Transition Metal Chemistry最新文献_第4页

Synthesis, characterization and studies of iridium (III) complexes inducing cell death via apoptosis and ferroptosis 铱（III）配合物的合成、表征及诱导细胞凋亡和铁凋亡的研究

IF 1.7 4区化学

Transition Metal Chemistry Pub Date : 2025-02-14 DOI: 10.1007/s11243-025-00642-w

Qiying Feng, Lin Zhou, Shuang Tian, Jiawan Yang, Yunjun Liu

{"title":"Synthesis, characterization and studies of iridium (III) complexes inducing cell death via apoptosis and ferroptosis","authors":"Qiying Feng, Lin Zhou, Shuang Tian, Jiawan Yang, Yunjun Liu","doi":"10.1007/s11243-025-00642-w","DOIUrl":"10.1007/s11243-025-00642-w","url":null,"abstract":"<div><p>Herein, we reported the synthesis and characterization of two new iridium(III) complexes [Ir(ppy)<sub>2</sub>(fpp)](PF<sub>6</sub>) (Ir1a, ppy = 2-phenylpyridine, fpp = 2-(2,2-difluorobenzo[1,3]dioxol-5-yl-1H-imidazo[4,5-f][1,10]phenanthroline) and [Ir(bzq)<sub>2</sub>(fpp)](PF<sub>6</sub>) (Ir1b, bzq = benzo[h]quinoline) through high resolution mass spectrometry (HRMS), <sup>1</sup>H NMR and <sup>13</sup>C NMR. The cytotoxicity in vitro of Ir1a and Ir1b on normal NIH3T3 cells and cancer SGC-7901, A549, SK-Hep1 cells was tested using MTT (3-(4,5-dimethylthiazole-2-yl)-diphenyltetrazolium bromide) method. Ir1a exhibits high cytotoxicity on SGC-7901 cells (IC<sub>50</sub> = 2.7 ± 0.7 µM), whereas Ir1b shows moderate cytotoxicity toward the selected cancer cells. The ROS content was investigated using a fluorescence probe of 2′,7′-dichlorodihydrofluorescein diacetate (DCHF-DA), the results show that Ir1a and Ir1b elevate ROS content. The co-localization and the change of mitochondrial membrane potential were explored. Apoptotic studies using Annex V/PI double staining method demonstrate that Ir1a and Ir1b can efficiently cause apoptosis. Ir1a and Ir1b inhibit the cell proliferation at the G2/M period. Additionally, lipid peroxidation and downregulation of ferritin protein suggest that Ir1a and Ir1b can trigger ferroptosis.</p></div>","PeriodicalId":803,"journal":{"name":"Transition Metal Chemistry","volume":"50 4","pages":"589 - 600"},"PeriodicalIF":1.7,"publicationDate":"2025-02-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145165497","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Synthesis, spectroscopic characterization, DFT-D2 analysis and BSA binding studies of Co(II), Ni(II) and Cu(II) complexes with a novel Benzothiazole-based ligand 新型苯并噻唑基配体Co（II）、Ni（II）和Cu（II）配合物的合成、光谱表征、DFT-D2分析和BSA结合研究

IF 1.7 4区化学

Transition Metal Chemistry Pub Date : 2025-02-07 DOI: 10.1007/s11243-025-00632-y

Mohan Kumar, Deepak Tomar, Madhuri Chaurasia, Ashish Kumari, Jogender, Sulekh Chandra

