Annual review of physical chemistry最新文献_第10页

Vibrational Sum-Frequency Generation Hyperspectral Microscopy for Molecular Self-Assembled Systems. 分子自组装系统的振动和频率产生高光谱显微镜。

IF 14.7 1区化学

Annual review of physical chemistry Pub Date : 2021-04-20 Epub Date: 2021-01-13 DOI: 10.1146/annurev-physchem-090519-050510

Haoyuan Wang, Wei Xiong

{"title":"Vibrational Sum-Frequency Generation Hyperspectral Microscopy for Molecular Self-Assembled Systems.","authors":"Haoyuan Wang, Wei Xiong","doi":"10.1146/annurev-physchem-090519-050510","DOIUrl":"https://doi.org/10.1146/annurev-physchem-090519-050510","url":null,"abstract":"In this review, we discuss the recent developments and applications of vibrational sum-frequency generation (VSFG) microscopy. This hyperspectral imaging technique can resolve systems without inversion symmetry, such as surfaces, interfaces and noncentrosymmetric self-assembled materials, in the spatial, temporal, and spectral domains. We discuss two common VSFG microscopy geometries: wide-field and confocal point-scanning. We then introduce the principle of VSFG and the relationships between hyperspectral imaging with traditional spectroscopy, microscopy, and time-resolved measurements. We further highlight crucial applications of VSFG microscopy in self-assembled monolayers, cellulose in plants, collagen fibers, and lattice self-assembled biomimetic materials. In these systems, VSFG microscopy reveals relationships between physical properties that would otherwise be hidden without being spectrally, spatially, and temporally resolved. Lastly, we discuss the recent development of ultrafast transient VSFG microscopy, which can spatially measure the ultrafast vibrational dynamics of self-assembled materials. The review ends with an outlook on the technical challenges of and scientific potential for VSFG microscopy.","PeriodicalId":7967,"journal":{"name":"Annual review of physical chemistry","volume":"72 ","pages":"279-306"},"PeriodicalIF":14.7,"publicationDate":"2021-04-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38749446","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 8

Cryogenic Super-Resolution Fluorescence and Electron Microscopy Correlated at the Nanoscale. 低温超分辨率荧光和电子显微镜在纳米尺度上的相关性。

IF 14.7 1区化学

Annual review of physical chemistry Pub Date : 2021-04-20 Epub Date: 2021-01-13 DOI: 10.1146/annurev-physchem-090319-051546

Peter D Dahlberg, W E Moerner

{"title":"Cryogenic Super-Resolution Fluorescence and Electron Microscopy Correlated at the Nanoscale.","authors":"Peter D Dahlberg, W E Moerner","doi":"10.1146/annurev-physchem-090319-051546","DOIUrl":"https://doi.org/10.1146/annurev-physchem-090319-051546","url":null,"abstract":"We review the emerging method of super-resolved cryogenic correlative light and electron microscopy (srCryoCLEM). Super-resolution (SR) fluorescence microscopy and cryogenic electron tomography (CET) are both powerful techniques for observing subcellular organization, but each approach has unique limitations. The combination of the two brings the single-molecule sensitivity and specificity of SR to the detailed cellular context and molecular scale resolution of CET. The resulting correlative data is more informative than the sum of its parts. The correlative images can be used to pinpoint the positions of fluorescently labeled proteins in the high-resolution context of CET with nanometer-scale precision and/or to identify proteins in electron-dense structures. The execution of srCryoCLEM is challenging and the approach is best described as a method that is still in its infancy with numerous technical challenges. In this review, we describe state-of-the-art srCryoCLEM experiments, discuss the most pressing challenges, and give a brief outlook on future applications.","PeriodicalId":7967,"journal":{"name":"Annual review of physical chemistry","volume":"72 ","pages":"253-278"},"PeriodicalIF":14.7,"publicationDate":"2021-04-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8877847/pdf/nihms-1779529.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38749866","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 38

