Annals of hepatology最新文献

{"title":"#168 - HEPATIC STEATOSIS AND STEATOHEPATITIS PREDICT ATHEROGENIC RISK IN METABOLIC DYSFUNCTION-ASSOCIATED STEATOTIC LIVER DISEASE IN A LATIN AMERICAN MULTICENTER COHORT","authors":"Carlos Coronel-Castillo,&nbsp;Fátima Higuera-De-La-Tijera,&nbsp;Francisco Idalsoaga,&nbsp;Marco Arrese,&nbsp;Cristiane Villela-Nogueira,&nbsp;Nathalie Leite,&nbsp;Gil Salles,&nbsp;Claudia Cardoso,&nbsp;Mario Pessoa,&nbsp;Claudia Oliveira,&nbsp;Claudia Alves-Couto,&nbsp;Guilherme Cançado,&nbsp;Luciana Costa-Faria,&nbsp;José Velarde-Ruiz-Velasco,&nbsp;Graciela Castro-Narro,&nbsp;Eira Cerda-Reyes,&nbsp;Jacqueline Cordova-Gallardo,&nbsp;Manuel Mendizabal,&nbsp;Constanza Sabate,&nbsp;Francisco Valentin-Cortez,&nbsp;Luis Diaz","doi":"10.1016/j.aohep.2026.102281","DOIUrl":"10.1016/j.aohep.2026.102281","url":null,"abstract":"<div><h3>Introduction and Objectives</h3><div>In MASLD, hepatic steatosis and fibrosis are distinct pathophysiological processes with potentially independent effects on lipid metabolism and insulin resistance, yet their differential contribution to the atherogenic profile has not been evaluated.</div><div>To evaluate association of hepatic steatosis, fibrosis, and at-risk MASH with Triglyceride-Glucose Index (TyG) and Atherogenic Index of Plasma (AIP) in MASLD.</div></div><div><h3>Materials and Methods</h3><div>Multicenter retrospective cohort (19 centers across Latin America) of patients with MASLD and FibroScan (CAP, LSM, FAST score) and lipid profile. TyG and AIP were calculated. CAP (&lt;275 vs 275 dB/m; S1/S2/S3), LSM (&lt;8.0 vs 8.0 kPa), and FAST score (&lt;0.35, 0.35–0.67, 0.67) were categorized. Linear regression adjusted for age, sex, BMI, T2DM, and statins. Biopsy-proven patients served as sensitivity analysis.</div></div><div><h3>Results</h3><div>1,677 patients (age 55 years; 57% male; BMI 31.6 kg/m²; 58% T2DM). CAP 275 predicted higher TyG (=+0.204, 95%CI [0.125–0.283], p&lt;0.001) and AIP (=+0.073, 95%CI [0.038–0.108], p&lt;0.001). S3 vs S1 showed the strongest association (TyG =+0.227, p&lt;0.001). LSM did not predict TyG or AIP (p&gt;0.30). FAST predicted TyG and AIP only in biopsy-confirmed patients (n=576; p=0.004 and p=0.001, respectively; (Figure 1.)</div></div><div><h3>Conclusions</h3><div>Hepatic steatosis, but not fibrosis, independently predicts insulin resistance and atherogenic dyslipidemia in MASLD. FAST score identified at-risk MASH as a cardiometabolic determinant in biopsy-proven patients. These findings support steatosis quantification as a cardiometabolic biomarker in MASLD.</div></div>","PeriodicalId":7979,"journal":{"name":"Annals of hepatology","volume":"31 ","pages":"Article 102281"},"PeriodicalIF":6.2,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148810650","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"#75 - LIVER VOLUME IS ASSOCIATED WITH MORTALITY IN ALCOHOL ASSOCIATED HEPATITIS","authors":"Francisco Idalsoaga,&nbsp;Amy Hicks,&nbsp;Nawaz Safdar,&nbsp;Darwish Khizindar,&nbsp;Vincent Haghnejad,&nbsp;Joaquin Hevia,&nbsp;Ashwani K. Singal,&nbsp;Juan Arab,&nbsp;Richard Parker","doi":"10.1016/j.aohep.2026.102347","DOIUrl":"10.1016/j.aohep.2026.102347","url":null,"abstract":"<div><h3>Introduction and Objectives</h3><div>Alcohol-associated hepatitis (AH) is associated with high short-term mortality, yet prognostic assessment relies mainly on clinical and laboratory variables. We evaluated whether computed tomography (CT)-derived liver volume and steatosis were associated with clinically relevant outcomes in patients hospitalized with AH.