Annals of Clinical Biochemistry最新文献_第3页

Kidney stone analysis may miss diagnoses as demonstrated by a case of adenine phosphoribosyl transferase deficiency. 肾结石分析可能漏诊，如一例腺嘌呤磷酸核糖基转移酶缺乏。

IF 1 4区医学

Annals of Clinical Biochemistry Pub Date : 2025-08-14 DOI: 10.1177/00045632251367232

Roger Bramley, Daniel Herrera, Robert Barski, Michael Henderson

引用次数: 0

Real-life evaluation of an alert system to detect the risk of unreported dyskaelemia in haemolysed blood samples from a hospital emergency department. 在医院急诊科的溶血样本中检测未报告的血钾异常风险的警报系统的现实评估。

IF 1 4区医学

Annals of Clinical Biochemistry Pub Date : 2025-08-14 DOI: 10.1177/00045632251372764

Valery Brunel, Julie Fettig, Luc Marie Joly, Guillaume Feugray, François Fraissinet, Hélène Girot

{"title":"Real-life evaluation of an alert system to detect the risk of unreported dyskaelemia in haemolysed blood samples from a hospital emergency department.","authors":"Valery Brunel, Julie Fettig, Luc Marie Joly, Guillaume Feugray, François Fraissinet, Hélène Girot","doi":"10.1177/00045632251372764","DOIUrl":"10.1177/00045632251372764","url":null,"abstract":"BackgroundIn vitro haemolysis is a recurrent problem in emergency department samples. Potassium is one of the most critical tests and sensitive to increasing levels of in vitro haemolysis. Haemolysis results in a large number of invalidated potassium test results.MethodsWe set up an alert system to detect the risk of dyskalaemia based on potassium value and haemolysis index (HI). We retrospectively evaluated the effectiveness of the alert system for haemolysed blood samples from the emergency department.Results54 605 samples were included. Women more frequently had a sample with a high HI value, resulting in the invalidation of a potassium test result (3.22% vs 2.35%, P < 0.001). In the case of haemolysed samples, the frequency of alerts for hyperkalemia risk was similar in women and men. Hypokalaemia was significantly more frequent in women than in men (12.71% vs 9.38%, P < 0.001). Among the haemolyzed samples, no hypokalaemia risk alerts were observed and 42 patients had a hyperkalaemia risk alert. For these patients, the potassium value of a second sample was significantly higher in patients with an alert on the first sample (4.85 mmol/L vs 4.0 mmol/L, P < 0.001), with a higher rate of hyperkalaemia (57.14% vs 4.76%, P < 0.001) and critical hyperkalaemia (17.86% vs 0.3%, P < 0.001). Negative predictive value and positive predictive value to detect hyperkalaemia were 90.4% [89.6-91] and 41.3% [25.5%-59.1%].ConclusionsOur alert system was effective to detect the risk of hyperkalemia, and could help clinicians to better target patients requiring repeat sampling for potassium.","PeriodicalId":8005,"journal":{"name":"Annals of Clinical Biochemistry","volume":" ","pages":"45632251372764"},"PeriodicalIF":1.0,"publicationDate":"2025-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144854279","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Procalcitonin assay variation in an Australasian external quality assurance program. 降钙素原测定在澳大利亚外部质量保证计划中的变化。

IF 1 4区医学

Annals of Clinical Biochemistry Pub Date : 2025-08-14 DOI: 10.1177/00045632251372749

Alexander Richardson, Kristie Chapman, Peter Graham, Tony Badrick

{"title":"Procalcitonin assay variation in an Australasian external quality assurance program.","authors":"Alexander Richardson, Kristie Chapman, Peter Graham, Tony Badrick","doi":"10.1177/00045632251372749","DOIUrl":"10.1177/00045632251372749","url":null,"abstract":"Sepsis accounts for approximately 20% of global deaths, and early diagnosis is a critical factor in intervention. In 2017, the FDA approved procalcitonin (PCT) to guide antibiotic use for patients with suspected sepsis, and there are recognized intervals for clinical interpretation. Therapeutic algorithms incorporating PCT measurement have implications for antibiotic stewardship in the age of antibiotic resistance. A 2021 review of external quality assurance programs for PCT, including the Royal College of Pathologists of Australasia Quality Assurance Programs (RCPAQAP) PCT program, highlighted variable performance between assays. We reviewed the RCPAQAP's PCT program results from 2019 to 2021 to analyse any variation in reported results. The RCPAQAP's PCT program is conducted annually and consists of a lyophilized human/bovine serum albumin base with added recombinant PCT sent to participating laboratories. Results received for the 2019, 2020 and 2021 PCT programs were analysed using two-way ANOVA with Tukey's multiple comparison test and a Student's t-test to investigate variation in assay performance. We found significant variation between the different assay manufacturers at all PCT concentrations analysed. Additionally, bimodal reporting was observed, where bioMerieux/Beckman Coulter/Siemens methods had significantly higher results when compared to Roche/Abbott methods. There was also a significant increase in the average coefficient of variation between 2019 and 2020/2021, coinciding with reported method changes. Finally, variable performance of the semi-quantitative PCT method at both low and high PCT concentrations was detected. These findings suggest that clinical decision cut-offs must be validated for each assay. However, the commutability of the program material has yet to be determined.","PeriodicalId":8005,"journal":{"name":"Annals of Clinical Biochemistry","volume":" ","pages":"45632251372749"},"PeriodicalIF":1.0,"publicationDate":"2025-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144854278","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Automated management of internal quality control alarming for secondary measurement channels: An ICT solution. 二级测量通道内部质量控制报警的自动化管理：ICT解决方案。

