Annals of periodontology最新文献

{"title":"Associations Between Periodontal Disease and Risk for Atherosclerosis, Cardiovascular Disease, and Stroke. A Systematic Review","authors":"Frank A. Scannapieco,&nbsp;Renee B. Bush,&nbsp;Susanna Paju","doi":"10.1902/annals.2003.8.1.38","DOIUrl":"10.1902/annals.2003.8.1.38","url":null,"abstract":"<p><b>Background:</b> Recent studies implicate exposure to systemic conditions involving chronic inflammation, including chronic periodontitis, in the etiology of atherosclerosis</p><p><b>Rationale:</b> A systematic review of the literature was conducted to assess the association between chronic inflammatory periodontal disease and atherosclerosis.</p><p><b>Focused Question:</b>Does periodontal disease influence the initiation/ progression of atherosclerosis and, therefore, cardiovascular disease (CVD), stroke, and peripheral vascular disease (PVD)?</p><p><b>Search Protocol:</b> MEDLINE, pre-MEDLINE, MEDLINE Daily Update, and the Cochrane Controlled Trials Register were searched to identify human studies that related variables associated with atherosclerosis to periodontal disease. Searches were made for papers published from 1966 through March 2002.</p><p><b>Inclusion criteria:</b> Published randomized controlled clinical trials (RCTs), longitudinal, cohort, and case-control studies were included. Study participants included those with atherosclerosis, myocardial infarction (MI), stroke, or PVD. Oral conditions included periodontal disease.</p><p><b>Exclusion criteria:</b> Only studies on humans were included. Data Collection and Analysis: Because the studies used different oral assessment measures, it was not possible to perform a metaanalysis of the data reported. Weighted mean differences, relative risks, or odds ratios were compared for cohort studies.\u0000\u0000 </p><p><i>Ann Periodontol 2003;8:38-53.</i></p>","PeriodicalId":79473,"journal":{"name":"Annals of periodontology","volume":"8 1","pages":"38-53"},"PeriodicalIF":0.0,"publicationDate":"2003-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1902/annals.2003.8.1.38","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"24400612","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Localized Ridge Augmentation/Preservation. A Systematic Review","authors":"Joseph P. Fiorellini,&nbsp;Marc L. Nevins","doi":"10.1902/annals.2003.8.1.321","DOIUrl":"10.1902/annals.2003.8.1.321","url":null,"abstract":"<p><b>Background:</b> Osseointegrated implants have been documented as efficacious, however, their placement may be contraindicated in some patients due to insufficient bone volume. Techniques such as guided bone regeneration (GBR), immediate implantation, and distraction osteogenesis (DO) have been utilized as ridge enhancement therapies.</p><p><b>Rationale:</b> This systematic review evaluates dental implant survival rates in patients treated with ridge augmentation or preservation techniques.</p><p><b>Focused Question:</b> In patients requiring dental implant placement, what is the effect of localized ridge preservation versus implant placement without augmentation on implant survival and adverse effects?</p><p><b>Search Protocol:</b> MEDLINE and Cochrane Oral Health Group Specialized Trial Register were searched. Hand searches were performed on <i>Clinical Oral Implants Research, International Journal of Oral and Maxillofacial Implants, International Journal of Periodontics and Restorative Dentistry, Journal of Clinical Periodontology, Journal of Periodontology,</i> and <i>Journal of Periodontal Research</i>. All searches were performed for articles published through April 2002.</p><p><b>Selection Criteria:</b>Publications reporting survival rate of dental implants following ridge therapy were included in the analysis. Reports describing techniques were excluded.</p><p><b>Data Collection and Analysis:</b>Due to the absence of controlled studies, a meta-analysis was not performed. Descriptive statistics are used to report the data.\u0000\u0000 </p><p><b>Reviewers' Interpretations:</b> Survival rates were similar for both GBR and DO implants. These survival rates were similar to implants placed in native bone.</p><p><i>Ann Periodontol 2003;8:321-327.