IF 2.7 2区农林科学

Animals Pub Date : 2025-06-05 DOI: 10.3390/ani15111671

Long Zhu, Yueqi Zhao, Mei Zhou, Xiaotong Guo, Yinxian Zhang, Dongjun Liu, Xudong Guo

{"title":"VDAC2 Mediates the Apoptosis of Cashmere Goat Hair Follicle Stem Cells Through the P53 Signaling Pathway.","authors":"Long Zhu, Yueqi Zhao, Mei Zhou, Xiaotong Guo, Yinxian Zhang, Dongjun Liu, Xudong Guo","doi":"10.3390/ani15111671","DOIUrl":"10.3390/ani15111671","url":null,"abstract":"Hair follicle stem cells (HFSCs) are pluripotent stem cells located in the bulges of hair follicles. Apoptosis regulates tissue homeostasis by eliminating unnecessary or damaged cells during development and aging. VDAC2, located in the outer mitochondrial membrane (MOM), is a key apoptosis regulator, but its role in cashmere goat hair follicles remains unclear. In previous studies, through proteomic sequencing, we found that VDAC2 was significantly differentially expressed in the anagen, catagen, and telogen phases of the hair follicles of Albas cashmere goats. This study aimed to explore the role of VDAC2 in secondary hair follicle stem cells (SHFSCs) and preliminarily investigate its regulatory mechanism through RNA-seq. Overexpression of VDAC2 promoted apoptosis in SHFSCs, while knockdown had the opposite effect. RNA-seq analysis, together with expression validation of downstream genes, indicates that the P53 signaling pathway may be involved in VDAC2-mediated SHFSC regulation. RT-qPCR and Western blotting confirmed that VDAC2 activated the P53 signaling pathway in SHFSCs. Furthermore, the use of a P53 inhibitor after VDAC2 overexpression partially rescued the apoptosis of cells caused by VDAC2. These results demonstrate that VDAC2 plays an important role in SHFSC apoptosis. Our findings greatly enhance our understanding of the role of VDAC2 in SHFSC apoptosis and hair follicle growth.","PeriodicalId":7955,"journal":{"name":"Animals","volume":"15 11","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12153577/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144282203","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Probiotic Pediococcus acidilactici in the Feed of Salmonids: A Strategy to Improve Reproductive Parameters. 饲料中益生菌酸碱小叶球菌：改善鲑鱼繁殖参数的策略。

IF 2.7 2区农林科学

Animals Pub Date : 2025-06-04 DOI: 10.3390/ani15111659

Rommy Díaz, Doris Carrasco, John Quiñones, Ailín Martínez, Gastón Sepúlveda, Isabela Pérez-Núñez, Rodrigo Huaiquipán, David Cancino-Baier, Jorge F Beltrán, Jorge G Farías, Erwin A Paz, Néstor Sepúlveda

{"title":"The Probiotic Pediococcus acidilactici in the Feed of Salmonids: A Strategy to Improve Reproductive Parameters.","authors":"Rommy Díaz, Doris Carrasco, John Quiñones, Ailín Martínez, Gastón Sepúlveda, Isabela Pérez-Núñez, Rodrigo Huaiquipán, David Cancino-Baier, Jorge F Beltrán, Jorge G Farías, Erwin A Paz, Néstor Sepúlveda","doi":"10.3390/ani15111659","DOIUrl":"10.3390/ani15111659","url":null,"abstract":"This study investigated the effects of dietary supplementation with the probiotic Pediococcus acidilactici on the reproductive performance and offspring viability of male Atlantic salmon (Salmo salar). A total of 48 mature males were divided into three groups-Group A (control, no probiotic), Group B (60-day supplementation), and Group C (120-day supplementation). The fish were kept in 10 m3 tanks at a constant temperature of 9 °C under a natural photoperiod and evaluated for multiple reproductive and physiological parameters. The results demonstrate that Group C exhibited significantly higher gonad weight, gonadosomatic index (GSI), and sperm concentration than Groups A and B. The blood biochemistry revealed reduced bilirubin and alanine aminotransferase (ALT) levels in Group C; however, values were within normal reference ranges for the species in all groups. While sperm quality parameters such as membrane integrity and motility showed no significant differences, fertility and embryo viability were significantly higher in Group C across all three developmental stages (180, 300, and 380 accumulated thermal units, ATUs). Additionally, Group C showed lower rates of embryonic malformation and mortality at later stages of development. Statistical analyses confirmed a significant interaction between treatment duration and embryo viability, with the 120-day probiotic treatment (Group C) producing the best outcomes. These findings support the hypothesis that P. acidilactici supplementation positively influences male reproductive parameters and improves embryo quality and survival in Atlantic salmon.","PeriodicalId":7955,"journal":{"name":"Animals","volume":"15 11","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12153914/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144282216","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Activity Rhythm and Home Range Characteristics of Released Chinese Pangolins (Manis pentadactyla). 中国放生穿山甲的活动节律和活动范围特征。

