Annals of Maxillofacial Surgery最新文献

{"title":"Vital Staining Role in Resection and Reconstruction of Tongue Cancers with Free Flap - A Comparative Study.","authors":"Meghana Sri Ravali Puranapanda, Ananth Nag Jakkula, Tarun Gogineni, Srikanth Damera, Ganga Kishore Vatti","doi":"10.4103/ams.ams_62_23","DOIUrl":"10.4103/ams.ams_62_23","url":null,"abstract":"<p><strong>Introduction: </strong>The purpose of this study is to compare and infer the most suitable dye for visualisation of ipsilateral and contralateral sentinel lymph nodes (SLNs), positive, negative outcomes, sensitivity, their specificities and visualisation of anastomosed blood vessels in microvascular reconstruction of tongue cancers.</p><p><strong>Materials and methods: </strong>This is a prospective <i>in vivo</i> comparative study involving twenty patients diagnosed with squamous cell carcinoma of the tongue treated with wide excision of primary tongue tumour, modified functional neck dissection and microvascular reconstruction with radial forearm free flap. Consecutive random allocation was done into two groups with ten patients each. Patients were injected with methylene blue as the first group and near-infrared fluorescence indocyanine green (ICG) into the second. The patients were evaluated intraoperatively regarding the better dye in methylene blue and ICG for identification of ipsilateral and contralateral SLNs, their positive, negative outcomes, sensitivity and specificities. Apart from these, in cases of group B, after microvascular transfers, ICG is used for visualisation of anastomosed vessels to prevent abnormal perfusions, leaks and post-flap failures. Descriptive statistics, independent samples <i>t</i>-test, and Chi-square were used for statistical analysis.</p><p><strong>Results: </strong>The present study revealed ICG being the better dye in the parameters mentioned.</p><p><strong>Discussion: </strong>Lymph node yield in neck dissection is a prognostic factor in oral cancers. ICG is inferred as the better dye for identification of SLN with 100% outcomes and in blood vessel visualisation after microvascular free tissue transfers. It is also useful in identifying positive contralateral sentinel nodes, which is helpful in undertaking bilateral neck dissections related to tongue carcinoma.</p>","PeriodicalId":7972,"journal":{"name":"Annals of Maxillofacial Surgery","volume":"14 2","pages":"154-159"},"PeriodicalIF":0.0,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11828046/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143432374","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Accidental Infratemporal Displacement of Maxillary Third Molar during Impaction - A Case Report.","authors":"S M Balaji, Preetha Balaji, Vinodhini Priyanka","doi":"10.4103/ams.ams_125_24","DOIUrl":"10.4103/ams.ams_125_24","url":null,"abstract":"<p><strong>Rationale: </strong>There are very limited literature on successful removal of displaced maxillary third molar (MTM) into the infratemporal fossa (ITF) after a surgical misadventure. A corrective surgery of one such case, including the pre-operative planning, has been presented in this case report.</p><p><strong>Patient concerns: </strong>A 43-year-old male presented with a displaced right MTM following an attempted extraction elsewhere approximately 20 days ago.</p><p><strong>Diagnosis: </strong>Imaging revealed the tooth in the ITF, behind the posterior wall of the maxillary sinus with the resultant diagnosis of iatrogenic displacement of MTM into the ITF during attempted removal.</p><p><strong>Treatment: </strong>The patient underwent successful removal of the displaced tooth under general anaesthesia after proper planning.</p><p><strong>Outcomes: </strong>Displaced MTM was removed, and healing was uneventful with pain management and antibiotics.</p><p><strong>Take-away lessons: </strong>This case highlights the need for careful surgical technique during MTM removal and contributes to the limited literature on managing such complications.