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Annual review of microbiology最新文献

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The Corrinoid Model for Dissecting Microbial Community Interactions Across Scales. 跨尺度解剖微生物群落相互作用的Corrinoid模型。
IF 8.5 1区 生物学
Annual review of microbiology Pub Date : 2025-06-27 DOI: 10.1146/annurev-micro-051024-044734
Zoila I Alvarez-Aponte, Rebecca R Procknow, Michiko E Taga
{"title":"The Corrinoid Model for Dissecting Microbial Community Interactions Across Scales.","authors":"Zoila I Alvarez-Aponte, Rebecca R Procknow, Michiko E Taga","doi":"10.1146/annurev-micro-051024-044734","DOIUrl":"https://doi.org/10.1146/annurev-micro-051024-044734","url":null,"abstract":"<p><p>Microbial communities in different environments have major impacts on global nutrient cycling and on the health of host organisms. However, the complexity of microbial communities complicates the investigation of how interactions among numerous microbial species, each with distinct features and metabolic capabilities, affect global processes. In this review, we describe the corrinoid model for investigating microbial community interactions across scales, from individual microbes to complex natural communities. Corrinoids are the vitamin B12 (cobalamin) family of organometallic cofactors. While numerous metabolic processes across all domains of life require corrinoids, only a fraction of bacterial and archaeal species produce them. This structurally diverse set of shared nutrients influences community structure in different ways. Knowledge about corrinoid biology at each scale informs and reinforces a robust model that can be expanded to increase our understanding of microbial communities.</p>","PeriodicalId":7946,"journal":{"name":"Annual review of microbiology","volume":" ","pages":""},"PeriodicalIF":8.5,"publicationDate":"2025-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144511381","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Opportunistic Fungal Infections in Sub-Saharan Africa. 撒哈拉以南非洲的机会性真菌感染。
IF 8.5 1区 生物学
Annual review of microbiology Pub Date : 2025-06-26 DOI: 10.1146/annurev-micro-121423-115959
Lucian Duvenage, Emily Ruth Higgitt, Rachael Dangarembizi, J Claire Hoving
{"title":"Opportunistic Fungal Infections in Sub-Saharan Africa.","authors":"Lucian Duvenage, Emily Ruth Higgitt, Rachael Dangarembizi, J Claire Hoving","doi":"10.1146/annurev-micro-121423-115959","DOIUrl":"https://doi.org/10.1146/annurev-micro-121423-115959","url":null,"abstract":"<p><p>Opportunistic fungal infections are a major cause of morbidity and mortality in sub-Saharan Africa. The high prevalence of advanced HIV disease, limited surveillance and reporting of fungal disease, and lack of access to healthcare lead to a disproportionate number of fungal-related deaths in this region. This review explores selected fungal pathogens associated with the highest mortality rates: <i>Cryptococcus neoformans</i> and <i>Pneumocystis jirovecii</i>, as well as endemic dimorphic fungal pathogens <i>Histoplasma</i> spp. and <i>Emergomyces africanus</i>, which are underreported in the region. Recent advances in our understanding of pathogenesis and how this knowledge may be exploited for the development of novel antifungals and therapies are discussed. We reflect on the risk factors unique to sub-Saharan Africa and on the diagnostic and treatment challenges, and we highlight the current research priorities that are needed to reduce the burden of fungal disease in this endemic region.</p>","PeriodicalId":7946,"journal":{"name":"Annual review of microbiology","volume":" ","pages":""},"PeriodicalIF":8.5,"publicationDate":"2025-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144504727","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Genetic Exchange in Leishmania: Understanding the Cryptic Sexual Cycle. 利什曼原虫的基因交换：对隐秘性周期的理解。
IF 8.5 1区 生物学
Annual review of microbiology Pub Date : 2025-06-17 DOI: 10.1146/annurev-micro-050724-091231
Carolina M C Catta-Preta, David L Sacks
