{"title":"Mechanical Evaluation of Stenting for Saccular Abdominal Aortic Aneurysm Using Fluid-Structure Interaction Analysis: A Study on Stent Size.","authors":"Masanori Murakami, Fei Jiang, Seigo Osakada, Tatsuo Yamashita, Xian Chen","doi":"10.3400/avd.oa.26-00034","DOIUrl":"10.3400/avd.oa.26-00034","url":null,"abstract":"<p><p>We previously analyzed a saccular abdominal aortic aneurysm model and elucidated that saccular abdominal aortic aneurysms manifest abnormal hemodynamic factors from an early stage and that stenting improves these factors. In this study, we analyzed a model of a saccular abdominal aortic aneurysm implanted with stents of different diameters and lengths to determine the optimal stent size for improving hemodynamic factors. The stent diameter was set in 3 patterns as follows: 24 mm, the same as the aortic diameter; 26.4 mm, a 10% increase; and 28.8 mm, a +20% increase. The stent length was extended 10 mm vertically from the 28-mm length of the aneurysmal portion to 50 and 70 mm in 2 patterns, for a total of 6 types. The analysis revealed that all hemodynamic factors improved for all sizes compared with those prior to stenting. Streamlines entering the aneurysm were reduced with larger stent diameters; however, no difference in length was observed. Moreover, no clear differences in the mean flow velocity within the aneurysm, maximum shear stress, or pressure loss coefficient between the models were observed. An implanted stent was sufficient in terms of efficacy if it adhered to the aortic wall and covered the saccular aneurysm area. (This is a secondary publication from J Jpn Coll Angiol 2024; 64: 69-78.).</p>","PeriodicalId":7995,"journal":{"name":"Annals of vascular diseases","volume":"19 1","pages":""},"PeriodicalIF":0.6,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13092364/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147727916","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Prediction of Functional Outcomes at Discharge Using Plasma Concentration of von Willebrand Factor Antigen at Admission in Hospitalized Patients with COVID-19.","authors":"Masayuki Oki, Daisuke Yamasawa, Shinichi Goto, Hidetaka Yanagi, Saki Manabe, Takako Kobayashi, Ayumi Tsuda, Shota Sato, Seiji Morita, Yoshihide Nakagawa, Tsuyoshi Oguma, Koichiro Asano, Norio Yamamoto, Hideki Ozawa, Shinya Goto","doi":"10.3400/avd.oa.25-00153","DOIUrl":"10.3400/avd.oa.25-00153","url":null,"abstract":"<p><strong>Objectives: </strong>Coronavirus disease 2019 (COVID-19) causes endothelial injury through inflammatory and hypoxic stress, leading to vascular dysfunction and immunothrombosis. The plasma level of von Willebrand factor (VWF) could serve as a biomarker of vascular injury. While elevated VWF predicts mortality in severe COVID-19, its relationship with post-discharge functional outcomes remains unclear. This study aimed to determine whether plasma VWF antigen (VWF:Ag) levels at admission predict functional status at discharge in patients hospitalized for COVID-19.</p><p><strong>Methods: </strong>This was a single-center prospective cohort study conducted at Tokai University Hospital from July to September 2021. We evaluated the relationship between plasma VWF:Ag levels at admission and a Clinical Frailty Scale (CFS) score ≥4 at discharge using univariable and multivariable logistic regression analyses.</p><p><strong>Results: </strong>A total of 97 patients were enrolled in the study. The median VWF:Ag level at admission was 330.0% (95% confidence interval [CI]: 273.0-391.8). Univariable analysis showed a significant association between elevated VWF:Ag levels and CFS score ≥4 at discharge. This association remained significant after adjusting for age and sex (odds ratio 1.010, 95% CI: 1.000-1.010, p = 0.005).</p><p><strong>Conclusion: </strong>Elevated VWF:Ag levels at admission predict poor functional outcomes at discharge in COVID-19 patients, independent of age and sex.</p>","PeriodicalId":7995,"journal":{"name":"Annals of vascular diseases","volume":"19 1","pages":""},"PeriodicalIF":0.6,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12885762/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146155872","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Comparative Analysis of Adhesive Strength and Flexibility in Surgical Sealants for Cardiovascular Surgery.","authors":"Akiyoshi Yamamoto, Shinichiro Shimura, Kenji Kuwaki, Hidekazu Furuya, Sohsyu Kotani, Kimiaki Okada, Keisuke Ozawa, Goro Kishinami, Shigeyuki Ozaki, Yasunori Cho","doi":"10.3400/avd.oa.25-00100","DOIUrl":"10.3400/avd.oa.25-00100","url":null,"abstract":"<p><strong>Objectives: </strong>The objective of this study was to compare the adhesive strength and flexibility of 3 surgical sealants-synthetic (Hydrofit; Sanyo Chemical Industries, Kyoto, Japan), albumin-based (BioGlue; Artivion, Kennesaw, GA, USA), and fibrin-based (Beriplast; CSL Behring, Tokyo, Japan)-which are commonly used in cardiovascular surgery but unexplored under identical experimental conditions.