{"title":"Synthesis, spectroscopic characterization, DFT-D2 analysis and BSA binding studies of Co(II), Ni(II) and Cu(II) complexes with a novel Benzothiazole-based ligand","authors":"Mohan Kumar, Deepak Tomar, Madhuri Chaurasia, Ashish Kumari,  Jogender, Sulekh Chandra","doi":"10.1007/s11243-025-00632-y","DOIUrl":"10.1007/s11243-025-00632-y","url":null,"abstract":"<div><p>An equimolar mixture of 2-amino-6-methoxybenzothiazole and 2-hydroxy-4-methoxybenzaldehyde was used to produce a Schiff base ligand 5-methoxy-2-(((6-methoxybenzothiazol-2-yl)imino)methyl)phenol, <b>HL</b>, which was then examined by elemental analysis, IR, <sup>1</sup>H NMR, <sup>13</sup>C NMR and ESI-mass spectrometry. The Co(II), Ni(II) and Cu(II) chlorides, acetates and ligands were combined in ethanol in a molar ratio of 1:1 to create the metal complexes [<b>1</b>-C<sub>16</sub>H<sub>19</sub>CoClN<sub>2</sub>O<sub>6</sub>S, <b>2</b>- C<sub>18</sub>H<sub>22</sub>CoN<sub>2</sub>O<sub>8</sub>S, <b>3</b>- C<sub>16</sub>H<sub>15</sub>NiClN<sub>2</sub>O<sub>4</sub>S, <b>4</b>- C<sub>18</sub>H<sub>18</sub>NiN<sub>2</sub>O<sub>6</sub>S, <b>5</b>- C<sub>16</sub>H<sub>15</sub>CuClN<sub>2</sub>O<sub>4</sub>S and <b>6</b>- C<sub>18</sub>H<sub>18</sub>CuN<sub>2</sub>O<sub>6</sub>S]. To identify the structure of all metal complexes <b>1–6</b>, elemental analysis, molar conductance, electronic spectra and IR spectra were used. The ligand HL functions as an uninegative bidentate via phenolic O- and azomethine N- atoms, according to spectral data. Theoretical studies were performed to investigate the interaction between the metal ions and the ligand HL. This included analysis of the HOMO–LUMO gap to assess electronic properties, Hirshfeld charge distribution to understand electron density changes upon complexation and calculation of the binding energy to evaluate the stability of the metal–ligand complexes. The Co(II) complexes have been given an octahedral geometry, Ni(II) complexes a tetrahedral geometry and Cu(II) complexes a square planar geometry. Studies of the binding of the metal complex to bovine serum albumin (BSA) have been undertaken with the aid of fluorescence and circular dichroism spectrometry.</p></div>","PeriodicalId":803,"journal":{"name":"Transition Metal Chemistry","volume":"50 4","pages":"451 - 469"},"PeriodicalIF":1.7,"publicationDate":"2025-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145163211","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Study of efficiency of organic activator application to process difficult-to-beneficiate polymetallic ridder ores 有机活化剂在难选多金属矿中的应用效果研究

IF 1.7 4区化学

Transition Metal Chemistry Pub Date : 2025-02-04 DOI: 10.1007/s11243-025-00637-7

Bagdaulet Kenzhaliyev, Aigul Koizhanova, Dametken Fischer, David Magomedov, Mariya Yerdenova, Kenzhegali Smailov, Nurgali Abdyldayev

{"title":"Study of efficiency of organic activator application to process difficult-to-beneficiate polymetallic ridder ores","authors":"Bagdaulet Kenzhaliyev, Aigul Koizhanova, Dametken Fischer, David Magomedov, Mariya Yerdenova, Kenzhegali Smailov, Nurgali Abdyldayev","doi":"10.1007/s11243-025-00637-7","DOIUrl":"10.1007/s11243-025-00637-7","url":null,"abstract":"<div><p>The article presents the results of flotation beneficiation experiments for polymetallic ore of complex mineralogical composition with the use of alkylbenzenesulfonic acid (ABSA) as a frothing reagent. Additional experiments showed the highest efficiency of ABSA application for samples of mixed-type ores, showing a significant increase in the recovery of gold, copper, zinc, and lead in the collective concentrates of flotation beneficiation. The use of an ABSA activator promotes the additional cleaning of fragments containing valuable metals from oxide films and coatings, as well as the transfer of microparticles of valuable metals due to the adsorption properties of organics and the formation of metal–carbon bonds. Another effect of this reagent use is an increase in the mass yield of concentrate while maintaining the quality parameters. Gold recovery in the main collective flotation concentrate more than doubled from 46.81 to 97.06%; copper recovery increased from 67.5 to 90.8%, zinc from 22.04 to 58.81%; and lead from 51.13 to 81.1% during the beneficiation process of polymetallic ore with the use of ABSA. A similar effect was observed for beneficiation of copper ore with complex composition; copper recovery in the main concentrate increased from 33.57 to 87.61%. Selective flotation with the development of gold concentrate from difficult-to-beneficiate polymetallic ore also showed a significant increase in gold recovery from 60.41 to 90.24% with ABSA pretreatment.</p></div>","PeriodicalId":803,"journal":{"name":"Transition Metal Chemistry","volume":"50 4","pages":"515 - 527"},"PeriodicalIF":1.7,"publicationDate":"2025-02-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s11243-025-00637-7.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145161707","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Optimized adsorption of Acid Green 25 (AG-25) dye using zinc sulfide (ZnS) nanoparticles: a Response Surface Methodology approach 硫化锌纳米颗粒对酸性绿25 （AG-25）染料的优化吸附：响应面法

