APL Materials最新文献

3D-printed oxygen-releasing scaffolds promote bone repair via angiogenesis and osteogenesis 3d打印释氧支架通过血管生成和成骨促进骨修复

2区材料科学

APL Materials Pub Date : 2025-12-01 DOI: 10.1063/5.0305073

Hao Wu, Xiqiang Zhong, Pengyuan Leng, Chuchu Sun, Bingju Xie, Liangle Liu, Chun-Yuan Cai

{"title":"3D-printed oxygen-releasing scaffolds promote bone repair via angiogenesis and osteogenesis","authors":"Hao Wu, Xiqiang Zhong, Pengyuan Leng, Chuchu Sun, Bingju Xie, Liangle Liu, Chun-Yuan Cai","doi":"10.1063/5.0305073","DOIUrl":"https://doi.org/10.1063/5.0305073","url":null,"abstract":"The treatment of large bone defects is rendered challenging owing to ischemia, hypoxia, and insufficient osteogenesis in the defect sites. Consequently, the use of oxygen-releasing osteogenic materials has been studied extensively in recent years. This study aimed to construct and test a 3D-printed composite scaffold with both angiogenic and bone-repair functions. A “sandwich”-like structure containing polycaprolactone, hydroxyapatite, and calcium peroxide was fabricated using fused deposition modeling 3D printing technology. The polycaprolactone/hydroxyapatite/calcium peroxide composite scaffolds exhibited excellent mechanical properties and sustained oxygen release for over three weeks. Compared to the control groups, the polycaprolactone/hydroxyapatite/calcium peroxide scaffolds also significantly promoted rat bone marrow mesenchymal stem cell proliferation, migration, adhesion, and osteogenic differentiation, with the scaffold containing 1% calcium peroxide showing the most potent pro-angiogenic and bone-repairing effects. In a rat calvarial defect model, radiographic and histological analyses revealed that the synergistic effects of calcium peroxide and hydroxyapatite significantly induced vascular network formation, accelerated bone regeneration across the entire defect area, and markedly enhanced new bone formation. In summary, this work proposes a novel strategy for fabricating cell- and growth factor-free bone tissue engineering scaffolds with potential for tissue regeneration and clinical replacement.","PeriodicalId":7985,"journal":{"name":"APL Materials","volume":"13 12","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147330678","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Crossover of critical behavior and magnetocaloric effect in FePd2Te2 with one-dimensional Fe chains 一维铁链FePd2Te2的临界行为和磁热效应的交叉

2区材料科学

APL Materials Pub Date : 2025-11-01 DOI: 10.1063/5.0300224

Hongyuan Wang, Lanfeng Liu, Wei Li, Si Wu, Baomin Wang

{"title":"Crossover of critical behavior and magnetocaloric effect in FePd2Te2 with one-dimensional Fe chains","authors":"Hongyuan Wang, Lanfeng Liu, Wei Li, Si Wu, Baomin Wang","doi":"10.1063/5.0300224","DOIUrl":"https://doi.org/10.1063/5.0300224","url":null,"abstract":"Recently, a two-dimensional ferromagnet FePd2Te2 exhibiting easy-plane anisotropy with a quasi-one-dimensional spin system has been discovered. We report the magnetic critical behavior and magnetocaloric effect of FePd2Te2 single crystals with magnetic fields applied both in-plane and out-of-plane. Conventional iterative methods failed to determine the critical exponents of the material. Using a modified iterative method, we obtained two sets of critical exponents on both sides of the critical temperature TC: for the in-plane magnetic field direction, β−=0.7155 and γ−=1.0255 below TC and β+=0.6205 and γ+=0.9005 above TC. The reliability of the estimated critical exponents is confirmed through scaling analysis. Under a 7 T magnetic field applied near TC, the maximum entropy change (−ΔSMmax) is 1.38 J kg−1 K−1 and the relative cooling power (RCP) is 73.95 J kg−1. The critical exponents extracted using the magnetic entropy scaling analysis exhibit good consistency with those obtained from the analysis of magnetization isotherms. The renormalization group theory analysis of the critical exponents reveals that FePd2Te2 exhibits long-range magnetic interactions intermediate between the 3D Heisenberg model and mean-field model, displaying weak itinerant ferromagnetism due to the presence of itinerant electrons.","PeriodicalId":7985,"journal":{"name":"APL Materials","volume":"13 11","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147331797","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Probing millikelvin temperature sensitivity in chiral nanoparticles via optical forces. 利用光学力探测手性纳米颗粒的毫开尔文温度灵敏度。

