Antimicrobial Resistance and Infection Control最新文献

{"title":"Re-evaluating microbiological testing and isolation measures for suspected MRSA carriers: insights from a retrospective study in a Dutch tertiary care center.","authors":"Sofie C M Tops, Laura Meddens, Corianne Meijer, Suzan D Pas, Janette Rahamat-Langendoen, Edmée C Bowles, Alma Tostmann","doi":"10.1186/s13756-026-01759-y","DOIUrl":"10.1186/s13756-026-01759-y","url":null,"abstract":"<p><strong>Background: </strong>The Netherlands has one of the lowest prevalences of methicillin-resistant Staphylococcus aureus (MRSA) in Europe due to its stringent Search and Destroy policy, including isolation of suspected carriers. Unexpected MRSA detection in non-isolated patients triggers contact tracing and screening of exposed patients and healthcare workers (HCWs). Given evolving epidemiology and healthcare practices, periodic re-evaluation of control measures is essential to sustain low prevalence while minimizing burden.</p><p><strong>Methods: </strong>This retrospective study at a Dutch tertiary hospital (2022-2024) assessed (1) diagnostic accuracy and utility of rapid MRSA PCR using Copan eSwab and Xpert MRSA NxG (Cepheid, GeneXpert); (2) proportion of unexpected MRSA among newly detected carriers; (3) transmission risk after unprotected MRSA exposure; (4) implications for optimizing screening and isolation. Data were extracted from electronic patient and laboratory records. MRSA culture and PCR results (throat, nose, rectum combined) were compared and stratified by screening indication.</p><p><strong>Results: </strong>Among 1939 MRSA screenings, 89 (4.6%) were positive. Major screening indications were 'foreign healthcare exposure' (42.8%; 1.6% positive), 'residing in an asylum seekers' centre' (24.9%; 7.8% positive), or 'livestock contact' (14.5%; 8.6% positive). MRSA-positive household contacts had the highest MRSA test positivity (16/87; 18.4%). Compared with culture, PCR (n = 830) showed 63.9% sensitivity and 99.2% specificity, 21% of positive PCRs were false positives (7/32). Unexpected MRSA findings triggered 78 contact investigations involving 143 patients and 1550 HCWs. Nosocomial transmission occurred in 0.3% of HCWs, none in patients. Incidental MRSA was found in 0.4% of HCWs (6/1550). 30% of patients with \"unexpected MRSA\" lacked known risk factors; parental origin abroad was observed in 38% (exploratory analysis). \"Suspected MRSA\" accounted for 23% of strict isolation days.</p><p><strong>Conclusions: </strong>Current MRSA screening remains effective but could be optimized. Given the low transmission risk, limited PCR sensitivity, and low MRSA prevalence in high-risk groups, contact isolation instead of strict isolation may suffice while awaiting culture results in suspected carriers. A revised, risk-based approach could improve efficiency, reduce unnecessary isolation, and lower costs without compromising safety. As 30% of unexpected MRSA cases lacked established risk factors, updating screening criteria to include emerging risk factors may further strengthen detection and containment.</p>","PeriodicalId":7950,"journal":{"name":"Antimicrobial Resistance and Infection Control","volume":" ","pages":""},"PeriodicalIF":5.2,"publicationDate":"2026-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13360875/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147969944","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analyzing infection prevention and control program in Egyptian university hospitals: strengths and areas for improvement.","authors":"Moustapha Ramadan, Nesrine Fathi Hanafi, Amany Mohamed Aboelenein, Asmaa Abdel-Aziz, Abeer Ezzat Elsayed, Mahmod Arabi, Hoda Mohamed Owais","doi":"10.1186/s13756-026-01758-z","DOIUrl":"10.1186/s13756-026-01758-z","url":null,"abstract":"<p><strong>Background: </strong>Healthcare-associated infections are a major global health problem. Published international guidelines aim to provide technical support for countries and healthcare facilities to implement efficient infection prevention and control (IPC) programs and evaluate them.</p><p><strong>Aim: </strong>This study aims to evaluate Egyptian university hospitals' current IPC program and activities status, using an international standardized tool. Afterwards, the identification of existing strengths and weaknesses of the IPC program is needed for improvement.