{"title":"Another piece in the hypertension puzzle","authors":"Janet Fricker (Freelance science writer)","doi":"10.1016/S1357-4310(00)01797-4","DOIUrl":"10.1016/S1357-4310(00)01797-4","url":null,"abstract":"","PeriodicalId":79448,"journal":{"name":"Molecular medicine today","volume":"6 10","pages":"Pages 378-379"},"PeriodicalIF":0.0,"publicationDate":"2000-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S1357-4310(00)01797-4","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21839839","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Gastroenteritis viruses: research update and perspectives","authors":"Ulrich Desselberger","doi":"10.1016/S1357-4310(00)01760-3","DOIUrl":"10.1016/S1357-4310(00)01760-3","url":null,"abstract":"<div><p>Gastroenteritis Viruses, Novartis Foundation Symposium 238</p><p>London, UK, 16–18 May 2000</p></div>","PeriodicalId":79448,"journal":{"name":"Molecular medicine today","volume":"6 10","pages":"Pages 383-384"},"PeriodicalIF":0.0,"publicationDate":"2000-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S1357-4310(00)01760-3","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"56514738","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Nurture leads the race in the control of cancer","authors":"Stephen A Bustin","doi":"10.1016/S1357-4310(00)01787-1","DOIUrl":"10.1016/S1357-4310(00)01787-1","url":null,"abstract":"","PeriodicalId":79448,"journal":{"name":"Molecular medicine today","volume":"6 10","pages":"Page 380"},"PeriodicalIF":0.0,"publicationDate":"2000-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S1357-4310(00)01787-1","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21839840","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Memory cells in the immune system: how to be efficient, even in small numbers","authors":"Colin Michie FRCPCH","doi":"10.1016/S1357-4310(00)01785-8","DOIUrl":"10.1016/S1357-4310(00)01785-8","url":null,"abstract":"","PeriodicalId":79448,"journal":{"name":"Molecular medicine today","volume":"6 10","pages":"Page 381"},"PeriodicalIF":0.0,"publicationDate":"2000-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S1357-4310(00)01785-8","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21839842","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Vaccine against breast and ovarian cancer still on the horizon","authors":"Jane Bradbury (Freelance science writer)","doi":"10.1016/S1357-4310(00)01795-0","DOIUrl":"10.1016/S1357-4310(00)01795-0","url":null,"abstract":"","PeriodicalId":79448,"journal":{"name":"Molecular medicine today","volume":"6 10","pages":"Page 378"},"PeriodicalIF":0.0,"publicationDate":"2000-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S1357-4310(00)01795-0","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21839838","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Yoel Kloog PhD (Professor of Biochemistry) , Adrienne D Cox PhD (Assistant Professor)
{"title":"RAS inhibitors: potential for cancer therapeutics","authors":"Yoel Kloog PhD (Professor of Biochemistry) , Adrienne D Cox PhD (Assistant Professor)","doi":"10.1016/S1357-4310(00)01789-5","DOIUrl":"10.1016/S1357-4310(00)01789-5","url":null,"abstract":"<div><p>As RAS oncoproteins play a major role in human malignancy, inhibiting RAS function is a promising approach for developing anticancer therapies. Among these approaches are agents such as farnesyltransferase inhibitors (FTIs) and the nontoxic farnesylcysteine analogue farnesylthiosalicylic acid (FTS) that dislodges all RAS isoforms from the membrane, as well as methods to restore regulation of RAS–GTP levels and to alter the interaction of RAS–GTP with downstream targets.</p></div>","PeriodicalId":79448,"journal":{"name":"Molecular medicine today","volume":"6 10","pages":"Pages 398-402"},"PeriodicalIF":0.0,"publicationDate":"2000-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S1357-4310(00)01789-5","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21839847","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Robert C. Stein PhD, MRCP (Clinical Scientist and Senior Lecturer in Oncology) , Michael D. Waterfield FRS (Director of Research and Head of Department)
{"title":"PI3-kinase inhibition: a target for drug development?","authors":"Robert C. Stein PhD, MRCP (Clinical Scientist and Senior Lecturer in Oncology) , Michael D. Waterfield FRS (Director of Research and Head of Department)","doi":"10.1016/S1357-4310(00)01770-6","DOIUrl":"10.1016/S1357-4310(00)01770-6","url":null,"abstract":"<div><p>The phosphoinositide 3-kinases (PI3-kinases) are a ubiquitously expressed enzyme family that, through the generation of phospholipid second messengers, play a key role in the regulation of many cellular processes. These include motility, proliferation and survival, and carbohydrate metabolism. Members of the PI3-kinase family and related kinases, their mechanism of activation and the cellular events that they influence are described in this review. As knowledge of their involvement in disease processes increases, the PI3-kinases appear to be an increasingly attractive target for drug development, particularly in the fields of cancer and other proliferative diseases, and in the treatment of inflammatory and immunological conditions. Evidence of the functional specialization of PI3-kinase isoforms suggests that selective inhibition with acceptable toxicity might be possible.</p></div>","PeriodicalId":79448,"journal":{"name":"Molecular medicine today","volume":"6 9","pages":"Pages 347-358"},"PeriodicalIF":0.0,"publicationDate":"2000-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S1357-4310(00)01770-6","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21792627","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Gene therapy in inflammatory diseases – are we there yet?","authors":"George C Tsokos MD (Professor of Medicine)","doi":"10.1016/S1357-4310(00)01764-0","DOIUrl":"10.1016/S1357-4310(00)01764-0","url":null,"abstract":"","PeriodicalId":79448,"journal":{"name":"Molecular medicine today","volume":"6 9","pages":"Page 341"},"PeriodicalIF":0.0,"publicationDate":"2000-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S1357-4310(00)01764-0","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"56514780","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Esther H Chang PhD (Professor), Kathleen F Pirollo PhD (Research Associate Professor), Kerrie B Bouker BA (Graduate Student)
{"title":"Tp53 gene therapy: a key to modulating resistance to anticancer therapies?","authors":"Esther H Chang PhD (Professor), Kathleen F Pirollo PhD (Research Associate Professor), Kerrie B Bouker BA (Graduate Student)","doi":"10.1016/S1357-4310(00)01767-6","DOIUrl":"10.1016/S1357-4310(00)01767-6","url":null,"abstract":"<div><p>Abnormalities in the p53 tumor suppressor have been identified in over 60% of human cancers. The status of p53 within tumor cells has been proposed to be one of the major determinants of the response to anticancer therapies. In this review we examine the relationship between functional p53 and sensitivity, or resistance, to chemotherapy and radiotherapy. We also discuss the potential of current gene-therapy approaches to restore functional p53 to tumors as a means of modulating the effects of radiation and chemotherapy.</p></div>","PeriodicalId":79448,"journal":{"name":"Molecular medicine today","volume":"6 9","pages":"Pages 358-365"},"PeriodicalIF":0.0,"publicationDate":"2000-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S1357-4310(00)01767-6","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21792628","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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