APL Materials最新文献_第2页

Lateral size effect in Ti3C2Tx MXene as electromagnetic wave absorber Ti3C2Tx MXene作为电磁波吸收剂的横向尺寸效应

2区材料科学

APL Materials Pub Date : 2025-07-01 DOI: 10.1063/5.0282658

Danyao Qu, Fushan Li, Zhenkun Long, Zheng Wang, Lujie Zhang, Yuelong Pan, Xiangwen Xu, Zidong Zhang, Weiwei Wu, Siwu Li

{"title":"Lateral size effect in Ti3C2Tx MXene as electromagnetic wave absorber","authors":"Danyao Qu, Fushan Li, Zhenkun Long, Zheng Wang, Lujie Zhang, Yuelong Pan, Xiangwen Xu, Zidong Zhang, Weiwei Wu, Siwu Li","doi":"10.1063/5.0282658","DOIUrl":"https://doi.org/10.1063/5.0282658","url":null,"abstract":"Electromagnetic wave (EMW) absorption is essential for protection against multi-frequency electromagnetic pollution and interference. Ideal EMW absorbing materials should be thin, lightweight, durable, and capable of operating across a broad frequency range through multiple absorption mechanisms. Ti3C2Tx MXene (TM), a 2D nanomaterial, has emerged as a promising EMW-absorbing candidate. However, the influence of lateral size on EMW absorption performance remains insufficiently explored. In this study, TM with controllable lateral dimensions was mass-produced using an organic solvent-assisted intercalation and collection (OAIC) method, enabling a systematic investigation of lateral size effect on EMW absorption. TM with a large lateral area (4.678 μm2) exhibited the highest absorption capacity, achieving an effective absorption bandwidth (EAB) of 6.3 GHz and a reflection loss (RL) of −24.08 dB at a low filler loading of only 5%. Electromagnetic simulations further confirmed that this optimized sample can efficiently attenuate radar signals. The EMW absorption mechanisms influenced by lateral size, such as dipole polarization, interface polarization, and conduction loss, are systematically analyzed, offering valuable insights into the size-dependent behavior of MXene-based EMW absorbers.","PeriodicalId":7985,"journal":{"name":"APL Materials","volume":"13 7","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147332499","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Achieving 0.05 Ω-mm contact resistance in non-alloyed Ti/Au ohmics to β-Ga₂O₃ by removing surface carbon. 通过去除表面碳，获得非合金Ti/Au欧米对β-Ga2O3的0.05 Ω-mm接触电阻。

IF 5.3 2区材料科学

APL Materials Pub Date : 2025-06-01 DOI: 10.1063/5.0276786

Naomi Pieczulewski, Kathleen T Smith, Corey M Efaw, Arjan Singh, Cameron A Gorsak, Joshua T Buontempo, Jesse Wensel, Kathy Azizie, Katie Gann, Michael O Thompson, Darrell G Schlom, Farhan Rana, Hari P Nair, Steven M Hues, Elton Graugnard, Paul H Davis, Debdeep Jena, Huili Grace Xing, David A Muller

