Anticancer research最新文献

{"title":"Synergistic Effect of Antimicrobial Resistance and Cytogenetic Risk on Mortality in Acute Myeloid Leukemia.","authors":"Deivide DE Sousa Oliveira, Flávia Melo Cunha DE Pinho Pessoa, Isadora Lima Pontes, Kaira Mara DE Albuquerque Cordeiro, Beatriz Maria Dias Nogueira, Guilherme Passos DE Morais, Rodrigo Monteiro Ribeiro, Fabiana Aguiar Carneiro Silva, Lívia Andrade Gurgel, Manoel Odorico DE Moraes Filho, Maria Elisabete Amaral DE Moraes, Caroline Aquino Moreira-Nunes","doi":"10.21873/anticanres.17690","DOIUrl":"https://doi.org/10.21873/anticanres.17690","url":null,"abstract":"<p><strong>Background/aim: </strong>Acute myeloid leukemia (AML) is an aggressive hematological malignancy requiring intensive chemotherapy, which induces profound immunosuppression. Multidrug-resistant Gram-negative (MDRGN) bacterial colonization and infection are an emerging challenge in AML management, potentially worsening survival outcomes. This retrospective single-center cohort study evaluated the impact of MDRGN colonization and infection on overall survival (OS) in patients with AML undergoing chemotherapy.</p><p><strong>Materials and methods: </strong>MDRGN status was determined <i>via</i> routine cultures, while infection was defined by positive sterile-site cultures accompanied by clinical symptoms. Cytogenetic risk was stratified according to ELN 2022 criteria. Survival analysis was performed using the Kaplan-Meier method.</p><p><strong>Results: </strong>A total of 64 patients with AML were analyzed, with a median OS of 8.03 months. MDRGN-colonized patients had significantly shorter OS (3.53 months) than non-colonized patients (18.83 months; <i>p</i>=0.024). High-risk cytogenetics independently reduced OS (4.63 <i>vs.</i> 18.93 months; <i>p</i>=0.011). Patients with both high-risk cytogenetics and MDRGN colonization had the poorest prognosis, with a median OS of 1.47 months. MDRGN colonization was associated with significantly increased infection risk, treatment-related complications, and reduced survival in AML. The combined effect of antimicrobial resistance and high-risk cytogenetics suggests a synergistic impact on prognosis. Delayed targeted antibiotic therapy, chemotherapy modifications, and increased septic episodes likely contributed to the observed mortality.</p><p><strong>Conclusion: </strong>MDRGN colonization is a critical negative prognostic factor in AML, particularly in patients with adverse cytogenetics. Strengthening infection control measures, implementing rapid molecular diagnostics, and optimizing antimicrobial stewardship are essential to improve outcomes.</p>","PeriodicalId":8072,"journal":{"name":"Anticancer research","volume":"45 8","pages":"3295-3304"},"PeriodicalIF":1.7,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144764412","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rash and Endocrine Disorders Predict Improved Survival in Metastatic Renal Cell Carcinoma Treated With Immunotherapy.","authors":"Koichi Sugimoto, Takafumi Minami, Shingo Toyoda, Lan Inoki, Takuhisa Nukaya, Kiyoshi Takahara, Takahiro Adachi, Takeshi Hashimoto, Ryoichi Maenosono, Takuya Tsujino, Wataru Fukuokaya, Takafumi Yanagisawa, Takehiro Iwata, Kensuke Bekku, Motoo Araki, Takahiro Kimura, Haruhito Azuma, Yoshio Ohno, Ryoichi Shiroki, Kazutoshi Fujita","doi":"10.21873/anticanres.17696","DOIUrl":"https://doi.org/10.21873/anticanres.17696","url":null,"abstract":"<p><strong>Background/aim: </strong>Immune-related adverse events (irAEs) are associated with improved clinical outcomes in patients with metastatic renal cell carcinoma (mRCC) treated with immuno-oncology therapy. However, various irAEs occur during such therapy. In this study, we analyzed the association between irAEs and prognosis of patients with mRCC treated with nivolumab and ipilimumab.</p><p><strong>Patients and methods: </strong>We retrospectively collected data from 193 patients with mRCC who were treated with nivolumab and ipilimumab as first-line treatment between September 2018 and February 2023 at multiple institutions. We performed Cox proportional hazards analysis for progression-free (PFS) and overall (OS) survival to identify specific irAEs associated with prognosis.