Annals of tropical medicine and parasitology最新文献

{"title":"The Genus Setaria","authors":"J. Thwaite","doi":"10.1080/00034983.1927.11684550","DOIUrl":"https://doi.org/10.1080/00034983.1927.11684550","url":null,"abstract":"(1927). The Genus Setaria. Annals of Tropical Medicine & Parasitology: Vol. 21, No. 4, pp. 427-466.","PeriodicalId":8019,"journal":{"name":"Annals of tropical medicine and parasitology","volume":"90 1","pages":"427-466"},"PeriodicalIF":0.0,"publicationDate":"2016-03-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/00034983.1927.11684550","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"58707050","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Habits of Adult Mosquitoes in Malaya","authors":"R. Wharton","doi":"10.1080/00034983.1951.11685483","DOIUrl":"https://doi.org/10.1080/00034983.1951.11685483","url":null,"abstract":"","PeriodicalId":8019,"journal":{"name":"Annals of tropical medicine and parasitology","volume":"47 1","pages":"155-160"},"PeriodicalIF":0.0,"publicationDate":"2016-03-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/00034983.1951.11685483","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"58744715","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Identification of the Poisonous Snakes of British West Africa","authors":"B. Maegraith","doi":"10.1080/00034983.1944.11685186","DOIUrl":"https://doi.org/10.1080/00034983.1944.11685186","url":null,"abstract":"","PeriodicalId":8019,"journal":{"name":"Annals of tropical medicine and parasitology","volume":"167 1","pages":"21-34"},"PeriodicalIF":0.0,"publicationDate":"2016-03-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/00034983.1944.11685186","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"58740588","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The patterns of some proteolytic enzymes of Entamoeba histolytica and Acanthamoeba sp. II. The action E. histolytica and acanthamoeba sp. on various synthetic substrates.","authors":"R. Jarumilinta, B. Maegraith","doi":"10.1080/00034983.1961.11686081","DOIUrl":"https://doi.org/10.1080/00034983.1961.11686081","url":null,"abstract":"","PeriodicalId":8019,"journal":{"name":"Annals of tropical medicine and parasitology","volume":"55 1","pages":"518-28"},"PeriodicalIF":0.0,"publicationDate":"2016-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/00034983.1961.11686081","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"58750393","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Vascular Matrix Metalloproteinase Inhibition, a New Mechanism for How Peroxisome Proliferator-Activated Receptor-γ Protects Target Organ Damage.","authors":"Steven J Forrester, Satoru Eguchi","doi":"10.1161/HYPERTENSIONAHA.115.06532","DOIUrl":"10.1161/HYPERTENSIONAHA.115.06532","url":null,"abstract":"","PeriodicalId":8019,"journal":{"name":"Annals of tropical medicine and parasitology","volume":"36 1","pages":"36-7"},"PeriodicalIF":8.3,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4679578/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80751695","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cost-effectiveness of triple drug administration (TDA) with praziquantel, ivermectin and albendazole for the prevention of neglected tropical diseases in Nigeria.","authors":"D Evans,&nbsp;D McFarland,&nbsp;W Adamani,&nbsp;A Eigege,&nbsp;E Miri,&nbsp;J Schulz,&nbsp;E Pede,&nbsp;C Umbugadu,&nbsp;P Ogbu-Pearse,&nbsp;F O Richards","doi":"10.1179/2047773211Y.0000000010","DOIUrl":"https://doi.org/10.1179/2047773211Y.0000000010","url":null,"abstract":"<p><p>Onchocerciasis, lymphatic filariasis (LF), schistosomiasis and soil transmitted, helminthiasis (STH) are all co-endemic in Nigeria. Annual mass drug administration (MDA) with ivermectin (for onchocerciasis), albendazole (for STH and with ivermectin for LF) and praziquantel (for schistosomiasis) is the WHO-recommended treatment strategy for preventive chemotherapy. Separate delivery rounds for distribution of these drugs have been the usual approach to MDA. All three drugs, however, have now been shown to be clinically and programmatically safe for co-administration with what has come to be known as triple drug administration (TDA). We examined the cost savings of converting from separate delivery rounds to TDA in two states in Nigeria. In 2008, eight local government areas received a single round of ivermectin with albendazole followed at least 1 week later by a single round of praziquantel to school-aged children. The following year, a single round was administered with TDA. The number of treated individuals was essentially unchanged during both years (1,301,864 in 2008 and 1,297,509 in 2009) and no change in adverse events was reported. The total programmatic costs for the MDA, not including drug and overhead costs, reduced by 41% from $123,624 to $72,870. Cost savings were limited in larger populations due to economies of scale. TDA is recommended for mature MDA.