Annals of vascular diseases最新文献

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Current Status of Diagnostic Process in Asymptomatic Abdominal Aortic Aneurysm in Japan. 日本无症状腹主动脉瘤的诊断现状
IF 0.6
Annals of vascular diseases Pub Date : 2025-01-01 Epub Date: 2025-03-28 DOI: 10.3400/avd.oa.25-00025
Yoshimasa Seike, Nobuyoshi Azuma, Takao Ohki, Noriyasu Morikage, Akio Kodama, Makoto Sumi, Koji Maeda, Hitoshi Matsuda
{"title":"Current Status of Diagnostic Process in Asymptomatic Abdominal Aortic Aneurysm in Japan.","authors":"Yoshimasa Seike, Nobuyoshi Azuma, Takao Ohki, Noriyasu Morikage, Akio Kodama, Makoto Sumi, Koji Maeda, Hitoshi Matsuda","doi":"10.3400/avd.oa.25-00025","DOIUrl":"10.3400/avd.oa.25-00025","url":null,"abstract":"<p><p><b>Objectives:</b> This study aimed to investigate the actual detection process and diagnostic methods for asymptomatic abdominal aortic aneurysm (AAA) in a multicenter setting, and to plan an effective screening strategy for asymptomatic AAA. <b>Methods:</b> The subjects of this multicenter study were collected in a retrospective manner at 7 facilities. A total of 1894 patients with AAA, including iliac artery aneurysms, who were considered asymptomatic with a confirmed initial diagnosis from January 2018 to December 2022, were collected and reviewed. <b>Results:</b> A total of 1666 patients who were diagnosed with asymptomatic AAA were included [83.9% males, median age of 75 (69-81) years]. Asymptomatic AAAs were frequently diagnosed during examinations for other diseases in 1339 patients (80.4%), whereas health screenings accounted for only 313 (18.8%). Computed tomography (CT) was the most commonly used diagnostic method (n = 1352, 81.2%) compared to abdominal ultrasonography (n = 252, 15.2%). <b>Conclusions:</b> Asymptomatic AAAs are detected incidentally during examinations for other diseases, and there is an urgent need to promote health screening. Most AAAs are diagnosed by CT; nevertheless, we consider that abdominal ultrasonography would be the most appropriate modality for AAA screening because of its reasonable accuracy, noninvasiveness, and low cost.</p>","PeriodicalId":7995,"journal":{"name":"Annals of vascular diseases","volume":"18 1","pages":""},"PeriodicalIF":0.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11957909/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143750786","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Acute Inflammatory Pseudoaneurysm of the Gastroepiploic Artery in a Patient with Multiple Aneurysms: A Case Highlighting Systemic Vascular Remodeling. 多发性动脉瘤患者胃网膜动脉急性炎性假性动脉瘤:一例系统性血管重构。
IF 0.6
Annals of vascular diseases Pub Date : 2025-01-01 Epub Date: 2025-08-20 DOI: 10.3400/avd.cr.25-00072
Yuri Yoshida, Shinsuke Kikuchi, Daiki Uchida, Naoya Kuriyama, Yuki Tada, Atsuhiro Koya, Sayaka Yuzawa, Hisashi Uchida, Mishie Tanino, Nobuyoshi Azuma
{"title":"Acute Inflammatory Pseudoaneurysm of the Gastroepiploic Artery in a Patient with Multiple Aneurysms: A Case Highlighting Systemic Vascular Remodeling.","authors":"Yuri Yoshida, Shinsuke Kikuchi, Daiki Uchida, Naoya Kuriyama, Yuki Tada, Atsuhiro Koya, Sayaka Yuzawa, Hisashi Uchida, Mishie Tanino, Nobuyoshi Azuma","doi":"10.3400/avd.cr.25-00072","DOIUrl":"10.3400/avd.cr.25-00072","url":null,"abstract":"<p><p>A 52-year-old man with scoliosis and psoriasis vulgaris, treated with infliximab, presented with a large right gastroepiploic artery aneurysm (GEAA). Following surgical resection, additional aneurysms of the anterior communicating artery and abdominal aorta were identified. Histopathological examination revealed a pseudoaneurysm with organizing thrombus and marked acute inflammation, including neutrophilic infiltration of the medial wall. Despite negative cultures, an infection-related vascular insult could not be excluded. This case highlights a rare immune-mediated vascular pathology in the context of chronic inflammatory disease, emphasizing the potential role of acute inflammation and psoriasis-associated immune dysregulation in visceral artery aneurysm formation.