Annals of Medicine and Surgery最新文献

{"title":"Zidesamtinib in ROS1-positive NSCLC with brain metastases: clinical evidence and therapeutic implications.","authors":"Abdihakim Sheikh, Saima Saleem, Sakan Binte Imran, Ehtisham Haider","doi":"10.1097/MS9.0000000000005710","DOIUrl":"https://doi.org/10.1097/MS9.0000000000005710","url":null,"abstract":"","PeriodicalId":8025,"journal":{"name":"Annals of Medicine and Surgery","volume":"88 10","pages":"6924-6925"},"PeriodicalIF":1.6,"publicationDate":"2026-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13657547/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149179199","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advent of robotic assistance in modern total knee arthroplasty (TKA): paradigm shift in orthopedic surgery.","authors":"Iqra Akhtar, Ania Mushtaq","doi":"10.1097/MS9.0000000000005455","DOIUrl":"https://doi.org/10.1097/MS9.0000000000005455","url":null,"abstract":"","PeriodicalId":8025,"journal":{"name":"Annals of Medicine and Surgery","volume":"88 10","pages":"6914-6915"},"PeriodicalIF":1.6,"publicationDate":"2026-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13657589/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149178344","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Giant primary hydatid cyst of the sigmoid mesocolon: a surgical case report.","authors":"Unaiza Erum, Omer Bin Khalid Jamil, Muhammad Imran, Ayesha Noman, Reem Shahid, Muhammad Khalid Siddique, Ali Raza Arshad","doi":"10.1097/MS9.0000000000005508","DOIUrl":"https://doi.org/10.1097/MS9.0000000000005508","url":null,"abstract":"<p><p>Giant primary hydatid cysts of the sigmoid mesocolon are exceptionally rare, and their exact site of origin may be difficult to establish before surgery. We report a 51-year-old woman with an 8-year history of progressive abdominal distension and vague abdominal discomfort. CT showed a multilocular cystic lesion of size 30 × 22 × 28 cm extending from the pelvis to the upper abdomen, with internal septations and multiple daughter cysts. <i>Echinococcus</i> serology was positive, with no radiological evidence of hepatic or pulmonary hydatid disease. The patient had received several previous courses of albendazole without sustained improvement, although the duration and adherence of these courses could not be independently verified. At laparotomy, the cyst was found to arise from the sigmoid mesocolon and was excised by total pericystectomy, with preservation of the sigmoid colon and mesocolic vessels. Recovery was uneventful. Albendazole was continued postoperatively for three months, and no recurrence was seen on clinical and ultrasonographic follow-up at 6 months. This case illustrates a rare giant primary sigmoid mesocolon hydatid cyst in which the diagnosis was suspected radiologically, but the precise mesocolic origin was confirmed only intraoperatively.</p>","PeriodicalId":8025,"journal":{"name":"Annals of Medicine and Surgery","volume":"88 10","pages":"6768-6772"},"PeriodicalIF":1.6,"publicationDate":"2026-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13657574/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149178951","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The application of tubeless anesthesia technique in tracheal tumor resection surgery: a case report.","authors":"Jing-Ting Tang, Huilu Li, Bo Wu, Qian Liu, Ju-Ke Ma","doi":"10.1097/MS9.0000000000005657","DOIUrl":"https://doi.org/10.1097/MS9.0000000000005657","url":null,"abstract":"<p><p>Systemic hemangioma after neoadjuvant immunotherapy for hypopharyngeal carcinoma is one of the common complications of neoadjuvant immunotherapy. Its pathogenesis may be related to multiple immune regulatory imbalances and vascular biological changes. This case was a locally advanced hypopharyngeal cancer patient who received neoadjuvant immunotherapy and total laryngectomy with partial hypopharyngectomy. During follow-up, a mass was found in the middle part of the trachea, protruding into the tracheal lumen. The peculiarity of this case was that the tracheal mass was located in the middle part of the trachea, with a narrow lumen. During anesthesia, whether the tracheal intubation was placed above or below the mass would affect the operation. After multidisciplinary team discussion, a no-intubation anesthesia plan was adopted, using esketamine, which could maintain spontaneous breathing well, ensure sufficient depth of anesthesia, and reduce the occurrence of bronchospasm. The airway management mainly used high-flow nasal cannula to provide a large flow and flow rate, prolonging the safe period without breathing and oxygenation, providing a safety guarantee for the operation and ensuring its successful completion.