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The effect of nitrogen oxide level modulation on the content of thiol compounds and anaerobic sulfur metabolism in mice brains. 氮氧化物水平调节对小鼠脑内硫醇类化合物含量及厌氧硫代谢的影响。
Neurobiology (Budapest, Hungary) Pub Date : 1999-01-01
M Sokołowska, L Włodek, Z Srebro, M Wróbel
{"title":"The effect of nitrogen oxide level modulation on the content of thiol compounds and anaerobic sulfur metabolism in mice brains.","authors":"M Sokołowska,&nbsp;L Włodek,&nbsp;Z Srebro,&nbsp;M Wróbel","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Aminoguanidine (AG) an inhibitor of NO-synthase reduces cysteine (Cys), cystine (CC), sulfane sulfur (SS) and glutathione (GSH) in brain stems but practically has no effects on the levels of reactive oxygen species (ROS). In cortex AG decreases to a lower degree the concentration of Cys, CC, GSH but in this brain part significantly decreases ROS levels and increases SS. Under the AG action cystathionase (CST) activity very seriously decreases in stems and in cortex and simultaneously activity of 3-mercaptopyruvate sulfurtransferase (MPST) increases. The morpholinosydnonimine (SIN-1) the specific donor of NO and O2 only slightly reduces Cys and GSH in brain stems and ROS and SS remain at the control levels. Simultaneously, there is an increase in cortex of the amounts of GSH with the reduction of ROS and SS. Furthermore, SIN-1 seriously decreases in stems and cortex the activity of CST and increases the activity of MPST. These results confirmed the relationship between intracellular levels of NO, sulfhydryl groups, ROS, and anaerobic sulfur metabolism.</p>","PeriodicalId":79356,"journal":{"name":"Neurobiology (Budapest, Hungary)","volume":"7 4","pages":"461-77"},"PeriodicalIF":0.0,"publicationDate":"1999-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21738818","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The behaviour of aryl pyrrolines with monoamine oxidase. 芳基吡咯啉与单胺氧化酶的行为。
Neurobiology (Budapest, Hungary) Pub Date : 1999-01-01
C H Williams, J Lawson
{"title":"The behaviour of aryl pyrrolines with monoamine oxidase.","authors":"C H Williams,&nbsp;J Lawson","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>We have examined the effects of monoamine oxidase (MAO) on two pyrrolines, 1-methyl-3-phenyl-delta 3-pyrroline and its 4-chlorophenyl analogue. They act as substrates but also inhibit the enzyme in a time-dependent manner. This behaviour is similar to that shown by the neural pro-toxin 1-methyl-4-phenyl-1,2,3,6-tetrahydro pyridine (MPTP) which is metabolised by MAO to produce the toxin 4-phenyl pyridinium (MPP+). The end product of the oxidation of the pyrrolines appears to be the corresponding pyrrole. The latter were found to inhibit MAO reversibly. The aryl pyrrolines bear close structural resemblance to MPTP and probably generate a pyrrolium ion, analogous to MPDP or MPP+, during the oxidation by MAO. Whether pyrrolines or their metabolites might mimic the effects of MPTP on mitochondrial respiration remains an unanswered question.</p>","PeriodicalId":79356,"journal":{"name":"Neurobiology (Budapest, Hungary)","volume":"7 2","pages":"225-33"},"PeriodicalIF":0.0,"publicationDate":"1999-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21448111","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
MAO-A and -B gene knock-out mice exhibit distinctly different behavior.