IF 5.3 2区材料科学

APL Materials Pub Date : 2025-10-01 DOI: 10.1063/5.0282973

Seongmin Im, Wei Hong, Gayatri P Chandran, Xing Wang, Yang Zhao

{"title":"Probing millikelvin temperature sensitivity in chiral nanoparticles via optical forces.","authors":"Seongmin Im, Wei Hong, Gayatri P Chandran, Xing Wang, Yang Zhao","doi":"10.1063/5.0282973","DOIUrl":"10.1063/5.0282973","url":null,"abstract":"With increasing interest in utilizing nanostructures as nanoscale heat sources, the ability to precisely measure photothermal effects at the nanoscale has become increasingly significant. Techniques based on fluorescence or Raman signals often suffer from challenges in accurate calibration; far-field imaging methods are limited by diffraction-limited spatial resolution; and electron microscopy requires vacuum conditions, restricting in situ applicability. In contrast, tip-based measurement techniques offer sub-diffraction spatial resolution under ambient conditions, making them well-suited for nanoscale photothermal mapping. In this study, we employ tip-based optical force nanoscopy combined with phase-informed decomposition to investigate the origin of the photothermal force, enable nanoscale mapping, and evaluate temperature sensitivity. Our system achieves a temperature sensitivity of ∼0.1 K without necessitating an additional temperature-sensitive layer. We anticipate that our approach has the potential to serve as a versatile platform for investigating localized thermal effects in fields such as semiconductors, nanophotonics, and photocatalysis.","PeriodicalId":7985,"journal":{"name":"APL Materials","volume":"13 10","pages":"101112"},"PeriodicalIF":5.3,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12548564/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145375954","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Transactional spinal cord injury repair using water-memory hyperelastic sponge scaffold with inflammatory regulated microenvironment 具有炎症调节微环境的水记忆超弹性海绵支架修复交易性脊髓损伤

2区材料科学

APL Materials Pub Date : 2025-09-01 DOI: 10.1063/5.0295407

Runquan Zheng, Zhenyu Yao, Jiawei Li, Suode Li, Xuesong Yan, Hongming Wang, Zhiang Wu, Ning Zhang, Zhangying Chen, Xianhu Yue

{"title":"Transactional spinal cord injury repair using water-memory hyperelastic sponge scaffold with inflammatory regulated microenvironment","authors":"Runquan Zheng, Zhenyu Yao, Jiawei Li, Suode Li, Xuesong Yan, Hongming Wang, Zhiang Wu, Ning Zhang, Zhangying Chen, Xianhu Yue","doi":"10.1063/5.0295407","DOIUrl":"https://doi.org/10.1063/5.0295407","url":null,"abstract":"Despite over 20 × 106 patients worldwide suffering from spinal cord injury (SCI), there have been no significant breakthroughs in treatment to date. Although stem cell transplantation has demonstrated initial success, its therapeutic application is restricted by low survival rates, inadequate rates of neuronal differentiation, and a lack of spatial specificity. In this study, we aimed to address the aforementioned challenges in neural stem cell (NSC) transplantation by integrating porous silk fibroin (SF) scaffolds, exosomes, and NSCs to investigate their roles and efficacy in SCI repair. Initially, we screened for the optimal SF concentration to achieve mechanical biomimicry. Subsequently, we combined SF with exosomes and characterized their structural, compositional, elemental, hydrophilic, and shape memory properties, which demonstrated that the addition of exosomes did not significantly influence these characteristics. Furthermore, in vitro live/dead staining and gene expression analyses confirmed that the scaffold exhibits excellent biocompatibility and promotes neuronal differentiation. Finally, in vivo studies on SCI repair demonstrated that this strategy significantly enhances the recovery of motor and sensory functions as well as promotes axonal regeneration and reduces glial scar formation—ideal outcomes for neural repair. In addition, immune-inflammatory assays revealed that this strategy facilitates the transformation of microglia into an anti-inflammatory phenotype, thereby mitigating local inflammation.","PeriodicalId":7985,"journal":{"name":"APL Materials","volume":"13 9","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147332436","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Lateral size effect in Ti3C2Tx MXene as electromagnetic wave absorber Ti3C2Tx MXene作为电磁波吸收剂的横向尺寸效应

