Annals of hepatology最新文献

{"title":"From NAFLD to MASLD: Promise and pitfalls of a new definition","authors":"Kenneth Cusi, Zobair Younossi, Michael Roden","doi":"10.1016/j.aohep.2023.101179","DOIUrl":"10.1016/j.aohep.2023.101179","url":null,"abstract":"","PeriodicalId":7979,"journal":{"name":"Annals of hepatology","volume":"29 4","pages":"Article 101179"},"PeriodicalIF":3.7,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S166526812300282X/pdfft?md5=76756a8075f3685bd2d6d48eeb951e7b&pid=1-s2.0-S166526812300282X-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138823421","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Key points for imaging diagnosis and response assessment for hepatocellular carcinoma in Latin America","authors":"Federico Diaz Telli , Juan Manuel Perez Hidalgo , Adriana Varón , Lorena Castro , Norberto Chavez Tapia , Federico Piñero","doi":"10.1016/j.aohep.2024.101514","DOIUrl":"10.1016/j.aohep.2024.101514","url":null,"abstract":"","PeriodicalId":7979,"journal":{"name":"Annals of hepatology","volume":"29 4","pages":"Article 101514"},"PeriodicalIF":3.7,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1665268124003089/pdfft?md5=743396f9ad17502192a625a3589bc28b&pid=1-s2.0-S1665268124003089-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141465732","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Protean strictures: Shifting severity beneath the diagnostic façade","authors":"Fateh Bazerbachi , Najib Nassani , Klaus Mönkemüller","doi":"10.1016/j.aohep.2024.101513","DOIUrl":"10.1016/j.aohep.2024.101513","url":null,"abstract":"","PeriodicalId":7979,"journal":{"name":"Annals of hepatology","volume":"29 4","pages":"Article 101513"},"PeriodicalIF":3.7,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1665268124003077/pdfft?md5=dd66b9bffcd55d31e50a4e141018c089&pid=1-s2.0-S1665268124003077-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141465733","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reply to: “From NAFLD to MASLD: Promise and pitfalls of a new definition’","authors":"Mary E. Rinella, Graciela E.Castro Narro, Aleksander Krag, Norah Terrault, Philip N. Newsome","doi":"10.1016/j.aohep.2023.101178","DOIUrl":"10.1016/j.aohep.2023.101178","url":null,"abstract":"","PeriodicalId":7979,"journal":{"name":"Annals of hepatology","volume":"29 4","pages":"Article 101178"},"PeriodicalIF":3.7,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1665268123002818/pdfft?md5=23656857fcbaf542d68de08ae38afa14&pid=1-s2.0-S1665268123002818-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138823462","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"NAFLD-MASLD-MAFLD continuum: A swinging pendulum?","authors":"","doi":"10.1016/j.aohep.2024.101526","DOIUrl":"10.1016/j.aohep.2024.101526","url":null,"abstract":"","PeriodicalId":7979,"journal":{"name":"Annals of hepatology","volume":"29 5","pages":"Article 101526"},"PeriodicalIF":3.7,"publicationDate":"2024-06-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S166526812400320X/pdfft?md5=f3cd39cd6fb3df3f3751aba93aafd5ba&pid=1-s2.0-S166526812400320X-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141465731","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy of blood plasma spectroscopy for early liver cancer diagnostics in obese patients","authors":"Petr Hříbek ,&nbsp;Ondřej Vrtělka ,&nbsp;Kateřina Králová ,&nbsp;Johana Klasová ,&nbsp;Markéta Fousková ,&nbsp;Lucie Habartová ,&nbsp;Kristýna Kubíčková ,&nbsp;Tomáš Kupsa ,&nbsp;Tomáš Tůma ,&nbsp;Vladimír Setnička ,&nbsp;Petr Urbánek","doi":"10.1016/j.aohep.2024.101519","DOIUrl":"10.1016/j.aohep.2024.101519","url":null,"abstract":"<div><h3>Introduction and Objectives</h3><p>Hepatocellular carcinoma (HCC) represents one of the most common cancers worldwide. A considerable proportion of HCC is caused by cirrhosis related to metabolic dysfunction-associated steatohepatitis (MASH). Due to the increasing prevalence of metabolic syndrome, it is estimated that MASH-related HCC will become the most prevalent etiology of HCC. Currently, HCC screening is based on liver ultrasonography; however, the sensitivity of ultrasonography for early HCC stages in obese patients only reaches 23 %. To date, no studied biomarker shows sufficient efficacy for screening purposes. Nevertheless, the usage of spectroscopic methods offers a new perspective, as its potential use would provide cheap, fast analysis of samples such as blood plasma.