</i></p>","PeriodicalId":79473,"journal":{"name":"Annals of periodontology","volume":"8 1","pages":"321-327"},"PeriodicalIF":0.0,"publicationDate":"2003-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1902/annals.2003.8.1.321","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"24400523","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Periodontal Disease as a Risk Factor for Adverse Pregnancy Outcomes. A Systematic Review","authors":"Frank A. Scannapieco,&nbsp;Renee B. Bush,&nbsp;Susanna Paju","doi":"10.1902/annals.2003.8.1.70","DOIUrl":"10.1902/annals.2003.8.1.70","url":null,"abstract":"<p><b>Background:</b> Recent studies have implicated a variety of infections, including periodontal diseases, as risk factors for adverse pregnancy outcomes such as prematurity and low birth weight.</p><p><b>Rationale:</b> A number of studies have shown that bacterial vaginosis is related to preterm and/or low birth weight (PT/LBW), which continues to be a significant cause of infant morbidity and mortality. It is also possible that other infectious processes, including periodontal diseases, contribute to PT/LBW. This systematic review examines the literature to determine the possible relationship between PT/LBW and periodontal diseases.</p><p><b>Focused Question:</b> Does prevention/control of periodontal disease as compared to controls have an impact on the initiation/progression of adverse pregnancy outcomes?</p><p><b>Search Protocol:</b> MEDLINE, pre-MEDLINE, MEDLINE Daily Update, and the Cochrane Oral Controlled Trials Register were searched to identify published studies that related variables associated with PT/LBW and periodontal disease. Searches were performed for articles published through October 2002.</p><p><b>Inclusion criteria:</b> Randomized controlled clinical trials (RCTs), case-control, and cohort studies were included. Study populations included mothers, with or without periodontal disease, who gave birth to preterm and/or mature infants. The interventions considered included all forms of periodontal therapy.</p><p><b>Exclusion criteria:</b> Only studies on humans were included.</p><p><b>Data Collection and Analysis:</b> Due to study heterogeneity, meta-analysis was not possible.\u0000\u0000 </p><p>Ann Periodontol 2003;8:70-78</p>","PeriodicalId":79473,"journal":{"name":"Annals of periodontology","volume":"8 1","pages":"70-78"},"PeriodicalIF":0.0,"publicationDate":"2003-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1902/annals.2003.8.1.70","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"24400614","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy of Chemical Root Surface Modifiers in the Treatment of Periodontal Disease. A Systematic Review","authors":"Angelo Mariotti","doi":"10.1902/annals.2003.8.1.205","DOIUrl":"10.1902/annals.2003.8.1.205","url":null,"abstract":"<p><b>Background:</b> Periodontal regeneration has been a relentless goal of the periodontist. Perhaps the oldest and most frequently attempted type of regeneration has involved chemical modification of the root surface. Varying results from histological and clinical studies have created controversy about the clinical effectiveness of root surface decalcification.</p><p><b>Rationale:</b> This systematic review assesses the efficacy of root surface biomodification through the use of citric acid, tetracycline, or ethylenediaminetetraacetic acid (EDTA) in patients with chronic periodontitis. Focused Question: Does the use of chemical root decalcification result in effective periodontal regeneration and improved clinical outcomes in patients with chronic periodontitis?</p><p><b>Search Protocol:</b> The Cochrane Database of Systematic Reviews; Database of Abstracts of Reviews of Effectiveness; Cochrane Central Register of Controlled Trials; American College of Physicians Journal Club, evidence-based MEDLINE journals; and National Center for Biotechnology Information PubMed Journals, as well as Dogpile, Google, and Copernic search engines were screened. Hand searches were performed on the <i>Journal of Clinical Periodontology, Journal of Periodontology, Journal of Periodontal Research,</i> and <i>Periodontology 2000</i>. Searches were performed for relevant clinical trials published through September 25, 2002.</p><p><b>Selection Criteria</b></p><p><b>Inclusion criteria:</b> Histological and clinical studies evaluating the effects of citric acid, tetracycline, or EDTA on root surfaces of patients with chronic periodontitis were considered for inclusion.