IF 2.7 2区农林科学

Animals Pub Date : 2025-06-04 DOI: 10.3390/ani15111658

Haochen Huang, Zhenhui Shen, Xinhao Zhang, Hongyi Cheng, Chungang Xie, Rongquan Zheng

{"title":"The Activity Rhythm and Home Range Characteristics of Released Chinese Pangolins (Manis pentadactyla).","authors":"Haochen Huang, Zhenhui Shen, Xinhao Zhang, Hongyi Cheng, Chungang Xie, Rongquan Zheng","doi":"10.3390/ani15111658","DOIUrl":"10.3390/ani15111658","url":null,"abstract":"As a mammal with unique ecological habits, the Chinese pangolin, Manis pentadactyla, exhibits nocturnal behavior and has a hidden, cave-dwelling lifestyle. Severe habitat degradation and fragmentation have led to a rapid decline in its wild population. Moreover, the immature state of artificial breeding technology restricts the availability of research samples, particularly with regard to behavioral and ecological data. This makes it extremely difficult to continuously monitor the pangolin's ecological habits and population dynamics for a long time. The comprehensive research archive is yet to be established, greatly limiting the in-depth understanding of this species' ecological behavior. To mitigate this data shortage, this study installed GPS positioning and accelerometer technology devices on five Chinese pangolins that were rescued from Zhejiang and released into the wild. Activity rhythms and home ranges were then analyzed based on the collected data. The results showed that all the five released Chinese pangolins were active in the wild and survived throughout the tracking period (21-72 days). The pangolins were mainly active at night, with activity starting after 18:00 and being mainly concentrated between 22:00 and 4:00. The home range of the Chinese pangolins based on MCP was 777.41 ± 426.26 hm2, and the core range based on KDE was 596.21 ± 265.58 hm2 (50% KDE). This result confirms that high-frequency GPS positioning combined with accelerometer data can effectively determine the home range sizes, habitat utilization, and fine-scale activity rhythms of wild-released pangolins.","PeriodicalId":7955,"journal":{"name":"Animals","volume":"15 11","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12153525/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144282213","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

From Bench to Piglet: A Comparison of In Vivo and In Vitro Effects of Phytogenics on Post-Weaning Diarrhea, Growth Performance, and Bacterial Behavior. 从实验台到仔猪：体内和体外植物源对断奶后腹泻、生长性能和细菌行为影响的比较

IF 2.7 2区农林科学

Animals Pub Date : 2025-06-04 DOI: 10.3390/ani15111661

Anika Weitmann, Sonja Axmann, Klaus Männer, Teemu Rinttilä, Tobias Aumiller

{"title":"From Bench to Piglet: A Comparison of In Vivo and In Vitro Effects of Phytogenics on Post-Weaning Diarrhea, Growth Performance, and Bacterial Behavior.","authors":"Anika Weitmann, Sonja Axmann, Klaus Männer, Teemu Rinttilä, Tobias Aumiller","doi":"10.3390/ani15111661","DOIUrl":"10.3390/ani15111661","url":null,"abstract":"Finding effective alternatives to antibiotics and zinc oxide in livestock feed remains challenging, but phytogenic compounds show promising potential. In the first part of the present study, the in vitro antimicrobial activities of carvacrol, eugenol, garlic oil, star anise oil, and tea tree oil as well as their effects on the biofilm formation of two Escherichia coli field isolates, quorum sensing of Chromobacterium violaceum, and the adhesion of an E. coli field isolate to piglets' small intestinal mucus were determined. Based on these results, two prototypes were formulated. Phytogenic feed additive (PFA) Core 2, containing carvacrol, eugenol, and star anise oil, showed stronger in vitro antimicrobial activity, inhibition of biofilm formation, and quorum sensing than PFA Core 1, which was mainly composed of garlic oil and tea tree oil. In the second part of the present study, 1000 post-weaning piglets were divided into four groups receiving a control or diets with either PFA Core 1, PFA Core 2, or zinc oxide. Only PFA Core 2 and zinc oxide significantly improved body weight, daily gain, feed efficiency, and fecal scores compared with the control, while PFA Core 1 increased the feed efficiency and fecal scores. The results show that feed additives based on carvacrol and eugenol can improve the growth performance of post-weaning piglets and reduce the incidence of diarrhea, possibly by influencing detrimental bacteria. Furthermore, the present study demonstrates the potential of combinations of in vitro assays to support the development of effective feed additives.","PeriodicalId":7955,"journal":{"name":"Animals","volume":"15 11","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12153809/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144282093","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Natural Spawning, Early Development, and First Successful Hatchery Production of the Vermiculated Angelfish (Chaetodontoplus mesoleucus), Exploring the Influence of Temperature and Salinity. 微孔天使鱼（Chaetodontoplus mesoleucus）的自然产卵、早期发育和首次成功孵化，探讨温度和盐度的影响。