IF 1.7 4区化学

Transition Metal Chemistry Pub Date : 2025-02-04 DOI: 10.1007/s11243-025-00636-8

Naureen Hussain, Mahnoor Zeb, Muhammad Irfan, Muhammad Zeeshan, F. Akbar Jan

{"title":"Optimized adsorption of Acid Green 25 (AG-25) dye using zinc sulfide (ZnS) nanoparticles: a Response Surface Methodology approach","authors":"Naureen Hussain, Mahnoor Zeb, Muhammad Irfan, Muhammad Zeeshan, F. Akbar Jan","doi":"10.1007/s11243-025-00636-8","DOIUrl":"10.1007/s11243-025-00636-8","url":null,"abstract":"<div><p>This study explores the synthesis, characterization, and optimization of zinc sulfide nanoparticles (ZnS-NPs) for the adsorption of <i>Acid Green 25 (AG-25)</i> dye from wastewater. ZnS-NPs were synthesized via the co-precipitation method and characterized by SEM, EDX, UV–Vis, FTIR, and XRD analyses, confirming a granular hierarchical structure, high purity showing a significant absorption peak at 310 nm and face-centered cubic crystal lattice with characteristic peaks matching with JCPDS file number 5-0566. The calculated band gap was 3.5 eV and the point of zero charge (PZC) was 5.84 indicating pH-dependent surface charge properties. Maximum adsorption was achieved using 0.3 g of ZnS-NPs adsorbent dose and 10 ppm of dye at pH 3 in 30 min; adsorption process followed the pseudo-first-order model (<i>R</i><sup>2</sup> = 0.997) suggesting physisorption, while followed isotherm model was Temkin isotherm with <i>R</i><sup>2</sup> = 0.8202 describing the adsorption equilibrium highlighting interactions between adsorbate molecules. Response Surface Methodology (RSM) optimization was used with Central Composite Design (CCD) to evaluate four factors such as pH, adsorbent dose, dye concentration and contact time to maximize adsorption efficiency. ANOVA analysis revealed a highly significant quadratic model (<i>p</i> < 0.0001) with optimal conditions for dye removal and validated experimentally with a negligible error of 1.2% compared to predicted values. The RSM model demonstrated high predictive accuracy with <i>R</i><sup>2</sup> = 0.9784 and an insignificant lack of fit (<i>p</i> = 0.1337) underscoring ZnS-NPs as a robust, cost-effective and environmentally friendly adsorbent for industrial wastewater treatment.</p></div>","PeriodicalId":803,"journal":{"name":"Transition Metal Chemistry","volume":"50 4","pages":"499 - 513"},"PeriodicalIF":1.7,"publicationDate":"2025-02-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145161747","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pd catalysts supported on γ-Al2O3 immobilized with ionic liquids: an efficient and recyclable system for C‒C bond formation 离子液体固定化γ-Al2O3负载Pd催化剂：一种高效、可回收的C-C键形成体系