Quantitative Mass Spectrometry Imaging of Biological Systems. 生物系统的定量质谱成像。

IF 14.7 1区化学

Annual review of physical chemistry Pub Date : 2021-04-20 Epub Date: 2021-01-13 DOI: 10.1146/annurev-physchem-061020-053416

Daisy Unsihuay, Daniela Mesa Sanchez, Julia Laskin

引用次数: 0

α-Crystallins in the Vertebrate Eye Lens: Complex Oligomers and Molecular Chaperones. 脊椎动物眼球晶状体中的α-晶体蛋白：复杂的低聚物和分子伴侣。

IF 14.7 1区化学

Annual review of physical chemistry Pub Date : 2021-04-20 Epub Date: 2020-12-15 DOI: 10.1146/annurev-physchem-090419-121428

Marc A Sprague-Piercy, Megan A Rocha, Ashley O Kwok, Rachel W Martin

引用次数: 0

The Maximum Caliber Variational Principle for Nonequilibria. 非平衡态的最大口径变分原理。

IF 14.7 1区化学

Annual review of physical chemistry Pub Date : 2020-04-20 DOI: 10.1146/annurev-physchem-071119-040206

Kingshuk Ghosh, Purushottam D Dixit, Luca Agozzino, Ken A Dill

引用次数: 42

A free radical. 一个自由基。

IF 14.7 1区化学

Annual review of physical chemistry Pub Date : 2020-02-07 DOI: 10.1146/ANNUREV.PHYSCHEM.52.1.1

A. Carrington

{"title":"A free radical.","authors":"A. Carrington","doi":"10.1146/ANNUREV.PHYSCHEM.52.1.1","DOIUrl":"https://doi.org/10.1146/ANNUREV.PHYSCHEM.52.1.1","url":null,"abstract":"This chapter describes my research career, spanning the period from 1955 to 2000. My initial PhD work at the University of Southampton was concerned with the electronic structure and spectra of transition metal complexes and included studies of the electronic spin resonance (ESR) spectra of magnetically dilute single crystals. After a year at the University of Minnesota, I went to Cambridge University and for the next six years studied the ESR spectra of liquid phase organic free radicals. I commenced work on the microwave magnetic resonance (MMR) spectra of gaseous free radicals in 1965, and this work continued until 1975. I moved from Cambridge to Southampton in 1967. In 1975 I turned to the study of gas phase molecular ions, using ion beam methods. In the earlier years of this period I concentrated on simple fundamental species like H(+)2, HD(+), and H(+)3. In the later years until my retirement in 1999, I concentrated on the observation and analysis of microwave spectra involving energy levels lying very close to a dissociation asymptote. DEDICATION This chapter is dedicated to the memory of Harry E. Radford, who died while it was being written. Harry was a quiet and shy man, who often worked alone and never indulged in self-promotion. So far as I know, he was never awarded any medals or prizes, nor elected to any academies or learned societies. Nevertheless he was an experimentalist of the highest originality and quality, a theorist of true intellectual depth, and a remarkable pioneer in many of the techniques of studying free radicals that are now commonplace.","PeriodicalId":7967,"journal":{"name":"Annual review of physical chemistry","volume":"24 1","pages":"1-13"},"PeriodicalIF":14.7,"publicationDate":"2020-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83842987","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 122

Spatially Resolved Exciton and Charge Transport in Emerging Semiconductors. 新兴半导体中空间分辨激子和电荷输运。

IF 14.7 1区化学

Annual review of physical chemistry Pub Date : 2019-11-22 DOI: 10.1146/annurev-physchem-052516-050703