{"title":"Achieving 0.05 Ω-mm contact resistance in non-alloyed Ti/Au ohmics to β-Ga2O3 by removing surface carbon.","authors":"Naomi Pieczulewski, Kathleen T Smith, Corey M Efaw, Arjan Singh, Cameron A Gorsak, Joshua T Buontempo, Jesse Wensel, Kathy Azizie, Katie Gann, Michael O Thompson, Darrell G Schlom, Farhan Rana, Hari P Nair, Steven M Hues, Elton Graugnard, Paul H Davis, Debdeep Jena, Huili Grace Xing, David A Muller","doi":"10.1063/5.0276786","DOIUrl":"10.1063/5.0276786","url":null,"abstract":"Preserving a contamination-free metal-semiconductor interface in β-Ga2O3 is critical to achieve consistently low resistance ( <math><mo><</mo></math> 1 Ω-mm) ohmic contacts. Here, we report a scanning transmission electron microscopy study on the variation in Ti/Au ohmic contact quality to (010) β-Ga2O3 in a conventional lift-off vs a metal-first process. We observe a thin ∼1 nm carbon barrier between the Ti and Ga2O3 in a non-conductive contact fabricated by a conventional lift-off process, which we attribute to photoresist residue, not previously detected by x-ray photoelectron spectroscopy due to the thinness and patchy coverage of the carbon layer, as well as roughness of the Ga2O3 surface. This thin carbon barrier is confirmed by electron energy loss spectroscopy and atomic force microscopy-infrared spectroscopy. We believe that the presence of the thin and patchy carbon layer leads to the highly inconsistent contact behavior in previous reports on non-alloyed contacts. Adventitious carbon is also observed in a conductive ohmic contact metal-first processing on an as-grown sample. We find that a five minute active oxygen descum is sufficient to remove this carbon on as-grown samples, further improving the ohmic behavior and reducing the contact resistance Rc to 0.06 Ω-mm. We also show that an hour long UV-ozone treatment of the Ga2O3 surface can eliminate carbon residue from the lift-off processing, resulting in a low Rc of 0.05 Ω-mm.","PeriodicalId":7985,"journal":{"name":"APL Materials","volume":"13 6","pages":"061122"},"PeriodicalIF":5.3,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12183788/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144482909","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Electro–optic coupling modulation on persistent photoconductivity and memristive states in thin-film devices with MoOx/ZnO heterostructured electrodes MoOx/ZnO异质结构电极薄膜器件中持续光导和忆阻态的电光耦合调制

2区材料科学

APL Materials Pub Date : 2025-06-01 DOI: 10.1063/5.0262605

Fushun Li, Xuanhe Li, J. Su, Zhenxin Yang, Haikun Zhu, Jinquan Huang, Dengke Wang, Zheng‐Hong Lu, Qiang Zhu

{"title":"Electro–optic coupling modulation on persistent photoconductivity and memristive states in thin-film devices with MoOx/ZnO heterostructured electrodes","authors":"Fushun Li, Xuanhe Li, J. Su, Zhenxin Yang, Haikun Zhu, Jinquan Huang, Dengke Wang, Zheng‐Hong Lu, Qiang Zhu","doi":"10.1063/5.0262605","DOIUrl":"https://doi.org/10.1063/5.0262605","url":null,"abstract":"Persistent photoconductivity (PPC)-based devices that utilize light regulation for non-volatile memristors not only enable biological neural functions and integrate memory and computing capabilities, thereby eliminating energy consumption for signal conversion, but also mitigate Joule heating through optical control, thus promising higher energy efficiency. However, the PPC-based devices are limited to write-only operations because the photoconductivity state cannot be erased by physical means, such as applied bias voltage. In this study, we introduced a concise thin-film device with an asymmetric MoOx/ZnO heterojunction electrode structure (HES) fabricated using an economical solution process. The PPC and memristive states of the HES device can be activated via photoexcitation to a high-conductivity state and subsequently erased or reactivated by modulating the applied voltage for read/write and erasure operations. This functionality enables potential applications in flash memory with switchable memory states, thereby addressing the limitations of PPC-based devices in write-only memory. The memristive mechanism in the HES device was investigated with respect to the charge reconfiguration at the asymmetric MoOx/ZnO type-II heterointerfaces. In practical applications, the programmatically electro-optic manipulation of the HES device for read/write and erasure operations, as well as its advancement in artificial neuron image processing, were demonstrated. The modulated PPC and memristive states observed from the HES device present a new pathway for future fabrication of next-generation information storage and non-volatile logic devices.","PeriodicalId":7985,"journal":{"name":"APL Materials","volume":"13 6","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147911870","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Multivariate MOF nanozyme utilizes glucose-activated self-cascade strategy for enhanced antibacterial efficacy and accelerated diabetic wounds healing 多变量MOF纳米酶利用葡萄糖激活的自级联策略增强抗菌效果并加速糖尿病伤口愈合