</p><p><strong>Method: </strong>A cross-sectional study design using a convenience sample to assess the implementation of the IPC program at 26 healthcare facilities running the IPC activities for at least 5 years, amounting to > 11,000 beds, from four selected Egyptian Universities. The WHO IPCAF assessment tool and scoring were used to assess the level of compliance for each core component.</p><p><strong>Results: </strong>The weighted median of participating facilities was 600 ( IQR = 571.25-646.88). The arithmetic mean of participating facilities was 587.19. None of the studied facilities had an inadequate level of IPC, and (50%) of facilities showed an advanced level. IPC guidelines had the highest mean score (83.46%), followed by the IPC program (76.73%). On the other hand, the multimodal strategies in IPC had the lowest mean score (65.57%) following the IPC training and education (69.23%).</p><p><strong>Conclusion: </strong>Although the IPC program is appropriately implemented in the studied hospitals, some challenges exist, and enhancement of multidisciplinary integration optimizes multimodal IPC strategies, implementation of antimicrobial stewardship, training programs, and monitoring and feedback systems are required.</p>","PeriodicalId":7950,"journal":{"name":"Antimicrobial Resistance and Infection Control","volume":"15 1","pages":""},"PeriodicalIF":5.2,"publicationDate":"2026-05-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13185206/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147969989","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Time-related changes in bacterial air contamination of sterile covered items in operating rooms: a systematic review and meta-analysis.","authors":"Camilla Wistrand, Elisabeth Westerdahl, Ann-Sofie Sundqvist","doi":"10.1186/s13756-026-01764-1","DOIUrl":"10.1186/s13756-026-01764-1","url":null,"abstract":"<p><strong>Background: </strong>There is still only limited evidence regarding how bacterial air contamination of sterile items changes over time in the operating room, even when protected by sterile covers. This review aimed to synthesize the available data to inform safe handling and preparation of sterile equipment.</p><p><strong>Methods: </strong>A systematic search was conducted for controlled studies that assessed time-related bacterial contamination of covered sterile items in operating rooms and that reported the outcome as colony forming units (CFU) measured at two or more time points, generating distinct timelines. Six databases were searched from inception to 1 September 2025: Ovid MEDLINE, the Cochrane Central Register of Controlled Trials, CINAHL, the Cochrane Database of Systematic Reviews, Embase, and Web of Science. A meta-analysis was performed using linear regression with CFU as the dependent variable and time (minutes) as the independent variable. The review followed PRISMA guidelines and was registered in PROSPERO (CRD420251018280).</p><p><strong>Results: </strong>Five timelines from four studies evaluating CFU counts yielded an R² of 0.085, indicating that time explained 8.5% of CFU variation. Similarly, analysis of eight timelines from four studies assessing mean CFU values produced an R² of 0.070, attributing 7% of variation to time. Neither analysis demonstrated a statistically significant linear association between time and CFU count (p = 0.176, CI: -1.319 < β < 4.863) or mean CFU values (p = 0.108, CI: 0.191 < β < 0.420) when sterile covers were used. Three additional timelines excluded from the meta-analysis showed mixed results: two indicated a positive association, while one showed no relationship.</p><p><strong>Conclusions: </strong>Time has only a modest impact on bacterial contamination of sterile items when protective covers are used, with minimal increases in CFU over different waiting periods. Clinically, this confirms that properly covered sterile items can be prepared in advance without compromising microbial safety, thus supporting efficient operating room organization and workflow. These findings reinforce the effectiveness of sterile covers as a key measure to reduce the risk of surgical site infections and ensure the safe handling of sterile equipment. Although covered storage appears safe, minimizing unnecessary waiting time, even with coverage, is good clinical practice.