</p><p><b>Exclusion criteria:</b> Studies evaluating extracellular matrix proteins (e.g., fibronectin), enamel matrix proteins (e.g., amelogenins), or other proteins or growth factors applied to the root surface were not included.</p><p><b>Data Collection and Analysis:</b> Primary outcome measures included changes in connective tissue attachment, cementogenesis, clinical attachment levels, probing depths, and gingival recession. Secondary outcome measures included changes in bone level, gingival inflammation, and plaque levels. Results for continuous outcome measures for primary variables (clinical attachment levels, probing depths, and recession) were expressed as mean differences or standardized mean differences. Clinical attachment levels and reduction in probing depth were evaluated using meta-analysis. All papers were rated according to methodological strength of evidence.\u0000\u0000 </p><p><i>Ann Periodontol 2003;8:205-226.</i></p>","PeriodicalId":79473,"journal":{"name":"Annals of periodontology","volume":"8 1","pages":"205-226"},"PeriodicalIF":0.0,"publicationDate":"2003-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1902/annals.2003.8.1.205","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"24400519","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Efficacy of Bone Replacement Grafts in the Treatment of Periodontal Osseous Defects. A Systematic Review","authors":"Mark A. Reynolds,&nbsp;Mary Elizabeth Aichelmann-Reidy,&nbsp;Grishondra L. Branch-Mays,&nbsp;John C. Gunsolley","doi":"10.1902/annals.2003.8.1.227","DOIUrl":"10.1902/annals.2003.8.1.227","url":null,"abstract":"<p><b>Background:</b> Bone replacement grafts (BRG) are widely used in the treatment of periodontal osseous defects; however, the clinical benefits of this therapeutic practice require further clarification through a systematic review of randomized controlled studies.</p><p><b>Rationale:</b> The purpose of this systematic review is to access the efficacy of bone replacement grafts in proving demonstrable clinical improvements in periodontal osseous defects compared to surgical debridement alone.</p><p><b>Focused Question:</b> What is the effect of bone replacement grafts compared to other interventions on clinical, radiographic, adverse, and patient-centered outcomes in patients with periodontal osseous defects?</p><p><b>Search Protocol:</b> The computerized bibliographical databases MEDLINE and EMBASE were searched from 1966 and 1974, respectively, to October 2002 for randomized controlled studies in which bone replacement grafts were compared to other surgical interventions in the treatment of periodontal osseous defects. The search strategy included screening of review articles and reference lists of retrieved articles as well as hand searches of selected journals.</p><p><b>Inclusion criteria:</b> All searches were limited to human studies in English language publications.</p><p><b>Exclusion criteria:</b> Non-randomized observational studies (e.g., case reports, case series), publications providing summary statistics without variance estimates or data to permit computation, and studies without BRG intervention alone were excluded.</p><p><b>Data Collection and Analysis:</b> The therapeutic endpoints examined included changes in bone level, clinical attachment level, probing depth, gingival recession, and crestal resorbtion. For purposes of meta-analysis, change in bone level (bone fill) was used as the primary outcome measure, measured upon surgical re-entry or transgingival probing (sounding).\u0000\u0000 </p><p><i>Ann Periodontol 2003;8:227-265.</i></p>","PeriodicalId":79473,"journal":{"name":"Annals of periodontology","volume":"8 1","pages":"227-265"},"PeriodicalIF":0.0,"publicationDate":"2003-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1902/annals.2003.8.1.227","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"24400520","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Participants and Observers: 2003 Workshop on Contemporary Science in Clinical Periodontics","authors":"","doi":"10.1902/annals.2003.8.1.344","DOIUrl":"https://doi.org/10.1902/annals.2003.8.1.344","url":null,"abstract":"","PeriodicalId":79473,"journal":{"name":"Annals of periodontology","volume":"8 1","pages":"344-346"},"PeriodicalIF":0.0,"publicationDate":"2003-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1902/annals.2003.8.1.344","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138024280","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Periodontal