N. Ginsberg, W. Tisdale

{"title":"Spatially Resolved Exciton and Charge Transport in Emerging Semiconductors.","authors":"N. Ginsberg, W. Tisdale","doi":"10.1146/annurev-physchem-052516-050703","DOIUrl":"https://doi.org/10.1146/annurev-physchem-052516-050703","url":null,"abstract":"We review recent advances in the characterization of electronic forms of energy transport in emerging semiconductors. The approaches described all temporally and spatially resolve the evolution of initially localized populations of photogenerated excitons or charge carriers. We first provide a comprehensive background for describing the physical origin and nature of electronic energy transport both microscopically and from the perspective of the observer. We introduce the new family of far-field, time-resolved optical microscopies developed to directly resolve not only the extent of this transport but also its potentially temporally and spatially dependent rate. We review a representation of examples from the recent literature, including investigation of energy flow in colloidal quantum dot solids, organic semiconductors, organic-inorganic metal halide perovskites, and 2D transition metal dichalcogenides. These examples illustrate how traditional parameters like diffusivity are applicable only within limited spatiotemporal ranges and how the techniques at the core of this review, especially when taken together, are revealing a more complete picture of the spatiotemporal evolution of energy transport in complex semiconductors, even as a function of their structural heterogeneities. Expected final online publication date for the Annual Review of Physical Chemistry, Volume 71 is April 20, 2020. Please see http://www.annualreviews.org/page/journal/pubdates for revised estimates.","PeriodicalId":7967,"journal":{"name":"Annual review of physical chemistry","volume":"23 1","pages":""},"PeriodicalIF":14.7,"publicationDate":"2019-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85086866","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 70

Chiral Plasmonic Nanostructures Enabled by Bottom-Up Approaches. 自下而上方法实现的手性等离子体纳米结构。

IF 14.7 1区化学

Annual review of physical chemistry Pub Date : 2019-06-14 Epub Date: 2019-05-21 DOI: 10.1146/annurev-physchem-050317-021332

Maximilian J Urban, Chenqi Shen, Xiang-Tian Kong, Chenggan Zhu, Alexander O Govorov, Qiangbin Wang, Mario Hentschel, Na Liu

{"title":"Chiral Plasmonic Nanostructures Enabled by Bottom-Up Approaches.","authors":"Maximilian J Urban, Chenqi Shen, Xiang-Tian Kong, Chenggan Zhu, Alexander O Govorov, Qiangbin Wang, Mario Hentschel, Na Liu","doi":"10.1146/annurev-physchem-050317-021332","DOIUrl":"https://doi.org/10.1146/annurev-physchem-050317-021332","url":null,"abstract":"We present a comprehensive review of recent developments in the field of chiral plasmonics. Significant advances have been made recently in understanding the working principles of chiral plasmonic structures. With advances in micro- and nanofabrication techniques, a variety of chiral plasmonic nanostructures have been experimentally realized; these tailored chiroptical properties vastly outperform those of their molecular counterparts. We focus on chiral plasmonic nanostructures created using bottom-up approaches, which not only allow for rational design and fabrication but most intriguingly in many cases also enable dynamic manipulation and tuning of chiroptical responses. We first discuss plasmon-induced chirality, resulting from the interaction of chiral molecules with plasmonic excitations. Subsequently, we discuss intrinsically chiral colloids, which give rise to optical chirality owing to their chiral shapes. Finally, we discuss plasmonic chirality, achieved by arranging achiral plasmonic particles into handed configurations on static or active templates. Chiral plasmonic nanostructures are very promising candidates for real-life applications owing to their significantly larger optical chirality than natural molecules. In addition, chiral plasmonic nanostructures offer engineerable and dynamic chiroptical responses, which are formidable to achieve in molecular systems. We thus anticipate that the field of chiral plasmonics will attract further widespread attention in applications ranging from enantioselective analysis to chiral sensing, structural determination, and in situ ultrasensitive detection of multiple disease biomarkers, as well as optical monitoring of transmembrane transport and intracellular metabolism.","PeriodicalId":7967,"journal":{"name":"Annual review of physical chemistry","volume":"70 ","pages":"275-299"},"PeriodicalIF":14.7,"publicationDate":"2019-06-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1146/annurev-physchem-050317-021332","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37263308","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 85