</p>","PeriodicalId":8025,"journal":{"name":"Annals of Medicine and Surgery","volume":"88 10","pages":"6860-6864"},"PeriodicalIF":1.6,"publicationDate":"2026-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13657576/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149179101","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Two-stage surgical resection of a massive primary posterior mediastinal dedifferentiated liposarcoma with bilateral thoracic extension: a case report.","authors":"Chong Zhang, Chao Feng, Yong Long, Yuhao Wang, Yanhe Su, Na Han, Guiming Hu, Jin Zhang","doi":"10.1097/MS9.0000000000005678","DOIUrl":"https://doi.org/10.1097/MS9.0000000000005678","url":null,"abstract":"<p><strong>Introduction and importance: </strong>Primary mediastinal dedifferentiated liposarcoma (DDLPS) is a rare and aggressive tumor, often diagnosed late due to nonspecific symptoms. The optimal surgical strategy for tumors with bilateral thoracic extension remains unclear.</p><p><strong>Case presentation: </strong>A 59-year-old woman presented with a 1-year history of exertional dyspnea. Chest computed tomography revealed a large posterior mediastinal mass extending into both thoracic cavities with compression of adjacent structures. A two-stage surgical approach was performed, with initial right thoracotomy followed by left thoracotomy for complete resection. Histopathology confirmed DDLPS with CDK4, MDM2, and S-100 positivity and MDM2 gene amplification.</p><p><strong>Clinical discussion: </strong>Complete surgical resection is the mainstay of treatment for mediastinal DDLPS. In cases with bilateral thoracic involvement, staged surgery may reduce operative risk and improve surgical safety compared to a single-stage approach.</p><p><strong>Conclusion: </strong>Staged surgical resection is a feasible and safe strategy for massive mediastinal DDLPS involving both thoracic cavities. Careful surgical planning is essential to achieve optimal outcomes.</p>","PeriodicalId":8025,"journal":{"name":"Annals of Medicine and Surgery","volume":"88 10","pages":"6884-6889"},"PeriodicalIF":1.6,"publicationDate":"2026-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13657571/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149179178","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Iberdomide enters multiple myeloma care: A new CELMoD with deep responses but uncertain long-term benefit.","authors":"Basit Ali Shah, Javed Miandad, Ansar Said, Muhammad Qasim Safi, Nowshin Jamil Chaity, Marium Khan, Sharmin Rumana, Nazmun Naher Mouri","doi":"10.1097/MS9.0000000000005701","DOIUrl":"https://doi.org/10.1097/MS9.0000000000005701","url":null,"abstract":"","PeriodicalId":8025,"journal":{"name":"Annals of Medicine and Surgery","volume":"88 10","pages":"6235-6239"},"PeriodicalIF":1.6,"publicationDate":"2026-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13657489/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149179010","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Primary thyroid hydatid cyst: a case report.","authors":"Yosef Halawa, Ehsan Albakri, Sulieman Marrawi, Zain Altouka, Ahmad Dokmak, Samer Muhsen","doi":"10.1097/MS9.0000000000005643","DOIUrl":"https://doi.org/10.1097/MS9.0000000000005643","url":null,"abstract":"<p><strong>Introduction and importance: </strong>Hydatid cyst is a zoonotic infection caused by the larval form of <i>Echinococcus granulosus</i>, with the liver and lungs being the most frequently involved organs. Thyroid gland involvement is exceptionally rare, accounting for approximately 1% of all human hydatid cases and posing significant diagnostic challenges, particularly in endemic regions.</p><p><strong>Case presentation: </strong>A 48-year-old woman from a rural area presented with a 5-year history of a slowly enlarging anterior neck mass, with recent progression to dysphagia and dysphonia. She reported regular consumption of raw vegetables from fields irrigated with potentially contaminated water. Ultrasound revealed a complex cystic lesion in the left thyroid lobe (WHO-IWGE type CE1), and fine-needle aspiration was non-diagnostic. Total thyroidectomy was performed due to progressive compressive symptoms and the inability to exclude malignancy. Intraoperatively, a hydatid cyst was unexpectedly encountered and managed with hypertonic saline instillation and careful excision. Histopathology confirmed a primary hydatid cyst co-existing with lymphocytic thyroiditis and multinodular goiter. Staging investigations revealed no other organ involvement. She received postoperative albendazole and remained disease-free at 12-month follow-up.