2区材料科学

APL Materials Pub Date : 2025-07-01 DOI: 10.1063/5.0282658

Danyao Qu, Fushan Li, Zhenkun Long, Zheng Wang, Lujie Zhang, Yuelong Pan, Xiangwen Xu, Zidong Zhang, Weiwei Wu, Siwu Li

{"title":"Lateral size effect in Ti3C2Tx MXene as electromagnetic wave absorber","authors":"Danyao Qu, Fushan Li, Zhenkun Long, Zheng Wang, Lujie Zhang, Yuelong Pan, Xiangwen Xu, Zidong Zhang, Weiwei Wu, Siwu Li","doi":"10.1063/5.0282658","DOIUrl":"https://doi.org/10.1063/5.0282658","url":null,"abstract":"Electromagnetic wave (EMW) absorption is essential for protection against multi-frequency electromagnetic pollution and interference. Ideal EMW absorbing materials should be thin, lightweight, durable, and capable of operating across a broad frequency range through multiple absorption mechanisms. Ti3C2Tx MXene (TM), a 2D nanomaterial, has emerged as a promising EMW-absorbing candidate. However, the influence of lateral size on EMW absorption performance remains insufficiently explored. In this study, TM with controllable lateral dimensions was mass-produced using an organic solvent-assisted intercalation and collection (OAIC) method, enabling a systematic investigation of lateral size effect on EMW absorption. TM with a large lateral area (4.678 μm2) exhibited the highest absorption capacity, achieving an effective absorption bandwidth (EAB) of 6.3 GHz and a reflection loss (RL) of −24.08 dB at a low filler loading of only 5%. Electromagnetic simulations further confirmed that this optimized sample can efficiently attenuate radar signals. The EMW absorption mechanisms influenced by lateral size, such as dipole polarization, interface polarization, and conduction loss, are systematically analyzed, offering valuable insights into the size-dependent behavior of MXene-based EMW absorbers.","PeriodicalId":7985,"journal":{"name":"APL Materials","volume":"13 7","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147332499","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Achieving 0.05 Ω-mm contact resistance in non-alloyed Ti/Au ohmics to β-Ga₂O₃ by removing surface carbon. 通过去除表面碳，获得非合金Ti/Au欧米对β-Ga2O3的0.05 Ω-mm接触电阻。

IF 5.3 2区材料科学

APL Materials Pub Date : 2025-06-01 DOI: 10.1063/5.0276786

Naomi Pieczulewski, Kathleen T Smith, Corey M Efaw, Arjan Singh, Cameron A Gorsak, Joshua T Buontempo, Jesse Wensel, Kathy Azizie, Katie Gann, Michael O Thompson, Darrell G Schlom, Farhan Rana, Hari P Nair, Steven M Hues, Elton Graugnard, Paul H Davis, Debdeep Jena, Huili Grace Xing, David A Muller