</p>","PeriodicalId":7950,"journal":{"name":"Antimicrobial Resistance and Infection Control","volume":"15 1","pages":""},"PeriodicalIF":5.2,"publicationDate":"2026-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13173913/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147925754","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical and cost benefit of rapid molecular screening for carbapenem-resistant organisms: a seven-year analysis in a tertiary hospital.","authors":"Riccardo Bollini, Davide F Bavaro, Francesco De Fazio, Raffaella Renzulli, Cristina Scuderi, Alessandra Belati, Veronica Ciorba, Alessandra Calabrese, Benedetta Varisco, Filippo Medioli, Linda Bussini, Zian Asif, Sara Carloni, Giorgio Da Rin, Antonio Voza, Maurizio Cecconi, Elena Vanni, Erminia Casari, Michele Bartoletti, Valeria Cento","doi":"10.1186/s13756-026-01750-7","DOIUrl":"10.1186/s13756-026-01750-7","url":null,"abstract":"<p><strong>Background: </strong>The endemic spread of carbapenem-resistant organisms (CROs) is often driven by inadequate prevention of patient-to-patient transmission. This study evaluates the impact of rapid molecular surveillance on in-hospital CRO spread, invasive infections, and costs.</p><p><strong>Methods: </strong>In this retrospective, single-center study (Jan 2017-Dec 2023), adult patients at IRCCS Humanitas Research Hospital underwent CRO simultaneous screening using PCR (Xpert™ Carba-R) and culture (Brilliance™ CRE Agar) on admission, with weekly follow-ups in ICUs and onco-hematology wards. Upon PCR result availability, patients were isolated/cohorted. Bloodstream infections (BSIs) were defined by positive blood cultures. Cox regression estimated the risk of incident BSIs. In parallel an economic analysis of the two methods was conducted to asses their impact on resources.</p><p><strong>Results: </strong>Among 21,525 samples, PCR and culture showed high concordance (Cohen's Kappa: 0.909, 95% CI: 0.89-0.93). PCR excluded CRO colonization with 99.7% specificity (95% CI: 99.61-99.76) and a negative likelihood ratio of 0.02. Negative PCR results were available in a median of 2.6 h versus 50 h for culture (p < 0.001), reducing isolation time and adding ~ 10 bed-days annually in our two-bed setup. PCR sensitivity for culture-proven colonization was 97.7% (95% CI: 96.2-99.18). K. pneumoniae accounted for 88% of isolates, with blaKPC as the predominant gene, followed by blaVIM (32.1% culture-negative). CRO acquisition rates were low in ICUs (1.3/1000 patient-days) and onco-hematology wards (0.32/1000 person-days). CRO-BSIs occurred in 75 patients after a median of 12 days, with incidences of 2.35/1000 person-days in colonized versus 0.17/1000 in non-colonized patients. Cox regression identified acquired CRO colonization (aHR = 8.11, 95% CI: 2.38-27.61) and pre-existing blaNDM colonization (aHR = 6.23, 95% CI: 1.05-36.99) as independent predictors of CRO-BSI. The short turnaround times of molecular approach allows to free up beds, increasing the number of patient treatable each years.</p><p><strong>Conclusions: </strong>PCR screening is highly concordant with culture, while delivering faster results with positive impacts on isolation time, bed availability, and rapid identification of patients at high risk for CRO-BSIs. From an economic perspective, the molecular approach leads to an optimization of scarce and precious resources.</p>","PeriodicalId":7950,"journal":{"name":"Antimicrobial Resistance and Infection Control","volume":" ","pages":""},"PeriodicalIF":5.2,"publicationDate":"2026-05-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13464901/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147866234","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Global landscape of locally produced alcohol-based handrub in health care settings: a scoping review.","authors":"Hiroki Saito, Ermira Tartari, Jacopo Garlasco, Didier Pittet, Benedetta Allegranzi","doi":"10.1186/s13756-026-01757-0","DOIUrl":"10.1186/s13756-026-01757-0","url":null,"abstract":"<p><strong>Background: </strong>Reliable access to alcohol-based handrub (ABHR) is essential for hand hygiene and infection prevention, yet many low- and middle-income countries (LMICs) continue to face supply constraints. A 2011 WHO global assessment demonstrated that WHO-recommended ABHR formulations produced locally at low cost, were well accepted by healthcare workers, but also highlighted persistent barriers, including challenges in procuring ingredients and dispensers and in ensuring adequate quality control. This review aimed to provide an updated global synthesis of evidence on local ABHR production in healthcare settings.</p><p><strong>Methods: </strong>Following the Joanna Briggs Institute framework and the Preferred Reporting Items for Systematic reviews and Meta-Analyses extension for Scoping Reviews (PRISMA-ScR) guidelines, we systematically searched Embase, Medline, and CINAHL from inception to 19 March 2025. Two reviewers independently conducted title-abstract screening, full-text screening and data extraction. Primary research articles reporting local ABHR production in healthcare settings in LMICs were eligible for data extraction and descriptive synthesis.