2区材料科学

APL Materials Pub Date : 2025-05-01 DOI: 10.1063/5.0267620

Yuxin Huang, Ding‐Shinn Chen, Tak Man Wong, Baolin Li, Yongxin Shi

{"title":"Multivariate MOF nanozyme utilizes glucose-activated self-cascade strategy for enhanced antibacterial efficacy and accelerated diabetic wounds healing","authors":"Yuxin Huang, Ding‐Shinn Chen, Tak Man Wong, Baolin Li, Yongxin Shi","doi":"10.1063/5.0267620","DOIUrl":"https://doi.org/10.1063/5.0267620","url":null,"abstract":"The impaired immune function observed in diabetic patients significantly increases their susceptibility of diabetic wounds to bacterial infections. Conventional treatment for bacterial infections relies heavily on antibiotics; however, this approach is often accompanied by the development of bacterial resistance. In this study, a nanozyme (Q@CuMn@G) exhibiting exceptional antibacterial efficacy with the capability to circumvent drug resistance was ingeniously designed. It operates through the generation of hydroxyl radicals (•OH) via a self-cascade reaction. The glucose oxidase (GOx) encapsulated within the Cu-metal–organic framework (MOF) generates H2O2 by degrading glucose present in the wound environment, which is subsequently catalyzed by the Cu-MOF to produce •OH, thereby exerting potent antibacterial effects. Meanwhile, MnO2 loaded within Cu-MOF generates O2, ameliorating the hypoxic environment of the wound and further supporting the degradation of glucose by GOx. Quaternized chitosan is employed as a shell to envelop the nanozyme, thus preventing the rapid degradation of GOx. In vitro experiments demonstrated that Q@CuMn@G exhibits sustained release of •OH and significant bactericidal effects against Escherichia coli and Staphylococcus aureus, confirming the high antibacterial activity of the nanozyme. Moreover, in vivo experiments revealed that Q@CuMn@G effectively kills bacteria in infected diabetic wounds, modulates the immune microenvironment, and accelerates wound healing, achieving a healing ratio of 96.78%. This study employs the Q@CuMn@G nanozyme to achieve highly effective antibacterial efficacy through chemodynamic therapy, thereby offering an innovative strategy for antibiotic-free treatment of diabetic wound repair.","PeriodicalId":7985,"journal":{"name":"APL Materials","volume":"13 5","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147331408","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Integrating ZnS microspheres with Bi2Se3 sponge ball structures to realize high energy density with good stability for supercapacitors 将ZnS微球与Bi2Se3海绵球结构集成，实现高能量密度、稳定性好的超级电容器

2区材料科学

APL Materials Pub Date : 2025-05-01 DOI: 10.1063/5.0265964

Syed Awais Ahmad, Muhammad Arif, Iftikhar Hussain, Yingkai Liu, Weibin Zhang, Ting Zhu

{"title":"Integrating ZnS microspheres with Bi2Se3 sponge ball structures to realize high energy density with good stability for supercapacitors","authors":"Syed Awais Ahmad, Muhammad Arif, Iftikhar Hussain, Yingkai Liu, Weibin Zhang, Ting Zhu","doi":"10.1063/5.0265964","DOIUrl":"https://doi.org/10.1063/5.0265964","url":null,"abstract":"The growing demand for renewable energy has ignited an interest in novel materials to improve the efficiency of energy storage. This study introduces a straightforward hydrothermal technique to synthesize the pristine ZnS, Bi2Se3, and their composite ZnS–Bi2Se3, which is intended as a high-performance electrode material for supercapacitors. We evaluate the as-synthesized materials for their structural, morphological, and electrochemical properties for a better understanding of the charge storage mechanisms. The ZnS–Bi2Se3 composite exhibits high electrochemical activity and chemical stability, owing to a high specific capacitance of 745 F g−1 at 1 A g−1. Furthermore, an asymmetric supercapacitor with the ZnS–Bi2Se3||activated carbon configuration delivers a remarkable energy density of 56.66 Wh kg−1 and a power density of 4990.90 W kg−1. Density functional theory calculations further elucidate these results, showing optimized work function, total density of states, and atomic structure, which enhance the composite’s electronic conductivity and charge transfer capabilities. Based on these findings, metal sulfide–selenide composites may be economically feasible choices for the high-performance electrochemical storage of energy.","PeriodicalId":7985,"journal":{"name":"APL Materials","volume":"13 5","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147922839","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

