{"title":"Intranasal Dexmedetomidine on Post-operative Pain and Swelling after Third Molar Impaction Surgery - A Comparative Study.","authors":"Ramadevi Matta, Divya Puvvada, Shivaji Raju Uddarraju, Kishore Moturi, Anil Budumuru, Sravani Pampana, Sravani Malapati","doi":"10.4103/ams.ams_101_25","DOIUrl":"10.4103/ams.ams_101_25","url":null,"abstract":"<p><strong>Introduction: </strong>Surgical removal of impacted mandibular third molars often results in post-operative discomfort, including pain, swelling and trismus. Dexmedetomidine, an alpha-2 adrenergic agonist, offers analgesic and sedative benefits with minimal respiratory depression. Its intranasal (IN) use in oral surgery remains underexplored. This study evaluates the efficacy and safety of intranasal dexmedetomidine (IN DEX) in managing post-operative pain, swelling, sedation and haemodynamic parameters in third molar surgery.</p><p><strong>Materials and methods: </strong>A randomised, double-blind, split-mouth controlled trial was conducted in a tertiary dental teaching hospital. Forty-eight healthy patients aged 18-40 underwent bilateral mandibular third molar extractions across two sessions. One side received IN DEX (1 μg/kg); the contralateral side received a saline placebo. Pain was measured using the Visual Analogue Scale, swelling by five-line facial measurements, sedation by the Modified Observer Assessment of Alertness/Sedation (OAA/S) scale, and haemodynamic parameters were monitored perioperatively.</p><p><strong>Results: </strong>Data were analysed using paired <i>t</i>-tests and repeated measures ANOVA. <i>P</i> < 0.05 was considered statistically significant. Pain scores were significantly lower with IN DEX at 6, 12 and 24 h (<i>P</i> < 0.001). Peak sedation occurred at 40 min without respiratory compromise. IN DEX caused transient hypotension and bradycardia from 20 to 50 min. Swelling reduction was not statistically significant.</p><p><strong>Discussion: </strong>IN DEX is a safe, non-invasive adjunct that effectively manages short-term pain and sedation in third molar surgeries, especially in moderate to severe anxiety patients, with stable respiratory function and manageable haemodynamic changes. It may be a promising addition to multimodal analgesic protocols in oral surgery.</p>","PeriodicalId":7972,"journal":{"name":"Annals of Maxillofacial Surgery","volume":"15 2","pages":"149-154"},"PeriodicalIF":0.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12919877/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147269244","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Custom-made Total Joint Replacement for the Management of Recurrent Bilateral Temporomandibular Joint Ankylosis - A Retrospective Study.","authors":"Mohammed Hasan Osman","doi":"10.4103/ams.ams_65_25","DOIUrl":"10.4103/ams.ams_65_25","url":null,"abstract":"<p><strong>Introduction: </strong>Recurrent bilateral temporomandibular joint (TMJ) ankylosis poses a significant challenge due to limited treatment options and extensive functional impairment. Alloplastic total joint replacement (TJR) represents a potential solution, particularly custom-made devices that allow for precise anatomical reconstruction. However, data on the efficacy of custom-made TJR in this specific population remains limited. This study aimed to evaluate the functional outcomes of custom-made alloplastic TJR in managing recurrent bilateral TMJ ankylosis. Specific outcomes assessed include maximal incisal opening (MIO), postsurgical malocclusion, heterotopic bone formation and dietary restriction patient satisfaction.</p><p><strong>Materials and methods: </strong>This study was a retrospective study on six patients who underwent custom-made alloplastic TJR for recurrent bilateral TMJ ankylosis at a single institution. Preoperative and postoperative MIO and dietary restrictions were evaluated. Radiographic assessments, complications, patient satisfaction and quality of life after surgery were documented.</p><p><strong>Results: </strong>Custom-made TJR resulted in a significant increase in mean MIO from 5.5 mm (standard deviation [SD]: 5.54 mm) preoperatively to 35.17 mm (SD: 2.99 mm) at 1-year follow-up. All patients demonstrated improvement in dietary restrictions. The radiographic assessment showed stable prostheses. No major complications were observed, and all patients reported satisfaction with the surgical outcome.