</p>","PeriodicalId":8019,"journal":{"name":"Annals of tropical medicine and parasitology","volume":"105 8","pages":"537-47"},"PeriodicalIF":0.0,"publicationDate":"2011-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1179/2047773211Y.0000000010","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"30452431","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Beta-carboline-3-carboxamide derivatives as promising antileishmanial agents.","authors":"R B Pedroso,&nbsp;L T D Tonin,&nbsp;T Ueda-Nakamura,&nbsp;B P Dias Filho,&nbsp;M H Sarragiotto,&nbsp;C V Nakamura","doi":"10.1179/2047773211Y.0000000005","DOIUrl":"https://doi.org/10.1179/2047773211Y.0000000005","url":null,"abstract":"<p><p>Leishmaniasis has an overwhelming impact on global public health especially in tropical and subtropical countries and the currently available antileishmanial drugs have serious side effects and low efficacy. Natural and synthetic compounds have been tested in the past few years against Leishmania and the beta-carboline class of compounds have shown great results in antiparasitic chemotherapy. In the present study, three 1-substituted beta-carboline-3-carboxamides (3-5) and 1-substituted beta-carboline-3-carboxylic acid (2) were synthesized and screened for in vitro activity against L. amazonensis. Compound 5 (N-benzyl 1-(4-methoxy)phenyl-9H-beta-carboline-3-carboxamide) had the best activity against promastigote and axenic amastigote forms with IC(50) of 2·6 and 1·0 μM, respectively. Its CC(50) on macrophages cell line was higher than 2457·0 μM with an SI ratio of 930·2. Against intracellular amastigote forms, it had a dose-dependent relationship with a 50% growth inhibitory concentration of 1·0 μM. Through morphological and ultrastructure analysis of promastigote forms treated with compound 5, alterations on cell shape and number of flagella and nuclear membrane damage were observed. For this, compound 5 supports the idea for more in vitro and in vivo studies.</p>","PeriodicalId":8019,"journal":{"name":"Annals of tropical medicine and parasitology","volume":"105 8","pages":"549-57"},"PeriodicalIF":0.0,"publicationDate":"2011-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1179/2047773211Y.0000000005","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"30452432","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Epidemiological assessment of continuing transmission of lymphatic filariasis in Samoa.","authors":"H Joseph, F Maiava, T Naseri, U Silva, P Lammie, W Melrose","doi":"10.1179/2047773211Y.0000000008","DOIUrl":"10.1179/2047773211Y.0000000008","url":null,"abstract":"<p><p>Ongoing transmission of lymphatic filariasis (LF) was assessed in five Samoan villages by measuring microfilaraemia (Mf), circulating filarial antigen (CFA) and antibody prevalence. Compared to the other villages, Fasitoo-Tai had a significantly higher Mf prevalence (3·2%), CFA prevalence (14·6%) and antibody prevalence in children (62·0%) (P<0·05). Puapua had a significantly lower CFA prevalence (2·5%), no detectable Mf-positive individuals and significantly low antibody prevalence in children (7·9%) (P<0·05). Siufaga, previously believed to be LF-free, recorded >1% CFA prevalence and a high antibody prevalence in children (46·6%). Overall, antibody prevalence in children appeared to reflect the transmission dynamics in the villages and, in Siufaga, identified an area of ongoing transmission. The Filariasis Cellabs Enzyme-Linked Immunosorbent Assay (CELISA), based on recombinant antigen Bm14, to detect antibodies, could potentially be a promising diagnostic tool for inclusion in future surveillance in the South Pacific.</p>","PeriodicalId":8019,"journal":{"name":"Annals of tropical medicine and parasitology","volume":"105 8","pages":"567-78"},"PeriodicalIF":0.0,"publicationDate":"2011-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4089807/pdf/atm-105-08-567.