Radiatsionnaia biologiia, radioecologiia最新文献_第2页

Contemporary Understanding of Radioactive Contamination of the Techa River in 1949-1956. 1949-1956年特查河放射性污染的当代认识。

Radiatsionnaia biologiia, radioecologiia Pub Date : 2016-09-01

M O Degteva, N B Shagina, M I Vorobiova, E A Shishkina, E I Tolstykh, A V Akleyev

{"title":"Contemporary Understanding of Radioactive Contamination of the Techa River in 1949-1956.","authors":"M O Degteva, N B Shagina, M I Vorobiova, E A Shishkina, E I Tolstykh, A V Akleyev","doi":"","DOIUrl":"","url":null,"abstract":"Analysis of recently available archive materials regarding the liquid radioactive waste storage and reprocessing at the \"Mayak\" Production Association in 1949-1956 has led to a more accurate reconstruction of radionuclide releases into the Techa River. Radionuclide concentrations in the Techa River water, bottom sediments and floodplain soils in 1949-1951 were reconstructed with the use of a purposely-developed Techa River model. Model calculations agree with the measurements of the specific activity in the river water and bottom sediments conducted since 1951. The model output for the (90)Sr concentration in the river water shows a good agreement with the retrospective estimates derived from (90)Sr measurements in teeth and the whole body of the Techa riverside residents. Modeled (137)Cs-contamination of the floodplain shows agreement with the values reconstructed from (137)Cs measurements in the floodplain soils obtained in later years. Reconstructed contamination levels by radionuclides in the Techa River water and floodplain are being used to refine internal and external doses and risk estimates of late effects in the population chronically exposed to radiation.","PeriodicalId":79368,"journal":{"name":"Radiatsionnaia biologiia, radioecologiia","volume":"56 5","pages":"523-534"},"PeriodicalIF":0.0,"publicationDate":"2016-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36904512","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Changes in the Relative Number of SP Cells of Melanoma Line B16 after Radiation Exposure in vivo. 辐照后黑素瘤B16细胞系SP细胞相对数量的体内变化

Radiatsionnaia biologiia, radioecologiia Pub Date : 2016-09-01

O N Matchuk, N V Orlova, I A Zamulaeva

{"title":"Changes in the Relative Number of SP Cells of Melanoma Line B16 after Radiation Exposure in vivo.","authors":"O N Matchuk, N V Orlova, I A Zamulaeva","doi":"","DOIUrl":"","url":null,"abstract":"The quantitative regularities of changes of cancer stem cell (CSC) population were explored after local γ-irradiation of experimental tumors (murine melanoma line B16). CSCs were detected by the ability of these cells to exclude Hoechst 33342 fluorescent dye and to form a so-called side population (SP) under flow cytometry study. In the control group of unexposed mice a positive correlation was found between the proportion of CSCs (SP) and tumorweight at the initial stage of growth (R = 0.77, p = 0.009). In the advanced stages of tumor growth similar relationship was not revealed. Statistically significant increase in the proportion of CSCs (SP) occurred 2-5 days after exposure of tumor to a dose of 10 Gy as compared to control; this index returned to the control level 8 days after irradiation. On the second day after exposure to radiation a linear correlation between the percentage of CSCs and a radiation dose in the range of 2-10 Gy was established (R = 0.98, p = 0.003), confirming a higher radioresistance of this population as compared to other cells not only in vitro (as it was previously shown by us and other authors), but also in vivo. These results suggest the possibility of application of this model system to assess the CSC sensitivity to various antitumor agents in vivo, including preclinical trials, and clarify the details of the practical application of this method.","PeriodicalId":79368,"journal":{"name":"Radiatsionnaia biologiia, radioecologiia","volume":"56 5","pages":"487-493"},"PeriodicalIF":0.0,"publicationDate":"2016-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36905556","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Functional Features of Microcirculation System and its Possibilities of Oxygen Transport in Children and Youths of Bryansk Region in Conditions of Radioecological Pressure. 放射生态压力条件下布良斯克地区儿童和青少年微循环系统功能特征及其氧输送可能性