</div></div><div><h3>Materials and Methods</h3><div>We performed a multicenter retrospective cohort study of patients hospitalized with AH between 2009 and 2023 who underwent abdominal CT within 5 days of admission. Liver volume was measured by CT volumetry and hepatic steatosis was assessed using the liver-to-spleen attenuation ratio. The primary outcome was 90-day mortality; secondary outcomes were corticosteroid response, infection, and 30-day mortality. Associations were assessed using Cox and logistic regression models.</div></div><div><h3>Results</h3><div>We included 122 patients with AH. Mean age was 46 [41–53] years, 33% were women, and median MELD was 22 [19–26]. Ninety-day mortality occurred in 28 patients (23%). Body surface area-adjusted liver size was associated with 90-day mortality (HR 0.32, 95% CI 0.12–0.83, p=0.019), remaining significant after adjustment for age, sex, and MELD. Patients in the intermediate and largest liver volume tertiles had lower mortality than those in the smallest tertile. Liver volume was not associated with corticosteroid response or infection. Hepatic steatosis was not associated with mortality, infection, or corticosteroid response. Discrimination of liver volume for 90-day mortality was moderate (AUROC 0.70).</div></div><div><h3>Conclusions</h3><div>In this multicenter cohort of patients with AH, smaller CT-derived liver volume was independently associated with higher 90-day mortality, whereas steatosis was not associated with outcomes.</div></div>","PeriodicalId":7979,"journal":{"name":"Annals of hepatology","volume":"31 ","pages":"Article 102347"},"PeriodicalIF":6.2,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148810661","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"#5 - TRANSJUGULAR INTRAHEPATIC PORTOSYSTEMIC SHUNT IN AN EMERGING PROGRAM: THE ROLE OF INTRAVASCULAR ULTRASOUND AND MULTIDISCIPLINARY CARE","authors":"Wagner Ramirez,&nbsp;Katherine Bolaños,&nbsp;Pablo Coste,&nbsp;Bruno Solis-Ugalde,&nbsp;Adrián Agüero-Fernández,&nbsp;María Lynch,&nbsp;Francisco Vargas,&nbsp;Daniel Pérez,&nbsp;Andrés Solera-Vega,&nbsp;Fiorella Ajún,&nbsp;Rodrigo Álvarez,&nbsp;Alejandra Ochoa","doi":"10.1016/j.aohep.2026.102288","DOIUrl":"10.1016/j.aohep.2026.102288","url":null,"abstract":"<div><h3>Introduction and Objectives</h3><div>Transjugular intrahepatic portosystemic shunt (TIPS) is the most effective therapy for complications of portal hypertension, but its implementation remains limited in low- and middle- income countries. Technical complexity, higher costs, and fragmented care compromise outcomes during early program development. We evaluated the impact of intracardiac-echocardiography (ICE) catheter guidance and post-procedural care on outcomes in a new-established program.</div></div><div><h3>Materials and Methods</h3><div>Retrospective, observational study including adults with cirrhosis undergoing TIPS between July 2018 and November 2022 at a liver transplant referral center in Costa Rica. Procedural metrics, hemodynamic-response, complications, and survival were analyzed. Duration was compared between ICE-and US-guided TIPS. Survival was assessed according to continuation of care at our center versus follow-up at referring hospitals.</div></div><div><h3>Results</h3><div>20 patients underwent TIPS; median MELD was 12, and indications included variceal bleeding (65%), refractory ascites (30%), and hepatic hydrothorax (5%). Mean pre-TIPS pressure gradient was 16mmHg,with a mean reduction of 56%.ICE guidance was associated with a shorter procedure duration compared with conventional guidance (135min vs 237min,p=0.002).Hepatic encephalopathy was the most frequent complication(45%).Overall survival at 6 and 12 months was 75% and 70%.Patients who continued care within the transplant center showed higher survival at 6 and 12 months (100% and 94%).