</p>","PeriodicalId":7995,"journal":{"name":"Annals of vascular diseases","volume":"18 1","pages":""},"PeriodicalIF":0.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12375504/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144939377","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Risk Factors for Acute Hemorrhagic Rectal Ulcers after Bypass Surgery for Chronic Limb-Threatening Ischemia. 慢性肢体缺血旁路手术后急性出血性直肠溃疡的危险因素。
IF 0.6
Annals of vascular diseases Pub Date : 2025-01-01 Epub Date: 2025-04-01 DOI: 10.3400/avd.oa.24-00125
Yohei Kawai, Masayuki Sugimoto, Takuya Osawa, Changi Lee, Shuta Ikeda, Kiyoaki Niimi, Hiroshi Banno
{"title":"Risk Factors for Acute Hemorrhagic Rectal Ulcers after Bypass Surgery for Chronic Limb-Threatening Ischemia.","authors":"Yohei Kawai, Masayuki Sugimoto, Takuya Osawa, Changi Lee, Shuta Ikeda, Kiyoaki Niimi, Hiroshi Banno","doi":"10.3400/avd.oa.24-00125","DOIUrl":"10.3400/avd.oa.24-00125","url":null,"abstract":"<p><p><b>Objectives:</b> Acute hemorrhagic rectal ulcer (AHRU) occurs with a sudden onset of painless bloody stools and is caused by impaired blood flow in the rectal mucosa due to arteriosclerosis or prolonged bedridden status. Little information is available about AHRU in patients with chronic limb-threatening ischemia (CLTI). This study aimed to identify factors related to AHRU among CLTI patients after bypass surgery. <b>Methods:</b> Between 2019 and 2023, we enrolled 80 CLTI patients at our institution who underwent bypass surgery using autogenous veins. Data were collected prospectively and supplemented with retrospective medical record reviews. Information regarding demographic and clinical characteristics was collected. The outcomes of patients without AHRU (non-AHRU group) and those with AHRU (AHRU group) were compared. Logistic regression analysis was used to assess factors associated with AHRU after bypass surgery. <b>Results:</b> During the study period, 6 of the 80 patients (7.5%) experienced AHRU after bypass surgery. There was no significant difference in the global limb anatomic staging system (GLASS) or wound ischemia and foot infection (WIfI) stage between the 2 groups. The percentage of patients taking oral steroids was significantly greater in the AHRU group. In addition, the AHRU group had a significantly greater percentage of postoperative ambulatory failure and a longer hospital stay. In the univariate analysis of factors associated with the incidence of AHRU after bypass surgery, steroid use (odds ratio [OR], 13.8; 95% confidence interval [CI], 2.19-86.9; P = 0.005) and nonambulatory status after surgery (OR, 7.22; 95% CI, 1.26-41.4; P = 0.026) were significant factors. <b>Conclusions:</b> Steroid use and postoperative nonambulatory status were associated with AHRU after bypass surgery for CLTI.</p>","PeriodicalId":7995,"journal":{"name":"Annals of vascular diseases","volume":"18 1","pages":""},"PeriodicalIF":0.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11964780/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143770949","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Interface Pressures Derived from a Calibrated Bandage Applied for Compression Therapy. 应用于压缩治疗的校准绷带产生的界面压力。
IF 0.6
Annals of vascular diseases Pub Date : 2025-01-01 DOI: 10.3400/avd.oa.24-00103
Kotaro Suehiro, Hitoshi Sakuda, Takasuke Harada, Yuriko Takeuchi, Takahiro Mizoguchi, Ryunosuke Sakamoto, Hiroshi Kurazumi, Ryo Suzuki, Kimikazu Hamano