Radiatsionnaia biologiia, radioecologiia Pub Date : 2016-09-01

F B Litvin, G V Vasilieva, V V Baranov

{"title":"Functional Features of Microcirculation System and its Possibilities of Oxygen Transport in Children and Youths of Bryansk Region in Conditions of Radioecological Pressure.","authors":"F B Litvin, G V Vasilieva, V V Baranov","doi":"","DOIUrl":"","url":null,"abstract":"The questions of influence of low radiation doses on microcirculation of blood in ontogeny of males from 7 to 27 years are presented in the article. Using the method of laser Doppler ultrasounds, optical oximetry and laser fluorescent diagnostics, we studied the blood perfusion level in the microcirculation system of 315 schoolchildren and students, considered the regulation mechanisms of microcirculation, the level of oxygen saturation of hemoglobin both in the circulation system and mixed blood, the index of oxygen utilization in tissues and the value of fluorescent use of oxygen. We received the information about the changes in the frequency of occurrence of different microcirculation types associated with the age and region of residence. In the case of higher radiation levels we marked a significant increase of individuals with the \"extreme\" microcirculation type (hypoemic and hyperemic) against the background of the decreased mesoemic type. A special feature of the metabolism process in children, teenagers, and youths is a decrease of the microcirculation density with an increase of the myogenic tone of metaarterioles and precapillary sphincters. The tone of arterioles grows with age. As a result of the limited blood volume, oxygen. is pulled compensatory from blood in larger amounts; it is shown from a significant decrease of the level of oxygen saturation in mixed blood. The strongest differences are shown for the hypoemic and hyperemic microcirculation type. Dwelling on the areas with radio-ecological pressure is accompanied by an increase in the fluorescent index of oxygen use. The level of the total oxygen use in these individuals is higher than in those living in radiation favorable areas.","PeriodicalId":79368,"journal":{"name":"Radiatsionnaia biologiia, radioecologiia","volume":"56 5","pages":"514-522"},"PeriodicalIF":0.0,"publicationDate":"2016-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36905559","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Dose-Response of Micronuclei in Binucleated and Mononucleated Lymphocytes from Cytochalasin Culture (Irradiation in vivo and in vitro). 细胞松弛素培养双核和单核淋巴细胞微核的剂量反应(体内和体外辐照)。

Radiatsionnaia biologiia, radioecologiia Pub Date : 2016-09-01

I E Vorobtsova, A V Semenov

引用次数: 0

Induction of Heat Shock Protein 70 as a Predictive Marker of the Tumor Cell Radiosensitization with Inhibitors of the Heat Shock Protein 90 Activity. 用热休克蛋白90活性抑制剂诱导热休克蛋白70作为肿瘤细胞放射致敏的预测标志物

Radiatsionnaia biologiia, radioecologiia Pub Date : 2016-09-01

V A Kudryavtsev, A V Khokhlova V, A Mosina, Yu M Makarova, A E Kabakov

{"title":"Induction of Heat Shock Protein 70 as a Predictive Marker of the Tumor Cell Radiosensitization with Inhibitors of the Heat Shock Protein 90 Activity.","authors":"V A Kudryavtsev, A V Khokhlova V, A Mosina, Yu M Makarova, A E Kabakov","doi":"","DOIUrl":"","url":null,"abstract":"Inhibitors of the heat shock protein 90 (HSP90) activity are considered as potential radiosensitizers of tumors with a perspective of their application in radiotherapy. However, there are tumors and tumor cell lines whose radioresistance is not decreased after treatment with the HSP90 activity inhibitors; therefore, a predictive marker is needed, which would allow one to predict the response of target cells. As such a marker, herein it is proposed to use induction of the heat shock protein 70 (HSP70) that is an early cellular response to the HSP90 dysfunction and can easily be immunodetected. It follows from the data obtained that the radiosensitization of HSP90 inhibitor-treated cells occurs only when this treatment causes the prominent induction of HSP70 in them. Determination of this marker enables one: 1) to predict a possibility of radiosensitization of any cells by means of the HSP90 activity inhibitors, 2) to design the inhibitor concentration range upon which the radiosensitizing effect seems likely to occur, 3) to find whether this radiosensitization will be selective towards cancer cells.","PeriodicalId":79368,"journal":{"name":"Radiatsionnaia biologiia, radioecologiia","volume":"56 5","pages":"494-502"},"PeriodicalIF":0.0,"publicationDate":"2016-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36904513","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