</p><p><strong>Clinical discussion: </strong>This case highlights the diagnostic pitfalls of thyroid hydatid cysts, which are rarely suspected preoperatively due to their non-specific presentation. Fine-needle aspiration is potentially hazardous and contraindicated when hydatid disease is suspected. Surgical excision with scolicidal precautions remains the mainstay of treatment, and postoperative albendazole is recommended in cases of intraoperative spillage. The co-occurrence with lymphocytic thyroiditis and multinodular goiter broadens the spectrum of pathology associated with thyroid hydatid disease.</p><p><strong>Conclusion: </strong>Hydatid cyst should be considered in the differential diagnosis of cystic thyroid lesions in patients from endemic regions with appropriate epidemiological risk factors. A high index of suspicion, avoidance of FNA when hydatid disease is suspected, and adherence to principles of hydatid surgery are essential for optimal outcomes.</p>","PeriodicalId":8025,"journal":{"name":"Annals of Medicine and Surgery","volume":"88 10","pages":"6834-6840"},"PeriodicalIF":1.6,"publicationDate":"2026-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13657500/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149179079","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A case report of femorocele mimicking a spermatic hydrocele in a male patient: the first laparoscopic repair.","authors":"Koki Miya, Fumitaka Yagi, Takeshi Kato, Takashi Saitoh, Katsuhiko Suzuki","doi":"10.1097/MS9.0000000000005666","DOIUrl":"https://doi.org/10.1097/MS9.0000000000005666","url":null,"abstract":"<p><strong>Introduction: </strong>Femorocele, defined as fluid accumulation within a femoral hernia sac, is an extremely rare condition; to our knowledge, previously reported cases have predominantly occurred in female patients, and laparoscopic management has rarely been described.</p><p><strong>Case presentation: </strong>A 75-year-old man presented with a gradually enlarging, painless swelling in the left groin. Computed tomography revealed a cystic lesion that was initially diagnosed as a spermatic hydrocele. In response to rapid enlargement and onset of pain, elective laparoscopic transabdominal preperitoneal (TAPP) repair was performed. Intraoperatively, the hernial orifice corresponded to the femoral ring, and the neck of the hernial sac was constricted by thickened preperitoneal fat with minimal communication with the peritoneal cavity. The sac contained only clear fluid without bowel or omentum, leading to a diagnosis of a primary femorocele. Mesh repair was successfully completed; the postoperative course was uneventful.</p><p><strong>Discussion: </strong>Given their rarity and nonspecific imaging findings, femoroceles are frequently misdiagnosed preoperatively. To our knowledge, this appears to be the first reported case of a femorocele being treated laparoscopically. Laparoscopic TAPP repair provides excellent visualization of the femoral ring and surrounding anatomical structures, thereby enabling both accurate intraoperative diagnosis and definitive treatment. Compared with open or robotic approaches, laparoscopic repair is widely available, cost-effective, and particularly suitable for use in community hospital settings.</p><p><strong>Conclusion: </strong>Femoroceles can occur in male patients and should be considered in the differential diagnosis of cystic groin masses. Laparoscopic TAPP repair demonstrates the feasibility that offers combined diagnostic and therapeutic advantages for this rare condition.