</p><p><strong>Results: </strong>Of 2343 articles screened, 31 studies from 19 countries were included (2006-2023). Over half (n = 18, 58%) were conducted during the COVID-19 pandemic; 22 described health-facility production and 9 described factory-level manufacturing. Of the 22 health-facility production studies, 12 (55%) used WHO Formulation 1 (ethanol-based) or modifications thereof. Pharmacists most commonly led production at the health-facility level. Only 6% (two articles) reported the source of alcohol, and less than half evaluated efficacy or organoleptic properties (13 and 12, respectively). Most funded studies relied on high-income-country (HIC) grants (17 of 24, 71%).</p><p><strong>Conclusions: </strong>Local ABHR production remains infrequently reported in the literature, although publications increased during the COVID-19 pandemic. Heavy reliance on short-term, HIC-funded initiatives raises concerns about the long-term scalability and sustainability of local ABHR production in LMICs. Strengthening national regulatory capacity, quality-control laboratories, and sustainable financing is critical to maintain safe ABHR access beyond pandemic contexts, for resilient national supply chains and in-country quality control capacity.</p>","PeriodicalId":7950,"journal":{"name":"Antimicrobial Resistance and Infection Control","volume":" ","pages":""},"PeriodicalIF":5.2,"publicationDate":"2026-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13326558/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147863410","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prospective genomic and epidemiologic surveillance of Klebsiella pneumoniae in a tertiary NICU.","authors":"Carolin Böhne, Claas Baier, Jelena Erdmann, Ella Ebadi, Carina Zirkler, Marc Lindenberg, Dirk Schlüter, Sabine Pirr, Corinna Peter, Bettina Bohnhorst, Leonard Knegendorf","doi":"10.1186/s13756-026-01753-4","DOIUrl":"10.1186/s13756-026-01753-4","url":null,"abstract":"<p><strong>Background: </strong>Klebsiella pneumoniae complex (Kp) is a relevant neonatal pathogen colonizing preterm infants. While outbreak investigations often focus on multidrug-resistant strains, the epidemiology and genomic dynamics of wild-type Kp in nonoutbreak neonatal intensive care unit (NICU) settings remain elusive.</p><p><strong>Methods: </strong>We conducted a 30-month (October 2021 to March 2024) cohort study with weekly active, unselective colonization surveillance of all NICU patients to identify risk factors for nosocomial Kp acquisition and drivers of transmission in a tertiary 21-bed NICU/intermediate care unit (IMC) in Germany.</p><p><strong>Results: </strong>Among 936 patients, 8.7% carried Kp, of which 70.4% were nosocomial. Very low birth weight (VLBW; < 1500 g) was the only independent risk factor for nosocomial acquisition (adjusted odds ratio [aOR], 3.42; 95% CI, 1.29-9.32). Kp infections occurred in three Kp carriers (3.7%). Genomic analyses of at least the first isolate per patient (83 in total) revealed an oligoclonal population structure, with ten distinct sequence types (STs) underlying temporally overlapping clusters. Ten genomic clusters (median size, four patients) were identified, with markedly higher odds in VLBW infants (aOR, 8.76; 95% CI, 2.45-34.16). Nosocomial cluster-assigned cases had higher rates and longer durations of noninvasive ventilation and peripheral venous catheter use. Cluster prevalence showed climate-associated variation, with a six-feature extreme gradient boosting (XGBoost) model identifying temperature and humidity among the strongest predictors.</p><p><strong>Conclusions: </strong>Patient- and climate-associated parameters are main drivers of nosocomial wild-type Kp acquisition and cluster occurrence. Comprehensive surveillance and risk-adapted infection prevention and control support sustainable Kp control in VLBW infants.</p>","PeriodicalId":7950,"journal":{"name":"Antimicrobial Resistance and Infection Control","volume":"15 1","pages":""},"PeriodicalIF":5.2,"publicationDate":"2026-04-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13126709/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147760247","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Genomic investigation of the vancomycin-resistant Enterococcus faecium in a tertiary hospital in China.","authors":"Huimei Zhang, Ying Deng, You-Xiang Chan, Qing Wei, Yi Xie, Dongxian Jiang, Chuangchuang Cai, Zhiwei Huang, Yuzhen Li, Shuo Jiang","doi":"10.1186/s13756-026-01755-2","DOIUrl":"10.1186/s13756-026-01755-2","url":null,"abstract":"<p><strong>Objectives: </strong>In light of a VREfm spread in a large tertiary hospital in China, this study aimed to explore the transmission dynamics and genetic characteristics of these isolates within a global context.