Screening anti-inflammatory and neuroprotective effects of nanozyme with human cortical organoid-on-a-chip 纳米酶对人体皮质类器官芯片的抗炎和神经保护作用的筛选

2区材料科学

APL Materials Pub Date : 2025-05-01 DOI: 10.1063/5.0272502

Guojian Wu, Hong Wang, Lukui Chen

{"title":"Screening anti-inflammatory and neuroprotective effects of nanozyme with human cortical organoid-on-a-chip","authors":"Guojian Wu, Hong Wang, Lukui Chen","doi":"10.1063/5.0272502","DOIUrl":"https://doi.org/10.1063/5.0272502","url":null,"abstract":"Neuroinflammation plays a vital role in neural development as well as the pathogenesis and progression of neurodegenerative diseases. It is recognized as a promising therapeutic target for neurological disorders. Although multiple anti-inflammatory drugs have been examined for their therapeutic potential in neurodegenerative diseases, the development of new model systems to evaluate the safety and efficiency of anti-inflammatory agents is still greatly needed. Here, we presented a human cortical organoid-on-a-chip for modeling neuroinflammation and exploring the neuroprotective activity of cerium oxide (CeO2) nanozyme, a novel antioxidant, on neuroinflammation-induced neurotoxicity. hiPSC-derived cortical organoids, resembling the key characteristics of early human brain development, were generated on micropillar arrays. We showed that lipopolysaccharide (LPS) treatment induced inflammatory responses and neurological impairments in cortical organoids. Notably, the adverse responses caused by LPS administration could be effectively attenuated by treatment with nanozyme at a proper concentration, indicating that the CeO2 nanozyme exerts anti-neuroinflammatory and neuroprotective effects and could serve as a potential candidate to alleviate neuroinflammation-associated diseases. Together, the human cortical organoid-on-a-chip model presents a biomimetic system to investigate the complicated impacts of neuroinflammation on neural development and exhibits high potential in neurological study and drug evaluation.","PeriodicalId":7985,"journal":{"name":"APL Materials","volume":"13 5","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147884615","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Photonic crystal band edge coupled enhanced fluorescence from magneto-plasmonic cryosoret nano-assemblies for ultra-sensitive detection. 光子晶体带边耦合增强荧光从磁等离子体低温冷冻纳米组件超灵敏检测。

IF 4.5 2区材料科学

APL Materials Pub Date : 2025-04-01 DOI: 10.1063/5.0251312

Seemesh Bhaskar, Leyang Liu, Weinan Liu, Joseph Tibbs, Lucas D Akin, Amanda Bacon, Brian T Cunningham