IF 2.7 2区农林科学

Animals Pub Date : 2025-06-04 DOI: 10.3390/ani15111657

Yu-Hsuan Sun, Yu-Ru Lin, Hung-Yen Hsieh, Pei-Jie Meng

{"title":"Natural Spawning, Early Development, and First Successful Hatchery Production of the Vermiculated Angelfish (Chaetodontoplus mesoleucus), Exploring the Influence of Temperature and Salinity.","authors":"Yu-Hsuan Sun, Yu-Ru Lin, Hung-Yen Hsieh, Pei-Jie Meng","doi":"10.3390/ani15111657","DOIUrl":"10.3390/ani15111657","url":null,"abstract":"The marine ornamental species trade relies heavily on wild-caught specimens, including the Vermiculated angelfish (Chaetodontoplus mesoleucus). Captive breeding of this species faces challenges with limited detailed knowledge available beyond 2 days post-hatch (dph) regarding the influence of environmental factors. This study provides a detailed characterization of C. mesoleucus from early development to 381 dph. Under controlled laboratory conditions, the effect of temperature (22-37 °C) on hatching rate, deformity rate, hatching period duration, time to 50% hatch, and survival rate is investigated. Additionally, the influence of different salinities (0-38 psu) on hatching rates and larval deformity rates was also examined. The optimal incubation temperatures for high hatching rate and minimal larval deformities are found to be within 25-28 °C. A lower salinity threshold of 10 psu was established for successful hatching, and the optimal salinity range for minimizing larval deformities was 33-36 psu. These findings provide crucial baseline data and practical recommendations for optimizing hatchery protocols for C. mesoleucus, contributing to enhanced larval survival and the potential for sustainable aquaculture production, thereby reducing the pressure on wild populations.","PeriodicalId":7955,"journal":{"name":"Animals","volume":"15 11","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12153641/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144282155","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Porcine SCD1 Regulates Lipid Droplet Number via CLSTN3B in PK15 Cells. 猪SCD1通过CLSTN3B调控PK15细胞的脂滴数量。

IF 2.7 2区农林科学

Animals Pub Date : 2025-06-04 DOI: 10.3390/ani15111663

Wenzhe Bai, Qianhai Fang, Yanzhen Bi, Rui Wang, Ke Xu, Ao Zhou, Hao Gu, Hongbo Chen

{"title":"Porcine SCD1 Regulates Lipid Droplet Number via CLSTN3B in PK15 Cells.","authors":"Wenzhe Bai, Qianhai Fang, Yanzhen Bi, Rui Wang, Ke Xu, Ao Zhou, Hao Gu, Hongbo Chen","doi":"10.3390/ani15111663","DOIUrl":"10.3390/ani15111663","url":null,"abstract":"Fat deposition plays a key role in determining porcine meat quality traits, with lipid droplets serving as critical organelles for lipid storage in adipose tissue. Inhibiting lipid droplet biogenesis disrupts the lipid storage capacity of adipocytes. The Stearoyl-CoA Desaturase (SCD) family is crucial in regulating polyunsaturated fatty acid/monounsaturated fatty acid (PUFA/MUFA) composition, while its role in lipid droplet formation remains unclear. This study employed CRISPR/Cas9 to create SCD1-deficient porcine renal epithelial cells (PK15), enabling an investigation into SCD1's role in fatty acid composition and lipid droplet regulation. RNA-seq analysis was conducted to elucidate the mechanisms underlying SCD1's impact on lipid droplet numbers. Results showed that SCD1 deletion significantly decreased triacylglycerols (TAG) content, altered fatty acid composition, and decreased lipid droplet numbers. Conversely, SCD1 overexpression increased lipid droplet numbers, confirming SCD1's role in regulating lipid droplet abundance. RNA-seq analysis revealed that SCD1 regulates lipid metabolism via Calsyntenin 3β (CLSTN3B). Experimental validation confirmed the SCD1-CLSTN3B regulation of lipid droplet numbers. In summary, we discovered the role of SCD1 in regulating the number of lipid droplets, highlighting its potential impact on lipid metabolism and adipocyte function in pigs.","PeriodicalId":7955,"journal":{"name":"Animals","volume":"15 11","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12153863/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144282168","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Replacing Soybean Meal with Hemp Leaves with Very Low THC Content in the Diet for Dairy Cows: Impact on Digestibility, Nitrogen Use Efficiency and Energy Metabolism. 饲粮中THC含量极低的大麻叶替代豆粕对奶牛消化率、氮利用效率和能量代谢的影响

