Antimicrobial Resistance and Infection Control最新文献

{"title":"Global knowledge, attitudes, and practices towards antimicrobial resistance among healthcare workers: a systematic review and meta-analysis.","authors":"Abdolreza Sotoodeh Jahromi, Negin Namavari, Mohammad Jokar, Nader Sharifi, Samira Soleimanpour, Negin Naserzadeh, Vahid Rahmanian","doi":"10.1186/s13756-025-01562-1","DOIUrl":"10.1186/s13756-025-01562-1","url":null,"abstract":"<p><strong>Background: </strong>The rising prevalence of antimicrobial resistance (AMR) poses a critical global health challenge. Healthcare workers (HCWs) play a pivotal role in combating AMR by implementing effective preventive strategies and adhering to good practices. This study aimed to evaluate the global knowledge, attitudes, and practices (KAP) of HCWs towards AMR.</p><p><strong>Methods: </strong>A comprehensive search of PubMed/MEDLINE, ScienceDirect, Scopus, Web of Science, Cochrane Library, and Google Scholar was conducted for English-language articles published up to August 2024. Inclusion criteria were observational studies reporting KAP data among HCWs related to AMR. Study quality was assessed using the Joanna Briggs Institute critical appraisal checklist. Statistical analyses, including heterogeneity (I² statistic, Cochran Q), were conducted using STATA version 14. Random-effects models were applied for pooled estimates, and subgroup analyses, meta-regression, and sensitivity analyses were performed. Publication bias was assessed via Egger's test and adjusted using the trim-and-fill method. Geographical distribution was analyzed with ArcGIS 10.3 software, and evidence certainty was evaluated using the GRADE framework.</p><p><strong>Results: </strong>A meta-analysis of 108 studies involving 29,433 HCWs assessed their knowledge of AMR. Additionally, 51 studies with 13,660 HCWs evaluated attitudes, and 43 studies with 10,569 HCWs examined practices regarding AMR. The pooled proportion of HCWs with good knowledge of AMR was 56.5% (95% CI: 50.4-62.6%, I² = 99.5%), with the highest prevalence in Europe (70.3%) and the lowest in the Western Pacific (45.9%). Positive attitudes towards AMR were reported in 60.4% (95% CI: 48.5-72.3%, I² = 99.8%), with the highest prevalence in the Eastern Mediterranean Region (64.5%) and among those with less than five years of experience (77.8%). Good practices were observed in 48.5% (95% CI: 36.5-60.5%, I² = 99.7%), with the highest adherence in Europe (56.6%) and the lowest in Africa (39.1%). Subgroup analysis revealed that younger HCWs (under 30 years) showed better KAP scores across all domains.</p><p><strong>Conclusion: </strong>The findings underscore the need for targeted interventions to enhance the knowledge, attitudes, and practices of HCWs regarding AMR. Priority should be given to designing and implementing robust training programs tailored to the specific needs of HCWs in resource-constrained settings. Strengthening AMR-related education and practice among HCWs is crucial for combating the global AMR crisis effectively.</p>","PeriodicalId":7950,"journal":{"name":"Antimicrobial Resistance and Infection Control","volume":"14 1","pages":"47"},"PeriodicalIF":4.8,"publicationDate":"2025-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12076913/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143962659","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Digitalised measures for the prevention of central line-associated bloodstream infections: a scoping review.","authors":"Basilice Minka Obama, Rebecca Grant, Stephan Harbarth, Niccolò Buetti, Gaud Catho","doi":"10.1186/s13756-025-01549-y","DOIUrl":"10.1186/s13756-025-01549-y","url":null,"abstract":"<p><strong>Background: </strong>Central line-associated bloodstream infections (CLABSI) increase morbidity, mortality, and healthcare costs of hospitalised patients, despite being largely preventable. While evidence-based guidelines for preventing CLABSI are well-established, the implementation of these measures remain suboptimal. Digitalization presents a promising approach to improve guideline adherence, streamline implementation processes, and ultimately reduce CLABSI rates.</p><p><strong>Methods: </strong>This scoping review aims to synthesize the available evidence on digitalised interventions for the prevention of CLABSI. A systematic search was conducted using Medline to identify studies published between January 1, 2014, and March 20, 2024, that reported on the implementation of digitalised preventive measures for CLABSI and evaluated their impact on CLABSI rates. Data extraction included study characteristics, features of the digitalised preventive measures, effectiveness in reducing CLABSI rates, and relevant process outcomes.