PRIMARY MALIGNANT LIVER TUMORS: A 20-YEAR RETROSPECTIVE POSTMORTEM REVIEW

IF 4.4 3区医学 Q2 GASTROENTEROLOGY & HEPATOLOGY

Annals of hepatology Pub Date : 2025-09-01 DOI:10.1016/j.aohep.2025.102007

Jessica Mejía Ramírez , Fatima Higuerade la Tijera , Gerardo Aristi Urista , A. Paola Escobedo Zuñiga , Paola Daniela Guerrero Ramírez , Félix Alberto Pérez Cardenas , Jose Luis Pérez Hernández

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引用次数: 0

Abstract

Introduction and Objectives

Primary malignant liver tumors represent one of the leading causes of cancer-related mortality worldwide. Their incidence has increased over recent decades, paralleling the rise in chronic liver diseases.

To determine the prevalence of different non-metastatic primary malignant liver tumors found in autopsies performed between 2003 and 2023 at a tertiary care center.

Materials and Methods

A retrospective, descriptive, observational study of autopsies performed in the pathology department of a tertiary care center between 2003 and 2023. Descriptive statistics were used, including measures of central tendency and dispersion.

Results

Autopsy was performed on 10,139 patients, 126 (1.24%) were classified as malignant primary liver tumors with 63±12 years, 52 females (41.3%) and 74 males (58.7%) and were distributed as follows: Hepatocarcinoma 99 (78.5%) with 63±12 years, 39 women (38.6%) and 60 men (59.4%); 38 (37.6%) had metastases mainly in lung followed by lymph nodes, only 9% were not related to cirrhosis; Intrahepatic cholangiocarcinoma 24 (19%) with 65 ±14 years, 12 males (50%), 12 females (50%), 70.8% had pulmonary metastases and 47.8% were not related to cirrhosis.Hepatic primitive neuroectodermal tumor 2 (1.59%) with 54 ±5.6 years with pleural and pulmonary metastases. Fibrolamellar carcinoma 1 (0.79%) with 24 years and metastasis in lymph nodes.

Conclusions

The prevalence of liver tumors in autopsy is low, the most prevalent being hepatocarcinoma followed by cholangiocarcinoma.

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原发性恶性肝脏肿瘤：20年回顾性尸检回顾

简介和目的原发性恶性肝肿瘤是全球癌症相关死亡的主要原因之一。近几十年来，这些疾病的发病率一直在上升，与慢性肝病的发病率上升相当。确定2003年至2023年在三级医疗中心进行的尸检中发现的不同非转移性原发性恶性肝肿瘤的患病率。材料和方法回顾性、描述性、观察性研究2003年至2023年在三级医疗中心病理部门进行的尸检。使用描述性统计，包括集中趋势和离散度的测量。结果共解剖10139例患者，其中原发性恶性肝肿瘤126例（1.24%），年龄63±12岁，女性52例（41.3%），男性74例（58.7%），分布如下：肝癌99例（78.5%），年龄63±12岁，女性39例（38.6%），男性60例（59.4%）；38例（37.6%）以肺转移为主，其次为淋巴结转移，与肝硬化无关的仅有9%；肝内胆管癌24例（19%），年龄65±14岁，男性12例（50%），女性12例（50%），70.8%发生肺转移，47.8%与肝硬化无关。肝原始神经外胚层肿瘤2例（1.59%），54±5.6年伴胸膜和肺转移。纤维板层癌1(0.79%)，24年，淋巴结转移。结论肝脏肿瘤在尸检中的检出率较低，以肝癌居首，其次为胆管癌。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Annals of hepatology 医学-胃肠肝病学

CiteScore

7.90

自引率

2.60%

发文量

183

审稿时长

4-8 weeks

期刊介绍： Annals of Hepatology publishes original research on the biology and diseases of the liver in both humans and experimental models. Contributions may be submitted as regular articles. The journal also publishes concise reviews of both basic and clinical topics.