IF 2.7 2区农林科学

Animals Pub Date : 2025-06-04 DOI: 10.3390/ani15111662

Jessica Schwerdtfeger, Solvig Görs, Björn Kuhla

{"title":"Replacing Soybean Meal with Hemp Leaves with Very Low THC Content in the Diet for Dairy Cows: Impact on Digestibility, Nitrogen Use Efficiency and Energy Metabolism.","authors":"Jessica Schwerdtfeger, Solvig Görs, Björn Kuhla","doi":"10.3390/ani15111662","DOIUrl":"10.3390/ani15111662","url":null,"abstract":"The aim was to investigate the suitability of Santhica 27 industrial hemp leaves as a protein source in dairy cow nutrition. Twelve Holstein dairy cows received a total mixed ration (TMR) containing 7.4% industrial hemp leaves (HEMP) and a TMR containing 3.5% soya extraction meal (CON) in a crossover design. Cows were kept in a free-stall barn for 2 weeks to measure feed intake, milk yield and sample plasma, ruminal fluid, and urine. In week 3, cows were housed in a respiration chamber to measure gas exchange, urine, and feces excretions. In the first two weeks, cows of the HEMP group rested longer but spent less time ruminating. Feeding the HEMP diet reduced dry matter intake (DMI), milk yield, and urinary N-metabolite concentrations and tended to lower total N-excretion, milk fat, and lactose concentrations. During the stay in the respiration chamber, DMI, milk yield, apparent digestibility, and crude protein degradability were similar between groups, but feeding the HEMP diet tended to reduce methane yield. In conclusion, Santhica 27 hemp leaves are a suitable protein source for dairy cows as they have no negative effects on animal health, apparent digestibility, and crude protein degradability. Nevertheless, inadequate adaptation to the diet reduces feed intake and milk yield.","PeriodicalId":7955,"journal":{"name":"Animals","volume":"15 11","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12153878/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144282178","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Administration of Heat Shock Protein-70 Bacterial Homolog (DnaK) Improves the Cumulative Survival and the Expression of Immune-Related Genes in Gnotobiotic Full-Sibling Sea Bass Larvae Challenged with Vibrio anguillarum. 热休克蛋白-70细菌同源物（DnaK）可提高鳗鲡弧菌攻毒的非生全同胞海鲈鱼幼鱼的累积存活率和免疫相关基因的表达。

IF 2.7 2区农林科学

Animals Pub Date : 2025-06-04 DOI: 10.3390/ani15111655

Eva Vallejos-Vidal, Camino Fierro-Castro, María Jesús Santillán-Araneda, Merari Goldstein, Sebastián Reyes-Cerpa, Joan Carles Balasch, Ali Reza Khansari, Kristof Dierckens, Peter Bossier, Lluis Tort, Felipe E Reyes-López