RBE of α-Particles for Delayed Production of Colonies by Irradiated Yeast Cells. 辐照酵母细胞延迟菌落产生α-粒子的RBE

Radiatsionnaia biologiia, radioecologiia Pub Date : 2016-09-01

E S Evstratova, O V Pereklad, A V Khryachkova

{"title":"RBE of α-Particles for Delayed Production of Colonies by Irradiated Yeast Cells.","authors":"E S Evstratova, O V Pereklad, A V Khryachkova","doi":"","DOIUrl":"","url":null,"abstract":"The effect of delayed colony appearance by irradiated cells exemplifying genetic instability is confirmed to be more expressed for diploid wild-type yeast cells characterized by a sigmoidal shape of the survival curve and capable of recovery from radiation damage in contrast to isogenic haploid strain incapable of diploid-specific recovery and characterized by the exponential form of the survival curve. The dependence of the delayed appearance of colonies by diploid yeast cells on the dose of ionizing radiation shows more pronounced manifestation after the action of α-particles (RBE = 4.2 ± 0.3) than after irradiation with y-rays. This effect may be associated with the greater efficiency of densely ionizing radiation to produce lethal radiation damage and accompanying sublesions responsible for the delay in the formation of colonies by the cells surviving after irradiation. It is shown that the dependence of the delayed colony appearance by diploid yeast cells on their survival was substantially the same after exposure to sparsely and densely ionizing radiation. Since exposure to ionizing radiation of different quality induced equally effective number of lethal damage and the same survival rates, these data indicate that the identical number of the accompanying sublesions responsible for the delayed colony appearance are produced by irradiated cells.","PeriodicalId":79368,"journal":{"name":"Radiatsionnaia biologiia, radioecologiia","volume":"56 5","pages":"481-486"},"PeriodicalIF":0.0,"publicationDate":"2016-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36905555","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effectiveness of Protective Activities for Rehabilitation of the Forage Lands in Russia and Belarus Contaminated as a Result of the Chernobyl Accident. 俄罗斯和白俄罗斯受切尔诺贝利事故污染的饲草地恢复保护活动的有效性。

Radiatsionnaia biologiia, radioecologiia Pub Date : 2016-07-01

N M Belous, A G Podolyak, A F Karpenko, E V Smolskiy

引用次数: 0

High Level of Radiation-Induced Heat Shock Protein with a Molecular Weight of 27 and 70 kDa is the Hallmark of Radioresistant SP Cells of MCF-7 Breast Cancer Culture. MCF-7乳腺癌培养的高水平辐射诱导热休克蛋白(分子量为27和70 kDa)是耐辐射SP细胞的标志。

Radiatsionnaia biologiia, radioecologiia Pub Date : 2016-07-01

O N Matchuk, I A Zamulaeva

引用次数: 0

Spatial and Temporal Reconstruction of Chernobyl (137)Cs Initial Fallout Field on Soil Within upper Lokna River Basin. Lokna河上游地区土壤切尔诺贝利(137)Cs初始沉降场时空重建

Radiatsionnaia biologiia, radioecologiia Pub Date : 2016-07-01

E N Shamshurina, V N Golosov, M M Ivanov