</p><p><strong>Discussion: </strong>This study suggests that custom-made alloplastic TJR is a viable treatment option for patients with recurrent bilateral TMJ ankylosis, leading to substantial improvements in mouth opening, pain reduction and overall function. Larger, prospective, multi-centre studies are needed to confirm these findings and further evaluate the long-term outcomes.</p>","PeriodicalId":7972,"journal":{"name":"Annals of Maxillofacial Surgery","volume":"15 2","pages":"207-212"},"PeriodicalIF":0.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12919876/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147269557","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Lida Mary Nidhin Philip, Vikas Dhupar, Francis Akkara, Nidhin Philip Jose, Srikant Natarajan
{"title":"Fracture Fixation Using Three-dimensional Plate versus Two-dimensional Plate in Mandibular Angle Fractures - A Comparative Study.","authors":"Lida Mary Nidhin Philip, Vikas Dhupar, Francis Akkara, Nidhin Philip Jose, Srikant Natarajan","doi":"10.4103/ams.ams_34_25","DOIUrl":"10.4103/ams.ams_34_25","url":null,"abstract":"<p><strong>Introduction: </strong>Management of mandibular fractures has changed over time, yet controversy still exists regarding the optimal treatment. Presently, open reduction and internal fixation is the mainstay of treatment and is achievable with different plating systems.</p><p><strong>Materials and methods: </strong>This is a clinical comparative study to compare the treatment outcomes using three-dimensional (3D) plate versus two-dimensional plate for management of mandibular angle fractures. Thirty cases of mandibular angle fractures were randomly divided into two groups. Routine follow-up was done post-operatively at the intervals of 1 week, 3 months and 6 months. Surgical time, pre- and post-operative occlusion and mouth opening were recorded. Patients were assessed for post-operative complications. Radiographic tracing pre- and post-operatively was done on the pre-operative panoramic to evaluate the gap between the bony segments.</p><p><strong>Results: </strong>Mouth opening improved significantly in both the groups. There was no statistically significant difference in surgical time between both the groups. The fracture line tracings used to evaluate the gap between the bony segments showed that the gap between the bony segments measured at point A was significantly lesser compared to that in Group II (<i>P</i> = 0.04; statistically significant). However, we noted no difference at the other points. There was no statistically significant difference in post-operative mobility, occlusion and post-operative complications between the groups.</p><p><strong>Discussion: </strong>3D plates offered better occlusal stability, thereby avoiding the need for inter-maxillary fixation and ensuring early restoration of mandibular function. It is an easy alternative to conventional titanium miniplates and has low morbidity and infection rates.</p>","PeriodicalId":7972,"journal":{"name":"Annals of Maxillofacial Surgery","volume":"15 2","pages":"137-142"},"PeriodicalIF":0.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12919866/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147269532","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"A Reflection on the Relevance of Bioethics in Current Oral and Maxillofacial Surgery - A Short Communication.","authors":"Martín Fernández-Ferro","doi":"10.4103/ams.ams_114_25","DOIUrl":"10.4103/ams.ams_114_25","url":null,"abstract":"<p><p>In today's medicine, decisions may not be so simple or unequivocal. The debate forested by scientific development is not alien to the needs of human beings. Now more than ever, new disciplines such as bioethics are gaining relevance in the face of these scientific, technical and biomedical advances that challenge professionals regarding moral and ethical limits. All these uncertainties will be the subject of deliberation and debate. Currently, it is necessary for health professionals to have the necessary tools to reflect and decide on issues such as respect, dignity and the autonomy of people.