</div></div><div><h3>Conclusions</h3><div>ICE guidance was associated with shorter duration, facilitating safer implementation during early experience. Differences in survival according to care setting reflect a combination of patient selection, disease severity, procedural decision-making, and structured multidisciplinary management. These findings highlight that both technology and integrated care pathways are critical for successful TIPS program development in resource-limited settings.</div></div>","PeriodicalId":7979,"journal":{"name":"Annals of hepatology","volume":"31 ","pages":"Article 102288"},"PeriodicalIF":6.2,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148810708","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"#88 - EDUCATIONAL LEVEL, EMPLOYMENT STATUS, AND GRAFT REJECTION IN LIVER TRANSPLANT RECIPIENTS: A MEXICAN COHORT STUDY.","authors":"Orfanel Pineda,&nbsp;Erik Jasso-Baltazar,&nbsp;Luis Rubio-Acosta,&nbsp;Claudia López-López,&nbsp;Araceli López-Nepomuceno,&nbsp;Inés Méndez-Guerrero,&nbsp;Oscar Fierro-Angulo,&nbsp;Ricardo Gutiérrez-Monterrubio,&nbsp;Liz Toapanta-Yanchapaxi,&nbsp;Ignacio García-Juárez","doi":"10.1016/j.aohep.2026.102358","DOIUrl":"10.1016/j.aohep.2026.102358","url":null,"abstract":"<div><h3>Introduction and Objectives</h3><div>Sociodemographic factors may affect outcomes after liver transplantation. However, limited data are available regarding the association between educational level, employment status, and graft rejection in Latin American populations.</div><div>To evaluate the association between educational level, employment status, and graft rejection in liver transplant recipients at a tertiary care center in Mexico</div></div><div><h3>Materials and Methods</h3><div>We conducted a retrospective study including 100 adult liver transplant recipients. Educational level, employment status, clinical characteristics, and rejection episodes were recorded. Continuous variables were compared using Student’s t-test, and categorical variables using Chi-square tests.</div></div><div><h3>Results</h3><div>A total of 100 patients were included; the mean age was 50.7±12.8 years, and rejection occurred in 14%. No significant association was observed between rejection and educational level or employment status. Patients with rejection were significantly younger than those without rejection. No significant differences were identified regarding sex, follow-up time, MELD score, or disease etiology, although autoimmune liver disease was more frequent among patients with rejection. Educational attainment and employment status showed no measurable impact on rejection risk in univariate analyses, Table 1.</div></div><div><h3>Conclusions</h3><div>Educational level and employment status were not associated with graft rejection in this cohort, suggesting that sociodemographic characteristics alone may not predict rejection risk after liver transplantation. Further studies are needed to evaluate additional psychosocial and healthcare-related factors that may influence post-transplant outcomes in Latin American populations.