Triplet-Pair States in Organic Semiconductors. 有机半导体中的三重对态。

IF 14.7 1区化学

Annual review of physical chemistry Pub Date : 2019-06-14 DOI: 10.1146/annurev-physchem-042018-052435

Andrew J Musser, Jenny Clark

{"title":"Triplet-Pair States in Organic Semiconductors.","authors":"Andrew J Musser, Jenny Clark","doi":"10.1146/annurev-physchem-042018-052435","DOIUrl":"https://doi.org/10.1146/annurev-physchem-042018-052435","url":null,"abstract":"Entanglement of states is one of the most surprising and counterintuitive consequences of quantum mechanics, with potent applications in cryptography and computing. In organic semiconductor materials, one particularly significant manifestation is the spin-entangled triplet-pair state, which consists of a pair of localized triplet excitons coupled into an overall spin-0, -1, or -2 configuration. The most widely analyzed of these is the spin-0 pair, denoted 1(TT), which was initially invoked in the 1960s to explain delayed fluorescence in acene films. It is considered an essential gateway state for triplet-triplet annihilation and the reverse process, singlet fission, enabling interconversion between one singlet and two triplet excitons without any change in overall spin. This state has returned to the forefront of organic materials research in recent years, thanks both to its central role in the resurgent field of singlet fission and to its implication in a host of exotic new photophysical behaviors. Here we review the properties of triplet-pair states, from first principles to recent experimental results.","PeriodicalId":7967,"journal":{"name":"Annual review of physical chemistry","volume":"70 ","pages":"323-351"},"PeriodicalIF":14.7,"publicationDate":"2019-06-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1146/annurev-physchem-042018-052435","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37314437","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 81

Kinetics of Drug Binding and Residence Time. 药物结合动力学和停留时间。

IF 14.7 1区化学

Annual review of physical chemistry Pub Date : 2019-06-14 Epub Date: 2019-02-20 DOI: 10.1146/annurev-physchem-042018-052340

Mattia Bernetti, Matteo Masetti, Walter Rocchia, Andrea Cavalli

{"title":"Kinetics of Drug Binding and Residence Time.","authors":"Mattia Bernetti, Matteo Masetti, Walter Rocchia, Andrea Cavalli","doi":"10.1146/annurev-physchem-042018-052340","DOIUrl":"https://doi.org/10.1146/annurev-physchem-042018-052340","url":null,"abstract":"The kinetics of drug binding and unbinding is assuming an increasingly crucial role in the long, costly process of bringing a new medicine to patients. For example, the time a drug spends in contact with its biological target is known as residence time (the inverse of the kinetic constant of the drug-target unbinding, 1/koff). Recent reports suggest that residence time could predict drug efficacy in vivo, perhaps even more effectively than conventional thermodynamic parameters (free energy, enthalpy, entropy). There are many experimental and computational methods for predicting drug-target residence time at an early stage of drug discovery programs. Here, we review and discuss the methodological approaches to estimating drug binding kinetics and residence time. We first introduce the theoretical background of drug binding kinetics from a physicochemical standpoint. We then analyze the recent literature in the field, starting from the experimental methodologies and applications thereof and moving to theoretical and computational approaches to the kinetics of drug binding and unbinding. We acknowledge the central role of molecular dynamics and related methods, which comprise a great number of the computational methods and applications reviewed here. However, we also consider kinetic Monte Carlo. We conclude with the outlook that drug (un)binding kinetics may soon become a go/no go step in the discovery and development of new medicines.","PeriodicalId":7967,"journal":{"name":"Annual review of physical chemistry","volume":"70 ","pages":"143-171"},"PeriodicalIF":14.7,"publicationDate":"2019-06-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1146/annurev-physchem-042018-052340","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36974515","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 85