发布求助
文献互助 智能选刊 最新文献

Annual review of microbiology最新文献

筛选
英文 中文
The Microbe, the Infection Enigma, and the Host. 微生物、感染之谜和宿主。
IF 8.5 1区 生物学
Annual review of microbiology Pub Date : 2024-11-01 Epub Date: 2024-11-07 DOI: 10.1146/annurev-micro-092123-022855
Jean-Laurent Casanova, Laurent Abel
{"title":"The Microbe, the Infection Enigma, and the Host.","authors":"Jean-Laurent Casanova, Laurent Abel","doi":"10.1146/annurev-micro-092123-022855","DOIUrl":"10.1146/annurev-micro-092123-022855","url":null,"abstract":"<p><p>Human infectious diseases are unique in that the discovery of their environmental trigger, the microbe, was sufficient to drive the development of extraordinarily effective principles and tools for their prevention or cure. This unique medical prowess has outpaced, and perhaps even hindered, the development of scientific progress of equal magnitude in the biological understanding of infectious diseases. Indeed, the hope kindled by the germ theory of disease was rapidly subdued by the infection enigma, in need of a host solution, when it was realized that most individuals infected with most infectious agents continue to do well. The root causes of disease and death in the unhappy few remained unclear. While canonical approaches in vitro (cellular microbiology), in vivo (animal models), and in natura (clinical studies) analyzed the consequences of infection with a microbe, considered to be the cause of disease, in cells, tissues, or organisms seen as a uniform host, alternative approaches searched for preexisting causes of disease, particularly human genetic and immunological determinants in populations of diverse individuals infected with a trigger microbe.</p>","PeriodicalId":7946,"journal":{"name":"Annual review of microbiology","volume":" ","pages":"103-124"},"PeriodicalIF":8.5,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141578798","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Apicomplexan Pore-Forming Toxins. 吸虫毛孔形成毒素
IF 8.5 1区 生物学
Annual review of microbiology Pub Date : 2024-11-01 Epub Date: 2024-11-07 DOI: 10.1146/annurev-micro-041222-025939
Vern B Carruthers
{"title":"Apicomplexan Pore-Forming Toxins.","authors":"Vern B Carruthers","doi":"10.1146/annurev-micro-041222-025939","DOIUrl":"10.1146/annurev-micro-041222-025939","url":null,"abstract":"<p><p>Pore-forming toxins (PFTs) are released by one cell to directly inflict damage on another cell. Hosts use PFTs, including members of the membrane attack complex/perforin protein family, to fight infections and cancer, while bacteria and parasites deploy PFTs to promote infection. Apicomplexan parasites secrete perforin-like proteins as PFTs to egress from infected cells and traverse tissue barriers. Other protozoa, along with helminth parasites, utilize saposin-like PFTs prospectively for nutrient acquisition during infection. This review discusses seminal and more recent advances in understanding how parasite PFTs promote infection and describes how they are regulated and fulfill their roles without causing parasite self-harm. Although exciting progress has been made in defining mechanisms of pore formation by PFTs, many open questions remain to be addressed to gain additional key insights into these remarkable determinants of parasitic infections.</p>","PeriodicalId":7946,"journal":{"name":"Annual review of microbiology","volume":" ","pages":"277-291"},"PeriodicalIF":8.5,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141873978","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Innovative Strategies to Study the Pathogenesis of Elusive Spirochetes and Difficulties Managing the Chronic Infections They Cause. 研究难以捉摸的螺旋体致病机理的创新战略及其导致的慢性感染的管理难题。
IF 8.5 1区 生物学
Annual review of microbiology Pub Date : 2024-11-01 Epub Date: 2024-11-07 DOI: 10.1146/annurev-micro-100423-030847
Mohamed Abdallah Mohamed Moustafa, Samantha Schlachter, Nikhat Parveen