{"title":"Achieving 0.05 Ω-mm contact resistance in non-alloyed Ti/Au ohmics to β-Ga2O3 by removing surface carbon.","authors":"Naomi Pieczulewski, Kathleen T Smith, Corey M Efaw, Arjan Singh, Cameron A Gorsak, Joshua T Buontempo, Jesse Wensel, Kathy Azizie, Katie Gann, Michael O Thompson, Darrell G Schlom, Farhan Rana, Hari P Nair, Steven M Hues, Elton Graugnard, Paul H Davis, Debdeep Jena, Huili Grace Xing, David A Muller","doi":"10.1063/5.0276786","DOIUrl":"10.1063/5.0276786","url":null,"abstract":"Preserving a contamination-free metal-semiconductor interface in β-Ga2O3 is critical to achieve consistently low resistance ( <math><mo><</mo></math> 1 Ω-mm) ohmic contacts. Here, we report a scanning transmission electron microscopy study on the variation in Ti/Au ohmic contact quality to (010) β-Ga2O3 in a conventional lift-off vs a metal-first process. We observe a thin ∼1 nm carbon barrier between the Ti and Ga2O3 in a non-conductive contact fabricated by a conventional lift-off process, which we attribute to photoresist residue, not previously detected by x-ray photoelectron spectroscopy due to the thinness and patchy coverage of the carbon layer, as well as roughness of the Ga2O3 surface. This thin carbon barrier is confirmed by electron energy loss spectroscopy and atomic force microscopy-infrared spectroscopy. We believe that the presence of the thin and patchy carbon layer leads to the highly inconsistent contact behavior in previous reports on non-alloyed contacts. Adventitious carbon is also observed in a conductive ohmic contact metal-first processing on an as-grown sample. We find that a five minute active oxygen descum is sufficient to remove this carbon on as-grown samples, further improving the ohmic behavior and reducing the contact resistance Rc to 0.06 Ω-mm. We also show that an hour long UV-ozone treatment of the Ga2O3 surface can eliminate carbon residue from the lift-off processing, resulting in a low Rc of 0.05 Ω-mm.","PeriodicalId":7985,"journal":{"name":"APL Materials","volume":"13 6","pages":"061122"},"PeriodicalIF":5.3,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12183788/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144482909","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Multivariate MOF nanozyme utilizes glucose-activated self-cascade strategy for enhanced antibacterial efficacy and accelerated diabetic wounds healing 多变量MOF纳米酶利用葡萄糖激活的自级联策略增强抗菌效果并加速糖尿病伤口愈合

2区材料科学

APL Materials Pub Date : 2025-05-01 DOI: 10.1063/5.0267620

Yuxin Huang, Ding‐Shinn Chen, Tak Man Wong, Baolin Li, Yongxin Shi

{"title":"Multivariate MOF nanozyme utilizes glucose-activated self-cascade strategy for enhanced antibacterial efficacy and accelerated diabetic wounds healing","authors":"Yuxin Huang, Ding‐Shinn Chen, Tak Man Wong, Baolin Li, Yongxin Shi","doi":"10.1063/5.0267620","DOIUrl":"https://doi.org/10.1063/5.0267620","url":null,"abstract":"The impaired immune function observed in diabetic patients significantly increases their susceptibility of diabetic wounds to bacterial infections. Conventional treatment for bacterial infections relies heavily on antibiotics; however, this approach is often accompanied by the development of bacterial resistance. In this study, a nanozyme (Q@CuMn@G) exhibiting exceptional antibacterial efficacy with the capability to circumvent drug resistance was ingeniously designed. It operates through the generation of hydroxyl radicals (•OH) via a self-cascade reaction. The glucose oxidase (GOx) encapsulated within the Cu-metal–organic framework (MOF) generates H2O2 by degrading glucose present in the wound environment, which is subsequently catalyzed by the Cu-MOF to produce •OH, thereby exerting potent antibacterial effects. Meanwhile, MnO2 loaded within Cu-MOF generates O2, ameliorating the hypoxic environment of the wound and further supporting the degradation of glucose by GOx. Quaternized chitosan is employed as a shell to envelop the nanozyme, thus preventing the rapid degradation of GOx. In vitro experiments demonstrated that Q@CuMn@G exhibits sustained release of •OH and significant bactericidal effects against Escherichia coli and Staphylococcus aureus, confirming the high antibacterial activity of the nanozyme. Moreover, in vivo experiments revealed that Q@CuMn@G effectively kills bacteria in infected diabetic wounds, modulates the immune microenvironment, and accelerates wound healing, achieving a healing ratio of 96.78%. This study employs the Q@CuMn@G nanozyme to achieve highly effective antibacterial efficacy through chemodynamic therapy, thereby offering an innovative strategy for antibiotic-free treatment of diabetic wound repair.","PeriodicalId":7985,"journal":{"name":"APL Materials","volume":"13 5","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147331408","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Itaconate-loaded metal–organic framework (MOF) nanomedicine for the sustained treatment of intervertebral disk degeneration 钛酸盐负载金属有机框架（MOF）纳米药物用于椎间盘退变的持续治疗