</p>","PeriodicalId":7972,"journal":{"name":"Annals of Maxillofacial Surgery","volume":"14 2","pages":"258-260"},"PeriodicalIF":0.0,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11828053/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143432012","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Orthodontic-Surgical Management of Triple Impacted Mesiodens and Maxillary Incisors - A Case Report.","authors":"K R Ashok Kumar, S Varsha, R Mahesh Kumar, B Jambukeshwar Kumar, Supriyo Pal, Swadhinata Handique","doi":"10.4103/ams.ams_98_24","DOIUrl":"10.4103/ams.ams_98_24","url":null,"abstract":"<p><strong>Rationale: </strong>Mesiodens are supernumerary teeth located in the pre-maxilla between the two central incisors with a prevalence rate of 0.15-1.9%. An impacted mesiodens may cause delayed eruption of permanent incisors, ectopic eruption, pathological disturbances and malalignment of teeth.</p><p><strong>Patient concerns: </strong>The patient complained of missing upper front teeth associated with pain in the same region for two weeks.</p><p><strong>Diagnosis: </strong>Upon clinical and radiographic examination, it was diagnosed as triple impacted mesiodens with impacted permanent maxillary central incisors.</p><p><strong>Treatment: </strong>The clinicians in the study approached the issue by surgical removal of the impacted mesiodens and orthodontic treatment for extrusion of the impacted permanent maxillary central incisors.</p><p><strong>Outcomes: </strong>The patient was relieved of the pre-operative concerns and followed up regularly for the eruption of permanent maxillary central incisors.</p><p><strong>Take-away lessons: </strong>The authors advocate the importance of timely diagnosis and proper management of such rare pathologies.</p>","PeriodicalId":7972,"journal":{"name":"Annals of Maxillofacial Surgery","volume":"14 2","pages":"255-257"},"PeriodicalIF":0.0,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11828061/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143432298","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Salivary Levels of Malondialdehyde and Total Antioxidant Capacity Following Third Molar Surgery - An Evaluative Study.","authors":"Seyyed Amir Seyyedi, Mir Mehdi Seyyed Ashrafi, Yousef Rasmi, Amir Ali Marzban, Saman Taram","doi":"10.4103/ams.ams_129_23","DOIUrl":"10.4103/ams.ams_129_23","url":null,"abstract":"<p><strong>Introduction: </strong>Impacted and semi-impacted third molar surgery can lead to considerable distress and discomfort in patients.</p><p><strong>Aims: </strong>The present study aimed to assess the changes in salivary levels of malondialdehyde (MDA) and total antioxidant capacity (TAC) after third molar surgery.</p><p><strong>Materials and methods: </strong>In this study, 210 patients scheduled for third molar surgery were selected. Unstimulated whole saliva samples were collected from patients preoperatively and one week after the surgery, via the 'spitting method'. The collected samples were immediately centrifuged and the supernatants were stored at -20°C until testing. The levels of MDA and TAC were measured with a spectrophotometer.</p><p><strong>Results: </strong>The results were presented as mean ± standard deviation and paired <i>t</i>-test was used to statistically analyse the changes in pre-operative and post-operative values of MDA and TAC. A decrease of mean salivary TAC (<i>P</i> = 0.031) and an increase of mean salivary MDA (<i>P</i> = 0.034) were detected postoperatively.</p><p><strong>Discussion: </strong>Following third molar surgery, the increase of mean salivary MDA and the decrease of mean salivary TAC were detected; however, these changes were not statistically significant.</p>","PeriodicalId":7972,"journal":{"name":"Annals of Maxillofacial Surgery","volume":"14 2","pages":"196-199"},"PeriodicalIF":0.0,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11828071/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143432368","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of Bleeding Time after Dental Extractions during Uninterrupted Single or Dual Antiplatelet Treatment - A Comparative Study.","authors":"Nitin Anand Krishnan, S Vijay Kumar, Aarya H Nair, M Remya, Reuben Bensy Thomas, K S Deepak, P S Indu","doi":"10.4103/ams.ams_31_24","DOIUrl":"10.4103/ams.ams_31_24","url":null,"abstract":"<p><strong>Introduction: </strong>This study aimed to assess the duration of bleeding after dental extractions amongst subjects with uninterrupted single antiplatelet therapy and dual antiplatelet therapy (DAPT) and to compare the bleeding time after dental extractions amongst those subjects undergoing various antiplatelet therapies.