</p><p><strong>Results: </strong>A systematic search yielded 263 articles, of which six studies were included. Digitalised interventions were predominantly designed for use by nurses in tertiary-level hospitals (n = 6), primarily in intensive care units (n = 5) and targeted pediatric patient populations (n = 5). These measures were often implemented as part of multimodal strategies. The digital interventions included hospital dashboards (n = 2), mobile applications (n = 2), automatic notifications of catheter days (n = 1), and e-learning modules with electronic reminders (n = 1). The most common study design was quasi-experimental without an external control group. All included studies reported a reduction in CLABSI rates, ranging from 21 to 73%. Healthcare workers generally perceived these digital interventions positively.</p><p><strong>Discussion: </strong>Digitalised interventions for CLABSI prevention seem to be effective in reducing infection rates, likely because of increasing compliance to established guidelines for CLABSI prevention.</p>","PeriodicalId":7950,"journal":{"name":"Antimicrobial Resistance and Infection Control","volume":"14 1","pages":"45"},"PeriodicalIF":4.8,"publicationDate":"2025-05-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12067738/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143967165","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Genomic surveillance reveals different transmission patterns between third-generation cephalosporin and carbapenem resistance in Klebsiella pneumoniae in the Comunidad Valenciana (Spain), 2018-2020.","authors":"Neris García-González, Beatriz Beamud, Jordi Sevilla-Fortuny, Victoria Sánchez-Hellín, Inmaculada Vidal, Juan Carlos Rodríguez, Begoña Fuster, Nuria Tormo, Carme Salvador, Concepción Gimeno, Barbara Gomila-Sard, Salvador Giner, Olalla Martínez, Javier Colomina, David Navarro, Victoria Domínguez, Fernando González-Candelas","doi":"10.1186/s13756-025-01553-2","DOIUrl":"https://doi.org/10.1186/s13756-025-01553-2","url":null,"abstract":"<p><strong>Background: </strong>The emergence and spread of third-generation cephalosporins (3GC) and carbapenem-resistant Klebsiella pneumoniae pose a global critical challenge. Understanding the transmission dynamics within and between hospital environments is crucial to develop effective control strategies.</p><p><strong>Methods: </strong>From 2017 to 2019, we conducted a genomic surveillance program in eight hospitals of the Comunitat Valenciana, Spain, collecting and sequencing 1,768 3GC- and carbapenem-resistant isolates. We quantified the overall transmission using core genomes and assessed the contribution of national and global isolates to the spread of AMR in the region by including 11,967 database genomes in the analysis.</p><p><strong>Results: </strong>The local collection was highly diverse, involving 188 lineages, including global high-risk clones such as ST307 and ST11, and 3GC and carbapenem resistance determinants. Half of the isolates were involved in transmission, with 70.5% occurring within hospitals.</p><p><strong>Conclusions: </strong>Different transmission patterns characterized the spread of 3GC- and carbapenem resistance in the region. While inter-hospital transmission played a significant role in the spread of 3GC-resistance, this was only sporadic for carbapenem resistance. Moreover, the factors behind inter-hospital spread for each type of resistance differed: while 3GC-resistance likely disseminated between hospitals through intermediate steps, carbapenem resistance was driven by more direct transmission routes. The burden of national and global cases on the ongoing regional AMR dissemination was low. Moreover, we revealed the rapid expansion in the region and globally of lineage ST307 carrying the bla_CTX-M-15 gene, a main driver of local transmissions, providing a deeper understanding of the successful spread of this high-risk clone.</p>","PeriodicalId":7950,"journal":{"name":"Antimicrobial Resistance and Infection Control","volume":"14 1","pages":"44"},"PeriodicalIF":4.8,"publicationDate":"2025-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12060429/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143956209","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction: Healthcare workers' knowledge, attitude and practices on infection prevention and control in the context of the COVID-19 pandemic at the Faranah regional hospital and associated healthcare centers, Guinea.","authors":"Lena Landsmann, Anna Borodova, Carlos Rocha, Aziz Amadou Diallo, Kamis Mamadou Diallo, Matthias Borchert, Mardjan Arvand, Mamadou Diallo, Rebekah R Wood, Sophie A Müller","doi":"10.1186/s13756-025-01566-x","DOIUrl":"https://doi.org/10.1186/s13756-025-01566-x","url":null,"abstract":"","PeriodicalId":7950,"journal":{"name":"Antimicrobial Resistance and Infection Control","volume":"14 1","pages":"43"},"PeriodicalIF":4.8,"publicationDate":"2025-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12057052/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143957631","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Isolation