IF 1 4区医学

Annals of Clinical Biochemistry Pub Date : 2025-08-14 DOI: 10.1177/00045632251367233

Marije van der Schaar, Ruben Moritz, Huub H van Rossum

引用次数: 0

Bilirubin interference on a Roche creatinine enzymatic method. 胆红素对罗氏肌酐酶法的干扰。

IF 1 4区医学

Annals of Clinical Biochemistry Pub Date : 2025-08-12 DOI: 10.1177/00045632251367271

Stuart Bennett, Angela Woods

引用次数: 0

Efficacy and implications of minimum retesting intervals for HbA1c. HbA1c最小复检间隔的有效性和意义。

IF 1 4区医学

Annals of Clinical Biochemistry Pub Date : 2025-08-12 DOI: 10.1177/00045632251367278

Ibrahim Hersi, Rachel L Griffiths, Rousseau Gama, Tejas Kalaria

引用次数: 0

From analytical interference to the detection of intoxication. 从分析干扰到中毒检测。

IF 1 4区医学

Annals of Clinical Biochemistry Pub Date : 2025-08-12 DOI: 10.1177/00045632251367247

Sonali Suresh Karnani-Khemlani, María José de la Vega-Prieto, Juana Reyes Padrón-Morales, Fuensanta Gómez-Bernal, Elene Laburu-Dañobeitia, Marta Rodríguez-García, Darío Cabana-Ramos, Sergio Luis-Lima

引用次数: 0

Letter response: Metamizole (dipyrone) as an interferent in biochemical assays. 信函回复：甲氨唑（双吡咯酮）在生化检测中的干扰作用。

IF 1 4区医学

Annals of Clinical Biochemistry Pub Date : 2025-08-12 DOI: 10.1177/00045632251367239

D David Ceacero Marín

引用次数: 0

Sternal wound infection post cardiac surgery is a preventable complication. 心脏手术后胸骨伤口感染是一种可预防的并发症。

IF 1 4区医学

Annals of Clinical Biochemistry Pub Date : 2025-08-11 DOI: 10.1177/00045632251367237

Khaled Ebrahim Al-Ebrahim

引用次数: 0

Elevated CA19-9 in IgG4-related disease. igg4相关疾病中CA19-9升高。

IF 1 4区医学

Annals of Clinical Biochemistry Pub Date : 2025-08-07 DOI: 10.1177/00045632251370803

Derrick Hy Chong, Andre Mattman, Aaron Dou, Anthony So, Howard J Lim, Junyan Shi, Richard Cleve, David F Schaeffer, Eric Cs Lam, Jennifer J Telford, Luke Yc Chen, Mollie N Carruthers

{"title":"Elevated CA19-9 in IgG4-related disease.","authors":"Derrick Hy Chong, Andre Mattman, Aaron Dou, Anthony So, Howard J Lim, Junyan Shi, Richard Cleve, David F Schaeffer, Eric Cs Lam, Jennifer J Telford, Luke Yc Chen, Mollie N Carruthers","doi":"10.1177/00045632251370803","DOIUrl":"10.1177/00045632251370803","url":null,"abstract":"BackgroundIgG4-related disease (IgG4-RD) is an inflammatory disease that can clinically mimic pancreatic and hepatobiliary cancer. Serum carbohydrate antigen 19-9 (CA19-9) is a tumour marker that is frequently used to aid in the diagnosis of biliary cancer. There have been reported cases that patients with IgG4-RD also have elevated CA19-9.MethodsThis study has two components, first, a quality assurance component that observes paired IgG4 and CA19-9 measurements from patients with unknown diagnoses were compared to determine if serum IgG4 interferes with CA19-9 measurement. In addition, a mixing study is used to investigate if high levels of IgG4 interfered with CA19-9 measurements. Second, a retrospective chart review was performed to compare patients diagnosed with IgG4-RD with normal versus elevated CA19-9.ResultsAmong 487 unique individuals with paired measurements, no association between CA19-9 and serum IgG4 was found. Mixing studies revealed no interference. Among 20 patients with IgG4-RD, 11 had elevated CA19-9 (median 150 kU/L) and nine had normal CA19-9. There was no difference in bilirubin between the two groups (63.2 µmol/L vs 39.4 µmol/L, P = .47).ConclusionThere is no relationship between CA19-9 and serum IgG4. Patients with IgG4-RD and elevated CA19-9 did not have higher bilirubin than those with normal CA19-9. Together, these results suggest that elevated CA19-9 in IgG4-RD may be related to the disease rather than to interference from high serum IgG4 or from biliary obstruction.","PeriodicalId":8005,"journal":{"name":"Annals of Clinical Biochemistry","volume":" ","pages":"45632251370803"},"PeriodicalIF":1.0,"publicationDate":"2025-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144798028","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0