</div></div>","PeriodicalId":7979,"journal":{"name":"Annals of hepatology","volume":"31 ","pages":"Article 102358"},"PeriodicalIF":6.2,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148810713","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"#30 - SPONTANEOUS BACTERAEMIA IN PATIENTS WITH CIRRHOSIS AND SPONTANEOUS BACTERIAL PERITONITIS: MICROBIOLOGICAL PROFILE AND 30-DAY MORTALITY","authors":"Samuel Ubieta-Gallegos,&nbsp;Nayeli Ortiz-Olvera,&nbsp;Aldo Allende-Lopez,&nbsp;Segundo Moran-Villota","doi":"10.1016/j.aohep.2026.102308","DOIUrl":"10.1016/j.aohep.2026.102308","url":null,"abstract":"<div><h3>Introduction and Objectives</h3><div>Spontaneous bacterial peritonitis (SBP) is the leading cause of infection-related death in patients with liver cirrhosis (LC), with mortality approaching 30%. Spontaneous bacteraemia (SB) occurs in approximately 12% of hospitalised patients with LC; however, evidence remains limited regarding its frequency during episodes of SBP and its impact on mortality.</div></div><div><h3>Objective</h3><div>To describe the frequency of SB and its bacterial profile in patients with LC during an episode of SBP, and to evaluate its association with 30-day all-cause mortality.</div></div><div><h3>Materials and Methods</h3><div>A cross-sectional study was conducted including patients with LC and SBP who were hospitalised between January 2019 and April 2026. Sociodemographic and clinical characteristics, peripheral blood and ascites culture isolates were analysed. Active follow-up was performed to assess mortality.</div></div><div><h3>Results</h3><div>Twenty-eight patients were included. Most were women (60.7%), and the mean age was 57.5 ± 12.3 years. The most frequent aetiology of LC was metabolic dysfunction-associated steatotic liver disease. Overall, 60.7% of SBP episodes were nosocomial. SB was identified in 39.3% of cases, with gram-negative bacteria isolated in 21.4% and gram-positive bacteria in 17.8%. The most frequent microorganism was <em>Escherichia coli</em> (14.3%), followed by <em>Staphylococcus epidermidis</em> (10.7%). Mortality was higher among patients with positive cultures in both ascites and peripheral blood, reaching 50%, followed by patients with isolated positive blood cultures (28.6%) (p=0.18).</div></div><div><h3>Conclusions</h3><div>The bacterial profile showed a predominance of gram-negative microorganisms, although gram-positive isolates were also frequent. Concomitant positive cultures in ascites and peripheral blood present higher mortality.</div></div>","PeriodicalId":7979,"journal":{"name":"Annals of hepatology","volume":"31 ","pages":"Article 102308"},"PeriodicalIF":6.2,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148810725","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"#14 - ETIOLOGY AND SURVIVAL OUTCOMES IN HEPATOCELLULAR CARCINOMA AT A COLOMBIAN CLINICAL EXCELLENCE CENTER","authors":"Maria Ariza-De La Hoz,&nbsp;Angelica Sanabria-Jiménez,&nbsp;Oscar Beltran-Galvis,&nbsp;Cristina Torres-Caro,&nbsp;Martin Garzón-Olarte,&nbsp;Carolina Salinas-Gomez,&nbsp;Geovanny Hernandez-Cely,&nbsp;Adriana Varón-Puerta","doi":"10.1016/j.aohep.2026.102296","DOIUrl":"10.1016/j.aohep.2026.102296","url":null,"abstract":"<div><h3>Introduction and Objectives</h3><div>The epidemiology of hepatocellular carcinoma (HCC) is shifting worldwide, with metabolic dysfunction-associated steatotic liver disease (MASLD) emerging as a major cause. However, data linking etiology and survival outcomes in real-world cohorts from middle-income countries remain limited. To describe the distribution of underlying etiologies and their association with survival outcomes in patients with HCC managed in a multidisciplinary Center of Clinical Excellence (CCE) in Colombia.</div></div><div><h3>Materials and Methods</h3><div>We conducted a retrospective cohort study including 134 adult patients with confirmed HCC managed between September 2022 and December 2025. Etiology of liver disease was classified as MASLD, alcohol-related, viral hepatitis, autoimmune, and others. Baseline clinical variables included Child–Pugh class, MELD score, and BCLC stage. Overall survival was estimated using the Kaplan–Meier method.