and identification of Klebsiella pneumoniae phage ΦK2046: optimizing its antibacterial potential in combination with chlorhexidine.","authors":"Panjie Hu, Yao Sun, Zeyong Zhong, Sichen Liu, Deyi Zhao, Weijun Chen, Ying Zhang, Zhexiao Ma, Jianming Cao, Tieli Zhou","doi":"10.1186/s13756-025-01548-z","DOIUrl":"https://doi.org/10.1186/s13756-025-01548-z","url":null,"abstract":"<p><strong>Background: </strong>Hospital-acquired infections (HAIs) significantly increase morbidity and mortality worldwide, with Klebsiella pneumoniae (K. pneumoniae) being a leading HAI pathogen requiring targeted eradication in healthcare settings. The growing bacterial tolerance to chemical disinfectants, like chlorhexidine, highlights an urgent need for novel disinfection strategies. Bacteriophages, which employ unique mechanisms to lyse bacteria, offer a potential solution. Combining phages with disinfectants could reduce the use of chemical agents and delay the development of bacterial resistance. However, the use of phages for contamination control in clinical environments remains underexplored.</p><p><strong>Methods: </strong>ΦK2046 was isolated from hospital wastewater and characterized by transmission electron microscopy, one-step growth curve, optimal multiplicity of infection, and stability analysis. Whole-genome sequencing was performed to identify the genomic characteristics of ΦK2046. The antibacterial and antibiofilm effects of ΦK2046 combined with chlorhexidine were assessed through growth curves, time-kill assays, crystal violet staining, and scanning electron microscopy. A contaminated medical device model was established to assess the ΦK2046-chlorhexidine combination's biofilm reduction efficacy, and different dosing sequences and timing intervals were evaluated for their impact on biofilms formed on urinary catheters.</p><p><strong>Results: </strong>ΦK2046, characterized by a short latency period, strong environmental stability, safety, and tolerance to chlorhexidine, significantly enhanced the antibacterial and antibiofilm effects of chlorhexidine against FK2046, and reduce the emergence of resistant strains. In contaminated medical device models, the combination of ΦK2046 and chlorhexidine diminished bacterial load and biofilm formation on surfaces. A \"phage-first\" dosing sequence, particularly with a 90-min interval before chlorhexidine treatment, showed superior efficacy in biofilm reduction.</p><p><strong>Conclusions: </strong>This study, using ΦK2046 as an example, demonstrates the potential of phages to enhance the antibacterial and antibiofilm effects of chlorhexidine and their feasibility in medical device disinfection. This innovative approach not only improves chlorhexidine's disinfecting power but also effectively tackles the issue of reduced susceptibility of K. pneumoniae to chlorhexidine. The research advances the development and application of phage-based disinfectants and lays a foundation for establishing a phage library with adjuvant properties for disinfectants.</p>","PeriodicalId":7950,"journal":{"name":"Antimicrobial Resistance and Infection Control","volume":"14 1","pages":"42"},"PeriodicalIF":4.8,"publicationDate":"2025-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12053862/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143969799","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"High rate of multi-drug resistant Escherichia coli isolated from patients with urinary tract infections in Ifakara-Tanzania: implications for empirical antibiotic treatment guidelines and stewardship programs.","authors":"Magreth Erick Macha, Philipp Kohler, Anja Bösch, Honorathy Msami Urassa, Weihong Qi, Salome N Seiffert, Sabine Haller, Erin West, Maja Weisser Rohacek, Baharak Babouee Flury","doi":"10.1186/s13756-025-01557-y","DOIUrl":"https://doi.org/10.1186/s13756-025-01557-y","url":null,"abstract":"<p><strong>Background: </strong>Antimicrobial resistance (AMR) in Sub-Saharan Africa is a significant health threat, with limited data guide treatment. This study investigates multi-drug resistant Escherichia coli in urinary tract infections (UTIs) in rural Tanzania to guide empirical treatment strategies.</p><p><strong>Methods: </strong>A cross-sectional prospective study of adults with UTIs was conducted at St. Francis Regional Referral Hospital in Ifakara, Tanzania, from September 2021 to August 2023. Urine culture isolates underwent routine diagnostics in Tanzania and E. coli isolates underwent whole-genome sequencing in Switzerland.</p><p><strong>Results: </strong>Of 1055 patients, 248 (23.5%) had positive urine cultures, with E. coli as predominant pathogen (n = 87; 55.7%). Extended-spectrum beta-lactamase-producing E. coli (ESBL-E) was identified in 20 (23.0%) isolates, primarily sequence type ST167 carrying CTX-M-27. All ESBL-E cases (20/20, 100.0%) and half of non-ESBL-E cases (29/58, 50.0%) received empiric antibiotics to which the isolates were documented as resistant. ESBL-E showed higher resistance to cotrimoxazole (100.0%) and ciprofloxacin (90.0%) latter recommended for complicated UTIs in Tanzania's Standard Treatment Guidelines (STG) compared to non-ESBL-E. All ESBL-E isolates were susceptible to nitrofurantoin, as recommended by STG for uncomplicated UTIs, and fosfomycin showed potential alternative for complicated cases.