{"title":"Innovative Strategies to Study the Pathogenesis of Elusive Spirochetes and Difficulties Managing the Chronic Infections They Cause.","authors":"Mohamed Abdallah Mohamed Moustafa, Samantha Schlachter, Nikhat Parveen","doi":"10.1146/annurev-micro-100423-030847","DOIUrl":"10.1146/annurev-micro-100423-030847","url":null,"abstract":"<p><p>The major human spirochetal pathogens (<i>Leptospira</i>, <i>Borrelia</i>, and <i>Treponema</i>) are difficult to diagnose and lack vaccines to prevent infections. Infection by these spirochetes does not generate general protective immunity, allowing reinfection by different strains to occur. These stealth pathogens have uncommon physiology, pathogenesis, and clinical presentations and possess unique immune evasion mechanisms to facilitate their host adaptation and persistence. Collectively, host-spirochete interactions orchestrate systemic infections in a manner distinct from organ- and tissue-specific diseases caused by many bacterial pathogens. Difficulties in growing and genetic manipulation of infectious spirochetes have hindered the full understanding of their virulence factors despite decades to centuries of research. This article highlights the current understanding of the intricacies of spirochetal pathogenesis and diseases. Our comprehensive review of the progress versus gaps in knowledge lays a foundation for researchers to direct their studies toward the development of effective diagnostics and vaccines to protect patients from serious, chronic spirochetal diseases.</p>","PeriodicalId":7946,"journal":{"name":"Annual review of microbiology","volume":" ","pages":"337-360"},"PeriodicalIF":8.5,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141896565","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Novel Antibody-Based Protection/Therapeutics in Staphylococcus aureus. 基于抗体的金黄色葡萄球菌新型保护/治疗方法。
IF 8.5 1区 生物学
Annual review of microbiology Pub Date : 2024-11-01 Epub Date: 2024-11-07 DOI: 10.1146/annurev-micro-041222-024605
Xinhai Chen, Dominique Missiakas
{"title":"Novel Antibody-Based Protection/Therapeutics in <i>Staphylococcus aureus</i>.","authors":"Xinhai Chen, Dominique Missiakas","doi":"10.1146/annurev-micro-041222-024605","DOIUrl":"10.1146/annurev-micro-041222-024605","url":null,"abstract":"<p><p><i>Staphylococcus aureus</i> is a commensal of the skin and nares of humans as well as the causative agent of infections associated with significant mortality. The acquisition of antibiotic resistance traits complicates the treatment of such infections and has prompted the development of monoclonal antibodies. The selection of protective antigens is typically guided by studying the natural antibody responses to a pathogen. What happens when the pathogen masks these antigens and subverts adaptive responses, or when the pathogen inhibits or alters the effector functions of antibodies? <i>S. aureus</i> is constantly exposed to its human host and has evolved all these strategies. Here, we review how anti-<i>S. aureus</i> targets have been selected and how antibodies have been engineered to overcome the formidable immune evasive activities of this pathogen. We discuss the prospects of antibody-based therapeutics in the context of disease severity, immune competence, and history of past infections.</p>","PeriodicalId":7946,"journal":{"name":"Annual review of microbiology","volume":" ","pages":"425-446"},"PeriodicalIF":8.5,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141987310","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Molecular Mechanisms for Iron Uptake and Homeostasis in Marine Eukaryotic Phytoplankton. 海洋真核浮游植物铁吸收和平衡的分子机制。
IF 8.5 1区 生物学
Annual review of microbiology Pub Date : 2024-11-01 Epub Date: 2024-11-07 DOI: 10.1146/annurev-micro-041222-023252
Robert H Lampe, Tyler H Coale, Jeffrey B McQuaid, Andrew E Allen
{"title":"Molecular Mechanisms for Iron Uptake and Homeostasis in Marine Eukaryotic Phytoplankton.","authors":"Robert H Lampe, Tyler H Coale, Jeffrey B McQuaid, Andrew E Allen","doi":"10.1146/annurev-micro-041222-023252","DOIUrl":"10.1146/annurev-micro-041222-023252","url":null,"abstract":"<p><p>The micronutrient iron is essential for phytoplankton growth due to its central role in a wide variety of key metabolic processes including photosynthesis and nitrate assimilation. As a result of scarce bioavailable iron in seawater, marine primary productivity is often iron-limited with future iron supplies remaining uncertain. Although evolutionary constraints resulted in high cellular iron requirements, phytoplankton evolved diverse mechanisms that enable uptake of multiple forms of iron, storage of iron over short and long timescales, and modulation of their iron requirement under stress. Genomics continues to increase our understanding of iron-related proteins that are homologous to those characterized in other model organisms, while recently, molecular and cell biology have been revealing unique genes and processes with connections to iron acquisition or use. Moreover, there are an increasing number of examples showing the interplay between iron uptake and extracellular processes such as boundary layer chemistry and microbial interactions.</p>","PeriodicalId":7946,"journal":{"name":"Annual review of microbiology","volume":" ","pages":"213-232"},"PeriodicalIF":8.5,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141632381","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Viral Genome Delivery Across Bacterial Cell Surfaces. 通过细菌细胞表面传递病毒基因组