IF 1.7 4区化学

Transition Metal Chemistry Pub Date : 2025-02-03 DOI: 10.1007/s11243-025-00633-x

Ya-Jie Wang, Guo-Hua Li, Xu Wang, Hong-Xin Sun

{"title":"Pd catalysts supported on γ-Al2O3 immobilized with ionic liquids: an efficient and recyclable system for C‒C bond formation","authors":"Ya-Jie Wang, Guo-Hua Li, Xu Wang, Hong-Xin Sun","doi":"10.1007/s11243-025-00633-x","DOIUrl":"10.1007/s11243-025-00633-x","url":null,"abstract":"<div><p>A novel γ-Al<sub>2</sub>O<sub>3</sub>/IL-Pd catalyst was designed and synthesized; this catalyst features highly dispersed deposition of active palladium nanoparticles on the surface of porous γ-Al<sub>2</sub>O<sub>3</sub>, and its catalytic performance and recyclability are improved. The incorporation of ionic liquids is critical to catalyst design since it facilitates the complete dispersion of active metals through chelation; this effectively prevents the formation of palladium black and addresses catalyst deactivation. The interaction between the ionic liquid and the support likely occurs through specific coordination reactions; this interaction significantly enhances the recovery and reusability of the catalyst by preventing the leaching and sintering of the palladium nanoparticles. This approach not only resolves the agglomeration issue inherent to γ-Al<sub>2</sub>O<sub>3</sub>, but also further optimizes the catalyst performance. In the Suzuki‒Miyaura coupling reaction, the new catalyst demonstrates remarkable catalytic activity and achieves a tetramethoxybiphenyl yield of up to 99% within a remarkably short reaction time of just 30 min, without the need for inert gas protection. Notably, after ten consecutive cycles, the catalyst’s performance remains at 94%, outperforming many existing catalysts and confirming its exceptional stability and recyclability. Given its high efficiency, stability, and reusability, this catalyst can likely serve as a high-performance multifunctional catalytic platform for a range of significant organic synthesis reactions.</p><h3>Graphical abstract</h3>\u0000<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":803,"journal":{"name":"Transition Metal Chemistry","volume":"50 4","pages":"471 - 483"},"PeriodicalIF":1.7,"publicationDate":"2025-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145161681","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Versatility of various tungsten oxide nanostructures towards fostering electrochromic state of the art: a review 各种氧化钨纳米结构在促进电致变色方面的多功能性：综述

IF 1.6 4区化学

Transition Metal Chemistry Pub Date : 2025-02-01 DOI: 10.1007/s11243-024-00628-0

Jyothi Gupta, V. K. Gupta

引用次数: 0

Mechanistic insights into the redox reactions of chromium complexes containing picolinates as ligands, interaction with biomolecules 以吡啶甲酸酯为配体的铬配合物氧化还原反应的机理及与生物分子的相互作用

IF 1.7 4区化学

Transition Metal Chemistry Pub Date : 2025-01-31 DOI: 10.1007/s11243-025-00635-9

Mildred Rodríguez-Cordero, Vito Lubes, Hector Roman, Joe Berroteran, Fernando Hernández-Medina, William Castro

{"title":"Mechanistic insights into the redox reactions of chromium complexes containing picolinates as ligands, interaction with biomolecules","authors":"Mildred Rodríguez-Cordero, Vito Lubes, Hector Roman, Joe Berroteran, Fernando Hernández-Medina, William Castro","doi":"10.1007/s11243-025-00635-9","DOIUrl":"10.1007/s11243-025-00635-9","url":null,"abstract":"<div><p>Proton-coupled electron transfer (PCET) is a common reaction in biological systems, with potential implications for DNA damage and repair. This study showed that tris-(2-pyridine carboxylate) chromium (III) (complex 1) exhibited an increased electrochemical reaction rate in the presence of a strong acid, suggesting that PCET via proton donation promotes the reduction reaction. Conversely, complex 1 with picolinic acid showed a decreased electrochemical exchange constant, suggesting kinetic control by slow electronic exchange, consistent with PCET. Bis(pyridine-2,6-dicarboxylate) chromate (III) of sodium (complex 2), showed potential shifts and broadening of signals in the presence of dipicolinic and ascorbic acids, further supporting the involvement of PCET. Overall, the study highlighted the modulation of the electrochemical behavior of the chromium complexes through proton-coupled shifts in reduction potentials and kinetics, shedding light on their potential interactions with cellular reductant agents and protons. The weaker interactions of complexes 1 and 2 with BSA and DNA, together with their lower bioavailability and solubility compared to CQDP, contribute to our understanding of the potential biological effects of the chromium complexes studied. This abstract provides a comprehensive overview of the results of the study, highlighting the significance of the PCET reactions and their potential implications for biological processes and health effects.</p></div>","PeriodicalId":803,"journal":{"name":"Transition Metal Chemistry","volume":"50 4","pages":"485 - 497"},"PeriodicalIF":1.7,"publicationDate":"2025-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145171844","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Thickness-dependent photocatalytic performance and wettability of barium-doped ZnO thin films synthesized via SILAR technique 通过SILAR技术合成的掺钡ZnO薄膜的厚度依赖性光催化性能和润湿性