</p><p><strong>Conclusion: </strong>Nearly one-quarter of E. coli isolates causing UTIs were ESBL-E, predominantly ST167 harboring bla_CTX-M-27. Notably, nitrofurantoin remained effective for uncomplicated UTIs, similarly, fosfomycin emerged as a viable alternative. However, ciprofloxacin, despite being recommended in local guidelines for complicated UTIs, showed no efficacy. The genetic similarity between human and environmental isolates underscores the critical need for a One Health approach to tackle antimicrobial resistance (AMR) in the region.</p>","PeriodicalId":7950,"journal":{"name":"Antimicrobial Resistance and Infection Control","volume":"14 1","pages":"41"},"PeriodicalIF":4.8,"publicationDate":"2025-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12046935/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143968859","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Management and microbial monitoring of final rinse water for flexible endoscopes in 290 hospitals in Jiangsu Province, China: a multicenter cross-sectional study.","authors":"Zhanjie Li, Bo Liu, Qingtang Zhu, Zijun Ge, Feng Zang, Wensen Chen, Yongxiang Zhang, Xiafen Ding, Jing Ding, Weihong Zhang","doi":"10.1186/s13756-025-01560-3","DOIUrl":"https://doi.org/10.1186/s13756-025-01560-3","url":null,"abstract":"<p><strong>Background: </strong>There is a lack of a universally accepted standard or guideline for the frequency of disinfection in purified water pipelines. Furthermore, there is no standardized method for detecting microorganisms in the final rinse water utilized for endoscope cleaning.This study aims to examine the current management and microbial monitoring practices concerning the final rinse water used for flexible endoscope cleaning in medical institutions.</p><p><strong>Methods: </strong>A questionnaire was designed using a convenience sampling method to gather data on the maintenance and microbial monitoring of final rinse water for flexible endoscopes in 290 medical institutions across Jiangsu Province, China.</p><p><strong>Results: </strong>Purified water is used for endoscope rinsing by 93.45% of institutions, with 78.62% employing centralized water supply. Membrane filtration devices at the terminal are installed by 82.07%, mainly with a 0.2μm pore size (76.47%), and are replaced quarterly (32.77%). Disinfection devices are present at 52.76% of terminals, with varied disinfection frequencies; chlorine-containing disinfectants (48.15%) and peracetic acid (34.92%) are predominant. Inadequate disinfection, filter membrane neglect, sampling contamination, and biofilm formation are identified as reasons for non-compliant final rinse water. Actions include filter replacement, pipeline disinfection, and flushing. Microbial mornitoring occurs quarterly (70.96%), with faucet outlets as primary sampling sites. Standards are based on 10cfu/100ml (87.58%), using membrane filtration (40.81%) and nutrient agar plates (82.72%). A cultivation period of 2 days predominated (72.43%), with a temperature range of 35-37°C (76.47%).</p><p><strong>Conclusion: </strong>While purified water and terminal filters are common for final rinsing of endoscopes, there is variation in maintenance and supply line disinfection. Current microbiological methods' reliability is considered low, necessitating further research to establish unified standards for effective endoscope final rinse water management and monitoring.</p>","PeriodicalId":7950,"journal":{"name":"Antimicrobial Resistance and Infection Control","volume":"14 1","pages":"40"},"PeriodicalIF":4.8,"publicationDate":"2025-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12044760/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143959197","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Duration of hospitalization increases the risk for long-term carriage of linezolid-resistant enterococci in critically ill patients.","authors":"Vera Rauschenberger, Heike Claus, Charlotte Polzin, Vera Blaschke, Stefanie Kampmeier","doi":"10.1186/s13756-025-01551-4","DOIUrl":"https://doi.org/10.1186/s13756-025-01551-4","url":null,"abstract":"<p><strong>Background: </strong>Enterococci are gut commensal microorganisms, which can however cause life-threatening infections especially in patients suffering from intestinal barrier disorders. Treatment of these enterococcal infections is challenging due to a variety of intrinsic and acquired antibiotic resistances. In this context, linezolid is applied as last-resort antibiotic. Our study aimed at determining linezolid-resistant enterococci (LRE) long-term carriage (≥ 10 weeks), since this is a risk factor for the development of LRE infection.