Annals of Indian Academy of Neurology最新文献

{"title":"Chronic Immune Sensory Polyradiculopathy Plus: A Rare Variant Associated with Amphiphysin Positivity.","authors":"Betül Özenç, Ayşe Gamze Şahin, Ercan Köse, Uğur Burak Şimşek, Zeki Odabaşı","doi":"10.4103/aian.aian_990_23","DOIUrl":"10.4103/aian.aian_990_23","url":null,"abstract":"","PeriodicalId":8036,"journal":{"name":"Annals of Indian Academy of Neurology","volume":" ","pages":"615-616"},"PeriodicalIF":1.9,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11575860/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142456560","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Infantile-Onset Epileptic Encephalopathy - A Treatable Cause.","authors":"Dasaratha R Jinka, Lokesh Lingappa, Ramesh Konanki","doi":"10.4103/aian.aian_3_24","DOIUrl":"10.4103/aian.aian_3_24","url":null,"abstract":"","PeriodicalId":8036,"journal":{"name":"Annals of Indian Academy of Neurology","volume":" ","pages":"593-595"},"PeriodicalIF":1.9,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11575888/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142456563","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Autosomal Recessive Spastic Ataxia of Charlevoix-Saguenay Secondary to a Novel Mutation in the <i>SACS</i> Gene.","authors":"Akhil Sahib, Cankatika Choudhury, Rakesh Nagar, Arun Koul","doi":"10.4103/aian.aian_223_24","DOIUrl":"10.4103/aian.aian_223_24","url":null,"abstract":"","PeriodicalId":8036,"journal":{"name":"Annals of Indian Academy of Neurology","volume":"27 5","pages":"586-587"},"PeriodicalIF":1.9,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11575885/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142680066","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of Cognitive and Psychological Functions in Relapsing-Remitting Multiple Sclerosis: A Cross-Sectional Study.","authors":"Vinayaka Yadav, Shantala Hegde, M Netravathi, Mariamma Philip, Lee Cranberg","doi":"10.4103/aian.aian_434_24","DOIUrl":"10.4103/aian.aian_434_24","url":null,"abstract":"<p><strong>Background and objectives: </strong>To compare the cognitive functions and trait anxiety in patients diagnosed with relapsing-remitting multiple sclerosis (RRMS) to those of matched healthy controls (HCs). In addition, the study aims to investigate the correlations among cognitive functions, anxiety, depression, and quality of life (QOL) in this clinical population.</p><p><strong>Methods: </strong>The sample included RRMS patients ( n = 21) and an equal number of age-, education-, and sex-matched HCs. Participants were assessed on the Indian version of the Wechsler Adult Intelligence Scale-IV, auditory and visual learning and memory, and visual-spatial construction and memory. RRMS patients were also assessed for levels of anxiety, depression, and their QOL. Comparative analyses between RRMS patients and HCs were carried out for neuropsychological assessments. Correlations among cognitive functions, anxiety, depression, and QOL in RRMS patients were examined.</p><p><strong>Results: </strong>RRMS patients showed significant deficits across various cognitive domains, including processing speed and verbal learning, compared to HCs ( P < 0.05). In addition, they reported higher levels of trait anxiety compared to HCs ( P < 0.01), along with moderate state anxiety and mild depression. A significant correlation among anxiety, depression, and QOL was observed in RRMS patients.</p><p><strong>Conclusions: </strong>This study highlights significant cognitive impairments and psychological distress experienced by RRMS individuals, underscoring the critical need for comprehensive care addressing both cognitive impairments and psychological distress to enhance QOL.