</p></div><div><h3>Material and Methods</h3><p>We employed a combination of conventional and chiroptical spectroscopic methods to study differences between the blood plasma of obese cirrhotic patients with and without HCC. We included 20 subjects with HCC and 17 without evidence of liver cancer, all of them with body mass index ≥ 30.</p></div><div><h3>Results</h3><p>Sensitivities and specificities reached values as follows: 0.780 and 0.905 for infrared spectroscopy, 0.700 and 0.767 for Raman spectroscopy, 0.840 and 0.743 for electronic circular dichroism, and 0.805 and 0.923 for Raman optical activity. The final combined classification model based on all spectroscopic methods reached a sensitivity of 0.810 and a specificity of 0.857, with the highest area under the receiver operating characteristic curve among all models (0.961).</p></div><div><h3>Conclusions</h3><p>We suggest that this approach can be used effectively as a diagnostic tool in patients who are not examinable by liver ultrasonography.</p></div><div><h3>Clinical trial registration</h3><p>NCT04221347</p></div>","PeriodicalId":7979,"journal":{"name":"Annals of hepatology","volume":"29 5","pages":"Article 101519"},"PeriodicalIF":3.7,"publicationDate":"2024-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1665268124003132/pdfft?md5=aa85efaf3fef8364cea56366e9c07acb&pid=1-s2.0-S1665268124003132-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141309493","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"MAFLD or MASLD: Let the evidence decide again","authors":"Ziyan Pan,&nbsp;Mohammed Eslam","doi":"10.1016/j.aohep.2024.101521","DOIUrl":"10.1016/j.aohep.2024.101521","url":null,"abstract":"","PeriodicalId":7979,"journal":{"name":"Annals of hepatology","volume":"29 5","pages":"Article 101521"},"PeriodicalIF":3.7,"publicationDate":"2024-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1665268124003156/pdfft?md5=883363bfaa2ff3a6beb111c856608fa6&pid=1-s2.0-S1665268124003156-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141305207","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Emerging role of immunotherapy for cancer as a major cause of drug-induced liver injury","authors":"Nelia Hernandez,&nbsp;Fernando Bessone,&nbsp;Raul Andrade","doi":"10.1016/j.aohep.2024.101520","DOIUrl":"10.1016/j.aohep.2024.101520","url":null,"abstract":"","PeriodicalId":7979,"journal":{"name":"Annals of hepatology","volume":"29 5","pages":"Article 101520"},"PeriodicalIF":3.7,"publicationDate":"2024-06-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1665268124003144/pdfft?md5=ec94da16dab33cb3d207df870c48696f&pid=1-s2.0-S1665268124003144-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141295410","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hepatitis C virus NS5A and core protein induce fibrosis-related genes regulation on Huh7 cells through activation of LX2 cells","authors":"","doi":"10.1016/j.aohep.2024.101517","DOIUrl":"10.1016/j.aohep.2024.101517","url":null,"abstract":"<div><h3>Introduction and Objectives</h3><p>Liver fibrosis remains a complication derived from a chronic Hepatitis C Virus (HCV) infection even when it is resolved, and no liver antifibrotic drug has been approved. Molecular mechanisms on hepatocytes and activation of hepatic stellate cells (HSCs) play a central role in liver fibrogenesis. To elucidate molecular mechanisms, it is important to analyze pathway regulation during HSC activation and HCV infection.