{"title":"The Administration of Heat Shock Protein-70 Bacterial Homolog (DnaK) Improves the Cumulative Survival and the Expression of Immune-Related Genes in Gnotobiotic Full-Sibling Sea Bass Larvae Challenged with Vibrio anguillarum.","authors":"Eva Vallejos-Vidal, Camino Fierro-Castro, María Jesús Santillán-Araneda, Merari Goldstein, Sebastián Reyes-Cerpa, Joan Carles Balasch, Ali Reza Khansari, Kristof Dierckens, Peter Bossier, Lluis Tort, Felipe E Reyes-López","doi":"10.3390/ani15111655","DOIUrl":"10.3390/ani15111655","url":null,"abstract":"Heat shock proteins (HSPs), particularly HSP70, play a vital role in fish immune defense against pathogens. The administration of DnaK (bacterial homolog of HSP70) may be a strategy to potentiate the immune response and survival of aquatic organisms. This study evaluates the effect of cells overexpressing DnaK on mortality and immune-related gene expression in gnotobiotic sea bass larvae challenged with Vibrio anguillarum. Larvae were subjected to different treatments: NB (no bacteria), YS0 (E. coli with no plasmid), YS1 (E. coli expressing truncated DnaK), and YS2 (E. coli expressing DnaK), and then infected with V. anguillarum at 7 days post-hatching (dph). Mortality was monitored, and RT-qPCR was used to evaluate immune gene expression at 0, 18, 24, 36, and 120 hpc. While no significant variations were recorded in the non-challenged larvae, constant and sustained mortality was observed in challenged larvae from 60 to 120 hpc. However, lower mortality was observed in the larvae treated with DnaK. DnaK treatment promoted the expression of antimicrobial (hepcidin, transferrin) and chemotaxis genes (ccl4), which was further enhanced after a challenge with V. anguillarum, in conjunction with the modulation of il1β and il-8 at 120 hpc. These findings suggest that DnaK induces a potent innate immune response, improving survival against V. anguillarum and supporting its potential use as a disease-preventive strategy in aquaculture.","PeriodicalId":7955,"journal":{"name":"Animals","volume":"15 11","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12153677/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144282214","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Myocarditis in Cats with Feline Infectious Peritonitis Can Be Cured with GS-441524 and Symptomatic Cardiovascular Treatment. GS-441524联合对症治疗猫传染性腹膜炎并发心肌炎。

IF 2.7 2区农林科学

Animals Pub Date : 2025-06-04 DOI: 10.3390/ani15111660

Katharina Buchta, Jana Friederich, Anna-Maria Zuzzi-Krebitz, Jessica Schöbel, Jenny Eberhard, Katharina Zwicklbauer, Andrea M Spiri, Regina Hofmann-Lehmann, Katrin Hartmann, Gerhard Wess

{"title":"Myocarditis in Cats with Feline Infectious Peritonitis Can Be Cured with GS-441524 and Symptomatic Cardiovascular Treatment.","authors":"Katharina Buchta, Jana Friederich, Anna-Maria Zuzzi-Krebitz, Jessica Schöbel, Jenny Eberhard, Katharina Zwicklbauer, Andrea M Spiri, Regina Hofmann-Lehmann, Katrin Hartmann, Gerhard Wess","doi":"10.3390/ani15111660","DOIUrl":"10.3390/ani15111660","url":null,"abstract":"Feline infectious peritonitis (FIP) caused by feline coronavirus (FCoV) is a fatal disease in cats characterized by variable manifestations. Myocarditis represents a less commonly described pathology within the clinical spectrum of FIP. No research has described the successful treatment of FIP-induced myocarditis. In this study, 40 cats were included and treated with 15 mg/kg of GS-441524 every 24 h orally. All cats were diagnosed with FIP by reverse transcription quantitative PCR in effusion in combination with typical clinical and laboratory changes. Echocardiography was performed in all cats, and myocarditis was suspected in 4/40 cats. Equivocal wall thickness was diagnosed in 2/4 cats, while systolic dysfunction with biatrial dilation was diagnosed in the other 2/4 cats. One cat also presented with ventricular ectopy. A severe increase in cardiac troponin I was seen in all four cats (median 1.82 ng/mL (1.20-5.84 ng/mL)). Cardiac dimensions and electrocardiographic abnormalities completely normalized in all four cats during treatment with GS-441524 and remained stable after treatment discontinuation during a one-year follow-up period. Myocarditis can be a clinical feature of FIP and present with different cardiologic manifestations. FIP-induced myocarditis can be cured with GS-441524 in combination with symptomatic cardiovascular treatment including pimobendan, clopidogrel, furosemide, or atenolol, depending on the clinical presentation.","PeriodicalId":7955,"journal":{"name":"Animals","volume":"15 11","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12153921/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144282154","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Amino Acid Supplementation in Fish Nutrition and Welfare. 氨基酸在鱼类营养和福利中的补充。

IF 2.7 2区农林科学

Animals Pub Date : 2025-06-04 DOI: 10.3390/ani15111656

Cláudia Aragão, Sofia Engrola, Benjamín Costas

引用次数: 0

Animals最新文献