</p>","PeriodicalId":8036,"journal":{"name":"Annals of Indian Academy of Neurology","volume":" ","pages":"530-536"},"PeriodicalIF":1.9,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11575873/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142399194","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clarification on \"Myotonic Dystrophy Type 1 - An Atypical Presentation\".","authors":"Joydeep Mukherjee, Sourav Nanda, Amar Kumar Mishra, Arindam Biswas","doi":"10.4103/aian.aian_341_24","DOIUrl":"10.4103/aian.aian_341_24","url":null,"abstract":"","PeriodicalId":8036,"journal":{"name":"Annals of Indian Academy of Neurology","volume":" ","pages":"609-610"},"PeriodicalIF":1.9,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11575874/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141295415","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reduced Cerebellar White Matter Volume in Musicians: A Marker of Musical Expertise.","authors":"Aishwarya Ghosh, Palash Kumar Malo, Sadhana Singh, S Monisha, Thomas Gregor Issac","doi":"10.4103/aian.aian_261_24","DOIUrl":"10.4103/aian.aian_261_24","url":null,"abstract":"","PeriodicalId":8036,"journal":{"name":"Annals of Indian Academy of Neurology","volume":" ","pages":"605-607"},"PeriodicalIF":1.9,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11575891/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141987267","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Morvan's Syndrome with Myasthenia Gravis: An Autoimmune or Paraneoplastic Association?","authors":"Deepak Menon, Priyanka Chakkera, Shreyashi Jha, B Pradeep Kumar, Jss Anjusha, M Chandra Sena, Shilpa Rao, Faheem Arshad, Saraswati Nashi, Seena Vengalil, Suvarna Alladi, Atchayaram Nalini","doi":"10.4103/aian.aian_391_24","DOIUrl":"10.4103/aian.aian_391_24","url":null,"abstract":"","PeriodicalId":8036,"journal":{"name":"Annals of Indian Academy of Neurology","volume":"27 5","pages":"612-615"},"PeriodicalIF":1.9,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11575875/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142680594","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cardiac MRI in Duchenne and Becker Muscular Dystrophy.","authors":"Manu Santhappan Girija, Deepak Menon, Kiran Polavarapu, Veeramani Preethish-Kumar, Seena Vengalil, Saraswati Nashi, Madassu Keertipriya, Mainak Bardhan, Priya Treesa Thomas, Valasani Ravi Kiran, Vikas Nishadham, Arun Sadasivan, Akshata Huddar, Gopi Krishnan Unnikrishnan, Ashita Barthur, Atchayaram Nalini","doi":"10.4103/aian.aian_988_23","DOIUrl":"10.4103/aian.aian_988_23","url":null,"abstract":"<p><strong>Background and objectives: </strong>Cardiovascular magnetic resonance imaging (CMRI) is the noninvasive technique of choice for early detection of cardiac involvement in Duchenne and Becker muscular dystrophy (DMD and BMD, respectively), but is seldom used in routine clinical practice in the Indian context. We sought to determine the prevalence of CMRI abnormalities in patients with DMD and BMD and to compare the CMRI parameters with the phenotypic and genotypic characteristics.</p><p><strong>Methods: </strong>A prospective, observational study was conducted on patients genetically diagnosed with DMD and BMD who could complete CMRI between March 2020 and March 2022. Abnormal CMRI was the presence of any late gadolinium enhancement (LGE) that signifies myocardial fibrosis (LGE positivity), regional wall motion abnormality, or reduced left ventricular ejection fraction (LVEF <55%).</p><p><strong>Results: </strong>A total of 46 patients were included: 38 patients with DMD and eight with BMD. Cardiac abnormality was seen in 23 (50%) patients. LGE was more common than impaired LVEF in DMD (16, 42.1%), while impaired LVEF was more common in BMD (5, 62.5%). LGE was most frequently found in lateral wall (18/19) followed by inferior (6/19), septal (5/19), anterior (2/19), and apex (1/19). Among the various clinicodemographic parameters, only age ( r = 0.495, P = 0.002) and disease duration ( r = 0.407, P = 0.011) were found to significantly correlate with LGE in patients with DMD. No association was found between the various CMRI parameters and the genotype.</p><p><strong>Conclusions: </strong>The current study highlights the differences in myocardial fibrosis and LV dysfunction between DMD and BMD, along with other CMRI parameters. Notably, a genotype-CMRI correlation was not found in the current cohort, which needs to be further explored.