2区材料科学

APL Materials Pub Date : 2025-04-01 DOI: 10.1063/5.0267538

Haixin Song, Jianhua Li, Qibin Zhang, Bingjie Zheng, Changsheng Li, Yiran Wang, Jian Chen, Junhui Liu, Tom Wu, Xiaotian Yang, Xueqian Kong, Fengdong Zhao

{"title":"Itaconate-loaded metal–organic framework (MOF) nanomedicine for the sustained treatment of intervertebral disk degeneration","authors":"Haixin Song, Jianhua Li, Qibin Zhang, Bingjie Zheng, Changsheng Li, Yiran Wang, Jian Chen, Junhui Liu, Tom Wu, Xiaotian Yang, Xueqian Kong, Fengdong Zhao","doi":"10.1063/5.0267538","DOIUrl":"https://doi.org/10.1063/5.0267538","url":null,"abstract":"Intervertebral disk degeneration (IVDD) is a major cause of spinal pathology and pain and can lead to disability in adults in severe cases. The medication against disk degeneration is limited due to the lack of therapeutic drugs and ineffective delivery of molecular drugs to target microenvironment. Itaconate is a tricarboxylic acid cycle secondary metabolite with inflammatory and oxidative stress modulating functions, which could alleviate disk degeneration. However, the lack of in vivo stability limits the potential application of itaconate against disk degeneration. In this study, we prepared metal–organic framework (MOF) nanocarrier drug loaded with itaconate that can respond to the acidic environment during disk degeneration. The results showed that the acidic microenvironment could induce sustained drug release from MOF@itaconate. In vitro cellular evaluation showed that MOF@itaconate has good cytocompatibility and significantly attenuates the inflammatory injury of nucleus pulposus cells. The nanocarrier activates the nuclear factor erythroid 2-related factor 2 (Nrf 2) anti-oxidative pathway and promotes the expression of nucleus pulposus extracellular matrix components. For the treatment of intervertebral disk degeneration on animal models, the MOF@itaconate nanocarrier was further coated with hyaluronic acid (HA) to boost the therapeutic effect. The administration of MOF@itaconate@HA in a rat disk degeneration model effectively delayed the degenerative process, suggesting that this technology may provide an effective controlled-release strategy for the treatment of IVDD.","PeriodicalId":7985,"journal":{"name":"APL Materials","volume":"13 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147330609","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Polysaccharide-based aerogel dressing integrated with MOF-loaded quercetin with multifunctional effects for promoting infected wound healing 以多糖为基础的气凝胶敷料与负载mof的槲皮素结合，具有促进感染伤口愈合的多功能作用

2区材料科学

APL Materials Pub Date : 2025-04-01 DOI: 10.1063/5.0258842

Xiaomin Wu, Qisong Liu, Alena Rasiuk, Shkuryn Siarhei Vladimirovich, Yu Pan, Bilan Lin, Ying Liu, Wenqiang Li, Guanghao Li, Wensong Li, Cuiping Zhang, Xiaohua Pan