</p><p><strong>Methods: </strong>Adhesive strength was evaluated using a tensile adhesion test on collagen, polyester, and polytetrafluoroethylene substrates. Flexibility was assessed by measuring the maximum stress and elongation at failure in Hydrofit and BioGlue film samples. Beriplast was excluded as it failed to form films.</p><p><strong>Results: </strong>Hydrofit and BioGlue showed similar collagen-collagen adhesion strengths (p = 0.11), while Beriplast was significantly weaker (p <0.01). Hydrofit outperformed both BioGlue and Beriplast (p <0.01) in collagen-polyester and collagen-expanded polytetrafluoroethylene (ePTFE) adhesions. Hydrofit also demonstrated a significantly higher elongation rate, strength, and maximum stress before rupture than BioGlue.</p><p><strong>Conclusions: </strong>These surgical sealants possess distinct adhesive and mechanical characteristics. Hydrofit showed stable adhesion across various substrates, with notable flexibility. BioGlue displayed adequate adhesion on collagen surfaces but had restricted flexibility. Beriplast demonstrated reduced adhesion. Although only adhesive strength and flexibility were evaluated, such properties may offer valuable insights into sealant traits contextually. These potentially aid in the selection of appropriate sealants for cardiovascular procedures that require both durable adhesion and tissue compliance. Further <i>in vivo</i> validation is warranted.</p>","PeriodicalId":7995,"journal":{"name":"Annals of vascular diseases","volume":"19 1","pages":""},"PeriodicalIF":0.6,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12795642/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145965008","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Complete Modular Disconnection between AFX2 and VELA Leading to a Type IIIa Endoleak Two Years after Endovascular Aneurysm Repair.","authors":"Kotaro Mukasa, Yasunori Yakita, Ryosuke Marushima, Musashi Tsuda, Shinichiro Abe, Soichi Asano","doi":"10.3400/avd.cr.25-00129","DOIUrl":"https://doi.org/10.3400/avd.cr.25-00129","url":null,"abstract":"<p><p>The AFX endograft (Endologix, Irvine, CA, USA) is known to have a high incidence of late type III endoleaks. We report a 76-year-old male who developed a type IIIa endoleak due to complete modular separation 2 years after endovascular aneurysm repair with an AFX2 main body and a VELA extension. Open surgical graft replacement was performed, and the postoperative course was uneventful. This case demonstrates that in the presence of a large aneurysm diameter or significant neck angulation, even Instructions for Use-compliant and recommended overlap may be insufficient. It suggests the necessity of securing greater overlap and implementing stricter follow-up.</p>","PeriodicalId":7995,"journal":{"name":"Annals of vascular diseases","volume":"19 1","pages":""},"PeriodicalIF":0.6,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13038377/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147589462","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Preoperative Mural Thrombus Volume Ratio Predicts Aneurysm Enlargement in Type 2 Endoleak after Endovascular Aortic Repair.","authors":"Yuki Oga, Tomoaki Kudo, Yasuka Nakanishi, Mitsuru Yuzaki, Tomohiko Sakamoto, Yusuke Ki, Toru Kuratani","doi":"10.3400/avd.oa.26-00001","DOIUrl":"https://doi.org/10.3400/avd.oa.26-00001","url":null,"abstract":"<p><strong>Objectives: </strong>This study aimed to identify anatomical predictors of aneurysm enlargement in patients with lumbar artery (LA)-related type 2 endoleak (T2EL) after endovascular aortic repair (EVAR).</p><p><strong>Methods: </strong>This retrospective observational cohort study included 59 patients with infrarenal abdominal aortic aneurysms who developed T2EL caused exclusively by LAs after EVAR between January 2019 and July 2024. Computed tomography-based anatomical parameters, including mural thrombus volume ratio, calcified volume ratio, aneurysm diameter, and LA anatomy, were analyzed.