Radiatsionnaia biologiia, radioecologiia最新文献_第3页

Induction of Heat Shock Protein 70 as a Predictive Marker of the Tumor Cell Radiosensitization with Inhibitors of the Heat Shock Protein 90 Activity. 用热休克蛋白90活性抑制剂诱导热休克蛋白70作为肿瘤细胞放射致敏的预测标志物

Radiatsionnaia biologiia, radioecologiia Pub Date : 2016-09-01

V A Kudryavtsev, A V Khokhlova V, A Mosina, Yu M Makarova, A E Kabakov

{"title":"Induction of Heat Shock Protein 70 as a Predictive Marker of the Tumor Cell Radiosensitization with Inhibitors of the Heat Shock Protein 90 Activity.","authors":"V A Kudryavtsev, A V Khokhlova V, A Mosina, Yu M Makarova, A E Kabakov","doi":"","DOIUrl":"","url":null,"abstract":"Inhibitors of the heat shock protein 90 (HSP90) activity are considered as potential radiosensitizers of tumors with a perspective of their application in radiotherapy. However, there are tumors and tumor cell lines whose radioresistance is not decreased after treatment with the HSP90 activity inhibitors; therefore, a predictive marker is needed, which would allow one to predict the response of target cells. As such a marker, herein it is proposed to use induction of the heat shock protein 70 (HSP70) that is an early cellular response to the HSP90 dysfunction and can easily be immunodetected. It follows from the data obtained that the radiosensitization of HSP90 inhibitor-treated cells occurs only when this treatment causes the prominent induction of HSP70 in them. Determination of this marker enables one: 1) to predict a possibility of radiosensitization of any cells by means of the HSP90 activity inhibitors, 2) to design the inhibitor concentration range upon which the radiosensitizing effect seems likely to occur, 3) to find whether this radiosensitization will be selective towards cancer cells.","PeriodicalId":79368,"journal":{"name":"Radiatsionnaia biologiia, radioecologiia","volume":"56 5","pages":"494-502"},"PeriodicalIF":0.0,"publicationDate":"2016-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36904513","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

RBE of α-Particles for Delayed Production of Colonies by Irradiated Yeast Cells. 辐照酵母细胞延迟菌落产生α-粒子的RBE

Radiatsionnaia biologiia, radioecologiia Pub Date : 2016-09-01

E S Evstratova, O V Pereklad, A V Khryachkova

{"title":"RBE of α-Particles for Delayed Production of Colonies by Irradiated Yeast Cells.","authors":"E S Evstratova, O V Pereklad, A V Khryachkova","doi":"","DOIUrl":"","url":null,"abstract":"The effect of delayed colony appearance by irradiated cells exemplifying genetic instability is confirmed to be more expressed for diploid wild-type yeast cells characterized by a sigmoidal shape of the survival curve and capable of recovery from radiation damage in contrast to isogenic haploid strain incapable of diploid-specific recovery and characterized by the exponential form of the survival curve. The dependence of the delayed appearance of colonies by diploid yeast cells on the dose of ionizing radiation shows more pronounced manifestation after the action of α-particles (RBE = 4.2 ± 0.3) than after irradiation with y-rays. This effect may be associated with the greater efficiency of densely ionizing radiation to produce lethal radiation damage and accompanying sublesions responsible for the delay in the formation of colonies by the cells surviving after irradiation. It is shown that the dependence of the delayed colony appearance by diploid yeast cells on their survival was substantially the same after exposure to sparsely and densely ionizing radiation. Since exposure to ionizing radiation of different quality induced equally effective number of lethal damage and the same survival rates, these data indicate that the identical number of the accompanying sublesions responsible for the delayed colony appearance are produced by irradiated cells.","PeriodicalId":79368,"journal":{"name":"Radiatsionnaia biologiia, radioecologiia","volume":"56 5","pages":"481-486"},"PeriodicalIF":0.0,"publicationDate":"2016-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36905555","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effectiveness of Protective Activities for Rehabilitation of the Forage Lands in Russia and Belarus Contaminated as a Result of the Chernobyl Accident. 俄罗斯和白俄罗斯受切尔诺贝利事故污染的饲草地恢复保护活动的有效性。