</p></div><div><h3>Materials and Methods</h3><p>We evaluate the fibrosis-associated molecular mechanisms during a co-culture of human HSCs (LX2), with human hepatocytes (Huh7) that express HCV NS5A or Core protein. We evaluated LX2 activation induced by HCV NS5A or Core expression in Huh7 cells during co-culture. We determined a fibrosis-associated gene expression profile in Huh7 that expresses NS5A or Core proteins during the co-culture with LX2.</p></div><div><h3>Results</h3><p>We observed that NS5A induced 8.3-, 6.7- and 4-fold changes and that Core induced 6.5-, 1.8-, and 6.2-fold changes in the collagen1, TGFβ1, and timp1 gene expression, respectively, in LX2 co-cultured with transfected Huh7. In addition, NS5A induced the expression of 30 genes while Core induced 41 genes and reduced the expression of 30 genes related to fibrosis in Huh7 cells during the co-culture with LX2, compared to control. The molecular pathways enriched from the gene expression profile were involved in TGFB signaling and the organization of extracellular matrix.</p></div><div><h3>Conclusions</h3><p>We demonstrated that HCV NS5A and Core protein expression regulate LX2 activation. NS5A and Core-induced LX2 activation, in turn, regulates diverse fibrosis-related gene expression at different levels in Huh7, which can be further analyzed as potential antifibrotic targets during HCV infection.</p></div>","PeriodicalId":7979,"journal":{"name":"Annals of hepatology","volume":"29 5","pages":"Article 101517"},"PeriodicalIF":3.7,"publicationDate":"2024-06-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1665268124003119/pdfft?md5=6697ffa4182a04ac1f131291d6a06cee&pid=1-s2.0-S1665268124003119-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141295411","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Frailty and sarcopenia in patients with acute-on-chronic liver failure: Assessment and risk in the liver transplant setting","authors":"Isabel Campos-Varela ,&nbsp;Lluis Castells ,&nbsp;Sergi Quiroga ,&nbsp;Victor Vargas ,&nbsp;Macarena Simon-Talero","doi":"10.1016/j.aohep.2024.101515","DOIUrl":"10.1016/j.aohep.2024.101515","url":null,"abstract":"<div><p>Frailty and sarcopenia are well-recognized factors related to worse outcomes in patients with cirrhosis, including liver transplant (LT) candidates. Implications of pre-LT functional and muscle deterioration also affect post-LT outcomes. Patients with cirrhosis and acute-on-chronic liver failure (ACLF) have a lower survival rate, both before and after LT. There is a need to better identify those patients with ACLF who would benefit from LT. This review aims to present the available data about frailty and sarcopenia in patients with ACLF in the LT setting. An exhaustive review of the published literature was conducted. Data regarding frailty and sarcopenia in LT candidates with ACLF are scarce and heterogeneous. Studies evaluating frailty and sarcopenia in critically ill patients outside the liver literature are also presented in this review to enrich the knowledge of this field in expansion. Frailty and sarcopenia seem to contribute to worse outcomes in LT candidates with ACLF, both before and after LT. Sarcopenia evaluation may be the most prudent approach for those very sick patients. Skeletal muscle index assessed by computed tomography is recommended to evaluate sarcopenia. The role of muscle ultrasound and bioelectrical impedance analysis is to be determined. Frailty and sarcopenia are crucial factors to consider on a case-by-case basis in LT candidates with ACLF to improve patient outcomes.</p></div>","PeriodicalId":7979,"journal":{"name":"Annals of hepatology","volume":"29 5","pages":"Article 101515"},"PeriodicalIF":3.7,"publicationDate":"2024-06-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1665268124003090/pdfft?md5=f682b55cd6b436944728d638f91db468&pid=1-s2.0-S1665268124003090-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141293022","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}