{"title":"Interface Pressures Derived from a Calibrated Bandage Applied for Compression Therapy.","authors":"Kotaro Suehiro, Hitoshi Sakuda, Takasuke Harada, Yuriko Takeuchi, Takahiro Mizoguchi, Ryunosuke Sakamoto, Hiroshi Kurazumi, Ryo Suzuki, Kimikazu Hamano","doi":"10.3400/avd.oa.24-00103","DOIUrl":"10.3400/avd.oa.24-00103","url":null,"abstract":"<p><p><b>Objectives:</b> We sought to clarify the interface pressure (IP) and its variation by applying Biflex16, a calibrated bandage, to the lower leg. <b>Methods:</b> In Study I, 50 participants applied a bandage to the lower leg of a single subject in two ways: first, with 50% overlap, while the calibration rectangle became a square (Application 1), and then with 50% overlap without intentional stretch (Application 2) which served as a control. In Study II, another 51 participants applied the bandage to their lower leg via Application 1. The IP was measured at the level of the transposition of the medial gastrocnemius muscle into the Achilles tendon (B1). <b>Results:</b> In Study I, the median IP (37 mmHg) and interquartile range (IQR; 9 mmHg) in the standing position were the same for Applications 1 and 2. In Study II, the obtained IP and IQR values were 38 and 12 mmHg, respectively, in the sitting position. This IP was similar to that obtained in Study I, and no correlation was found between IP and leg circumference. <b>Conclusions:</b> The variation in the IP obtained by the calibrated bandage was reasonably small when applied via Application 1. The obtained IPs did not correlate with the leg circumference.</p>","PeriodicalId":7995,"journal":{"name":"Annals of vascular diseases","volume":"18 1","pages":""},"PeriodicalIF":0.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11771149/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143057713","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Practice of Percutaneous EVAR under Local Anesthesia. 局麻下经皮EVAR的实践。
IF 0.6
Annals of vascular diseases Pub Date : 2025-01-01 Epub Date: 2025-01-24 DOI: 10.3400/avd.oa.24-00129
Yuika Kameda, Naohiko Nemoto, Bon Inoue, Satoru Takaesu, Hiroki Takenaka, Yoshinori Nagashima, Hitoshi Anzai
{"title":"The Practice of Percutaneous EVAR under Local Anesthesia.","authors":"Yuika Kameda, Naohiko Nemoto, Bon Inoue, Satoru Takaesu, Hiroki Takenaka, Yoshinori Nagashima, Hitoshi Anzai","doi":"10.3400/avd.oa.24-00129","DOIUrl":"10.3400/avd.oa.24-00129","url":null,"abstract":"<p><p><b>Objectives:</b> Endovascular aortic repair (EVAR) should be performed using a less invasive procedure based on the patient's clinical condition, as many patients who undergo this procedure are elderly and have poor surgical tolerance. We report our experience and results of percutaneous EVAR under local anesthesia in order to practice minimally invasive EVAR at our hospital. <b>Methods:</b> In August 2019, we started percutaneous EVAR using Perclose ProGlide under local anesthesia. We compared the backgrounds and surgical outcomes of patients who underwent EVAR at our hospital before and after the introduction of percutaneous EVAR under local anesthesia. <b>Results:</b> We included 148 patients in this study. The age at surgery and prevalence of severe renal dysfunction were significantly higher in percutaneous EVAR under local anesthesia group. The operative time and postoperative hospital stay were significantly shorter in the percutaneous EVAR group under local anesthesia. <b>Conclusions:</b> The introduction of percutaneous EVAR under local anesthesia enabled minimally invasive EVAR to be performed safely even in high-risk patients. (This is a translation of J Jpn Coll Angiol 2022; 62: 1-5.).</p>","PeriodicalId":7995,"journal":{"name":"Annals of vascular diseases","volume":"18 1","pages":""},"PeriodicalIF":0.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11774565/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143057718","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Comparative Study of Endovascular Aneurysm Repair in Patients with Narrow Aortic Bifurcation Using the Unibody AFX2 vs the Bifurcated ALTO Endoluminal System. 单体AFX2与分体ALTO腔内系统修复狭窄主动脉分叉患者血管内动脉瘤的比较研究。