</div></div><div><h3>Results</h3><div>Median age was 68 years, and 61.2% were male. MASLD was the most frequent etiology (34.4%), followed by alcohol-related liver disease (15.6%) and hepatitis C (13.3%). The cohort showed a high burden of metabolic comorbidities, including hypertension (58.2%) and diabetes (49.3%). Most patients were diagnosed at early stages (BCLC 0–A: 64.2%). Overall survival was favorable, with estimated rates of 93.8% at 1 year and 80% at 3 years. Patients managed within the multidisciplinary program achieved outcomes consistent with early-stage diagnosis and access to locoregional and curative therapies.</div></div><div><h3>Conclusions</h3><div>In this real-world cohort, MASLD is the leading cause of HCC, reflecting an ongoing epidemiological transition in Latin America. Favorable survival outcomes may be associated with early-stage diagnosis and multidisciplinary care, highlighting the importance of surveillance strategies in metabolic-risk populations.</div></div>","PeriodicalId":7979,"journal":{"name":"Annals of hepatology","volume":"31 ","pages":"Article 102296"},"PeriodicalIF":6.2,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148810764","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"#4 - PORTAL VEIN THROMBOSIS AND MORTALITY AMONG LIVER TRANSPLANT CANDIDATES: A RETROSPECTIVE COHORT STUDY (2018–2024)","authors":"Laura Camargo,&nbsp;Oscar Beltran,&nbsp;Angelica Sanabria","doi":"10.1016/j.aohep.2026.102287","DOIUrl":"10.1016/j.aohep.2026.102287","url":null,"abstract":"<div><h3>Introduction and Objectives</h3><div>Liver cirrhosis is a prevalent disease with a heterogeneous clinical course. A major complication in its natural history is portal vein thrombosis (PVT), which is driven by multifactorial risk factors. This study aimed to evaluate the association between PVT and mortality among patients on the liver transplant waiting list at Fundación Cardioinfantil, while characterizing the population's demographic and clinical profile.</div></div><div><h3>Materials and Methods</h3><div>We conducted a retrospective cohort study of patients listed for liver transplantation between 2018 and 2024. Bivariate analysis was performed for the primary outcome, and a multivariate model was used to identify independent predictors of mortality and factors associated with PVT development.</div></div><div><h3>Results</h3><div>A total of 301 patients were included (mean age 58 years; 58% female). The most common cirrhosis etiology was autoimmune. PVT prevalence was 26% (n =78). The presence of PVT was not associated with a significant increase in mortality (OR: 1.25; 95% CI: 0.55–2.87). Significant independent predictors for the development of PVT were thrombocytopenia (OR: 7.46; 95% CI: 2.45–28.31) and ascites (OR: 2.03; 95% CI: 1.06–4.00).</div></div><div><h3>Conclusions</h3><div>PVT was not associated with significantly higher mortality in this cohort of transplant candidates. Thrombocytopenia and ascites were identified as independent risk factors associated with the development of PVT.</div></div>","PeriodicalId":7979,"journal":{"name":"Annals of hepatology","volume":"31 ","pages":"Article 102287"},"PeriodicalIF":6.2,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148810707","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"#43 - TEMPORAL TRENDS IN AUTOIMMUNE LIVER DISEASES OVER 34 YEARS: IMPACT OF THE COVID-19/POST-COVID-19 PANDEMIC, RISING PRIMARY BILIARY CHOLANGITIS FREQUENCY, AND AGING AT DIAGNOSIS IN A MEXICAN REFERRAL CENTER","authors":"Linda Muñoz-Espinosa,&nbsp;Samuel Rivas-López,&nbsp;Paula Cordero-Perez,&nbsp;Alexandra