</p><p><strong>Results: </strong>During a median follow-up of 33 months, aneurysm enlargement occurred in 9 patients (15.3%). Patients with aneurysm enlargement had a significantly lower mural thrombus volume ratio (<i>p</i> <0.001). Female sex (hazard ratio [HR], 0.23; 95% confidence interval [CI], 0.06-0.84; <i>p</i> = 0.026) and mural thrombus volume ratio (HR, 0.88 per 1% increase; 95% CI, 0.80-0.96; <i>p</i> = 0.003) were significantly associated with aneurysm enlargement, whereas LA anatomy was not. Receiver operating characteristic analysis identified an optimal cutoff value of 29.2% (area under the curve, 0.82).</p><p><strong>Conclusions: </strong>A low preoperative mural thrombus volume ratio was associated with aneurysm enlargement in patients with LA-related T2EL after EVAR. This parameter may serve as a practical imaging biomarker to support selective consideration of preemptive embolization.</p>","PeriodicalId":7995,"journal":{"name":"Annals of vascular diseases","volume":"19 1","pages":""},"PeriodicalIF":0.6,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13051297/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147632219","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Yoshihiko Onishi, Akihiro Sasahara, Saya Ishikawa, Kenjiro Sakaki, Ko Shibata, Masaki Nie, Kuniyoshi Ohara
{"title":"Distal Radial Artery Aneurysm of the Dorsal Branch with Ulnar Artery Occlusion: A Case Report.","authors":"Yoshihiko Onishi, Akihiro Sasahara, Saya Ishikawa, Kenjiro Sakaki, Ko Shibata, Masaki Nie, Kuniyoshi Ohara","doi":"10.3400/avd.cr.25-00064","DOIUrl":"10.3400/avd.cr.25-00064","url":null,"abstract":"<p><p>We report a rare case of a radial artery aneurysm associated with ulnar artery occlusion in an 80-year-old female. Preoperative imaging showed poor visualization of the palmar arch and absent ulnar flow, prompting aneurysmectomy and radial artery reconstruction using a vein graft. Intraoperative findings revealed good retrograde flow, suggesting preserved distal perfusion. This case highlights the importance of accurate preoperative assessment of hand arterial anatomy, particularly the palmar arch, in determining the need for revascularization in radial artery aneurysms with compromised collateral circulation.</p>","PeriodicalId":7995,"journal":{"name":"Annals of vascular diseases","volume":"19 1","pages":""},"PeriodicalIF":0.6,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12950523/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147347218","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Thoracic Aortic Aneurysm Following Blunt Trauma in a Patient with a Monoallelic <i>SLC2A10</i> Variant: A Case Report.","authors":"Satoshi Uesugi, Naoyuki Kimura, Shogo Saito, Mamoru Arakawa, Arata Muraoka, Yasushi Imai, Koji Kawahito","doi":"10.3400/avd.cr.25-00135","DOIUrl":"https://doi.org/10.3400/avd.cr.25-00135","url":null,"abstract":"<p><p>A female in her early 40s with no skeletal abnormalities was incidentally found to have a 45-mm saccular aneurysm at the aortic isthmus during evaluation for pharyngitis. She had sustained blunt trauma 20 years earlier, resulting in multiple fractures and pneumothorax. Her family history included premature vascular or sudden death and scoliosis. Imaging showed no arterial tortuosity. She underwent successful open surgical repair. Histologic examination revealed disorganized elastic fibers with irregular thickening and partial loss of lamellar architecture. Postoperative genetic testing identified a heterozygous missense variant in <i>SLC2A10</i>, suggesting a possible association between monoallelic variants and vascular fragility.</p>","PeriodicalId":7995,"journal":{"name":"Annals of vascular diseases","volume":"19 1","pages":""},"PeriodicalIF":0.6,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12956473/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147363648","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Extended Endarterectomy Across the Inguinal Ligament Using Inguinal-Lifting in the Surgery for Critical Limb Ischemia.","authors":"Anna Tsuji, Shun-Ichiro Sakamoto, Motohiro Maeda, Tomohiro Murata, Atsushi Hiromoto, Kenji Suzuki, Yoshiyuki Watanabe, Yosuke Ishii","doi":"10.3400/avd.cr.25-00122","DOIUrl":"10.3400/avd.cr.25-00122","url":null,"abstract":"<p><p>This case report presents a case of lower extremity peripheral arterial disease (PAD) with severe calcified lesions extending from the external iliac artery to the bifurcation of the superficial femoral artery, involving the groin region. Owing to the complexity and risk of complications, such as infections and delayed wound healing, revascularization was performed with extensive endarterectomy. The inguinal-lifting technique (ILT) was used to provide safe surgical access and minimize complications. The procedure resulted in successful revascularization with no major wound-related issues. The ILT proved to be an effective approach for safe, extensive endarterectomy in complex PAD cases.