</p><p><strong>Materials and methods: </strong>Post-extraction bleeding time was categorised as within 30 min, within 1 h and within 24 h. The bleeding time in different categories was compared and analysed using Chi-square. The antiplatelet agents assessed were aspirin, clopidogrel, ticagrelor and a combination of aspirin with clopidogrel and ticagrelor.</p><p><strong>Results: </strong>Bleeding time was significantly higher in patients under DAPT, compared to those under single antiplatelet therapy, and with an increase in the number of teeth extracted, there was an increase in bleeding time. All cases with prolonged bleeding could be managed with local haemostatic measures.</p><p><strong>Discussion: </strong>Simple extraction can be undertaken safely in patients under single antiplatelet therapy, considering that local haemostatic measures are available for use in the setup to control bleeding if necessary. Patients under DAPT are better managed if the therapy is altered, as there was a definite increase in bleeding time in patients under DAPT after extraction.</p>","PeriodicalId":7972,"journal":{"name":"Annals of Maxillofacial Surgery","volume":"14 2","pages":"137-140"},"PeriodicalIF":0.0,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11828070/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143432145","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of the Vertical Loop of the Inferior Alveolar Nerve at the Mental Foramen Region - A Retrospective Study.","authors":"B R Rajanikanth, Kavitha Prasad, Saumya Kapoor, Aakriti Choudhary","doi":"10.4103/ams.ams_89_24","DOIUrl":"10.4103/ams.ams_89_24","url":null,"abstract":"<p><strong>Introduction: </strong>The objective of this study was to assess the vertical loop of the inferior alveolar nerve (IAN) at the mental foramen region by measuring the vertical height of the loop from the lower border of the IAN canal to that of the lower border of the mental foramen using cone-beam computed tomography (CBCT) scan.</p><p><strong>Materials and methods: </strong>A retrospective study was conducted using CBCT scans of 541 patients aged 18 years and above from March 2015 to March 2022. These scans were analysed to determine the height of the vertical loop of IAN at the mental foramen.</p><p><strong>Results: </strong>Statistically significant value was obtained, with the highest value being 11.6 mm and a mean value of 3.81 mm. The right-side vertical loop of IAN at the mental foramen region was significantly higher in males (3.92 ± 1.78) than in females (3.59 ± 1.42). Statistically significant results were obtained on both sides amongst the different age groups.</p><p><strong>Discussion: </strong>The vertical loop at the mental foramen region is considered to be significant for planning and performing various oral and maxillofacial surgical procedures. A CBCT is a must, but in its absence, a safety zone of 7-10 mm is to be allowed to prevent inadvertent nerve damage.</p>","PeriodicalId":7972,"journal":{"name":"Annals of Maxillofacial Surgery","volume":"14 2","pages":"175-179"},"PeriodicalIF":0.0,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11828047/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143432147","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intraparotid Facial Nerve Schwannoma - A Case Report.","authors":"Yekula Kiran Kumar, Yadavalli R D Rajan","doi":"10.4103/ams.ams_53_23","DOIUrl":"10.4103/ams.ams_53_23","url":null,"abstract":"<p><strong>Rationale: </strong>Intraparotid facial nerve schwannoma (IPFNS) is a rare entity. Diagnosing these tumours is challenging as multiple differential diagnoses exist for swellings in the infraauricular region. Delay in diagnosis can lead to adverse outcomes.</p><p><strong>Patient concerns: </strong>A 27-year-old female presented with swelling over the left infraauricular region, which concerned her cosmetic appearance.</p><p><strong>Diagnosis: </strong>It was initially misdiagnosed with imaging techniques computerised tomography (CT scan) and fine-needle aspiration cytology, leading to a diagnostic dilemma.