Costilla-Martinez,&nbsp;Emilia Sepulveda-Gutierrez,&nbsp;Giselle Banda-Alvarez,&nbsp;Ricardo Rodriguez-Macias,&nbsp;Liliana Torres-Gonzalez,&nbsp;Fernando Iglesias-Hernández","doi":"10.1016/j.aohep.2026.102318","DOIUrl":"10.1016/j.aohep.2026.102318","url":null,"abstract":"<div><h3>Introduction and Objectives</h3><div>The global incidence of AILD has increased. Mexico ranks first in cirrhosis-related mortality in Latin America. The incidence of AILD has increased in our center, particularly during the COVID-19/post-COVID-19 pandemic. We aimed to evaluate the distribution of AIH, PBC, and OS (mainly AIH/PBC) across two periods: pre-pandemic (historical) and COVID-19/post-COVID-19 pandemic (2020-2024)</div></div><div><h3>Materials and Methods</h3><div>This analytical, observational, retrospective study included patients with AILD evaluated between 1990 and 2024 at a national referral center, with a minimum follow-up (FU) of 6 months</div></div><div><h3>Results</h3><div>This study represents the largest historical cohort of AILD reported in Mexico to date, including 519 patients: AIH(n=259, 50%), PBC(n=203, 39%), and OS(n=57, 11%). Female(87%), median age at diagnosis of 52 years [IQR 39-59]. Median FU, 26 months [IQR 6-72]. Baseline cirrhosis in 153 patients(30%), 91(25%) during FU. Transplant-free survival at 3, 5, 10, and 20 years was 88.5%, 84.8%, 82.5%, and 80.3%, respectively. AILD diagnoses increased by 48.6% during the COVID-19/post-COVID-19 pandemic vs historical period (20.6 vs. 13.9 cases/year; p&lt;0.001). Linear regression analysis demonstrated a significant upward trend in PBC (p=0.021) (Figures), unlike AIH and OS. Age at diagnosis progressively increased (p=0.022). The probability of diagnosis at 60 years increased by 4% annually (p=0.003;OR 1.04)</div></div><div><h3>Conclusions</h3><div>A significant increase in AILD diagnoses was observed during the COVID-19/post-COVID-19 pandemic. PBC has increased in the last decade. Our data demonstrate a shifting demographic pattern characterized by an increasing age at diagnosis.</div></div>","PeriodicalId":7979,"journal":{"name":"Annals of hepatology","volume":"31 ","pages":"Article 102318"},"PeriodicalIF":6.2,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148810506","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"#71 - PREVALENCE AND BODY COMPOSITION OF OPPORTUNISTICALLY DETECTED HEPATIC STEATOSIS ON COMPUTED TOMOGRAPHY: AN AUTOMATED STUDY IN A CHILEAN COHORT","authors":"Alejandro Pedraza,&nbsp;Cristian Olivares,&nbsp;Miguel Bonilla,&nbsp;Moisés Oropeza,&nbsp;Luis Vélez,&nbsp;Marina Becerra,&nbsp;Armando Godoy","doi":"10.1016/j.aohep.2026.102345","DOIUrl":"10.1016/j.aohep.2026.102345","url":null,"abstract":"<div><h3>Introduction and Objectives</h3><div>Hepatic steatosis is the hallmark feature of Metabolic dysfunction-Associated Steatotic Liver Disease (MASLD), which affects 25-30% of the global population. Electronic health record systems enable its opportunistic detection at scale. To estimate the prevalence of hepatic steatosis in abdominal CT reports using natural language processing (NLP) and to characterize the associated body composition profile.