</p>","PeriodicalId":7972,"journal":{"name":"Annals of Maxillofacial Surgery","volume":"15 2","pages":"269-270"},"PeriodicalIF":0.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12919875/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147269547","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"From Radiation to Weight Loss: The Self-perpetuating Cycle of Oral Mucositis: Insights from a Pilot Institutional Study.","authors":"Mohsina Hussain, Vishal Rana, Saurabh Chandalia, Humsini Ramprasad, Sirshendu Roy, Raj Nagarkar, Mayuresh Virkar","doi":"10.4103/ams.ams_200_24","DOIUrl":"10.4103/ams.ams_200_24","url":null,"abstract":"<p><strong>Introduction: </strong>Globally, head-and-neck cancers are the sixth most prevalent type of cancer, most frequently found in developing countries. Treatment modalities include surgery, radiotherapy (RT) or chemotherapy, either alone or in combination. Approximately two-thirds of these patients receive radiation therapy as part of their treatment approach. The pathological changes at the tumour site, along with acute toxic reactions to radiation therapy, can result in decreased taste sensitivity and harm to the oral mucosa can lead to conditions such as mucositis, xerostomia, pain and difficulties in swallowing and decreased mouth opening. Our aim is to evaluate the correlation between increasing weight loss and the escalating severity of mucositis, as this vicious cycle significantly affects patient outcomes and quality of life, as discussed in this paper.</p><p><strong>Materials and methods: </strong>We conducted a prospective pilot study from February 2024 to July 2024, during which we observed and gathered data from 50 consecutive patients with oral cancer and its various subsites with proven histopathology of squamous cell carcinoma who underwent adjuvant radiation or chemoradiation therapy (CRT) three to 6 weeks following surgical tumour resection.</p><p><strong>Results: </strong>The sample size consisted of patients who received adjuvant CRT and adjuvant RT only. The incidence of weight loss and the severity of mucositis is directly linked with each other.</p><p><strong>Discussion: </strong>The inference of this study is that weight management during adjuvant therapy leads to lesser radiation toxicity.</p>","PeriodicalId":7972,"journal":{"name":"Annals of Maxillofacial Surgery","volume":"15 2","pages":"192-197"},"PeriodicalIF":0.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12919865/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147269502","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Knotless Suture for Primary Wound Closure Following Surgical Removal of Impacted Mandibular Third Molars - A Comparative Study.","authors":"Aayushi Nimishbhai Vora, Neha Vyas, Nitu Shah, Darshan Patel, Prashant Malik, Akansha Bhatia","doi":"10.4103/ams.ams_3_25","DOIUrl":"10.4103/ams.ams_3_25","url":null,"abstract":"<p><strong>Introduction: </strong>Surgical extraction of impacted third molars is a common procedure in maxillofacial surgery. Wound closure is typically achieved using knotted sutures, which require time and may lead to knot-related complications. Knotless sutures, widely used in various surgical fields, offer potential benefits for intraoral applications. This study evaluated the clinical utility of knotless sutures following third molar surgery.</p><p><strong>Materials and methods: </strong>A randomised split-mouth clinical study was conducted on 29 patients undergoing bilateral mandibular third molar removal. Each patient received two types of sutures: knotless polyglyconate barbed sutures and control group: knotted polyglactin 910 sutures. Parameters assessed included suturing time, pain and discomfort during suturing (via Visual Analogue Scale) and post-operative outcomes on day 7, soft tissue healing (Modified Landry Index), wound dehiscence, facial swelling and maximum interincisal opening.</p><p><strong>Results: </strong>The knotless group showed significantly reduced suturing time and lower pain and discomfort scores. Improved soft tissue healing and reduced wound dehiscence were observed compared to the control group. No significant difference was found in facial swelling or mouth opening between the groups.