IF 8.5 1区 生物学
Annual review of microbiology Pub Date : 2024-11-01 Epub Date: 2024-11-07 DOI: 10.1146/annurev-micro-041222-124727
Stephano M Iglesias, Fenglin Li, Federica Briani, Gino Cingolani
{"title":"Viral Genome Delivery Across Bacterial Cell Surfaces.","authors":"Stephano M Iglesias, Fenglin Li, Federica Briani, Gino Cingolani","doi":"10.1146/annurev-micro-041222-124727","DOIUrl":"10.1146/annurev-micro-041222-124727","url":null,"abstract":"<p><p>In 1952, Hershey and Chase used bacteriophage T2 genome delivery inside <i>Escherichia coli</i> to demonstrate that DNA, not protein, is the genetic material. Over 70 years later, our understanding of bacteriophage structure has grown dramatically, mainly thanks to the cryogenic electron microscopy revolution. In stark contrast, phage genome delivery in prokaryotes remains poorly understood, mainly due to the inherent challenge of studying such a transient and complex process. Here, we review the current literature on viral genome delivery across bacterial cell surfaces. We focus on icosahedral bacterial viruses that we arbitrarily sort into three groups based on the presence and size of a tail apparatus. We inventory the building blocks implicated in genome delivery and critically analyze putative mechanisms of genome ejection. Bacteriophage genome delivery into bacteria is a topic of growing interest, given the renaissance of phage therapy in Western medicine as a therapeutic alternative to face the antibiotic resistance crisis.</p>","PeriodicalId":7946,"journal":{"name":"Annual review of microbiology","volume":" ","pages":"125-145"},"PeriodicalIF":8.5,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141578800","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
From Chaos Comes Order: Genetics and Genome Biology of Arbuscular Mycorrhizal Fungi. 从混沌到有序：丛枝菌根真菌的遗传学和基因组生物学》。
IF 8.5 1区 生物学
Annual review of microbiology Pub Date : 2024-11-01 Epub Date: 2024-11-07 DOI: 10.1146/annurev-micro-041522-105143
Jordana Oliveira, Gokalp Yildirir, Nicolas Corradi
{"title":"From Chaos Comes Order: Genetics and Genome Biology of Arbuscular Mycorrhizal Fungi.","authors":"Jordana Oliveira, Gokalp Yildirir, Nicolas Corradi","doi":"10.1146/annurev-micro-041522-105143","DOIUrl":"10.1146/annurev-micro-041522-105143","url":null,"abstract":"<p><p>Arbuscular mycorrhizal fungi (AMF) are obligate mutualists that can enhance nutrition and growth of their plant hosts while providing protection against pathogens. AMF produce spores and hyphal networks that can carry thousands of nuclei in a continuous cytoplasm, with no evidence of sexual reproduction. This review examines the impact of genomic technologies on our view of AMF genetics and evolution. We highlight how the genetics, nuclear dynamics, and epigenetics of these prominent symbionts follow trends preserved in distant multinucleate fungal relatives. We also propose new avenues of research to improve our understanding of their nuclear biology and their intricate genetic interactions with plant hosts.</p>","PeriodicalId":7946,"journal":{"name":"Annual review of microbiology","volume":" ","pages":"147-168"},"PeriodicalIF":8.5,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141578797","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Metals at the Host-Fungal Pathogen Battleground. 寄主-真菌病原体战场上的金属
IF 8.5 1区 生物学
Annual review of microbiology Pub Date : 2024-11-01 Epub Date: 2024-11-07 DOI: 10.1146/annurev-micro-041222-023745
Ritu Garg, Marika S David, Shuyi Yang, Valeria C Culotta
{"title":"Metals at the Host-Fungal Pathogen Battleground.","authors":"Ritu Garg, Marika S David, Shuyi Yang, Valeria C Culotta","doi":"10.1146/annurev-micro-041222-023745","DOIUrl":"10.1146/annurev-micro-041222-023745","url":null,"abstract":"<p><p>Fungal infections continue to represent a major threat to public health, particularly with the emergence of multidrug-resistant fungal pathogens. As part of the innate immune response, the host modulates the availability of metals as armament against pathogenic microbes, including fungi. The transition metals Fe, Cu, Zn, and Mn are essential micronutrients for all life forms, but when present in excess, these same metals are potent toxins. The host exploits the double-edged sword of these metals, and will either withhold metal micronutrients from pathogenic fungi or attack them with toxic doses. In response to these attacks, fungal pathogens cleverly adapt by modulating metal transport, metal storage, and usage of metals as cofactors for enzymes. Here we review the current state of understanding on Fe, Cu, Zn, and Mn at the host-fungal pathogen battleground and provide perspectives for future research, including a hope for new antifungals based on metals.