeriodicalId":8072,"journal":{"name":"Anticancer research","volume":"45 8","pages":"3543-3551"},"PeriodicalIF":1.7,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144764366","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Response-guided Strategy Based on Induction Chemotherapy Without Routine Use of Radiotherapy for Locally Advanced Rectal Cancer.","authors":"Atsushi Ogura, Yuki Murata, Masanori Sando, Ryutaro Kobayashi, Konosuke Yogo, Shingo Maeda, Kenji Okuda, Shoji Kawakatsu, Shizuki Sugita, Nobuyuki Watanabe, Kazushi Miyata, Junpei Yamaguchi, Takashi Mizuno, Tomoki Ebata","doi":"10.21873/anticanres.17700","DOIUrl":"https://doi.org/10.21873/anticanres.17700","url":null,"abstract":"<p><strong>Background/aim: </strong>Total neoadjuvant therapy (TNT) is promising in reducing distant metastasis and facilitating nonoperative management (NOM) in locally advanced rectal cancer. However, concerns arise regarding the quality of total mesorectal excision (TME) and local regrowth after NOM. This study investigated the feasibility of a response-guided strategy centered on induction chemotherapy to enhance patient selection and outcomes.</p><p><strong>Patients and methods: </strong>From 2020 to 2023, patients with clinical Stage II/III lower rectal cancer, located within 10 cm from the anal verge, were enrolled. Induction chemotherapy used either an oxaliplatin-based doublet or triplet regimen over three months. Long-course chemoradiotherapy was administered selectively based on multidisciplinary evaluations, targeting either NOM or minimizing local recurrence for patients with mesorectal fascia (MRF) involvement.</p><p><strong>Results: </strong>Eighteen consecutive patients were enrolled. At first restaging, 39% (seven patients) achieved a complete or near-complete response. Consequently, five patients underwent NOM after chemoradiotherapy, achieving a 100% TME-free survival rate. R0 resections were successful in all 13 surgical cases, including two patients with residual tumor who underwent TNT and one patient with MRF involvement even after TNT, as well as 10 patients without MRF involvement treated solely with induction chemotherapy, omitting chemoradiotherapy.</p><p><strong>Conclusion: </strong>Induction chemotherapy effectively filters suitable candidates for NOM in locally advanced rectal cancer, suggesting a potential to omit routine radiotherapy. This approach highlights personalized treatment strategies and aims to enhance patients' quality of life by reducing unnecessary surgeries and preserving rectal function.</p>","PeriodicalId":8072,"journal":{"name":"Anticancer research","volume":"45 8","pages":"3393-3398"},"PeriodicalIF":1.7,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144764315","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"microRNA in Chorioamnionitis: Emerging Biomarkers for Early Diagnosis.","authors":"Chihiro Kiyoshima, Daichi Urushiyama, Kenichi Yoshikawa, Koko Ishida, Fusanori Yotsumoto","doi":"10.21873/anticanres.17721","DOIUrl":"https://doi.org/10.21873/anticanres.17721","url":null,"abstract":"<p><p>Chorioamnionitis can lead to preterm birth, which elevates the short- and long-term mortality risks due to neonatal sepsis and brain disease in infants. The clinical diagnosis of chorioamnionitis is imprecise, making accurate maternal and fetal prognosis difficult. Amniocentesis, used as a diagnostic tool for chorioamnionitis, is an invasive test that can lead to preterm birth. microRNAs are brief, noncoding RNAs of 21-25 nucleotides that regulate the expression of target genes in various biological processes such as cell proliferation, differentiation, and apoptosis. Certain serum microRNAs have been identified as potential biomarkers for the early detection of placental insufficiency and associated conditions such as fetal growth restriction and preeclampsia. However, limited studies have explored the association between chorioamnionitis and the expression of microRNAs in amniotic fluid and serum. This review discusses the potential of microRNAs as a diagnostic tool for chorioamnionitis and summarizes recent research on the relationship between chorioamnionitis and microRNAs.