IF 1.7 4区化学

Transition Metal Chemistry Pub Date : 2025-01-29 DOI: 10.1007/s11243-025-00631-z

Hadjer Barkat, Elhachmi Guettaf Temam, Hachemi Ben Temam, Nourelhouda Mokrani, Saâd Rahmane, Mohammed Althamthami

{"title":"Thickness-dependent photocatalytic performance and wettability of barium-doped ZnO thin films synthesized via SILAR technique","authors":"Hadjer Barkat, Elhachmi Guettaf Temam, Hachemi Ben Temam, Nourelhouda Mokrani, Saâd Rahmane, Mohammed Althamthami","doi":"10.1007/s11243-025-00631-z","DOIUrl":"10.1007/s11243-025-00631-z","url":null,"abstract":"<div><p>The Successive Ionic Layer Adsorption and Reaction (SILAR) technique is a versatile method for depositing thin films with controlled thickness surfaces. However, achieving high-quality thin films with an optimal number of deposition cycles required to improve film properties applicable in photocatalysis is an important consideration. In this study, we investigate the influence of the number of cycles (3, 6, 9, 12, and 15 cycles) in the SILAR technique on the characteristic parameters, including the structural, morphological, and optical properties of deposited Ba/ZnO thin films on glass substrates. X-ray diffraction analysis reveals the hexagonal polycrystalline nature of Ba-doped ZnO films. The intensity of peaks increased with increasing of cycles number which the preferred orientation was (002), while the crystallite size decreasing from 11.105 to 10.904 nm. SEM shows grain size increasing from 29.71 to 44.79 nm as SILAR growth cycles rise from 3 to 15. The thin films' transmittance measurements ranged from 290 to 1200 nm. The thin films' energy band gaps decreased from 3.68 to 3.25. Additionally, the wettability of Ba-doped ZnO films increased with the number of SILAR cycles, rising from 21.23° at 3 cycles to 56.55° at 15 cycles. Furthermore, the photocatalytic performance of samples under visible sunlight was studied for methylene blue and amoxicillin at different cycle numbers. At 15 cycles, the degradation of methylene blue reached 93.51%, whereas amoxicillin was degraded by 54.31%. This study offers valuable insights into the influence of Ba-doped ZnO thin films with varying cycles on the quality of thin films, which is an applicable facility in photocatalytic degradation.</p><h3>Graphical abstract</h3>\u0000<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":803,"journal":{"name":"Transition Metal Chemistry","volume":"50 4","pages":"431 - 450"},"PeriodicalIF":1.7,"publicationDate":"2025-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145171371","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Study of effect of high annealing temperature on the photocatalytic activity of ZnO thin films prepared by dip-coating method 高退火温度对浸涂法制备ZnO薄膜光催化活性影响的研究

IF 1.6 4区化学

Transition Metal Chemistry Pub Date : 2025-01-24 DOI: 10.1007/s11243-024-00627-1

Khedidja Chehhat, Abd Elmadjid Chehhat, Rania Kara, Anfel Yacoub, Faiza Salhi, Abla Mecif, Abd Elouahab Noua