Host Modulation with Antiproteinase, Anti-Inflammatory, and Bone-Sparing Agents. A Systematic Review","authors":"Michael S. Reddy,&nbsp;Nico C. Geurs,&nbsp;John C. Gunsolley","doi":"10.1902/annals.2003.8.1.12","DOIUrl":"10.1902/annals.2003.8.1.12","url":null,"abstract":"<p><b>Background:</b>The use of modulating agents, including inhibition of matrix metalloproteinases (MMPs) with antiproteinases, blocking production of proinflammatory cytokines and prostaglandins with antiinflammatory drugs, and inhibiting activation of osteoclasts with bone-sparing agents, has been postulated to be of therapeutic value as an adjunctive therapy to the management of chronic periodontitis.</p><p><b>Rationale:</b>The objective of this systematic review of the literature was to assess the adjunctive efficacy of antiproteinase, anti-inflammatory, and bone-sparing host-modulating agents in the treatment of gingivitis, aggressive periodontitis, and chronic periodontitis.\u0000\u0000 </p><p><b>Search Protocol:</b>MEDLINE, Embase, and the Cochrane Library databases were searched without language restrictions through April 1, 2002 for studies that used tetracycline (TET)-related matrix metalloproteinase (MMP) inhibitors, or non-steroidal anti-inflammatory drugs (NSAIDs) and bisphosphonate anti-osteolytic agents. The investigation also included hand searching of journals and contacting authors and industry experts.</p><p><b>Selection Criteria</b></p><p><b>Inclusion criteria:</b>Only human studies (randomized controlled clinical trials, cohort studies, case-control studies, cross-sectional studies, and case series) were selected. Studies were on subjects with gingivitis, aggressive or chronic periodontitis, or dental implants. Interventions included TET-related MMP inhibitors, NSAIDs, or bisphosphonate anti-osteolytic agents.</p><p><b>Exclusion criteria:</b>Studies that used MMP tissue inhibitors as diagnostic or prognostic indicators of periodontal disease or that evaluated short-term systemic antibodies or locally delivered levels of drugs with antiproteinase activity were excluded.</p><p><b>Data Collection and Analysis:</b>The primary outcomes for assessment were changes in bone or clinical attachment levels (CAL); secondary outcomes included clinical measures of plaque, gingival inflammation, probing depth (PD), and mobility. Summary data appropriate for meta-analysis were pooled using a weighted average and analyzed using a standardized difference; the results were checked with both fixed-effects and random-effects models.\u0000\u0000 </p><p><i>Ann Periodontol 2003;74:12-37.</i></p>","PeriodicalId":79473,"journal":{"name":"Annals of periodontology","volume":"8 1","pages":"12-37"},"PeriodicalIF":0.0,"publicationDate":"2003-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1902/annals.2003.8.1.12","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"24400611","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Interactions of Oral Pathogens With Toll-Like Receptors: Possible Role in Atherosclerosis","authors":"George Hajishengallis Dr.,&nbsp;Ashu Sharma,&nbsp;Michael W. Russell,&nbsp;Robert J. Genco","doi":"10.1902/annals.2002.7.1.72","DOIUrl":"10.1902/annals.2002.7.1.72","url":null,"abstract":"Toll-like receptors (TLR) function as important signal transducers that mediate innate immune and inflammatory responses to pathogens through pattern recognition of virulence molecules. Although TLRs mediate protection against infection, it is also likely that they may have a pathophysiologic role in certain inflammatory diseases, such as atherosclerosis. In atherosclerotic lesions, endothelial cells and macrophages have been shown to upregulate TLR expression and may respond to TLR agonists of microbial origin, resulting in detrimental inflammatory reactions. Some of these potential TLR-activating virulence factors may be of oral origin. The detection in atherosclerotic plaques of DNA specific for Porphyromonas gingivalis and other periodontal pathogens suggests that these pathogens disseminate into the systemic circulation and localize in atheromas. The potential of periodontal and some other oral pathogens to activate TLRs in vivo is suggested by findings from cell culture experiments on interactions of selected virulence protein adhesins with TLRs and their