Epidemiological assessment of continuing transmission of lymphatic filariasis in Samoa.

Annals of tropical medicine and parasitology Pub Date : 2011-12-01 DOI:10.1179/2047773211Y.0000000008

H Joseph, F Maiava, T Naseri, U Silva, P Lammie, W Melrose

{"title":"Epidemiological assessment of continuing transmission of lymphatic filariasis in Samoa.","authors":"H Joseph, F Maiava, T Naseri, U Silva, P Lammie, W Melrose","doi":"10.1179/2047773211Y.0000000008","DOIUrl":null,"url":null,"abstract":"<p><p>Ongoing transmission of lymphatic filariasis (LF) was assessed in five Samoan villages by measuring microfilaraemia (Mf), circulating filarial antigen (CFA) and antibody prevalence. Compared to the other villages, Fasitoo-Tai had a significantly higher Mf prevalence (3·2%), CFA prevalence (14·6%) and antibody prevalence in children (62·0%) (P<0·05). Puapua had a significantly lower CFA prevalence (2·5%), no detectable Mf-positive individuals and significantly low antibody prevalence in children (7·9%) (P<0·05). Siufaga, previously believed to be LF-free, recorded >1% CFA prevalence and a high antibody prevalence in children (46·6%). Overall, antibody prevalence in children appeared to reflect the transmission dynamics in the villages and, in Siufaga, identified an area of ongoing transmission. The Filariasis Cellabs Enzyme-Linked Immunosorbent Assay (CELISA), based on recombinant antigen Bm14, to detect antibodies, could potentially be a promising diagnostic tool for inclusion in future surveillance in the South Pacific.</p>","PeriodicalId":8019,"journal":{"name":"Annals of tropical medicine and parasitology","volume":"105 8","pages":"567-78"},"PeriodicalIF":0.0000,"publicationDate":"2011-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4089807/pdf/atm-105-08-567.pdf","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Annals of tropical medicine and parasitology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1179/2047773211Y.0000000008","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}

引用次数: 0

Abstract

Ongoing transmission of lymphatic filariasis (LF) was assessed in five Samoan villages by measuring microfilaraemia (Mf), circulating filarial antigen (CFA) and antibody prevalence. Compared to the other villages, Fasitoo-Tai had a significantly higher Mf prevalence (3·2%), CFA prevalence (14·6%) and antibody prevalence in children (62·0%) (P<0·05). Puapua had a significantly lower CFA prevalence (2·5%), no detectable Mf-positive individuals and significantly low antibody prevalence in children (7·9%) (P<0·05). Siufaga, previously believed to be LF-free, recorded >1% CFA prevalence and a high antibody prevalence in children (46·6%). Overall, antibody prevalence in children appeared to reflect the transmission dynamics in the villages and, in Siufaga, identified an area of ongoing transmission. The Filariasis Cellabs Enzyme-Linked Immunosorbent Assay (CELISA), based on recombinant antigen Bm14, to detect antibodies, could potentially be a promising diagnostic tool for inclusion in future surveillance in the South Pacific.

查看原文本刊更多论文

萨摩亚淋巴丝虫病持续传播的流行病学评估。

通过测量微丝蚴血症（Mf）、循环丝虫抗原（CFA）和抗体流行率，评估了淋巴丝虫病（LF）在五个萨摩亚村庄的持续传播情况。与其他村庄相比，Fasitoo-Tai 村的微丝蚴血症流行率（3-2%）、循环丝虫抗原流行率（14-6%）和儿童抗体流行率（62-0%）明显较高（P1%的循环丝虫抗原流行率和较高的儿童抗体流行率（46-6%））。总体而言，儿童抗体流行率似乎反映了村庄的传播动态，并在 Siufaga 确定了一个持续传播的地区。丝虫病细胞酶联免疫吸附试验（CELISA）以重组抗原 Bm14 为基础检测抗体，有可能成为南太平洋未来监测的一种有前途的诊断工具。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Annals of tropical medicine and parasitology 医学-公共卫生、环境卫生与职业卫生

自引率

0.00%

发文量

审稿时长

>12 weeks