IF 0.6
Annals of vascular diseases Pub Date : 2025-01-01 Epub Date: 2025-06-14 DOI: 10.3400/avd.oa.25-00027
Nikolaos Kontopodis, Michalis Pesmatzoglou, Ifigeneia Tzartzalou, Konstantinos Litinas, George Tzouliadakis, Nikolaos Galanakis, Elias Kehagias, Christos Ioannou
{"title":"Comparative Study of Endovascular Aneurysm Repair in Patients with Narrow Aortic Bifurcation Using the Unibody AFX2 vs the Bifurcated ALTO Endoluminal System.","authors":"Nikolaos Kontopodis, Michalis Pesmatzoglou, Ifigeneia Tzartzalou, Konstantinos Litinas, George Tzouliadakis, Nikolaos Galanakis, Elias Kehagias, Christos Ioannou","doi":"10.3400/avd.oa.25-00027","DOIUrl":"10.3400/avd.oa.25-00027","url":null,"abstract":"<p><p><b>Objectives:</b> A narrow aortic bifurcation poses technical challenges during endovascular aneurysm repair (EVAR). We aim to compare the unibody AFX2 (Endologix, Irvine, CA, USA) vs the bifurcated ALTO (Endologix) system in EVAR patients with a narrow bifurcation. <b>Methods:</b> Retrospective single-center study, including patients undergoing standard EVAR over 3 years. Patients with a bifurcation diameter <20 mm were identified, and outcomes were compared between the AFX2 and ALTO groups. Primary endpoints were primary and overall technical success, primary and overall clinical success, rate of adverse limb events, rate of limb occlusion, and need for secondary interventions. The analysis was repeated using a diameter threshold of <18 mm. <b>Results:</b> Among 151 cases, 26 presented with bifurcations <20 mm and 12 with <18 mm. In the primary analysis, 15 patients were treated with the AFX2 and 11 with the ALTO endograft. Both groups achieved 100% technical and clinical success. No limb occlusions occurred, and no reinterventions were recorded. Preoperative anatomy was suitable for ALTO in all cases, while eligibility for AFX2 was 15 out of 26 cases. Secondary analysis displayed similar results. <b>Conclusions:</b> In patients with narrow aortic bifurcation, the AFX2 endograft can be safely used when appropriate anatomic conditions are met. If the AFX2 system is unsuitable due to other anatomic restrictions, the ALTO endograft is a viable alternative.</p>","PeriodicalId":7995,"journal":{"name":"Annals of vascular diseases","volume":"18 1","pages":""},"PeriodicalIF":0.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12170096/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144309442","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A Case of Surgery for Myxoma in the Inferior Vena Cava Using Deep Hypothermic Circulatory Arrest. 深低温停循环术治疗下腔静脉黏液瘤1例。
IF 0.6
Annals of vascular diseases Pub Date : 2025-01-01 Epub Date: 2025-03-25 DOI: 10.3400/avd.cr.24-00118
Masato Hayama, Kayo Wakamatsu, Yuko Teratani, Yuki Kunitomo, Chihaya Ito, Masayuki Shimizu, Hiromitsu Teratani, Yuta Sukehiro, Masato Furui, Mizuki Sumi, Mau Amako, Yoshio Hayashida, Go Kuwahara, Hideichi Wada
{"title":"A Case of Surgery for Myxoma in the Inferior Vena Cava Using Deep Hypothermic Circulatory Arrest.","authors":"Masato Hayama, Kayo Wakamatsu, Yuko Teratani, Yuki Kunitomo, Chihaya Ito, Masayuki Shimizu, Hiromitsu Teratani, Yuta Sukehiro, Masato Furui, Mizuki Sumi, Mau Amako, Yoshio Hayashida, Go Kuwahara, Hideichi Wada","doi":"10.3400/avd.cr.24-00118","DOIUrl":"10.3400/avd.cr.24-00118","url":null,"abstract":"<p><p>We experienced a case in which a myxoma in the inferior vena cava (IVC) was surgically removed along with the IVC using deep hypothermic circulatory arrest. A 42-year-old female with no subjective symptoms was incidentally found to have a mass in the IVC at the junction of the hepatic veins on contrast-enhanced computed tomography. Ultrasonography revealed a mobile tumor attached to the junction of the hepatic veins. Surgery was performed via median sternotomy and laparotomy. Cardiopulmonary bypass and deep hypothermic circulatory arrest were utilized to safely operate.</p>","PeriodicalId":7995,"journal":{"name":"Annals of vascular diseases","volume":"18 1","pages":""},"PeriodicalIF":0.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11947006/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143727522","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Brachial-Ankle Pulse Wave Velocity Reflects Regional Arterial Stiffness and Distensibility in Patients with Abdominal Aortic Aneurysm. 肱-踝脉波速度反映腹主动脉瘤患者局部动脉僵硬性和扩张性。
