Annals of Indian Academy of Neurology最新文献

{"title":"Association of Fecal Calprotectin with Motor and Nonmotor Features in Idiopathic Parkinson's Disease and Atypical Parkinsonism.","authors":"Ashish Sharma, Sahil Mehta, Anupam K Singh, Rajender Kumar, Jagdeep Singh, Kamalesh Chakravarty, Vivek Lal","doi":"10.4103/aian.aian_195_26","DOIUrl":"10.4103/aian.aian_195_26","url":null,"abstract":"<p><strong>Background and objectives: </strong>Gut inflammation and microbiota dysregulation are increasingly implicated in Parkinson's disease (PD). Fecal calprotectin, a neutrophil-derived protein and marker of intestinal inflammation, may serve as a non-invasive indicator of gut-brain axis dysfunction in parkinsonian disorders. To evaluate fecal calprotectin levels in idiopathic Parkinson's disease (IPD) and atypical parkinsonian syndromes-progressive supranuclear palsy (PSP) and multiple system atrophy (MSA)-and examine their relationship with motor and non-motor features.</p><p><strong>Methods: </strong>In this case-control study, 130 patients (IPD = 94, PSP = 23, MSA = 13) and 80 age- and sex-matched healthy controls were enrolled. All participants underwent detailed clinical evaluation, including the movement disorder society-unified Parkinson's disease rating scale (MDS-UPDRS), Hoehn and Yahr staging, the non-motor symptoms scale (NMSS), the Rome IV criteria for constipation, and the Montreal cognitive assessment (MoCA). Fecal calprotectin (μg/g stool) was quantified using enzyme-linked immunosorbent assay and correlated with clinical parameters.</p><p><strong>Results: </strong>Mean fecal calprotectin was significantly higher in IPD and PSP than in controls ( P < 0.01), whereas MSA showed no significant difference. Elevated fecal calprotectin correlated positively with total NMSS scores ( r ≈ 0.3, P < 0.05) and inversely with MoCA scores, indicating a greater non-motor symptom burden and poorer cognitive performance. No significant correlation was observed with MDS-UPDRS motor scores. Among the NMSS domains, sleep/fatigue, mood/apathy, perceptual problems, memory, and sexual domains exhibited the strongest associations.</p><p><strong>Conclusions: </strong>Fecal calprotectin is elevated in IPD and PSP and is more strongly associated with non-motor than motor manifestations. These findings support intestinal inflammation as a contributor to parkinsonian pathophysiology and highlight fecal calprotectin as a potential biomarker of gut-brain axis dysfunction.</p>","PeriodicalId":8036,"journal":{"name":"Annals of Indian Academy of Neurology","volume":" ","pages":"743-749"},"PeriodicalIF":1.8,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149179190","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Novel Compound Heterozygous NAGS Gene Variants in a Neonate with Hyperammonemic Encephalopathy: Importance of Early Metabolic Suspicion and Neuroimaging Clues.","authors":"Vykuntaraju K Gowda, Archana K Verghese, Varunvenkat M Srinivasan, Amena Nayyer","doi":"10.4103/aian.aian_403_26","DOIUrl":"https://doi.org/10.4103/aian.aian_403_26","url":null,"abstract":"","PeriodicalId":8036,"journal":{"name":"Annals of Indian Academy of Neurology","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2026-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148786967","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Relapsing Cavernous Sinus Pachymeningitis as a Paradoxical Reaction to Central Nervous System Tuberculosis Successfully Treated with Infliximab.","authors":"M Srinath, Vivek Jacob Phillip, Sandhya Pulukool, Gopal Krishna Dash, Kuldeep Shetty","doi":"10.4103/aian.aian_337_26","DOIUrl":"https://doi.org/10.4103/aian.aian_337_26","url":null,"abstract":"","PeriodicalId":8036,"journal":{"name":"Annals of Indian Academy of Neurology","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2026-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148787092","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Isolated Vestibular Nucleus Infarction Presenting as Vestibular Pseudoneuritis Mimicking Acute Peripheral Vestibulopathy.","authors":"Rambir Singh, Sudhir Kothari, Ajay K Vats, Pradeep Vundavilli, Alfarghal Mohamad","doi":"10.4103/aian.aian_294_26","DOIUrl":"https://doi.org/10.4103/aian.aian_294_26","url":null,"abstract":"","PeriodicalId":8036,"journal":{"name":"Annals of Indian Academy of Neurology","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2026-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148787021","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The \"Black Pituitary Sign\" in Rhino-Orbito-Cerebral Mucormycosis: An Imaging Manifestation of Central Skull