</p>","PeriodicalId":8025,"journal":{"name":"Annals of Medicine and Surgery","volume":"88 10","pages":"6865-6868"},"PeriodicalIF":1.6,"publicationDate":"2026-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13657446/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149179087","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Xinfeng capsule regulates pyroptosis and ameliorates cardiac fibrosis in rheumatoid arthritis through lncRNA GAS5 and TLR4/ROS/miR-21 pathways.","authors":"Hui Wang, Wanlan Fu, Yunxiang Cao, Jian Liu, Nanfei Zhu, Amin Wang","doi":"10.1097/MS9.0000000000005605","DOIUrl":"https://doi.org/10.1097/MS9.0000000000005605","url":null,"abstract":"<p><p>Xinfeng capsule (XFC) is a traditional Chinese medicinal compound that has been used clinically for several years to treat rheumatoid arthritis (RA)-related cardiac dysfunction. Nevertheless, the mechanism through which XFC treats RA-induced cardiac impairment remains unclear. This study investigates the mechanism by which XFC-containing serum regulates pyroptosis and ameliorates cardiac fibrosis in RA through the lncRNA GAS5 and TLR4/ROS/miR-21 pathways. A cardiac fibrosis model using human myocardial cells was established to study lncRNA GAS5, miR-21, TLR4, and NLRP3 expressions. Immunofluorescence, RT-qPCR, WB, dual-luciferase assay, CCK-8, flow cytometry, electron microscopy, and enzyme-linked immunosorbent assay were used to analyze various cellular processes and protein levels. Lactate dehydrogenase (LDH) releases were also analyzed. The mRNA and protein expressions of multiple genes were assessed. The optimal intervention conditions for AC16 cells were determined as follows: 20 µg/L for lipopolysaccharide (LPS) for 24 h, and 10% for XFC. In the LPS group, cell viability decreased, LDH release increased, and there was an elevation in pro-inflammatory cytokines and pyroptosis-related protein expression. GAS5 expression was reduced, while TLR4, ROS, and miR-21 showed increased levels compared to the NC group. GAS5 acted as an inhibitor by sponging miR-21. Conversely, XFC-containing serum, GAS5 overexpression, and miR-21 inhibition exhibited positive effects - enhancing cell viability, preventing LDH and pro-inflammatory cytokine release, and reducing pyroptosis and fibrosis-related protein levels. XFC can inhibit cellular pyroptosis, reduce pro-inflammatory cytokine levels, and improve RA cardiac fibrosis via lncRNA GAS5 and TLR4/ROS/miR-21 pathways.</p>","PeriodicalId":8025,"journal":{"name":"Annals of Medicine and Surgery","volume":"88 10","pages":"6384-6394"},"PeriodicalIF":1.6,"publicationDate":"2026-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13657457/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149179139","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Spontaneous fistulization of a giant pancreatic pseudocyst into the duodenum following acute pancreatitis: a case report.","authors":"Bikash Kumar Shah, Adesh Kantha, Abhisekh Bhattarai","doi":"10.1097/MS9.0000000000005650","DOIUrl":"https://doi.org/10.1097/MS9.0000000000005650","url":null,"abstract":"<p><strong>Introduction: </strong>Pancreatic pseudocysts are well-recognized sequelae of pancreatitis, but giant pseudocysts (>10 cm) are uncommon and rarely resolve through spontaneous fistulization. Spontaneous internal rupture into the gastrointestinal tract happens in less than 3% of cases and typically requires surgical or endoscopic intervention.</p><p><strong>Case presentation: </strong>We report the case of a 40-year-old male with a history of alcohol use who developed a giant pancreatic pseudocyst (22 × 12 cm) following acute pancreatitis. He presented with abdominal discomfort, early satiety, and vomiting. Imaging revealed a massive cyst compressing the stomach and duodenum. Although initially managed conservatively, the patient later experienced episodes of severe abdominal pain and coffee-ground vomiting.</p><p><strong>Clinical discussion: </strong>Spontaneous internal drainage of a giant pancreatic pseudocyst into the duodenum is very rare. This case highlights the potential for non-operative management in carefully selected, clinically stable patients, despite the size of the lesion and the risk of complications.</p><p><strong>Conclusion: </strong>We describe an unusual case of a giant pancreatic pseudocyst that resolved spontaneously through cystoduodenal fistulization. Conservative management led to full recovery, underscoring the importance of individualized treatment strategies in pancreatic pseudocyst management.</p>","PeriodicalId":8025,"journal":{"name":"Annals of Medicine and Surgery","volume":"88 10","pages":"6846-6850"},"PeriodicalIF":1.6,"publicationDate":"2026-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13657579/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149178917","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}