{"title":"Polysaccharide-based aerogel dressing integrated with MOF-loaded quercetin with multifunctional effects for promoting infected wound healing","authors":"Xiaomin Wu, Qisong Liu, Alena Rasiuk, Shkuryn Siarhei Vladimirovich, Yu Pan, Bilan Lin, Ying Liu, Wenqiang Li, Guanghao Li, Wensong Li, Cuiping Zhang, Xiaohua Pan","doi":"10.1063/5.0258842","DOIUrl":"https://doi.org/10.1063/5.0258842","url":null,"abstract":"Infectious wounds disrupt the progression through the stages of wound healing, resulting in the development of chronic wounds. However, the current therapeutic approach is limited and requires repeated administrations. A major challenge in infectious wounds is to achieve sustained drug release. Herein, quercetin with anti-inflammatory and antibacterial properties was encapsulated within amino-functionalized UIO-66 metal-organic framework (MOF) to form MOF@Que NPs. MOF@Que NPs were then loaded into an aerogel constructed with agarose, aldehyde hyaluronic acid, and carboxymethyl chitosan to obtain ACA-MOF@Que for targeting different phases of wound healing. The polysaccharide-based aerogel was formed by the entanglement of polymer chains and the Schiff base reaction, which exhibited uniform pore structures and low-swelling properties. Furthermore, the ACA-MOF@Que aerogel also exhibited antioxidant, anti-inflammatory, and antibacterial properties. In vivo and in vitro experiments confirmed that the ACA-MOF@Que aerogel could promote hemostasis in the initial stage of wound healing, reduce cellular inflammatory infiltration, and inhibit the inflammatory response by regulating macrophage polarization during the inflammatory stage of wound healing. Finally, the ACA-MOF@Que aerogel could promote angiogenesis and increase collagen deposition in the later stage of wound healing. Compared with the untreated group, the wounds of rats treated with the ACA-MOF@Que aerogel had almost completely healed on the 14th day. Therefore, the ACA-MOF@Que aerogel plays multiple roles at various stages of wound healing, providing a promising therapeutic approach for the clinical application of chronic wounds.","PeriodicalId":7985,"journal":{"name":"APL Materials","volume":"13 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147331423","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Neuralized and vascularized fast bone regeneration using recombinant humanized type 1 collagen and native bone composite inorganic salts 重组人源1型胶原与天然骨复合无机盐的神经化血管化快速骨再生

2区材料科学

APL Materials Pub Date : 2025-03-01 DOI: 10.1063/5.0257593

Peng Hou, Song Chen, Tuerxun Maimaitiaili, Shengjie Wang, Yan Wei, Jianfei Tang

{"title":"Neuralized and vascularized fast bone regeneration using recombinant humanized type 1 collagen and native bone composite inorganic salts","authors":"Peng Hou, Song Chen, Tuerxun Maimaitiaili, Shengjie Wang, Yan Wei, Jianfei Tang","doi":"10.1063/5.0257593","DOIUrl":"https://doi.org/10.1063/5.0257593","url":null,"abstract":"Bone injury is a prevalent condition in clinical therapy that can lead to significant functional impairments and substantially disrupt the quality of life for patients. However, there has been a limited breakthrough in achieving neuralized and vascularized rapid bone regeneration. In this study, we collaborated with recombinant humanized collagen 1 (rhCOL1), native bone composite inorganic salts (NBCISs), methacrylated silk fibroin (SilMA), and bone marrow mesenchymal stem cells (BMSCs) to construct biomimetic organic and bio-mineralized multifunctional organoids for the repair of bone defects, achieving neuralized and vascularized bone regeneration within just six weeks in rabbits. We first determined the optimal concentration of SilMA (10%) by comprehensively evaluating crosslinking, operability, and BMSC proliferation. The rhCOL1 and NBCIS mixture was prepared using a ratio of 3:7, in reference to native bone, and was subsequently added to create biomimetic organic and biomineralized microenvironments for the NCSilMA. Similarly, the proportions of the added mixture were optimized based on their effects on compressive modulus, swelling, and degradation. As a result, we successfully constructed a biomimetic organic and biomineralized multifunctional hydrogel scaffold for bone defect repair, characterized by excellent biodegradability, appropriate strength, good biocompatibility, and osteoinductive biological function. Finally, the BMSC-loaded NCSilMA (organoids) achieved neuralized and vascularized rapid bone regeneration, with up-regulated osteogenic genes and enhanced cell colonization, collagen, and polysaccharide deposition.","PeriodicalId":7985,"journal":{"name":"APL Materials","volume":"13 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.aip.org/aip/apm/article-pdf/doi/10.1063/5.0257593/20418432/031103_1_5.0257593.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147334096","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2