Base Angioinvasion.","authors":"Ankit Arora, C Thimmanna, R Rashma, S Shwetha, B K Akshay, Vikram V Kamath, Deepak V Haldipur, Sabha Ahmed","doi":"10.4103/aian.aian_613_26","DOIUrl":"https://doi.org/10.4103/aian.aian_613_26","url":null,"abstract":"","PeriodicalId":8036,"journal":{"name":"Annals of Indian Academy of Neurology","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2026-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148787087","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dual Diagnosis of Late-Onset Facioscapulohumeral Muscular Dystrophy and Myasthenia Gravis.","authors":"Tanay Satarkar, Ian C Smith, Ari Breiner, Gerd Melkus, Marcos L Sampaio, Jodi Warman-Chardon","doi":"10.4103/aian.aian_318_26","DOIUrl":"https://doi.org/10.4103/aian.aian_318_26","url":null,"abstract":"","PeriodicalId":8036,"journal":{"name":"Annals of Indian Academy of Neurology","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2026-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148787008","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Optic Neuropathy in Neurosarcoidosis Masquerading as Optic Nerve Sheath Meningioma: A Case Report and Literature Review.","authors":"Dhanush Mallesh, Prabhjit Kaur, Raza A Mahdi, Rajender Kumar, Raghav Lal, Debajyoti Chatterjee, Chirag K Ahuja, Aastha Takkar, Vivek Lal","doi":"10.4103/aian.aian_515_26","DOIUrl":"https://doi.org/10.4103/aian.aian_515_26","url":null,"abstract":"<p><strong>Abstract: </strong>Sarcoidosis is a multisystem granulomatous disorder that often mimics inflammatory, demyelinating, or neoplastic neuro-ophthalmic conditions. We describe a 39-year-old woman with two episodes of progressive visual loss in the right eye over 6 months, with partial responsiveness to steroid. Examination revealed optic disc edema and mild proptosis. Extensive evaluation for demyelinating, autoimmune, infectious, and neoplastic causes was unremarkable. A diagnosis of optic nerve sheath meningioma was initially made at a peripheral center based on the presence of a \"tram-track\" appearance along the optic nerve sheath on imaging. However, associated orbital fat stranding, lacrimal gland enlargement, and pachymeningeal enhancement prompted further systemic evaluation, which revealed mediastinal lymphadenopathy and omental deposits. Biopsy demonstrated noncaseating granulomas with Schaumann bodies, confirming sarcoidosis after exclusion of alternative granulomatous disorders, including tuberculosis. The patient was treated with immunosuppressive therapy. This case highlights that atypical features, responsiveness to steroid, and extraneural imaging findings should prompt systemic evaluation to enable timely diagnosis and appropriate immunosuppressive therapy.</p>","PeriodicalId":8036,"journal":{"name":"Annals of Indian Academy of Neurology","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2026-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148787041","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reversible Multisystem Lithium Neurotoxicity with Antecollis and Stridor: A Mimic of Atypical Parkinsonism.","authors":"Bhadra S Nair, Boby Varkey Maramattom","doi":"10.4103/aian.aian_362_26","DOIUrl":"https://doi.org/10.4103/aian.aian_362_26","url":null,"abstract":"","PeriodicalId":8036,"journal":{"name":"Annals of Indian Academy of Neurology","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2026-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148598024","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"SLC5A6 -Related Biotin-Responsive Neuropathy: Sustained Clinical Improvement Over 18 Months Following Targeted Multivitamin Therapy.","authors":"J P Padma, Poornima Nair, Kiren G Koshy, Syam Krishnan, Asish Vijayaraghavan","doi":"10.4103/aian.aian_431_26","DOIUrl":"https://doi.org/10.4103/aian.aian_431_26","url":null,"abstract":"","PeriodicalId":8036,"journal":{"name":"Annals of Indian Academy of Neurology","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2026-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148598017","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Non-Hepatitis C-Associated Cryoglobulinemic Vasculitic Neuropathy.","authors":"Rohan R Mahale, Pramod Khanda, Sushmita Upadhyay, Roshny John, Anita Mahadevan, Pooja Mailankody","doi":"10.4103/aian.aian_267_26","DOIUrl":"https://doi.org/10.4103/aian.aian_267_26","url":null,"abstract":"","PeriodicalId":8036,"journal":{"name":"Annals of Indian Academy of Neurology","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2026-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148598041","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}