</p>","PeriodicalId":7946,"journal":{"name":"Annual review of microbiology","volume":" ","pages":"23-38"},"PeriodicalIF":8.5,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141086368","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Dimethylsulfoniopropionate (DMSP): From Biochemistry to Global Ecological Significance. 二甲基硫代丙酸酯（DMSP）：从生物化学到全球生态意义。
IF 8.5 1区 生物学
Annual review of microbiology Pub Date : 2024-11-01 Epub Date: 2024-11-07 DOI: 10.1146/annurev-micro-041222-024055
Chun-Yang Li, Hai-Yan Cao, Rocky D Payet, Jonathan D Todd, Yu-Zhong Zhang
{"title":"Dimethylsulfoniopropionate (DMSP): From Biochemistry to Global Ecological Significance.","authors":"Chun-Yang Li, Hai-Yan Cao, Rocky D Payet, Jonathan D Todd, Yu-Zhong Zhang","doi":"10.1146/annurev-micro-041222-024055","DOIUrl":"10.1146/annurev-micro-041222-024055","url":null,"abstract":"<p><p>Dimethylsulfoniopropionate (DMSP) is one of Earth's most abundant organosulfur compounds with important roles in stress tolerance, chemotaxis, global carbon and sulfur cycling, and climate-active gas production. Diverse marine prokaryotes and eukaryotes produce DMSP via three known pathways (methylation, transamination, and decarboxylation) and metabolize DMSP via three further pathways (demethylation, cleavage, and oxidation). Over 20 key enzymes from these pathways have been identified that demonstrate the biodiversity and importance of DMSP cycling. The last dozen years have seen significant changes in our understanding of the enzymology and molecular mechanisms of these DMSP cycling enzymes through the application of biochemistry and structural biology. This has yielded more than 10 crystal structures and, in many cases, detailed explanations as to how and why organisms synthesis and metabolize DMSP. In this review, we describe recent progress in biochemical and mechanistic understandings of DMSP synthesis and metabolism, highlighting the important knowledge gleaned and current challenges that warrant further exploration.</p>","PeriodicalId":7946,"journal":{"name":"Annual review of microbiology","volume":" ","pages":"513-532"},"PeriodicalIF":8.5,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142131668","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Dickeya Diversity and Pathogenic Mechanisms. Dickeya 多样性和致病机制。
IF 8.5 1区 生物学
Annual review of microbiology Pub Date : 2024-11-01 DOI: 10.1146/annurev-micro-041222-012242
Jianuan Zhou, Ming Hu, Lianhui Zhang
{"title":"<i>Dickeya</i> Diversity and Pathogenic Mechanisms.","authors":"Jianuan Zhou, Ming Hu, Lianhui Zhang","doi":"10.1146/annurev-micro-041222-012242","DOIUrl":"10.1146/annurev-micro-041222-012242","url":null,"abstract":"<p><p>The <i>Dickeya</i> genus comprises numerous pathogenic species that cause diseases in various crops, vegetables, and ornamental plants across the globe. The pathogens have become very widespread in recent years, and numerous newly identified <i>Dickeya</i>-associated plant diseases have been reported, which poses an immense threat to agricultural production and is a serious concern internationally. Evidence is accumulating that a diversity of hosts, environmental habitats, and climates seems to shape the abundance of <i>Dickeya</i> species in nature and the differentiation of pathogenic mechanisms. This review summarizes the latest findings on the genome diversity and pathogenic mechanisms of <i>Dickeya</i> spp., with a focus on the intricate virulence regulatory mechanisms mediated by quorum sensing and pathogen-host interkingdom communication systems.</p>","PeriodicalId":7946,"journal":{"name":"Annual review of microbiology","volume":"78 1","pages":"621-642"},"PeriodicalIF":8.5,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142680634","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
下一页 尾页
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整，为了账户安全，请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
请完成安全验证×
相关产品
×
本文献相关产品
联系我们：info@booksci.cn Book学术提供免费学术资源搜索服务，方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号：481959085
Book学术官方微信