</p>","PeriodicalId":8036,"journal":{"name":"Annals of Indian Academy of Neurology","volume":" ","pages":"552-557"},"PeriodicalIF":1.9,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11575867/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142339789","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An Instructional Module for Functional Dissociative Seizures (FDS) in Hindi: Enhancing Communication and Management in India.","authors":"Manjari Tripathi, Sandhya Sharma, Avinash Ganapule, Rekha Dwivedi, Kirandeep Kaur, Vasundhara Shukla, Saranya Gomathy, Prarthana Chandra, Rajesh Kumar Singh, Deepti Vibha, Rajesh Sagar, Mamta Sood, Ashima Nehra, Shashank Tripathi","doi":"10.4103/aian.aian_305_24","DOIUrl":"10.4103/aian.aian_305_24","url":null,"abstract":"<p><strong>Background and objectives: </strong>Functional dissociative seizures (FDS) are very common in neurology clinics, they straddle both neurology and psychiatry. In India, scarce resources and guidelines are available for effectively conveying their diagnosis and management, which leads to a substantial gap in care. We aimed to provide an instructional module for FDS, tailored to clinicians, patients, and caregivers in Hindi, to enhance communication of diagnosis and facilitate suitable management strategies.</p><p><strong>Methods: </strong>The instructional module development process was based on clinical settings and expert opinions. A standard translation process was performed to ensure the linguistic and cultural equivalence. Validation was carried out by a panel of 15 validators, comprising 13 neurologists and two psychiatrists, to identify key psychoeducation components and their significance. They were provided a questionnaire consisting of five questions that were related to completeness, understandability, legibility, clarification, and usefulness of educational material for clinicians, patients, and caregivers. Items were rated using a 5-point Likert scale.</p><p><strong>Results: </strong>There was agreement on four items (Q1, Q3, Q4, and Q5), whereas approximately 85% of the validators agreed on the remaining one item (Q2). The instructional module demonstrated high content validity as indicated by both item level-content validity index (0.98) and scale-level content validity index (0.97), alongside content validity ratio and modified kappa statistics.</p><p><strong>Conclusions: </strong>The developed Hindi instructional module for FDS serves as a valuable tool to enhance the communication of FDS diagnosis and dispel misconceptions. This offers a comprehensive resource for clinicians, patients, and caregivers in India, potentially bridging gap in FDS care.</p>","PeriodicalId":8036,"journal":{"name":"Annals of Indian Academy of Neurology","volume":" ","pages":"520-523"},"PeriodicalIF":1.9,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11575857/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142456559","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Optic Neuritis - The Evolving Spectrum.","authors":"Abdullah Al-Ani, Fiona Costello","doi":"10.4103/aian.aian_602_24","DOIUrl":"10.4103/aian.aian_602_24","url":null,"abstract":"<p><p>Optic neuritis (ON) is an inflammatory condition that affects the optic nerve and may be associated with various central nervous system demyelinating conditions, infectious diseases, and systemic autoimmune syndromes. This manuscript sheds light on the epidemiologic patterns and diverse clinical features of ON, emphasizing the importance of early detection and prompt treatment. Various studies have revealed geographic and ethnic variations across ON subtypes, which are likely related to the incidence and prevalence of co-associated disorders. Distinguishing ON subtypes may be challenging and requires use of paraclinical tools. Treatment strategies differ depending on the etiology, further highlighting the importance of accurately identifying specific ON subtypes in a timely manner.</p>","PeriodicalId":8036,"journal":{"name":"Annals of Indian Academy of Neurology","volume":" ","pages":"471-481"},"PeriodicalIF":1.9,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11575883/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142456576","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}