Associations Between Periodontal Disease and Risk for Atherosclerosis, Cardiovascular Disease, and Stroke. A Systematic Review

Annals of periodontology Pub Date : 2003-12-01 DOI:10.1902/annals.2003.8.1.38

Frank A. Scannapieco, Renee B. Bush, Susanna Paju

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引用次数: 513

Abstract

Background: Recent studies implicate exposure to systemic conditions involving chronic inflammation, including chronic periodontitis, in the etiology of atherosclerosis

Rationale: A systematic review of the literature was conducted to assess the association between chronic inflammatory periodontal disease and atherosclerosis.

Focused Question:Does periodontal disease influence the initiation/ progression of atherosclerosis and, therefore, cardiovascular disease (CVD), stroke, and peripheral vascular disease (PVD)?

Search Protocol: MEDLINE, pre-MEDLINE, MEDLINE Daily Update, and the Cochrane Controlled Trials Register were searched to identify human studies that related variables associated with atherosclerosis to periodontal disease. Searches were made for papers published from 1966 through March 2002.

Inclusion criteria: Published randomized controlled clinical trials (RCTs), longitudinal, cohort, and case-control studies were included. Study participants included those with atherosclerosis, myocardial infarction (MI), stroke, or PVD. Oral conditions included periodontal disease.

Exclusion criteria: Only studies on humans were included. Data Collection and Analysis: Because the studies used different oral assessment measures, it was not possible to perform a metaanalysis of the data reported. Weighted mean differences, relative risks, or odds ratios were compared for cohort studies.

Ann Periodontol 2003;8:38-53.

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牙周病与动脉粥样硬化、心血管疾病和中风风险之间的关系。系统回顾

背景:最近的研究表明暴露于包括慢性牙周炎在内的系统性慢性炎症条件下与动脉粥样硬化的病因有关。理由:对文献进行了系统的回顾，以评估慢性炎症性牙周病与动脉粥样硬化之间的关系。重点问题:牙周病是否影响动脉粥样硬化的发生/进展，从而影响心血管疾病(CVD)、中风和周围血管疾病(PVD)?检索方案:检索MEDLINE、预MEDLINE、MEDLINE每日更新和Cochrane对照试验注册表，以确定与动脉粥样硬化与牙周病相关变量的人类研究。搜索的是1966年至2002年3月期间发表的论文。纳入标准:纳入已发表的随机对照临床试验(RCTs)、纵向、队列和病例对照研究。研究对象包括动脉粥样硬化、心肌梗死、中风或PVD患者。口腔疾病包括牙周病。排除标准:仅包括人类研究。数据收集和分析:由于研究使用了不同的口头评估方法，因此不可能对报告的数据进行荟萃分析。对队列研究的加权平均差异、相对风险或优势比进行比较。牙周病杂志2003;8:38-53。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Annals of periodontology

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