{"title":"Photonic crystal band edge coupled enhanced fluorescence from magneto-plasmonic cryosoret nano-assemblies for ultra-sensitive detection.","authors":"Seemesh Bhaskar, Leyang Liu, Weinan Liu, Joseph Tibbs, Lucas D Akin, Amanda Bacon, Brian T Cunningham","doi":"10.1063/5.0251312","DOIUrl":"10.1063/5.0251312","url":null,"abstract":"The fluorescence intensity associated with photon-emitters used as tags for the detection of molecular biomarkers for disease can be augmented by interfacing them with photonic crystal (PC) substrates. Although plasmonic nanomaterials are hybridized in such systems to facilitate better performance, the Ohmic losses associated with them still remain as a major bottleneck that limits the magnitude of achievable fluorescence enhancements. In this work, we present the design and synthesis of robust magneto-plasmonic, dielectric-metal, Fe3O4-Au cryosoret nano-assemblies for not only dequenching the quenched fluorescence signal but also for yielding directional steering emission output. The PC facilitates effective coupling of fluorescence emission to the PC band edge resonance and guided mode resonance by harnessing the transverse electric and transverse magnetic modes simultaneously. The resonance of the underlying PC is tailored to match the localized surface plasmon resonance of the magneto-plasmonic cryosorets (MCSs) and the emission of the radiating dipoles. The 450-fold PC band edge coupled enhancement achieved using the hottest hotspots from the MCSs in a cost-effective platform demonstrated ultra-sensitive (10 aM) sensing of a common chemical fluorophore used as a tag in biomolecular assays.","PeriodicalId":7985,"journal":{"name":"APL Materials","volume":"13 4","pages":""},"PeriodicalIF":4.5,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13193251/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148013218","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Itaconate-loaded metal–organic framework (MOF) nanomedicine for the sustained treatment of intervertebral disk degeneration 钛酸盐负载金属有机框架（MOF）纳米药物用于椎间盘退变的持续治疗

2区材料科学

APL Materials Pub Date : 2025-04-01 DOI: 10.1063/5.0267538

Haixin Song, Jianhua Li, Qibin Zhang, Bingjie Zheng, Changsheng Li, Yiran Wang, Jian Chen, Junhui Liu, Tom Wu, Xiaotian Yang, Xueqian Kong, Fengdong Zhao

{"title":"Itaconate-loaded metal–organic framework (MOF) nanomedicine for the sustained treatment of intervertebral disk degeneration","authors":"Haixin Song, Jianhua Li, Qibin Zhang, Bingjie Zheng, Changsheng Li, Yiran Wang, Jian Chen, Junhui Liu, Tom Wu, Xiaotian Yang, Xueqian Kong, Fengdong Zhao","doi":"10.1063/5.0267538","DOIUrl":"https://doi.org/10.1063/5.0267538","url":null,"abstract":"Intervertebral disk degeneration (IVDD) is a major cause of spinal pathology and pain and can lead to disability in adults in severe cases. The medication against disk degeneration is limited due to the lack of therapeutic drugs and ineffective delivery of molecular drugs to target microenvironment. Itaconate is a tricarboxylic acid cycle secondary metabolite with inflammatory and oxidative stress modulating functions, which could alleviate disk degeneration. However, the lack of in vivo stability limits the potential application of itaconate against disk degeneration. In this study, we prepared metal–organic framework (MOF) nanocarrier drug loaded with itaconate that can respond to the acidic environment during disk degeneration. The results showed that the acidic microenvironment could induce sustained drug release from MOF@itaconate. In vitro cellular evaluation showed that MOF@itaconate has good cytocompatibility and significantly attenuates the inflammatory injury of nucleus pulposus cells. The nanocarrier activates the nuclear factor erythroid 2-related factor 2 (Nrf 2) anti-oxidative pathway and promotes the expression of nucleus pulposus extracellular matrix components. For the treatment of intervertebral disk degeneration on animal models, the MOF@itaconate nanocarrier was further coated with hyaluronic acid (HA) to boost the therapeutic effect. The administration of MOF@itaconate@HA in a rat disk degeneration model effectively delayed the degenerative process, suggesting that this technology may provide an effective controlled-release strategy for the treatment of IVDD.","PeriodicalId":7985,"journal":{"name":"APL Materials","volume":"13 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147330609","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Polysaccharide-based aerogel dressing integrated with MOF-loaded quercetin with multifunctional effects for promoting infected wound healing 以多糖为基础的气凝胶敷料与负载mof的槲皮素结合，具有促进感染伤口愈合的多功能作用

2区材料科学

APL Materials Pub Date : 2025-04-01 DOI: 10.1063/5.0258842

Xiaomin Wu, Qisong Liu, Alena Rasiuk, Shkuryn Siarhei Vladimirovich, Yu Pan, Bilan Lin, Ying Liu, Wenqiang Li, Guanghao Li, Wensong Li, Cuiping Zhang, Xiaohua Pan