</p><p><strong>Methods: </strong>A total of 27 VREfm were collected from a hospital in Guangdong province, China. Antimicrobial susceptibility testing, whole-genome sequencing, and transmission dynamics analysis were performed. Additionally, global sequence type 80 (ST80) data were gathered for genetic comparison, and complete plasmid sequences were reconstructed to characterize the genetic environment surrounding the vanA genes.</p><p><strong>Results: </strong>The study identified VREfm ST80 as the main agent of the patient infection, with the exception of four ST789 isolates identified on environmental surfaces within one bed. The genomes displayed high clustering, with similar profiles of virulence factors and antimicrobial resistance genes. The study observed that genetically similar VREfm strains were distributed across different beds. Moreover, VREfm ST80 from the hospital clustered with other Chinese isolates and exhibited a higher number of VFs compared to other lineages. Although vanA genes were present in different STs, the vanA-carrying plasmids shared highly similar backbone structure, with Tn1546-associated elements detected in each.</p><p><strong>Conclusion: </strong>This study sheds light on the genetic epidemiology of a VREfm spread in a Chinese hospital through comparison with global isolates. To control the spread of VREfm within hospitals, the implementation of active screening programs and rigorous infection control measures is essential.</p>","PeriodicalId":7950,"journal":{"name":"Antimicrobial Resistance and Infection Control","volume":" ","pages":""},"PeriodicalIF":5.2,"publicationDate":"2026-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13255485/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147760238","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Antimicrobial use and stewardship activities in Swiss long-term care facilities: data from a national point-prevalence survey.","authors":"Simone Toppino, Fabian Grässli, Stefan P Kuster, Emmanouil Glampedakis, Celine Gardiol, Tanja Kudrnovsky, Vanja Piezzi, Matthias Schlegel, Philipp Kohler, Domenica Flury","doi":"10.1186/s13756-026-01749-0","DOIUrl":"10.1186/s13756-026-01749-0","url":null,"abstract":"<p><strong>Background: </strong>The first nation-wide point-prevalence survey (PPS) in Swiss long-term care facilities (LTCF) showed significant geographical differences in antimicrobial use. The aim of this study was to characterize these variations, identify associated factors, and assess antimicrobial stewardship (AMS) practices.</p><p><strong>Methods: </strong>The PPS was performed in September 2024. A sample of Swiss LTCFs was randomly selected for representativeness according to language region and size. The PPS was also open to all interested Swiss LTCFs. Data were collected using the adapted Healthcare-Associated Infections in European Long-Term Care Facilities (HALT)-4 protocol. Data on antimicrobial use and AMS elements were stratified by language region. To identify factors independently associated with antimicrobial use, multivariable logistic regression was performed including resident- and institution-level variables.</p><p><strong>Results: </strong>The sample included 7244 residents from 94 LTCFs (43 from German, 18 from French, and 33 from Italian language regions). Most common indications for antimicrobial treatment were urinary tract infections, respiratory tract infections and skin or soft tissue infections, across all language regions. Antimicrobial prophylaxis (32% 67/209) was more common in the French (41%, 26/64) compared to the Italian (29%, 24/82) and German language regions (27%, 17/63). Most commonly prescribed substances for prophylaxis were trimethoprim/sulfamethoxazole, nitrofurantoin and amoxicillin/clavulanic acid. Adoption of AMS elements was low and more common in the French and Italian language region. In multivariable analysis, residing in a LTCF from the French language region remained the strongest factor associated with antimicrobial use (adjusted odds ratio [aOR] 2.99, 95% CI 1.76-5.01). Further factors were recent hospitalisation or surgery (aOR 2.19, 95% CI 1.50-3.19), urinary catheter use (aOR 2.10, 95% CI 1.36-3.24) and use of proton pump inhibitor (aOR 1.49, 95% CI 1.11-2.00), but not the number of implemented AMS elements.