IF 0.6
Annals of vascular diseases Pub Date : 2025-01-01 DOI: 10.3400/avd.oa.24-00097
Toshiya Nishibe, Shinobu Akiyama, Masaki Kano, Shoji Fukuda, Fumio Chiba, Jun Koizumi, Masayasu Nishibe
{"title":"Brachial-Ankle Pulse Wave Velocity Reflects Regional Arterial Stiffness and Distensibility in Patients with Abdominal Aortic Aneurysm.","authors":"Toshiya Nishibe, Shinobu Akiyama, Masaki Kano, Shoji Fukuda, Fumio Chiba, Jun Koizumi, Masayasu Nishibe","doi":"10.3400/avd.oa.24-00097","DOIUrl":"10.3400/avd.oa.24-00097","url":null,"abstract":"<p><p><b>Objectives:</b> We investigated the association between brachial-ankle pulse wave velocity (PWV) and arterial stiffness and distensibility in the aneurysmal sac of abdominal aortic aneurysm (AAA). <b>Methods:</b> Data from 49 patients with AAA from June 2020 to November 2022 at Tokyo Medical University Hospital were retrospectively analyzed. Brachial-ankle PWV (cm/s) was obtained via an automated oscillometric method. Regional arterial stiffness and distensibility parameters, such as stiffness parameter (β), pressure-strain elasticity modulus (Ep, kPa), one-point PWV (PWV β, m/s), and arterial compliance (AC, mm<sup>2</sup>/kPa<sup>-1</sup>), were assessed using 2-dimensional automated tissue tracking (2DTT) ultrasonography. Patients were divided into two groups: high PWV (≥1800) and low PWV (<1800). <b>Results:</b> Patients with high PWV showed significantly higher β and PWV β (30.6 ± 10.1 vs. 25.2 ± 6.3, p = 0.047; 11.6 ± 2.3 vs. 10.5 ± 1.5, p = 0.048) and significantly lower AC in the aneurysmal sac (10.6 ± 5.3 vs. 14.7 ± 8.1, p = 0.045) than those with low PWV. AC was negatively correlated with PWV (r = -0.361, p = 0.011). <b>Conclusions:</b> Brachial-ankle PWV can reflect arterial stiffness and distensibility, as measured by 2DTT ultrasonography, in the aneurysmal sac of AAA, suggesting its potential as an elasticity index for assessing regional arterial stiffness and distensibility in AAA.</p>","PeriodicalId":7995,"journal":{"name":"Annals of vascular diseases","volume":"18 1","pages":""},"PeriodicalIF":0.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11771152/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143057711","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Clinical Outcomes after Revascularization in Patients with Chronic Limb-Threatening Ischemia. 慢性肢体缺血患者血运重建术后的临床结果。
IF 0.6
Annals of vascular diseases Pub Date : 2025-01-01 Epub Date: 2025-01-20 DOI: 10.3400/avd.ra.24-00135
Akio Kodama
{"title":"Clinical Outcomes after Revascularization in Patients with Chronic Limb-Threatening Ischemia.","authors":"Akio Kodama","doi":"10.3400/avd.ra.24-00135","DOIUrl":"10.3400/avd.ra.24-00135","url":null,"abstract":"<p><p>Chronic limb-threatening ischemia (CLTI) occurs in the advanced stage of peripheral artery disease and is associated with high risks of mortality and amputation. Universal management strategies are not always applicable, owing to population diversity, and the Western trials may not be applicable to Japanese patients, owing to differences in demographics and clinical profiles. This paper examines the outcomes of revascularization in Japanese CLTI patients and emphasizes the benefits of tailored management. Post-hoc analysis of the bypass versus angioplasty in severe ischemia of the