{"title":"Study of effect of high annealing temperature on the photocatalytic activity of ZnO thin films prepared by dip-coating method","authors":"Khedidja Chehhat, Abd Elmadjid Chehhat, Rania Kara, Anfel Yacoub, Faiza Salhi, Abla Mecif, Abd Elouahab Noua","doi":"10.1007/s11243-024-00627-1","DOIUrl":"10.1007/s11243-024-00627-1","url":null,"abstract":"<div><p>In this work, we discuss the effect of annealing temperature on the structural, morphological optical and photocatalytic properties of zinc oxide (ZnO) thin films prepared by using dip-coating technique on porous ceramic substrates at different annealing temperatures of 400 °C, 500 °C, 600 °C, and 700 °C for 2 h. The photocatalytic activity of the prepared ZnO photocatalysts was examined by evaluating the degradation of Orange II (OII) as a model of dyes under light irradiation. ZnO photocatalysts were characterized by X-ray diffraction (XRD), scanning electron microscopy (SEM), and UV–visible absorption spectroscopy. SEM analysis revealed that the annealing temperatures greatly affected the grain size and the topography of ZnO surfaces. XRD results showed that all samples have a polycrystalline nature with a hexagonal wurtzite structure. The experimental data demonstrated that the average crystallite size of the prepared ZnO thin films varied from 15 to 24 nm with the increase of the annealing temperatures from 400 °C to 700 °C. The UV–Vis data indicated an enhancement in the absorbance of ZnO thin films across the ultraviolet range with increased annealing temperatures. The photodegradation rate increased to 94.7% by increasing the annealing temperatures.</p></div>","PeriodicalId":803,"journal":{"name":"Transition Metal Chemistry","volume":"50 3","pages":"335 - 343"},"PeriodicalIF":1.6,"publicationDate":"2025-01-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143949612","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Multifunctional Ag/CuO nanocomposites: synthesis, antimycobacterial efficacy, and cytotoxicity against colon cancer cells 多功能Ag/CuO纳米复合材料：合成、抑菌效果和对结肠癌细胞的细胞毒性

IF 1.6 4区化学

Transition Metal Chemistry Pub Date : 2024-12-24 DOI: 10.1007/s11243-024-00623-5

B. R. Malini, G. K. Prashanth, P. A. Prashanth, H. S. Lalithamba, Srilatha Rao, N. P. Bhagya

{"title":"Multifunctional Ag/CuO nanocomposites: synthesis, antimycobacterial efficacy, and cytotoxicity against colon cancer cells","authors":"B. R. Malini, G. K. Prashanth, P. A. Prashanth, H. S. Lalithamba, Srilatha Rao, N. P. Bhagya","doi":"10.1007/s11243-024-00623-5","DOIUrl":"10.1007/s11243-024-00623-5","url":null,"abstract":"<div><p>Nanotechnology plays a crucial role in advancing medical research, particularly in developing effective therapeutic agents. However, challenges such as nanoparticle agglomeration and limited functionalization persist in optimizing their biological applications. This study addresses these issues by synthesizing copper oxide nanoparticles (CuO NPs) using a combustion method with aqueous <i>Acacia nilotica</i> gum as biofuel, and creating silver-doped CuO nanocomposites (Ag/CuO NCs) with varying silver compositions. Notably, silver doping significantly enhanced crystallinity and reduced agglomeration, resulting in average crystallite sizes ranging from 10 to 25 nm. Characterization techniques, including X-ray diffraction, scanning electron microscopy with energy dispersive spectroscopy, transmission electron microscopy, and ultraviolet–visible spectroscopy. Both CuO and Ag/CuO NCs exhibited strong antimycobacterial properties. Antioxidant activity was assessed through DPPH testing, demonstrating improved IC50 values as silver concentration increased (e.g., 2.40 mg/mL for Ag/CuO with 9 mol %Ag). Further, cytotoxicity tests using the HT-29 human colon cancer cell line revealed an IC50 of 4.932 µg/mL for Ag/CuO (9 mol %Ag), with anticancer activity evaluated across concentrations of 0.75–40 µg/mL. Importantly, toxicological evaluations indicated compatibility of both CuO NPs and Ag/CuO NCs with human red blood cells, underscoring their potential for biomedical applications. This work presents a novel approach to enhancing the functionalization of metal oxide nanoparticles, paving the way for future therapeutic advancements.</p></div>","PeriodicalId":803,"journal":{"name":"Transition Metal Chemistry","volume":"50 3","pages":"283 - 299"},"PeriodicalIF":1.6,"publicationDate":"2024-12-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143949611","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0