</p><p><strong>Conclusions: </strong>Antimicrobial use in Swiss LTCF is higher in the French compared to the Italian and the German language region, independent of other factors. These findings highlight the need for regional surveillance, AMS interventions tailored to local epidemiology, and assessment strategies for their implementation and effectiveness. The high proportion of prophylactic antimicrobials warrants further investigation to determine underlying causes and represents a target for AMS interventions.</p>","PeriodicalId":7950,"journal":{"name":"Antimicrobial Resistance and Infection Control","volume":" ","pages":""},"PeriodicalIF":5.2,"publicationDate":"2026-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13255504/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147760241","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Antibiotic and healthcare exposure impact on dynamics of third-generation cephalosporin-resistant Enterobacterales colonisation in Cambodian children: a six-month cohort study.","authors":"Cristina Ardura-Garcia, Sambou Bran, Poda Sar, Keang Suy, Sreymom Pol, Sue J Lee, Clare Louise Ling, Jukka Corander, Paul Turner","doi":"10.1186/s13756-026-01754-3","DOIUrl":"10.1186/s13756-026-01754-3","url":null,"abstract":"","PeriodicalId":7950,"journal":{"name":"Antimicrobial Resistance and Infection Control","volume":" ","pages":""},"PeriodicalIF":5.2,"publicationDate":"2026-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13238065/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147760182","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of awareness, perceptions, and compliance with infection prevention and control protocols among healthcare professionals at a tertiary hospital in Nasarawa State, Nigeria.","authors":"Hannah Ojonogecha Ocheni, Dennis Kudu Egga, Stephen Olaide Aremu, Adamu Ishaku Akyala, Abdillahi Abdi Barkhadle","doi":"10.1186/s13756-026-01751-6","DOIUrl":"10.1186/s13756-026-01751-6","url":null,"abstract":"<p><strong>Background: </strong>Healthcare associated infections (HAIs) remain a critical threat to patient safety, particularly in low and middle income countries where infection prevention and control (IPC) systems are inconsistently implemented. Strengthening healthcare workers (HCWs) adherence to IPC protocols is vital to curbing nosocomial transmission and improving healthcare quality in Nigeria.</p><p><strong>Methods: </strong>A descriptive cross-sectional study was conducted among 500 HCWs at the Federal Medical Centre, Keffi, Nasarawa State. Participants were selected through stratified random sampling across five professional cadres. Data were collected using a structured questionnaire and a World Health Organization (WHO)-adapted observational checklist. Quantitative data were analysed using descriptive and inferential statistics, including ANOVA and multiple regression, to determine predictors of IPC compliance.</p><p><strong>Results: </strong>Overall IPC knowledge among HCWs was high (mean = 40.01 ± 3.66; 82%), while adherence to standard IPC practices was moderate (mean = 36.39 ± 5.92; 74%). No statistically significant difference in knowledge was observed across professional categories (p = 0.092), but adherence differed significantly (p < 0.001), with nurses demonstrating the highest compliance. Regression analysis identified institutional support (β = 0.40, p < 0.001) and availability of IPC resources as major predictors of adherence. Barriers included inadequate personal protective equipment (PPE), limited supervision, and high workload.</p><p><strong>Conclusion: </strong>Although knowledge of IPC was satisfactory, adherence to standard practices among HCWs at FMC Keffi remains suboptimal due to systemic and institutional challenges rather than knowledge deficits. Strengthening leadership commitment, ensuring sustainable PPE supply chains, implementing continuous professional training, and reinforcing monitoring mechanisms are essential to enhance IPC compliance and reduce HAIs.</p>","PeriodicalId":7950,"journal":{"name":"Antimicrobial Resistance and Infection Control","volume":" ","pages":""},"PeriodicalIF":5.2,"publicationDate":"2026-04-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13224458/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147721619","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}