{"title":"Genetic Exchange in <i>Leishmania</i>: Understanding the Cryptic Sexual Cycle.","authors":"Carolina M C Catta-Preta, David L Sacks","doi":"10.1146/annurev-micro-050724-091231","DOIUrl":"https://doi.org/10.1146/annurev-micro-050724-091231","url":null,"abstract":"<p><p>While reproduction in <i>Leishmania</i> is primarily clonal, genomic analyses of natural isolates provide evidence for hybridization within and between species. Genetic exchange has been formally demonstrated via the generation of hybrids in the laboratory. Experimentally, genetic exchange in <i>Leishmania</i> is nonobligatory, relatively rare, and naturally confined to life cycle stages present in the sandfly midgut. Per whole genome sequencing, allele inheritance is Mendelian and involves meiosis-like recombination of the nuclear genome. Deletion of meiosis- and plasmogamy-related genes reveals their requirement for successful hybridization. Mitochondrial DNA inheritance appears uniparental for maxicircle kinetoplast DNA (kDNA) but biparental for minicircle kDNA. To account for the current absence of identified haploid gametes and for the hybridization of aneuploid genomes, alternative modes of genetic exchange have been proposed. Future studies will need to confirm the existence of gametes, explore the conditions promoting their development, and exploit the generation of sexual recombinants to map genes controlling important traits.</p>","PeriodicalId":7946,"journal":{"name":"Annual review of microbiology","volume":" ","pages":""},"PeriodicalIF":8.5,"publicationDate":"2025-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144315770","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
To Sporulate or Not to Sporulate: Developmental Checkpoints Monitoring Bacillus subtilis Sporulation. 产孢还是不产孢：监测枯草芽孢杆菌产孢的发育检查点。
IF 8.5 1区 生物学
Annual review of microbiology Pub Date : 2025-06-11 DOI: 10.1146/annurev-micro-041522-103140
Zachory M Park, Kumaran S Ramamurthi
{"title":"To Sporulate or Not to Sporulate: Developmental Checkpoints Monitoring <i>Bacillus subtilis</i> Sporulation.","authors":"Zachory M Park, Kumaran S Ramamurthi","doi":"10.1146/annurev-micro-041522-103140","DOIUrl":"https://doi.org/10.1146/annurev-micro-041522-103140","url":null,"abstract":"<p><p>Developmental processes are carefully regulated programs that are present in multiple kingdoms of life and that generally result in cell differentiation and specialization. This regulation can be mediated in part by checkpoints that monitor the progression of development to ensure that earlier steps occur successfully before later steps are initiated. Bacterial endospore formation (i.e., sporulation) is a well-studied developmental program that transforms a progenitor cell into a dormant cell type in response to environmental stress and that serves as a model for the discussion of checkpoint mechanisms used to monitor development. This review focuses on the checkpoints monitoring bacterial sporulation, with an emphasis on the model gram-positive bacterium <i>Bacillus subtilis</i>, to highlight general strategies that may be broadly conserved among disparate developmental programs.</p>","PeriodicalId":7946,"journal":{"name":"Annual review of microbiology","volume":" ","pages":""},"PeriodicalIF":8.5,"publicationDate":"2025-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144274035","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Motility in Filamentous Cyanobacteria. 丝状蓝藻的运动。
IF 8.5 1区 生物学
Annual review of microbiology Pub Date : 2025-06-10 DOI: 10.1146/annurev-micro-051024-033328
Douglas D Risser
{"title":"Motility in Filamentous Cyanobacteria.","authors":"Douglas D Risser","doi":"10.1146/annurev-micro-051024-033328","DOIUrl":"https://doi.org/10.1146/annurev-micro-051024-033328","url":null,"abstract":"<p><p>Filamentous cyanobacteria are multicellular organisms that perform oxygenic photosynthesis and frequently exhibit surface motility. This review discusses the underlying mechanism facilitating motility in these organisms, with a focus on recent molecular and genetic studies. While previous explanations for this motility have proposed exotic mechanisms, the current data indicate that all filamentous cyanobacteria produce a similar motility-associated extracellular polysaccharide (EPS) or slime essential for movement and employ a type IV pilus (T4P) motor to power motility. The (<i>a</i>) regulation of the motor to facilitate coordinated polarity and phototaxis and (<i>b</i>) possible bidirectional feedback between the T4P and motility-associated polysaccharide are discussed as well. Finally, the role of motility in promoting diverse biological phenomena, including dispersal, phototaxis, biofilm formation, granulation, and symbiosis, is explored.</p>","PeriodicalId":7946,"journal":{"name":"Annual review of microbiology","volume":" ","pages":""},"PeriodicalIF":8.5,"publicationDate":"2025-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144265100","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Microbial Specialized Metabolites in Phytopathogen-Host Citrus Interactions. 植物病原体与寄主柑橘相互作用中的微生物特化代谢物。
IF 8.5 1区 生物学