</div></div><div><h3>Materials and Methods</h3><div>Single-center cross-sectional study. A total of 10,422 abdominal CT reports were processed using regex-based NLP. Blinded validation was performed on 100 balanced cases (50 NLP-positive, 50 NLP-negative) reviewed by a physician. Body composition at the L3 level (SMA, VAT, SAT, and muscle density; SMI was not calculated due to absence of height records) was automatically quantified using TotalSegmentator in 200 DICOM studies (100 with steatosis and 100 sex-stratified controls); 184 met quality criteria. Groups were compared using the Mann-Whitney test</div></div><div><h3>Results</h3><div>NLP prevalence: 13.9% (1,444/10,422); males 17.6% vs. females 11.5%. Validation: sensitivity 98%, specificity 98%, Cohen's kappa 0.96. Cases with steatosis showed higher VAT (356 vs. 197 cm2, p&lt;0.001), higher VAT/SAT ratio (2.2 vs. 1.4; p&lt;0.001), and lower muscle density (HU 32.5 vs. 36.7; p=0.007; n=160 non-contrast series); SMA was comparable (p=0.40).</div></div><div><h3>Conclusions</h3><div>NLP enables accurate prevalence estimation of hepatic steatosis in large hospital cohorts. Reported steatosis was associated with higher visceral adiposity and lower muscle quality, a profile that may guide targeted interventions in populations identified through opportunistic CT detection.</div></div>","PeriodicalId":7979,"journal":{"name":"Annals of hepatology","volume":"31 ","pages":"Article 102345"},"PeriodicalIF":6.2,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148810642","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"#155 - ASSOCIATION BETWEEN SERUM VITAMIN D LEVELS AND HEPATIC DECOMPENSATIONS IN ADVANCED CHRONIC LIVER DISEASE: A MULTICENTER RETROSPECTIVE STUDY","authors":"Jesus Mazadiego,&nbsp;María Herrero,&nbsp;Fatima Higuera,&nbsp;Rodrigo Vazquez,&nbsp;César Miranda,&nbsp;Rogelio Zapata,&nbsp;Gerardo Kato,&nbsp;Scherezada Mejia","doi":"10.1016/j.aohep.2026.102279","DOIUrl":"10.1016/j.aohep.2026.102279","url":null,"abstract":"<div><h3>Introduction and Objectives</h3><div>Vitamin D deficiency has been associated with cirrhotic immune dysfunction and hepatic decompensation. This study evaluated the association between serum 25(OH)D levels and hepatic decompensations in advanced chronic liver disease.</div></div><div><h3>Materials and Methods</h3><div>A retrospective multicenter study was conducted in two tertiary-care hospitals between 2023 and 2025. Adult patients with advanced chronic liver disease and available serum 25(OH)D measurements were included. Hepatic decompensations evaluated included ascites, spontaneous bacterial peritonitis (SBP), variceal bleeding, hepatic encephalopathy, and acute kidney injury (AKI). Effect size was estimated using Hedges’ g. Multivariate logistic regression models adjusted for liver disease severity and clinically relevant confounders were performed.</div></div><div><h3>Results</h3><div>A total of 191 patients were included, of whom 40.3% had vitamin D deficiency. Patients with hepatic decompensations showed significantly lower serum 25(OH)D levels (Table 1). An inverse association was observed between vitamin D levels and decompensation burden. The strongest association was identified for SBP (Hedges’ g = 1.56), followed by ascites (g = 0.83), variceal bleeding (g = 0.64), hepatic encephalopathy (g = 0.45), and AKI (g = 0.41). In multivariate analysis, serum vitamin D levels remained independently associated with SBP (OR 0.822; 95%CI 0.768–0.879; p&lt;0.001), ascites (OR 0.929; p&lt;0.001), variceal bleeding (OR 0.946; p=0.003), and AKI (OR 0.960; p=0.035) (Figure 1).</div></div><div><h3>Conclusions</h3><div>Lower serum vitamin D levels were independently associated with hepatic decompensations, particularly SBP. These findings suggest that vitamin D deficiency may represent an integrated biomarker of cirrhotic immune dysfunction and disease progression.</div></div>","PeriodicalId":7979,"journal":{"name":"Annals of hepatology","volume":"31 ","pages":"Article 102279"},"PeriodicalIF":6.2,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148810647","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}