</p><p><strong>Treatment: </strong>Superficial parotidectomy was planned and intraoperatively, a cystic lesion was seen adherent to the temporal branch of the facial nerve, which was resected along with the nerve branch. Histopathology confirmed the diagnosis as facial nerve schwannoma.</p><p><strong>Outcomes: </strong>The patient's cosmetic concern was resolved but there was loss of wrinkles over the ipsilateral forehead region. No recurrence was seen.</p><p><strong>Take-away lessons: </strong>IPFNS often causes a diagnostic dilemma and an appropriate and timely diagnosis is required to decrease the morbidity and undertreatment.</p>","PeriodicalId":7972,"journal":{"name":"Annals of Maxillofacial Surgery","volume":"14 2","pages":"252-254"},"PeriodicalIF":0.0,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11828062/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143432279","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Melanocytic Neuroectodermal Tumour of Infancy-A Rare Case Report.","authors":"Ratna Kumari Beeram, Busa Vamshidhar, Sareen Seelam, Kotya Naik Maloth, Kundoor Vinay Kumar Reddy, Moni Thakur","doi":"10.4103/ams.ams_120_24","DOIUrl":"10.4103/ams.ams_120_24","url":null,"abstract":"<p><strong>Rationale: </strong>Melanotic neuroectodermal tumour of infancy (MNTI) is an unusual, rapid growing, pigmented tumour of neural crestal origin that is seen in infants. It is more common in males with predilection for the maxilla and an unpredictable malignant potential. It constitutes a great challenge in diagnosis, treatment planning and prognosis.</p><p><strong>Patient concerns: </strong>This is a case of MTNI in a 5-month-old female child, who presented to the Department of Oral and Maxillofacial Surgery with progressive swelling on the right side of the upper jaw over the last two weeks with 'teeth floating appearance on imaging'.</p><p><strong>Diagnosis: </strong>There was significant extraoral diffuse swelling and facial asymmetry. Intraorally a well-defined mass noted on alveolar ridge of anterior maxilla and hard palate, crossing midline and associated with unerupted teeth. A subsequent contrast-enhanced computed tomography (CECT) scan and 3D CT scan revealed an expansile radiolucent lesion involving the right maxilla with destruction of cortical bone and displacement of primary central, lateral, canine and molar teeth, which appeared as a 'free-floating teeth appearance' in axial and coronal sections, confirmed by an open biopsy as Melanotic neuro-ectodermal tumour of infancy. Immunohistochemistry was used for precise diagnosis due to biopsy sample limitations and tumour variability.</p><p><strong>Interventions: </strong>Surgical resection was done after obtaining informed consent from the parents under general anaesthesia. The removal of unerupted primary central and lateral incisors, canine and molar teeth and also peripheral ostectomy was done as visible flecks were observed.</p><p><strong>Outcome: </strong>The postoperative period was uneventful. Regular follow-up after 26 months postoperatively showed acceptable healing with no portent of recurrence.</p><p><strong>Take-away lessons: </strong>Early diagnosis and conservative surgical treatment and periodic follow-up postoperatively gives an excellent result with good prognosis.</p>","PeriodicalId":7972,"journal":{"name":"Annals of Maxillofacial Surgery","volume":"14 2","pages":"244-247"},"PeriodicalIF":0.0,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11828055/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143432287","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy of Intra-articular Platelet-rich Plasma versus Hydrocortisone with Local Anaesthetic Injection in Temporomandibular Joint Disorders - A Prospective Study.","authors":"Ankur Mittal, Smiti Jassar Klarie, Siddharth Sharma, Birsubhra Roy, Javaid Iqbal Paul, Shrikant Sharma","doi":"10.4103/ams.ams_237_23","DOIUrl":"10.4103/ams.ams_237_23","url":null,"abstract":"<p><strong>Introduction: </strong>Temporomandibular joint (TMJ) is subjected to many disorders commonly termed temporomandibular disorders (TMDs) which include TMJ hypermobility, ankylosis and internal derangement. In the past, many non-invasive conservative treatment modalities were tried out for their treatment which include joint unloading, the use of anti-inflammatory agents and physiotherapy. In recent times, injections of corticosteroids and platelet-rich plasma (PRP) into the TMJ have been proposed as alternative therapeutic methods. The main objective of the prospective study was to compare the efficacy of intra-articular injection of PRP and hydrocortisone with local anaesthetic agents in reducing the symptoms in patients with TMDs.