</p>","PeriodicalId":8072,"journal":{"name":"Anticancer research","volume":"45 8","pages":"3587-3594"},"PeriodicalIF":1.7,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144764349","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Proteomic and Metabolomic Analyses of Adipose-derived Mesenchymal Stem Cell Exosomes and Culture Supernatants.","authors":"Toyofumi Hirakawa, Tamotsu Kato, Yumiko Nakanishi, Daichi Urushiyama, Kohei Miyata, Tsukasa Baba, Hiroshi Ohno, Shin'ichiro Yasunaga, Fusanori Yotsumoto, Shingo Miyamoto","doi":"10.21873/anticanres.17703","DOIUrl":"https://doi.org/10.21873/anticanres.17703","url":null,"abstract":"<p><strong>Background/aim: </strong>Aberrant differentiation of fertilized eggs during <i>in vitro</i> fertilization is a major contributor to infertility, and adipose-derived mesenchymal stem cells (ASCs) and their exosomes have been reported to facilitate fertilized egg differentiation; however, the underlying mechanisms remain unclear. This study aimed to elucidate how ASC-derived exosomes promote fertilized egg differentiation through proteomic analysis of ASC-derived exosomal proteins and metabolomic profiling of culture supernatants.</p><p><strong>Materials and methods: </strong>Extracellular vesicles were isolated from ASC culture supernatants <i>via</i> differential ultracentrifugation, proteins were extracted and digested using a phase-transfer surfactant protocol for LC-MS/MS analysis, and metabolites were analyzed using GC-MS/MS following extraction and derivatization.</p><p><strong>Results: </strong>Exosomes from early passage ASCs were enriched with various proteins, including alpha and beta proteasome subunits, which exhibit proteasome activity. Gene ontology analysis revealed the presence of proteins associated with transmembrane transport and cytoplasmic translation. Metabolomic profiling of culture supernatants revealed markedly elevated levels of amino acids associated with glycine, serine, and methionine metabolism.</p><p><strong>Conclusion: </strong>ASC-derived culture supernatants can exert differentiation-promoting effects on fertilized eggs <i>via</i> exosomal proteins and soluble metabolites and may therefore be a novel option for infertility treatment.</p>","PeriodicalId":8072,"journal":{"name":"Anticancer research","volume":"45 8","pages":"3409-3424"},"PeriodicalIF":1.7,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144764357","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Combination of 3-(Trihydroxygermyl)propanoic Acid (THGP) and Lipopolysaccharide Promotes Macrophage Differentiation to M1, and Antitumor Activity.","authors":"Junya Azumi, Tomoya Takeda, Yasuhiro Shimada, Hisashi Aso, Hiroyuki Inagawa, Takashi Nakamura","doi":"10.21873/anticanres.17704","DOIUrl":"https://doi.org/10.21873/anticanres.17704","url":null,"abstract":"<p><strong>Background/aim: </strong>Macrophage polarization plays a critical role in cancer immunotherapy. This study aimed to evaluate the synergistic effects of 3-(trihydroxygermyl)propanoic acid (THGP), an organogermanium compound, and the immunostimulant lipopolysaccharide (LPS) derived from <i>Pantoea agglomerans</i> on M1 macrophage differentiation and antitumor activity.</p><p><strong>Materials and methods: </strong>RAW 264.7 cells were treated with THGP, LPS, or their combination for 1, 4, or 10 days. Morphological changes, M1 marker (CD80 and CD86) expression, cytokine production (IL-1β and IL-6), phagocytic activity, and cytotoxicity against B16-F10 melanoma cells were assessed using microscopy, qPCR, western blotting, immunofluorescence staining, and luciferase assays.</p><p><strong>Results: </strong>After one day of treatment, LPS treatment, both alone or in combination with THGP, increased M1 marker expression. By day 4, both agents individually induced M1 differentiation; their combination had a synergistic effect on cytokine production and phagocytic activity. Antitumor effects were observed only with the combined treatment. After 10 days, single and combined treatments resulted in comparable phagocytic and antitumor activities.</p><p><strong>Conclusion: </strong>The combination of THGP and LPS synergistically promotes M1 macrophage differentiation and enhances phagocytic and antitumor activities through distinct mechanisms. These findings suggest potential applications of this combination in cancer immunotherapy.