leg (BASIL)-1 trial validated the use of the Global Limb Anatomic Staging System for predicting the outcomes of endovascular therapy (EVT) but not bypass surgery (BS). The SPINACH (surgical reconstruction versus peripheral intervention in patients with critical limb ischemia) registry revealed comparable 3-year amputation-free survival rates between patients who underwent EVT and those who underwent BS, with patient-specific factors such as limb status and general health influencing its success. Revascularization improved the quality of life, but benefits declined over time, especially in non-ambulatory and older patients on dialysis. Surgical reconstruction is better for preserving ambulation. Retrospective studies revealed pedal branch artery bypass as a viable option, functional independence as a predictor of survival, and zinc supplementation as promising for wound healing. Future research should focus on refining these strategies and exploring innovative approaches to overcome persistent challenges in CLTI care.</p>","PeriodicalId":7995,"journal":{"name":"Annals of vascular diseases","volume":"18 1","pages":""},"PeriodicalIF":0.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11771150/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143057712","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Metagenomic Analysis of Gut Microbiota for Abdominal Aortic Aneurysm. 腹主动脉瘤患者肠道微生物群的宏基因组分析。
IF 0.6
Annals of vascular diseases Pub Date : 2025-01-01 Epub Date: 2025-01-07 DOI: 10.3400/avd.oa.24-00105
Eisaku Ito, Takao Ohki, Naoki Toya, Takuo Emoto, Tomoya Yamashita, Tomomi Sugiyama, Takuji Yamada, Hiroshi Mori, Atsushi Toyoda, Ken-Ichi Hirata
{"title":"Metagenomic Analysis of Gut Microbiota for Abdominal Aortic Aneurysm.","authors":"Eisaku Ito, Takao Ohki, Naoki Toya, Takuo Emoto, Tomoya Yamashita, Tomomi Sugiyama, Takuji Yamada, Hiroshi Mori, Atsushi Toyoda, Ken-Ichi Hirata","doi":"10.3400/avd.oa.24-00105","DOIUrl":"10.3400/avd.oa.24-00105","url":null,"abstract":"<p><p><b>Objectives:</b> The pathophysiological mechanism of abdominal aortic aneurysm (AAA) remains unclear. We previously reported that <i>Bifidobacterium adolescentis</i> levels were reduced in the feces of patients with AAA by 16S ribosomal ribonucleic acid (RNA) gene sequencing. In this study, we increased the number of cases and conducted metagenomic analyses to examine bacterial genes associated with the pathophysiology of AAA. <b>Methods:</b> For gut microbiota data, feces from 55 patients with AAA and 52 patients with no history of AAA, lower extremity artery disease, or coronary artery disease (control group) were collected. Metagenomic analysis was performed by collecting raw stool samples from patients. For intestinal microbiota analysis, metagenomic analysis of the fecal samples was performed. <b>Results:</b> Oral bacteria, including <i>Actinomyces oris</i> (<i>p</i> <0.0001), <i>Streptococcus salivarius</i> (<i>p</i> <0.001), <i>Lactobacillus salivarius</i> (<i>p</i> <0.001), and <i>Streptococcus</i> sp. (<i>p</i> <0.001), were increased in the feces of patients with AAA. In addition, bacterial genes related to alpha lipoic acid (ALA) biosynthesis (M00882, M00883, and M00884, <i>p</i> <0.0001) were decreased in patients with AAA. <b>Conclusions:</b> In the feces of patients with AAA, there was an increase in oral bacteria, and the expression of bacterial genes related to ALA biosynthesis was reduced. The results suggest the possibility of developing gut microbial drug treatments for AAA.</p>","PeriodicalId":7995,"journal":{"name":"Annals of vascular diseases","volume":"18 1","pages":""},"PeriodicalIF":0.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11771153/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143057715","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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