</p><p><strong>Methods: </strong>In a one-year cohort study, all patients on hemato-oncology, intensive and intermediate care units were screened for LRE. To determine the molecular epidemiology, all detected LRE isolates were subjected to whole genome sequencing-based typing to investigate whether in-host selection or pathogen transmission was causative for LRE occurrence. Clinical and demographic data were recorded to identify risk factors for LRE clearance and persistence.</p><p><strong>Results: </strong>Long-term LRE carriage was identified in 7 of 46 (15%) patients. Duration of hospitalization differed significantly between LRE persistence (mean: 110 days; range 28-225 days) and clearance group (mean: 53 days; range 5-213 days). LRE strains mostly exhibited a high genetic core genome diversity, indicating that transmission events played a minor role.</p><p><strong>Conclusions: </strong>Our study shows that the duration of hospitalization increases the risk for long-term carriage of LRE. In contrast to other multi drug resistant bacteria, LRE carriage was rarely caused by transmission events. Thus, future infection prevention measures should focus on antimicrobial stewardship approaches next to classical hygiene strategies.</p>","PeriodicalId":7950,"journal":{"name":"Antimicrobial Resistance and Infection Control","volume":"14 1","pages":"39"},"PeriodicalIF":4.8,"publicationDate":"2025-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12042563/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143956584","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of standard precautions and unrestricted movements of carbapenemase-producing Enterobacterales (CPE) carriers on CPE transmission in a nursing home in Singapore: a prospective cohort study.","authors":"Kyaw Zaw Linn, Xiaowei Huan, Pei Yun Hon, Sharifah Farhanah Syed Husen, Natascha May Thevasagayam, Oon Tek Ng, Shawn Vasoo, Moi Lin Ling, Dale Fisher, Kalisvar Marimuthu","doi":"10.1186/s13756-025-01554-1","DOIUrl":"https://doi.org/10.1186/s13756-025-01554-1","url":null,"abstract":"<p><strong>Background: </strong>In 2018, Singapore's National Infection Prevention & Control Committee (NIPC) recommended standard precautions and unrestricted movements for CPE carriers in nursing homes.</p><p><strong>Objective: </strong>This study investigates the short-term impact of this intervention on CPE transmission in a nursing home in Singapore.</p><p><strong>Methods: </strong>We conducted a prospective cohort study between 1st April and 11th July 2019 in a 255-bedded nursing home in Singapore. Stool samples from residents and environmental samples from sink strainers in the residents' bedrooms, bathrooms, and lavatories, and shower drain traps in bathrooms were collected at baseline, week 2, week 8, and week 12 and tested for CPE. We performed whole genomic sequencing (WGS) to find out if there was any bacterial or plasmid linkage among the residents and between the residents and environment.</p><p><strong>Results: </strong>A total of 32 residents, including six known CPE carriers, were recruited and completed the three-month follow-up visits. Of the six known CPE carriers, five tested negative for CPE, while one consistently tested positive for CPE throughout the study. Of the 28 sink strainers, six (21.43%) were positive for CPE. CPE was not detected in any shower drain trap throughout the study. Only one resident acquired CPE at week 12. WGS analysis of available CPE isolates showed no bacterial or plasmid linkage between residents or between residents and the environment.</p><p><strong>Conclusions: </strong>Standard precautions and unrestricted movement of CPE carriers may be sufficient to control CPE transmission in the nursing home setting. Larger studies with more extensive environmental sampling and longer follow-up periods are needed to confirm this.</p>","PeriodicalId":7950,"journal":{"name":"Antimicrobial Resistance and Infection Control","volume":"14 1","pages":"38"},"PeriodicalIF":4.8,"publicationDate":"2025-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12039280/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143965331","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction: Antimicrobial stewardship in the community setting: a qualitative exploratory study.","authors":"Rose I Okonkwo, Henry Ndukwe, Gary Grant, Sohil Khan","doi":"10.1186/s13756-025-01556-z","DOIUrl":"https://doi.org/10.1186/s13756-025-01556-z","url":null,"abstract":"","PeriodicalId":7950,"journal":{"name":"Antimicrobial Resistance and Infection Control","volume":"14 1","pages":"35"},"PeriodicalIF":4.8,"publicationDate":"2025-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12016336/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143965388","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}