</p><p><strong>Discussion: </strong>Knotless sutures are effective for intraoral wound closure after third molar extraction. They reduce operative time, minimise patient discomfort and enhance wound healing, offering a viable alternative to conventional knotted sutures.</p>","PeriodicalId":7972,"journal":{"name":"Annals of Maxillofacial Surgery","volume":"15 2","pages":"155-158"},"PeriodicalIF":0.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12919879/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147269478","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Adenoid Cystic Carcinoma of the External Auditory Canal and Temporomandibular Joint - A Case Report.","authors":"S M Balaji, Pritty Gobin, Preetha Balaji","doi":"10.4103/ams.ams_136_25","DOIUrl":"10.4103/ams.ams_136_25","url":null,"abstract":"<p><strong>Rationale: </strong>Adenoid cystic carcinoma (AdCC) of external auditory canal (EAC) is a rare malignancy. It presents significant diagnostic and surgical challenges due to complex anatomy and functional implications.</p><p><strong>Patient concerns: </strong>A 39-year-old female presented with progressive left ear pain, hearing loss and discharge, initially treated as otitis media.</p><p><strong>Diagnosis: </strong>Subsequent investigations confirmed AdCC of the EAC extending to the temporomandibular joint (TMJ).</p><p><strong>Treatment: </strong>The patient underwent wide local excision of the EAC AdCC lesion, including a superficial parotidectomy and partial TMJ tissue removal, guided by frozen section analysis. Final histopathology confirmed clear surgical margins across all 26 evaluated samples.</p><p><strong>Outcome: </strong>Post-operative recovery was uneventful with no residual disease or metastasis by 6 months. The patient reported mild trismus with preserved jaw function.</p><p><strong>Take-away lessons: </strong>Early diagnosis and multidisciplinary management are critical for EAC AdCC with TMJ involvement. Meticulous surgical planning, clear resection margins and vigilant follow-up are crucial for optimal outcomes.</p>","PeriodicalId":7972,"journal":{"name":"Annals of Maxillofacial Surgery","volume":"15 2","pages":"256-260"},"PeriodicalIF":0.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12919871/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147269544","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Clinical Biomarker Variations in Edentulous Patients Undergoing Prosthetic Rehabilitation - A Prospective Study.","authors":"Bharath B Nandan, Pankaj Dhawan, Sapna Rani","doi":"10.4103/ams.ams_226_24","DOIUrl":"10.4103/ams.ams_226_24","url":null,"abstract":"<p><strong>Introduction: </strong>Complete edentulism compromises masticatory efficiency, leading to nutritional deficiencies and systemic health impacts. This study aimed to evaluate variations in serum iron, total iron-binding capacity (TIBC) and alkaline phosphatase (ALP) levels amongst edentulous patients rehabilitated with removable partial dentures (control group), conventional complete dentures or mandibular implant-supported overdentures (ISO).</p><p><strong>Materials and methods: </strong>A randomised clinical trial was conducted on 30 patients aged 50-70 years. Participants were allocated into three groups: partially edentulous patients with removable partial dentures (Group 1, <i>n</i> = 10), completely edentulous patients rehabilitated with conventional dentures (Group 2, <i>n</i> = 10) and those with mandibular ISO (Group 3, <i>n</i> = 10). Serum markers were measured at baseline and after 3 months.</p><p><strong>Results: </strong>At baseline, Group 1 showed the highest serum iron (108.9 μg/dL), TIBC (311.5 μg/dL) and ALP (91.6 IU/L) levels (<i>P</i> < 0.05). At follow-up, serum iron improved significantly in Groups 2 and 3, with Group 3 showing the greatest increase (<i>P</i> = 0.001). TIBC levels increased significantly in Groups 1 and 3 (<i>P</i> < 0.05). ALP levels increased in Group 2 (<i>P</i> = 0.001) but remained stable in Group 3, suggesting reduced bone remodelling.</p><p><strong>Discussion: </strong>Prosthetic rehabilitation significantly influences serum iron, TIBC and ALP levels. ISO demonstrated superior benefits in nutritional and bone health compared to conventional dentures, underscoring their systemic advantages. Long-term studies are recommended to validate these findings.</p>","PeriodicalId":7972,"journal":{"name":"Annals of Maxillofacial Surgery","volume":"15 2","pages":"186-191"},"PeriodicalIF":0.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12919864/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147269509","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ovidiu Ionut Saracutu, Luca Guarda-Nardini, Marco Ferrari, Daniele Manfredini, Matteo Val