</p><p><strong>Results: </strong>Among the 153 eligible patients (median age=68 years; range=27-86 years, the median PFS was 7.8 months (95% confidence interval=6.0-12.5 months), and the median OS was 34.0 months (95% confidence interval=23.9 months - not reached). The most common irAEs were endocrine disorder (28.8%), rash (18.3%), pulmonary disorder (10.5%), and liver dysfunction (9.8%). In the multivariate analysis, endocrine disorder-related irAEs were identified as prognostic factors for significantly better PFS and OS. Additionally, rash-related irAEs were significant prognostic factors, specifically for better OS (<i>p</i><0.05).</p><p><strong>Conclusion: </strong>Both rash and endocrine disorder-related irAEs were predictors of survival outcomes in patients with mRCC treated with nivolumab and ipilimumab. Optimal management of these irAEs is essential for improving prognosis.</p>","PeriodicalId":8072,"journal":{"name":"Anticancer research","volume":"45 8","pages":"3355-3364"},"PeriodicalIF":1.7,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144764314","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"CD155 Expression Predicts Poor Prognosis in OTSCC and Correlates With TIGIT Expression and Tumor Budding.","authors":"Shoichi Kimura, Mikiko Aoki, Kensuke Nishi, Toranoshin Takeuchi, Takafumi Yamano, Toshifumi Sakata, Toshiyuki Tsunoda, Makoto Hamasaki","doi":"10.21873/anticanres.17712","DOIUrl":"https://doi.org/10.21873/anticanres.17712","url":null,"abstract":"<p><strong>Background/aim: </strong>Oral tongue squamous cell carcinoma (OTSCC) is the most common malignancy of the oral cavity, characterized by aggressive clinical behavior and poor prognosis. Despite treatment advancements, patient survival rates remain unsatisfactory. CD155, an immunoglobulin superfamily member, has been implicated in tumor progression and immune evasion, with its interaction with TIGIT serving as a potential therapeutic target. This study explored the association of CD155 and TIGIT expression with tumor budding (TB) and prognosis in OTSCC.</p><p><strong>Patients and methods: </strong>We retrospectively reviewed the clinicopathological data of patients with primary OTSCC who underwent surgical treatment at Fukuoka University Hospital from April 2002 to December 2021. The inclusion criteria were the availability of pre-treatment tissue specimens and adherence to a consistent treatment strategy. Patients with prior chemotherapy or radiation therapy, unavailable specimens, or non-compliance with the treatment protocol were excluded. CD155 and TIGIT expression levels were assessed with immunohistochemistry assays, and TB was graded.</p><p><strong>Results: </strong>Overall, 35 patients with OTSCC (60% male, mean age 67.1 years) were included. The median follow-up period was 35.1 months. High-grade CD155 expression was observed in eight patients (22.9%), while high TIGIT expression was noted in 13 patients (43.3%). High TB was significantly associated with high CD155 and high TIGIT expression. Patients with high CD155 expression had significantly shorter overall survival (median 21 months <i>vs.</i> 36 months for CD155-low), as did patients with high TIGIT expression (median 22 months <i>vs.</i> 37 months for TIGIT-Low) and those with TB-High (median 20 months <i>vs.</i> 38 months for TB-Low).</p><p><strong>Conclusion: </strong>CD155 and TIGIT are potential prognostic biomarkers and may serve as therapeutic targets in OTSCC. Our study highlights the importance of evaluating these markers to improve patient stratification and treatment approaches.</p>","PeriodicalId":8072,"journal":{"name":"Anticancer research","volume":"45 8","pages":"3511-3522"},"PeriodicalIF":1.7,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144764359","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dosing Time-Dependent Effects of Paclitaxel on Peripheral Neuropathy in Mice.","authors":"Yoshihiro Seto, Koichi Miyamoto, Daisuke Inoue, Fumiyasu Okazaki, Hideto To","doi":"10.21873/anticanres.17691","DOIUrl":"https://doi.org/10.21873/anticanres.17691","url":null,"abstract":"<p><strong>Background/aim: </strong>Paclitaxel (PTX) is a widely used anticancer drug that frequently causes peripheral neuropathy, particularly mechanical allodynia, which is the sensation of pain from mechanical stimuli that are not normally painful, as an adverse effect. In this study, we investigated the effectiveness of chronotherapy on PTX-induced mechanical allodynia in mice.