</p><p><strong>Materials and methods: </strong>This prospective study included 30 patients with TMDs, out of which 15 patients (Group I) received PRP injections and 15 patients (Group II) received hydrocortisone with local anaesthetics for arthrocentesis in their affected joints. The patients were assessed for pain, maximum interincisal mouth opening, TMJ sound and disc displacement.</p><p><strong>Results: </strong>The pain was markedly reduced in patients who received PRP injections (Group I) as compared to those who received hydrocortisone injection (Group II). An increase in mouth opening was similar in both the groups, and TMJ sounds were reduced in patients who received PRP. Magnetic resonance imaging also showed that PRP-treated patients showed better articular disc repair than patients treated with hydrocortisone.</p><p><strong>Discussion: </strong>PRP increases chondrocyte proliferation and production of matrix molecules and helps maintain the integrity of the chondral surface, thereby facilitating joint movement, whereas corticosteroids are more potent anti-inflammatory agents and they act by inhibiting prostaglandin synthesis which is the mediator of inflammation. Thus, the use of PRP has been proven to show better results in reducing the symptoms of TMDs and also helped in articular disc repair.</p>","PeriodicalId":7972,"journal":{"name":"Annals of Maxillofacial Surgery","volume":"14 2","pages":"166-170"},"PeriodicalIF":0.0,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11828050/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143432239","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ewing's Sarcoma Presenting in the Paranasal Sinus - A Case Report.","authors":"Yashika Kewalramani, Ajay Parihar, Prashanthi Reddy, Rashi Mandlik","doi":"10.4103/ams.ams_49_24","DOIUrl":"10.4103/ams.ams_49_24","url":null,"abstract":"<p><strong>Rationale: </strong>The aim of this study is to raise awareness among dentists regarding a potential outcome associated with the rapid growth of facial swellings.</p><p><strong>Patient concerns: </strong>We present a case of Ewing's sarcoma (ES) in a 23-year-old male who presented with a rapidly progressive swelling in the left maxillary region over six weeks.</p><p><strong>Diagnosis: </strong>There was no significant intraoral dental finding other than a missing left upper first molar. Panoramic imaging initially suggested chronic sinusitis, but the swelling persisted despite treatment. A subsequent cone-beam computed tomography (CBCT) scan revealed a soft-tissue tumour affecting multiple sinuses, confirmed by an open biopsy as a small round cell tumour. Immunohistochemistry was used for precise diagnosis due to biopsy sample limitations and tumour variability.</p><p><strong>Treatment: </strong>The patient's case was reviewed by our institution's tumour board. One month after diagnosis, chemotherapy began with alternating drugs for a total of 6 cycles.</p><p><strong>Outcomes: </strong>A follow-up Positron Emission Tomography (PET)/Computed Tomography (CT) scan after two months of chemotherapy showed resolution of the hypermetabolic mass on the left side without evidence of metastatic disease. The patient is currently under regular follow-up.</p><p><strong>Take-away lessons: </strong>Dentists should be vigilant for rapidly expanding oral or facial swellings. Early and accurate diagnosis can improve clinical management and survival rates for ES patients.</p>","PeriodicalId":7972,"journal":{"name":"Annals of Maxillofacial Surgery","volume":"14 2","pages":"228-231"},"PeriodicalIF":0.0,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11828065/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143432149","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}