{"title":"Polysaccharide-based aerogel dressing integrated with MOF-loaded quercetin with multifunctional effects for promoting infected wound healing","authors":"Xiaomin Wu, Qisong Liu, Alena Rasiuk, Shkuryn Siarhei Vladimirovich, Yu Pan, Bilan Lin, Ying Liu, Wenqiang Li, Guanghao Li, Wensong Li, Cuiping Zhang, Xiaohua Pan","doi":"10.1063/5.0258842","DOIUrl":"https://doi.org/10.1063/5.0258842","url":null,"abstract":"Infectious wounds disrupt the progression through the stages of wound healing, resulting in the development of chronic wounds. However, the current therapeutic approach is limited and requires repeated administrations. A major challenge in infectious wounds is to achieve sustained drug release. Herein, quercetin with anti-inflammatory and antibacterial properties was encapsulated within amino-functionalized UIO-66 metal-organic framework (MOF) to form MOF@Que NPs. MOF@Que NPs were then loaded into an aerogel constructed with agarose, aldehyde hyaluronic acid, and carboxymethyl chitosan to obtain ACA-MOF@Que for targeting different phases of wound healing. The polysaccharide-based aerogel was formed by the entanglement of polymer chains and the Schiff base reaction, which exhibited uniform pore structures and low-swelling properties. Furthermore, the ACA-MOF@Que aerogel also exhibited antioxidant, anti-inflammatory, and antibacterial properties. In vivo and in vitro experiments confirmed that the ACA-MOF@Que aerogel could promote hemostasis in the initial stage of wound healing, reduce cellular inflammatory infiltration, and inhibit the inflammatory response by regulating macrophage polarization during the inflammatory stage of wound healing. Finally, the ACA-MOF@Que aerogel could promote angiogenesis and increase collagen deposition in the later stage of wound healing. Compared with the untreated group, the wounds of rats treated with the ACA-MOF@Que aerogel had almost completely healed on the 14th day. Therefore, the ACA-MOF@Que aerogel plays multiple roles at various stages of wound healing, providing a promising therapeutic approach for the clinical application of chronic wounds.","PeriodicalId":7985,"journal":{"name":"APL Materials","volume":"13 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147331423","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Effect of microcellulose modification methods on the properties of polypropylene composites 微纤维素改性方法对聚丙烯复合材料性能的影响

2区材料科学

APL Materials Pub Date : 2025-04-01 DOI: 10.1063/5.0270360

Quan Yuan, Guimei Zhang, Chunxuan Li, Liping He, Shiwei Xu

{"title":"Effect of microcellulose modification methods on the properties of polypropylene composites","authors":"Quan Yuan, Guimei Zhang, Chunxuan Li, Liping He, Shiwei Xu","doi":"10.1063/5.0270360","DOIUrl":"https://doi.org/10.1063/5.0270360","url":null,"abstract":"Bio-based microcellulose/polymer composites are widely used in automotive interiors for their lightweight, environmentally friendly, and recyclable advantages, but their applications are limited due to the difficulty of dispersion in the matrix and their flammability. In this paper, we proposed the integrated functional modification of microcellulose with compatibility and flame retardancy, and then modified polypropylene composites with high strength, high thermal stability, and high flame retardancy were successfully prepared by extrusion–injection molding. Fourier infrared spectroscopy and x-ray diffraction analyses showed that the doping of Si/P/N synergistically modified microcellulose triggered a heterogeneous nucleation effect. Tests based on thermo-gravimetric analysis and differential scanning calorimetry showed that the polypropylene/synergistic modification of microcellulose by amino-silicone oil-phosphoric acid-melamine (PP/APMMCF) composites had the highest thermal stability and crystallinity; the compatibility between the modified microcellulose and PP matrix was improved as observed by scanning electron microscopy. Cone calorimeter and oxygen index meter analyses showed that PP/APMMCF could reduce the fire hazard.","PeriodicalId":7985,"journal":{"name":"APL Materials","volume":"13 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147906038","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3