</p><p><strong>Materials and methods: </strong>Male C57BL/6J mice were intravenously administered PTX at 1:00, 5:00, 9:00, 13:00, 17:00 or 21:00 of the day, and mechanical allodynia was assessed using the Von Frey test.</p><p><strong>Results: </strong>Significant circadian variations were observed at the 50% withdrawal threshold, with the lowest values observed in the PTX 9:00 group. When PTX was administered at 9:00 or 21:00, the 50% withdrawal threshold of the PTX 9:00 group was significantly lower than that of the control group. In contrast, the PTX 21:00 group recovered from mechanical allodynia earlier. Repeated administration of PTX showed that the PTX 21:00 group recovered from mechanical allodynia earlier than the PTX 9:00 group. The plasma concentrations of PTX 12 h after administration were significantly higher in the PTX 9:00 group than in the PTX 21:00 group, suggesting the involvement of circadian variations in drug metabolism. No significant differences were found in body weight changes or ALT levels among the control, PTX 9:00, and PTX 21:00 groups.</p><p><strong>Conclusion: </strong>Chronotherapy can ameliorate PTX-induced mechanical allodynia in mice, potentially contributing to improved cancer treatment in humans. Further studies on the pharmacokinetics and antitumor effects of PTX are required to understand the implications of chronotherapy fully.</p>","PeriodicalId":8072,"journal":{"name":"Anticancer research","volume":"45 8","pages":"3305-3314"},"PeriodicalIF":1.7,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144764303","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"3D-floating Culture for Cancer Research: A Mini-review.","authors":"Akiko Fukuyama, Takanori Kitaguchi, Kazumasa Yoshida, Taichi Matsumoto, Kazuhiro Koikawa, Michitaka Nakano, Gen Maruta, Hisanori Maeoka, Shuhei Ishikura, Senji Shirasawa, Toshiyuki Tsunoda","doi":"10.21873/anticanres.17702","DOIUrl":"https://doi.org/10.21873/anticanres.17702","url":null,"abstract":"<p><p>Unlike conventional two-dimensional cell cultures, three-dimensional (3D) culture systems can more accurately replicate key gene expression and drug sensitivity features of the <i>in vivo</i> tumor environment. Of the various 3D culture techniques, 3D-floating (3DF) culture has the unique ability to facilitate high-throughput screening while enabling both visual and quantitative appraisal of the interactions between cancer and immune cells in the presence of exogenous drugs. In this study, we used this method to evaluate treatment against adhesive and non-adhesive cancer cells and found Pyra-Metho-Carnil to be a promising new anticancer drug for refractory cancers. Thus, in this study, we discuss how the use of 3DF cultures can advance cancer research.</p>","PeriodicalId":8072,"journal":{"name":"Anticancer research","volume":"45 8","pages":"3401-3408"},"PeriodicalIF":1.7,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144764389","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Methionine Deprivation-induced Cancer Cell Death and Methylation Changes in Key Genes and Gene Promoters of Prostate Cancer Cell Lines.","authors":"Yatin Srinivash Ramesh Babu, Kallidaikurichi V Venkatachalam","doi":"10.21873/anticanres.17683","DOIUrl":"https://doi.org/10.21873/anticanres.17683","url":null,"abstract":"<p><strong>Background/aim: </strong>While normal cells are highly regulated, cancer cells take a dysregulated path which bolsters their survival. Currently, a limited number of uniform treatments are available for cancer cure. Our goal was to deprive cancer cells of the key nutrient methionine and determine what effect it would have on cell death and alterations in DNA methylation of prostate cancer cells.</p><p><strong>Materials and methods: </strong>PC3 and other cell lines were transfected with plasmid gene constructs for methionine gamma lyase deaminase (<i>MEGL</i>), a methionine-degrading enzyme, targeted for expression in the cytoplasm (cMEGL) or the nucleus (nMEGL). For assessing cell death due to <i>MEGL</i>-mediated methionine deprivation, a standard 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay was used. PC3, and DU145 prostate cancer cells were selected for whole-methylome sequencing to determine the effects of <i>MEGL</i> expression. Key gene products comprising the Prolaris Molecular Score, specifically 31 cell-cycle progression genes, were chosen for assessing putative differences in methylome.