</p>","PeriodicalId":7995,"journal":{"name":"Annals of vascular diseases","volume":"19 1","pages":""},"PeriodicalIF":0.6,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12826795/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146050016","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Cost Analysis of Abdominal Aortic Aneurysm Repair: The Economic Impact of Rising Surgical Material Costs on Public Health Insurance.","authors":"Etsuji Umeda, Kiyoshi Doi, Osamu Sakai, Takayoshi Kato, Hiroki Ogura, Masayuki Sato","doi":"10.3400/avd.oa.25-00109","DOIUrl":"10.3400/avd.oa.25-00109","url":null,"abstract":"<p><strong>Objectives: </strong>We conducted a detailed comparison of inpatient medical costs between endovascular aneurysm repair (EVAR) and open aneurysm repair (OAR) for abdominal aortic aneurysms.</p><p><strong>Methods: </strong>We evaluated 312 EVAR and 205 OAR cases performed at our institution between January 2007 and December 2017. Patient background characteristics were adjusted between the EVAR and OAR groups using propensity score matching (PSM). Surgical outcomes and inpatient medical costs were compared.</p><p><strong>Results: </strong>After PSM, 161 cases were included in each group for comparison. Operative time, blood loss, intensive care unit (ICU) stay, and hospital stay were significantly lower in the EVAR group than in the OAR group. Total inpatient medical costs were significantly higher in the EVAR group (3111× 10<sup>3</sup> vs. 2156 × 10<sup>3</sup> JPY [Japanese yen], p <0.01). The surgical material costs in the EVAR group were significantly higher than those in the OAR group, accounting for 58% of total medical expenses. Other costs (diagnosis procedure combination, ICU management, surgical procedure, transfusion, intraoperative injection, and room) were all lower in the EVAR group than in the OAR group.</p><p><strong>Conclusions: </strong>The cost-saving effects of EVAR, such as reduced transfusion costs and ICU stay fees, were offset by the significantly higher cost of surgical materials.</p>","PeriodicalId":7995,"journal":{"name":"Annals of vascular diseases","volume":"19 1","pages":""},"PeriodicalIF":0.6,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12895106/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146199861","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Long-Term Outcome of Spontaneous Isolated Dissection of the Superior Mesenteric Artery.","authors":"Zaiqiang Yu, Norihiro Kondo, Yoshiaki Saito, Kazuyuki Daitoku, Ikuo Fukuda, Masahito Minakawa","doi":"10.3400/avd.oa.25-00081","DOIUrl":"https://doi.org/10.3400/avd.oa.25-00081","url":null,"abstract":"<p><strong>Objectives: </strong>We aimed to elucidate the long-term outcomes of acute symptomatic spontaneous isolated dissection of the superior mesenteric artery (SIDSMA) to inform optimal decision-making during the acute phase.</p><p><strong>Methods: </strong>We retrospectively collected and analyzed data from 14 consecutive patients diagnosed with SIDSMA by using computed tomography angiography (CTA) between January 2010 and August 2024.</p><p><strong>Results: </strong>The cohort comprised 13 males and 1 female, with a mean age of 59.36 ± 14.90 years. All patients presented with acute abdominal pain, and some experienced vomiting. Thirteen patients received conservative treatment, while only 1 patient underwent open surgery with extra-anatomical bypass; this patient required no further intervention 10 years postoperatively. One of the patients, whose abdominal pain worsened with food intake, showed SMA stenosis and decreased intestinal blood flow. His symptoms improved after heparin anticoagulation therapy followed by direct oral anticoagulant therapy. Over a follow-up period of 7.20 ± 3.21 years, none of the patients experienced recurrent SIDSMA-related abdominal pain, and all survived without the need for additional invasive treatment.</p><p><strong>Conclusions: </strong>Conservative treatment effectively manages SIDSMA over the long term without reintervention. Early diagnosis and management of intestinal ischemia are essential for optimal treatment outcomes.</p>","PeriodicalId":7995,"journal":{"name":"Annals of vascular diseases","volume":"19 1","pages":""},"PeriodicalIF":0.6,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12921437/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147269602","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}