</p>","PeriodicalId":8072,"journal":{"name":"Anticancer research","volume":"45 8","pages":"3425-3440"},"PeriodicalIF":1.7,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144764362","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The C-reactive Protein to Albumin Ratio (CAR) Is an Independent Prognostic Factor for Recurrence in Patients With Esophageal Cancer After Esophagectomy.","authors":"Toru Aoyama, Yukio Maezawa, Itaru Hashimoto, Keisuke Kazama, Mamoru Uchiyama, Kentaro Hara, Hideaki Suematsu, Haruhiko Cho, Ayako Tamagawa, Aya Saito, Norio Yukawa","doi":"10.21873/anticanres.17697","DOIUrl":"https://doi.org/10.21873/anticanres.17697","url":null,"abstract":"<p><strong>Background/aim: </strong>The C-reactive protein to albumin ratio (CAR) is a promising prognostic factor in various malignancies. The aim of the present study was to evaluate the relationship between CAR and unresectable esophageal cancer, and to clarify the role of CAR as a prognostic factor in patients with unresectable esophageal cancer.</p><p><strong>Patients and methods: </strong>We retrospectively reviewed the medical records and collected data from consecutive patients with recurrent EC who received any treatment (including best supportive care) after recurrence at Yokohama City University from 2005 to 2022.</p><p><strong>Results: </strong>One hundred patients were included in this study. According to the previous studies and the 1- and 3-year overall survival (OS) rates, we set the cutoff value of CAR at 0.03. In the present study, 100 patients were divided into CAR-low (n=36) and CAR-high (n=64) groups. The 1- and 3-year OS rates were 84.4% and 58.6%, respectively, in the CAR-low group, and 34.7% and 11.1% in the CAR-high group. There were significant differences between the two groups (<i>p</i><0.001). In the multivariate analysis, CAR was selected as an independent prognostic factor (hazard ratio=4.771, 95% confidence interval=2.559-8.894, <i>p</i><0.001). When comparing the treatment clinical course between the CAR-low and CAR-high groups, there was a significant difference in the rate of first-line treatment introduction [CAR-low <i>vs.</i> CAR-high: 94.4% (34/36) <i>vs.</i> 73.4% (47/64); <i>p</i>=0.010].</p><p><strong>Conclusion: </strong>CAR may be a promising prognostic factor in patients with recurrent EC.</p>","PeriodicalId":8072,"journal":{"name":"Anticancer research","volume":"45 8","pages":"3365-3372"},"PeriodicalIF":1.7,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144764413","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Multifaceted Role of AASDH: From Metabolic Regulation to Cancer and Cardiomyopathies.","authors":"Jaber H Jaradat, Pooya Jalali, Raghad Amro, Hamza K Alsalhi, Ibrahim Serag, Ahmed M Al-Nusairi, Anwaar Saeed","doi":"10.21873/anticanres.17679","DOIUrl":"https://doi.org/10.21873/anticanres.17679","url":null,"abstract":"<p><p>The enzyme 2-aminoadipic-6-semialdehyde dehydrogenase (<i>AASDH</i>) plays a crucial role in metabolic pathways and has emerged as a significant player in multiple pathological conditions, including cancer and cardiomyopathies. <i>AASDH</i> has been implicated in colorectal cancer (CRC), particularly in microsatellite instability (MSI)-high tumors, in which genetic alterations may contribute to chemotherapy resistance and tumor progression. In addition to CRC, dysregulation of <i>AASDH</i> has been observed in hepatocellular carcinoma (HCC) and lung adenocarcinoma (LUAD), where it influences lipid metabolism and oncogenic pathways. Additionally, emerging evidence suggests a strong link between <i>AASDH</i> and cardiomyopathies, highlighting its potential as a biomarker of ischemic cardiomyopathy-induced heart failure. At the molecular level, <i>AASDH</i> functions in ATP binding and acid-thiol ligase activity, and plays a pivotal role in stress responses, lysine metabolism, and oxidative stress protection. Its association with metabolic reprogramming and the tumor microenvironment suggests that targeting <i>AASDH</i> could enhance current therapeutic strategies for cancer and cardiovascular diseases. This review comprehensively explores the diverse roles of <i>AASDH</i>, emphasizing its potential as a prognostic biomarker and therapeutic target for multiple diseases. A deeper understanding of <i>AASDH</i> may pave the way for novel treatment strategies that integrate metabolic modulation with conventional therapies and improve clinical outcomes in both oncology and cardiology.</p>","PeriodicalId":8072,"journal":{"name":"Anticancer research","volume":"45 8","pages":"3165-3174"},"PeriodicalIF":1.7,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144764414","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}