</p><p><strong>Results: </strong>Treatment with <i>MEGL</i> gene targeted for expression in either the cytoplasm or nucleus caused significant cell death, similar to that due to the anticancer drug methotrexate. Azacytidine showed no effect on PC3 cell death. Propargylglycine, an inhibitor of MEGL, prevented cell death. Methylome analysis showed increased methylation of two genes: Spindle and kinetochore-associated complex subunit 1 (<i>SKA1</i>), origin recognition complex subunit 6 (<i>ORC6L</i>), and reduced methylation of six promoters: BUB1 mitotic checkpoint serine/threonine kinase B (<i>BUB1B</i>), PDZ binding kinase (<i>PBK</i>), baculoviral IAP repeat-containing 5 (<i>BIRC5</i>), centromere protein M (<i>CENPM</i>), DNA topoisomerase II alpha (<i>TOP2A</i>), minichromosome maintenance 10 replication initiation factor (<i>MCM10</i>), upon forced expression of <i>MEGL</i>.</p><p><strong>Conclusion: </strong>Methionine deprivation through <i>MEGL</i>-targeted gene therapy may be a viable option for inducing cancer cell death compared to unrestricted levels of methionine.</p>","PeriodicalId":8072,"journal":{"name":"Anticancer research","volume":"45 8","pages":"3209-3219"},"PeriodicalIF":1.7,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144764348","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Endometrial Cancer Metastatic to the Sigmoid Colon and Pelvic Retroperitoneal Space: A Case Report.","authors":"Junko Mukohyama, Itaru Saito, Satoshi Mochizuki, Yasunori Ota, G O Ito, Jun Imaizumi, Satoko Monma, Naoki Sakuyama, Susumu Aikou, Dai Shida","doi":"10.21873/anticanres.17718","DOIUrl":"https://doi.org/10.21873/anticanres.17718","url":null,"abstract":"<p><strong>Background/aim: </strong>The majority of colorectal tumors are primary colorectal cancers (CRCs), which commonly develop distant metastases in advanced stages. In contrast, secondary involvement of the colon by tumors originating from other organs is rare. Endometrial cancer (EC) typically metastasizes to the vagina, lungs, and peritoneum, with colonic metastasis being exceedingly uncommon.</p><p><strong>Case report: </strong>A 76-year-old female patient presented with abdominal pain. Her medical history was notable for multiple malignancies, including Stage I left breast cancer, Stage IA endometrial cancer, and Stage IIA right breast cancer. Laboratory tests showed elevated levels of cancer antigen (CA)125 (234.5 U/ml) and CA19-9 (110.0 U/ml) were elevated. Contrast-enhanced computed tomography revealed large pelvic cystic tumor and irregular wall thickening of the sigmoid colon. Intraoperative findings showed that the small intestine and sigmoid colon were adherent to the pelvic tumor, forming a large single mass. To achieve en bloc and R0 resection, pelvic tumor resection, high anterior resection, enterectomy, and temporary ileostomy were performed. The histopathological diagnosis confirmed metastasis of EC to the sigmoid colon and pelvic retroperitoneal space, with 2 of 12 lymph nodes positive for metastasis. All surgical margins were negative, and no recurrences were observed nine months post-discharge.</p><p><strong>Conclusion: </strong>We present a rare case of EC metastasis to the colon and pelvic retroperitoneal space with lymph node metastases, successfully treated with en bloc surgical resection. Because EC and CRC exhibit morphological and pathological similarities, laboratory testing for tumor markers, including CA125, may be useful for the preoperative diagnosis of colonic tumors in patients with a history of EC.</p>","PeriodicalId":8072,"journal":{"name":"Anticancer research","volume":"45 8","pages":"3567-3573"},"PeriodicalIF":1.7,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144764308","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Resveratrol Enhances Sulfasalazine-induced Ferroptosis by Promoting Iron Ion Accumulation and Lipid Peroxidation in Cancer Cells.","authors":"Takumu Yamada, Takumi Iwasawa, Yui Shimizu, Kazunori Kato","doi":"10.21873/anticanres.17685","DOIUrl":"https://doi.org/10.21873/anticanres.17685","url":null,"abstract":"<p><strong>Background/aim: </strong>Sulfasalazine (SSZ) has traditionally been used as an immunomodulator; however, recent studies have highlighted its potential as a novel anticancer agent due to its ability to induce ferroptosis, an iron-dependent form of cell death. Resveratrol (RSV), a plant-derived bioactive compound commonly marketed as a dietary supplement, is known for its antioxidant and metabolic regulatory properties. This study aimed to investigate whether the combination of SSZ and RSV enhances antitumor activity and to elucidate their effects on ferroptosis.