Annual review of microbiology Pub Date : 2025-06-10 DOI: 10.1146/annurev-micro-051524-030837
Marina Ferreira Maximo, Mayra Suelen da Silva Pinheiro, Hellen Bertoletti Barbieri, Stephanie Nemesio da Silva, Taicia Pacheco Fill
{"title":"Microbial Specialized Metabolites in Phytopathogen-Host Citrus Interactions.","authors":"Marina Ferreira Maximo, Mayra Suelen da Silva Pinheiro, Hellen Bertoletti Barbieri, Stephanie Nemesio da Silva, Taicia Pacheco Fill","doi":"10.1146/annurev-micro-051524-030837","DOIUrl":"https://doi.org/10.1146/annurev-micro-051524-030837","url":null,"abstract":"<p><p>The world's citriculture has witnessed large-scale productivity decay due to microbial infections. The specialized metabolites produced during infection by pathogens are an important aspect of complex phytopathogen-host interactions and can be crucial for virulence and disease viability. In this review, we comprehensively explore microbial natural products produced during infection by the following citrus pathogens: <i>Penicillium digitatum</i>, <i>Penicillium italicum</i>, <i>Penicillium citrinum</i>, <i>Aspergillus flavus</i>, <i>Fusarium solani</i>, <i>Alternaria alternata</i>, <i>Alternaria citri</i>, <i>Pseudomonas syringae</i>, <i>Elsinoë fawcettii</i>, and <i>Elsinoë australis</i>. Additionally, we list the major microbial citrus diseases distributed worldwide and highlight the lack of consistent knowledge concerning the specialized metabolites that could play significant roles in some of the most important citrus diseases, such as Huanglongbing, citrus canker, citrus variegated chlorosis, citrus tristeza virus, citrus sudden death, sour rot, anthracnose, and citrus black spot.</p>","PeriodicalId":7946,"journal":{"name":"Annual review of microbiology","volume":" ","pages":""},"PeriodicalIF":8.5,"publicationDate":"2025-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144265099","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
My Life as a Pioneering Woman Scientist in a Golden Age of Science and Society. 在科学与社会的黄金时代，我作为一名先锋女科学家的生活。
IF 8.5 1区 生物学
Annual review of microbiology Pub Date : 2025-06-05 DOI: 10.1146/annurev-micro-052924-120235
Carol A Gross
{"title":"My Life as a Pioneering Woman Scientist in a Golden Age of Science and Society.","authors":"Carol A Gross","doi":"10.1146/annurev-micro-052924-120235","DOIUrl":"https://doi.org/10.1146/annurev-micro-052924-120235","url":null,"abstract":"<p><p>My time in science spans the period from the early 1960s to the present and has enabled me to experience science from the dawn of molecular biology to our current time of rapid technological advancement and knowledge explosion. I have also been privileged to be a part of the great democratization of science. I tell the story of this impactful time in science and society from the perspective of my personal and professional journey, starting from Lac repressor studies, progressing to studying bacterial transcription (most especially the \"σ universe\"), and now centering on the development and use of global technologies to solve the huge genotype-phenotype gap: how to acquire in years, not decades, gene function and pathway information in understudied organisms critical to human and planetary health. The scientific explosion I have witnessed also suggests that the potential for science to positively influence our world has never been higher.</p>","PeriodicalId":7946,"journal":{"name":"Annual review of microbiology","volume":" ","pages":""},"PeriodicalIF":8.5,"publicationDate":"2025-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144233011","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Mechanisms and Control of Heme Transport and Incorporation into Cytochrome c. 血红素转运和并入细胞色素c的机制和控制。
IF 8.5 1区 生物学
Annual review of microbiology Pub Date : 2025-06-03 DOI: 10.1146/annurev-micro-050624-031631
Robert G Kranz, Molly C Sutherland
{"title":"Mechanisms and Control of Heme Transport and Incorporation into Cytochrome <i>c</i>.","authors":"Robert G Kranz, Molly C Sutherland","doi":"10.1146/annurev-micro-050624-031631","DOIUrl":"https://doi.org/10.1146/annurev-micro-050624-031631","url":null,"abstract":"<p><p>Cytochrome <i>c</i> (cyt <i>c</i>) is ubiquitous in nature, having evolved billions of years ago to function in respiration and photosynthesis. All <i>c</i>-type cytochromes require covalently attached heme, typically at a CXXCH motif. We highlight new studies from the past five years that address the structural and mechanistic bases for the three cyt <i>c</i> biogenesis pathways (Systems I-III). The solved structures of most of