{"title":"Misdiagnosed Uterine Leiomyosarcoma with Metastasis to the Left Condylar Neck - A Case Report.","authors":"Ovidiu Ionut Saracutu, Luca Guarda-Nardini, Marco Ferrari, Daniele Manfredini, Matteo Val","doi":"10.4103/ams.ams_179_24","DOIUrl":"10.4103/ams.ams_179_24","url":null,"abstract":"<p><strong>Rationale: </strong>This is a case of metastatic leiomyosarcoma (LMS) lesion of the condyle arising from a primary LMS of the uterus in a 43-year-old woman.</p><p><strong>Patient concern: </strong>The patient presented an uncommon clinical manifestation not justified by the presence of a leiomyoma.</p><p><strong>Diagnosis: </strong>The diagnostic process revealed that the patient was affected by uterine LMS, previously misdiagnosed as a leiomyoma, with a secondary metastasis of the left temporomandibular joint condyle.</p><p><strong>Treatment: </strong>Surgery was proposed with total excision of the lesion and parotidectomy, together with radiotherapy and chemotherapy as adjuvant therapy.</p><p><strong>Outcome: </strong>One month after the start of the treatment, the systemic condition of the patient started to quickly worsen, and she passed away due to complications associated with the disease.</p><p><strong>Take-away lessons: </strong>Given the uncommon clinical scenario that the patient presented, guidelines for temporomandibular disorder should also include better indications on how to screen and intercept such possible life-threatening conditions.</p>","PeriodicalId":7972,"journal":{"name":"Annals of Maxillofacial Surgery","volume":"15 2","pages":"252-255"},"PeriodicalIF":0.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12919886/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147269489","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Guido Lobbia, Silvia Difonzo, Dario Ventorre, Walter Decaminada, Antonio D'Agostino, Lorenzo Trevisiol
{"title":"Mandibular Metastasis from Undiagnosed Hepatocellular Carcinoma - A Case Report.","authors":"Guido Lobbia, Silvia Difonzo, Dario Ventorre, Walter Decaminada, Antonio D'Agostino, Lorenzo Trevisiol","doi":"10.4103/ams.ams_98_25","DOIUrl":"10.4103/ams.ams_98_25","url":null,"abstract":"<p><strong>Rationale: </strong>Cancer metastatic to the oral cavity accounts for 1%-4% of all oral malignancies, spreading from a distant primary site. Nevertheless, oral metastasis is often the first presentation of primary cancer.</p><p><strong>Patient concerns: </strong>A 53-year-old male was referred to our institution because of painful swelling of the left parotid region that did not respond to medications. A firm mass extending towards the mandbular angle had caused trismus; furthermore, the patient complained about hypoesthesia in the V3 area. No noticeable findings could be seen intraorally.</p><p><strong>Diagnosis: </strong>Computed tomography imaging showed non-homogeneous post-contrast enhancement of the left vertical mandible branch; moreover, there were clear signs of bone erosion and swelling of the contiguous soft tissues.</p><p><strong>Treatment: </strong>Biopsy was performed under general anaesthesia, through a transoral approach.</p><p><strong>Outcomes: </strong>Histology and immunohistochemical analysis revealed hepatocellular carcinoma metastatis.</p><p><strong>Take-away lessons: </strong>In the differential diagnosis of oral neoplasms, metastasis coming from a distant site should always be taken into consideration.</p>","PeriodicalId":7972,"journal":{"name":"Annals of Maxillofacial Surgery","volume":"15 2","pages":"265-268"},"PeriodicalIF":0.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12919857/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147269483","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}