</p><p><strong>Materials and methods: </strong>Human melanoma cell lines expressing CD44 variant 9 and xCT, a transporter for SSZ, were used in this study. Cell viability was assessed using metabolic assays and flow cytometry. The accumulation of intracellular iron ions and lipid peroxides in cancer cells was analyzed <i>via</i> fluorescence microscopy.</p><p><strong>Results: </strong>The combination of SSZ and RSV significantly reduced the viability of melanoma cell lines. Treatment with SSZ led to an increase in reactive oxygen species (ROS) levels and a decrease in reduced glutathione (GSH) levels, both of which were further exacerbated by RSV. Furthermore, the combination of SSZ and RSV enhanced the accumulation of divalent iron ions and lipid peroxides within the mitochondria of cancer cells.</p><p><strong>Conclusion: </strong>SSZ and RSV exhibit a synergistic antitumor effect against cancer cells and enhance iron-dependent cell death, ferroptosis.</p>","PeriodicalId":8072,"journal":{"name":"Anticancer research","volume":"45 8","pages":"3231-3244"},"PeriodicalIF":1.7,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144764316","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Novel UF-5000-based Detection, Integrating Inflammatory Parameters, for Urothelial Carcinoma of the Urinary Bladder.","authors":"Kazuhiro Okada, Yoshiki Naito, Saori Irie, Chika Nakamoto, Kenji Kuboyama, Toshiki Tarumizu, Misaki Ikeda, Yuko Takuma, Ryo Makino, Akihiko Kawahara, Hiroyuki Kawano","doi":"10.21873/anticanres.17714","DOIUrl":"https://doi.org/10.21873/anticanres.17714","url":null,"abstract":"<p><strong>Background/aim: </strong>Urothelial carcinoma (UC) is the most common epithelial bladder malignancy. Although urine cytology is widely used for screening, its sensitivity in detecting low-grade UC is limited. This study evaluated the diagnostic accuracy of the research-use parameter \"Atyp.C\" from the fully automated urine particle analyzer UF-5000, in combination with the neutrophil-to-lymphocyte ratio (NLR), for UC detection.</p><p><strong>Patients and methods: </strong>Urine samples from 57 noninvasive UC, 41 invasive UC, and 61 non-UC cases (n=159) were examined at Kurume University Hospital between 2020 and 2023. Specimens with atypical cells were excluded from the study. Receiver operating characteristic curve analysis was conducted using Atyp.C data from the UF-5000 to determine the optimal cutoff value. An UC detection algorithm incorporating the NLR was examined using the AI platform DataRobot, and its diagnostic accuracy was assessed.</p><p><strong>Results: </strong>The diagnostic accuracy for invasive UC was assessed using an Atyp.C cut-off of 0.1/μl, yielding an area under the curve (AUC) of 0.824, sensitivity 70.7%, and specificity 90.3%. Noninvasive UC showed lower accuracy (AUC=0.565; sensitivity, 22.8%; specificity, 90.3%). Incorporating NLR improved invasive UC detection (AUC=0.892; sensitivity, 75.0%; specificity, 100%). NLR was the most influential factor in UC detection.</p><p><strong>Conclusion: </strong>The UF-5000, when combined with the NLR, may enhance UC screening and contribute to a more effective diagnostic strategy.</p>","PeriodicalId":8072,"journal":{"name":"Anticancer research","volume":"45 8","pages":"3531-3541"},"PeriodicalIF":1.7,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144764352","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Preface.","authors":"Takeo Fukushima","doi":"10.21873/anticanres.17701","DOIUrl":"https://doi.org/10.21873/anticanres.17701","url":null,"abstract":"","PeriodicalId":8072,"journal":{"name":"Anticancer research","volume":"45 8","pages":"3399"},"PeriodicalIF":1.7,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144764355","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}