the proteins that comprise these systems provide insights into heme transport, the binding of heme, and the mechanism of apocytochrome <i>c</i> (apocyt <i>c</i>) interaction with the synthases. Detailed analyses of the active sites of each cyt <i>c</i> synthase have elucidated chemical mechanisms underlying cyt <i>c</i> biogenesis and their potential as novel antimicrobial targets. This potential is suggested from an evolutionary perspective, as bacteria use two pathways (Systems I and II) that are structurally and mechanistically distinct from the mitochondrial System III. Genomic analyses of bacteria's respiratory capacity, including their use of <i>c</i>-type cytochromes, reveal how the inhibition of cyt <i>c</i> biogenesis could attenuate growth.</p>","PeriodicalId":7946,"journal":{"name":"Annual review of microbiology","volume":" ","pages":""},"PeriodicalIF":8.5,"publicationDate":"2025-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144214659","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Microbe, the Infection Enigma, and the Host. 微生物、感染之谜和宿主。
IF 8.5 1区 生物学
Annual review of microbiology Pub Date : 2024-11-01 Epub Date: 2024-11-07 DOI: 10.1146/annurev-micro-092123-022855
Jean-Laurent Casanova, Laurent Abel
{"title":"The Microbe, the Infection Enigma, and the Host.","authors":"Jean-Laurent Casanova, Laurent Abel","doi":"10.1146/annurev-micro-092123-022855","DOIUrl":"10.1146/annurev-micro-092123-022855","url":null,"abstract":"<p><p>Human infectious diseases are unique in that the discovery of their environmental trigger, the microbe, was sufficient to drive the development of extraordinarily effective principles and tools for their prevention or cure. This unique medical prowess has outpaced, and perhaps even hindered, the development of scientific progress of equal magnitude in the biological understanding of infectious diseases. Indeed, the hope kindled by the germ theory of disease was rapidly subdued by the infection enigma, in need of a host solution, when it was realized that most individuals infected with most infectious agents continue to do well. The root causes of disease and death in the unhappy few remained unclear. While canonical approaches in vitro (cellular microbiology), in vivo (animal models), and in natura (clinical studies) analyzed the consequences of infection with a microbe, considered to be the cause of disease, in cells, tissues, or organisms seen as a uniform host, alternative approaches searched for preexisting causes of disease, particularly human genetic and immunological determinants in populations of diverse individuals infected with a trigger microbe.</p>","PeriodicalId":7946,"journal":{"name":"Annual review of microbiology","volume":" ","pages":"103-124"},"PeriodicalIF":8.5,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11956784/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141578798","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Apicomplexan Pore-Forming Toxins. 吸虫毛孔形成毒素
IF 8.5 1区 生物学
Annual review of microbiology Pub Date : 2024-11-01 Epub Date: 2024-11-07 DOI: 10.1146/annurev-micro-041222-025939
Vern B Carruthers
{"title":"Apicomplexan Pore-Forming Toxins.","authors":"Vern B Carruthers","doi":"10.1146/annurev-micro-041222-025939","DOIUrl":"10.1146/annurev-micro-041222-025939","url":null,"abstract":"<p><p>Pore-forming toxins (PFTs) are released by one cell to directly inflict damage on another cell. Hosts use PFTs, including members of the membrane attack complex/perforin protein family, to fight infections and cancer, while bacteria and parasites deploy PFTs to promote infection. Apicomplexan parasites secrete perforin-like proteins as PFTs to egress from infected cells and traverse tissue barriers. Other protozoa, along with helminth parasites, utilize saposin-like PFTs prospectively for nutrient acquisition during infection. This review discusses seminal and more recent advances in understanding how parasite PFTs promote infection and describes how they are regulated and fulfill their roles without causing parasite self-harm. Although exciting progress has been made in defining mechanisms of pore formation by PFTs, many open questions remain to be addressed to gain additional key insights into these remarkable determinants of parasitic infections.</p>","PeriodicalId":7946,"journal":{"name":"Annual review of microbiology","volume":" ","pages":"277-291"},"PeriodicalIF":8.5,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141873978","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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