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"30452434","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Further characterization of Trypanosoma cruzi strains through a simple sequence repeat (SSR) of ferredoxin-NADP+ reductase 5' UTR.","authors":"L H Jaeger,&nbsp;A Brandao","doi":"10.1179/2047773211Y.0000000016","DOIUrl":"https://doi.org/10.1179/2047773211Y.0000000016","url":null,"abstract":"Trypanosoma cruzi displays clonal expansion, and genetic exchanges have contributed to the current complexity of its population (Machado and Ayala, 2001). Several clustering schemes have been proposed to aid the understanding of T. cruzi genetic nomenclature, including: zymodemes (Miles et al., 1978), two major phylogenetic lineages (Souto et al., 1996), discrete typing units (Brisse et al., 2000) and haplotype analysis (de Freitas et al., 2006). This clustering scheme shed light on T. cruzi population structure and also advanced the analysis of Chagas disease epidemiology. However, except for kDNA or the schizodeme analysis (Morel et al., 1980), no other molecular marker has been successfully deployed to narrow the characterization of particular strains and extend information beyond T. cruzi population structure. We have approached this question by looking at the untranslated regions (UTRs) in T. cruzi (Brandao, 2006; Brandao and Fernandes, 2006; Brandao and Jiang, 2009). In general, UTRs tend to accumulate mutations at rates higher than the respective open reading frame (ORF) (Makalowski and Boguski, 1998). Thus, molecular clusters for T. cruzi strains could be detected by inspecting UTR sequences. We have inspected UTR from low copy number genes such as ferredoxin-NADP+ reductase and reasoned that its 5′ UTR might be used for this purpose. Ferredoxin-NADP+ reductase is present in a wide range of organisms and modulates redox metabolic pathways such as the one involved in electron transfer (Paladini et al., 2009). In T. cruzi CL Brener, a search in its genome sequence (www.tritrypdb.org) shows that ferredoxin-NADP+ reductase is single copy, displaying an ORF and 5′ UTR of 2004 and 130 bp in length, respectively (according to sequence in GenBank accession no. {\"type\":\"entrez-nucleotide\",\"attrs\":{\"text\":\"AY206009\",\"term_id\":\"37782788\",\"term_text\":\"AY206009\"}}AY206009). Here, we discuss that it contains two segments that are useful for characterization of strains: a simple sequence repeat (SSR) which allows a narrow analysis at the strain level and an upstream open reading frame (uORF) that identifies two of the major T. cruzi populations.","PeriodicalId":8019,"journal":{"name":"Annals of tropical medicine and parasitology","volume":"105 8","pages":"651-4"},"PeriodicalIF":0.0,"publicationDate":"2011-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1179/2047773211Y.0000000016","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"30452909","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diagnosis and identification of Leishmania spp. from Giemsa-stained slides, by real-time PCR and melting curve analysis in south-west of Iran.","authors":"S Khademvatan,&nbsp;N Neisi,&nbsp;S Maraghi,&nbsp;J Saki","doi":"10.1179/2047773211Y.0000000014","DOIUrl":"https://doi.org/10.1179/2047773211Y.0000000014","url":null,"abstract":"<p><strong>Background: </strong>The aim of present study was describing a real-time PCR assay for the diagnosis and direct identification of Leishmania species on Giemsa-stained slides in south-west of Iran.</p><p><strong>Materials and methods: </strong>Altogether, 102 Giemsa-stained slides were collected from different part of south-west of Iran between 2008 and 2011. All the Giemsa-stained slides were examined under light microscope. After DNA extraction, real-time PCR amplification and detection were conducted with fluorescent SYBR Green I. For identification, PCR products were analysed with melting curve analysis.</p><p><strong>Results: </strong>One hundred and two archived slides from suspected lesion examined by microscopy and real-time PCR. The sensitivity of the real-time PCR on Giemsa-stained slid was 98% (96/102). The melting curve analysis (T(m)) were 88·3±0·2°C for L. tropica (MHOM/IR/02/Mash10), 86·5±0·2°C for L. major (MHOM/IR/75/ER) and 89·4±0·3°C for L. infantum (MCAN/IR/97/LON 49), respectively.</p><p><strong>Conclusion: </strong>This study is first report in use of real-time PCR for diagnosis and identification of Leishmania spp. in Iran. Up to now, in Iran, the majority of identification of Leishmania species is restriction fragment length polymorphism (PCR-RFLP) of ITS1 and kinetoplast DNA. Our data showed that Giemsa-stained slides that were stored more than 3 years, can be use for Leishmania DNA extraction and amplification by real-time PCR. Compared to conventional PCR-based methods, the real-time PCR is extremely rapid with results and more samples can be processed at one time.</p>","PeriodicalId":8019,"journal":{"name":"Annals of tropical medicine and parasitology","volume":"105 8","pages":"559-65"},"PeriodicalIF":0.0,"publicationDate":"2011-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1179/2047773211Y.0000000014","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"30452433","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}