coreceptors. Specifically, we have shown that proinflammatory cytokine induction by P. gingivalis fimbriae was inhibited by monoclonal antibodies to TLR2, TLR4, CD14, and beta2 integrins, but not by immunoglobulin isotype controls. Cytokine induction by Bacteroides forsythus protein A depended heavily on CD14 and TLR2. We also found that the ability of Streptococcus mutans protein AgI/II to stimulate cytokine release was partially dependent on CD14 and TLR4. Moreover, P. gingivalis fimbriae induced TLR-dependent activation of nuclear factor-kappaB and upregulation of costimulatory molecules in monocytic cells. These proinflammatory activities have been implicated in the pathogenesis of periodontitis, and similar inflammatory mechanisms could potentially operate in atherosclerosis. Studies by other groups have shown that P. gingivalis is capable of stimulating low-density lipoprotein oxidation, foam cell formation, and rupture of atherosclerotic plaque through induction of matrix metalloproteinases. Interestingly, at least some of these activities can be induced by TLR agonists (lipopolysaccharide and heat-shock protein-60) from Chlamydia pneumoniae, a major risk factor in atherosclerosis. Future research in animal models and in vitro cellular systems with defined mutations in TLRs may implicate TLR participation in oral pathogen-mediated atherosclerotic processes, thereby providing a mechanistic basis for the epidemiological findings linking oral pathogens to atherosclerotic disease.","PeriodicalId":79473,"journal":{"name":"Annals of periodontology","volume":"7 1","pages":"72-78"},"PeriodicalIF":0.0,"publicationDate":"2002-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1902/annals.2002.7.1.72","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25185533","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Porphyromonas gingivalis Lipopolysaccharide Displays Functionally Diverse Interactions With the Innate Host Defense System","authors":"Brian W. Bainbridge,&nbsp;Stephen R. Coats,&nbsp;Richard P. Darveau Dr.","doi":"10.1902/annals.2002.7.1.29","DOIUrl":"10.1902/annals.2002.7.1.29","url":null,"abstract":"<p>Periodontitis is a bacterially induced chronic inflammatory disease and a major cause of tooth loss in the world. The tissue damage and alveolar bone resorption characteristic of the disease are believed to be due to a destructive innate host response to a pathogenic subgingival biofilm. <i>Porphyromonas gingivalis</i>, a Gram-negative bacterium, is a member of this mixed microbial community that has been designated an etiologic agent of periodontitis. The innate host response to lipopolysaccharide (LPS) obtained from <i>P. gingivalis</i> is unusual in that different studies have reported that it can be an agonist for Toll-like receptor (TLR) 2 as well as an antagonist or agonist for TLR4. In addition, human monocytes respond to this LPS by secreting a variety of different inflammatory mediators, while endothelial cells do not. We have examined highly purified preparations of <i>P. gingivalis</i> LPS and found that they activate both TLR2 combined with TLR1 and TLR4 in transiently transfected human embryonic kidney (HEK) 293 cells. We have further demonstrated that highly purified <i>P. gingivalis</i> LPS preparations contain at least 3 major different lipid A species. We speculate that <i>P. gingivalis</i> lipid A structural heterogeneity contributes to the unusual innate host response to this LPS and its ability to interact with different TLR molecules. <i>Ann Periodontol 2002;7:29-37.</i></p>","PeriodicalId":79473,"journal":{"name":"Annals of periodontology","volume":"7 1","pages":"29-37"},"PeriodicalIF":0.0,"publicationDate":"2002-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1902/annals.2002.7.1.29","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25186099","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Molecular Determinants of Risk. Proceedings of the 20th International Conference on Periodontal Research. University of North Carolina, Chapel Hill, June 5-9, 2002.","authors":"","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":79473,"journal":{"name":"Annals of periodontology","volume":"7 1","pages":"i-iv, 1-129"},"PeriodicalIF":0.0,"publicationDate":"2002-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25197044","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}