Neurobiology (Budapest, Hungary) Pub Date : 1999-01-01
J C Shih, K Chen
{"title":"MAO-A and -B gene knock-out mice exhibit distinctly different behavior.","authors":"J C Shih,&nbsp;K Chen","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>MAO-A and -B are key isoenzymes that degrade biogenic and dietary amines. MAO-A preferentially oxidizes 5-HT and NE, whereas MAO-B preferentially oxidizes PEA. However, the substrate and inhibitor selectivity overlap depending on the concentration of the enzyme and substrate. A line of transgenic mice has been generated in which the gene that encodes MAO-A is disrupted. MAO-A KO mice have elevated brain levels of 5-HT, NE and DA and manifest aggressive behavior similar to men with a deletion of MAO-A. We have also generated mice deficient in MAO-B by homologous recombination. Interestingly, MAO-B KO mice do not exhibit aggression and only levels of PEA are increased. MAO-B-deficient mice are resistant to the Parkinsongenic neurotoxin, 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine. Thus, studies of MAO-A and -B KO mice have clearly shown that MAO-A and -B have distinct functions in neurotransmitter metabolism and behavior. MAO KO mice are valuable models for investigating the role of monoamines in aggression and neurodegenerative and stress-related disorders.</p>","PeriodicalId":79356,"journal":{"name":"Neurobiology (Budapest, Hungary)","volume":"7 2","pages":"235-46"},"PeriodicalIF":0.0,"publicationDate":"1999-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21448112","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Presence of SSAO in human and bovine meninges and microvessels. SSAO在人和牛脑膜和微血管中的存在。
Neurobiology (Budapest, Hungary) Pub Date : 1999-01-01
V Castillo, J M Lizcano, M Unzeta
{"title":"Presence of SSAO in human and bovine meninges and microvessels.","authors":"V Castillo,&nbsp;J M Lizcano,&nbsp;M Unzeta","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>In spite that SSAO enzyme is widely distributed in almost all tissues, specially in vascularized ones, its presence in brain microvessels is still controversy. Our results resolve this question showing that both human and bovine cerebrovascular tissues do contain the SSAO enzyme. This was achieved biochemically, using benzylamine and methylamine as substrates, and by immunoblot analysis, using polyclonal antibodies anti-SSAO that recognized a 100 kDa single band in tissue homogenates.</p>","PeriodicalId":79356,"journal":{"name":"Neurobiology (Budapest, Hungary)","volume":"7 3","pages":"263-72"},"PeriodicalIF":0.0,"publicationDate":"1999-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21541910","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Affinity labeling of opioid receptors in vivo and in vitro. 阿片受体在体内和体外的亲和标记。
Neurobiology (Budapest, Hungary) Pub Date : 1999-01-01
E Kicsi, B Bozó, J Farkas, M Mácsai, G Szabó, M Szücs
{"title":"Affinity labeling of opioid receptors in vivo and in vitro.","authors":"E Kicsi,&nbsp;B Bozó,&nbsp;J Farkas,&nbsp;M Mácsai,&nbsp;G Szabó,&nbsp;M Szücs","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":79356,"journal":{"name":"Neurobiology (Budapest, Hungary)","volume":"7 1","pages":"83-4"},"PeriodicalIF":0.0,"publicationDate":"1999-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21597328","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A second redox group in monoamine oxidase: its role in catalysis and inhibition. 单胺氧化酶的第二氧化还原基团:其催化和抑制作用。
Neurobiology (Budapest, Hungary) Pub Date : 1999-01-01
R R Ramsay, S O Sablin
{"title":"A second redox group in monoamine oxidase: its role in catalysis and inhibition.","authors":"R R Ramsay,&nbsp;S O Sablin","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The currently accepted and well-documented radical mechanism for MAO catalysis has certain limitations. No flavin radical has ever been observed or trapped, the role of the essential thiol groups is not defined, and the mechanism provides no clue as to how binding of substrate can raise the redox potential of the MAO flavin by 0.5 V and accelerate the rate of reoxidation of the reduced enzyme. Recent work demonstrated that 4 electrons were needed for full reduction of the enzyme. It is hypothesized that another redox group, in addition to the flavin, is located in the active site in close proximity to the cofactor and that this group may be a disulphide. If a new mechanism involving a disulfide can be established, it could explain, by formation of thiol adducts, the time-dependent and slowly reversible action of some inhibitors.</p>","PeriodicalId":79356,"journal":{"name":"Neurobiology (Budapest, Hungary)","volume":"7 2","pages":"205-12"},"PeriodicalIF":0.0,"publicationDate":"1999-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21448109","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The effects of long-term heparin application on ACh-induced isolated ileum contractility and structure. 长期应用肝素对乙酰胆碱诱导的离体回肠收缩力和结构的影响。
Neurobiology (Budapest, Hungary) Pub Date : 1999-01-01
E Koc, N Zaloglu, Y Saran, B Turan
{"title":"The effects of long-term heparin application on ACh-induced isolated ileum contractility and structure.","authors":"E Koc,&nbsp;N Zaloglu,&nbsp;Y Saran,&nbsp;B Turan","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The present study was designed to investigate the side-effects of long-term (one and two months), overdoses (1000 and 2000 IU/kg/day) heparin (Liquamine) applications on the isolated ileum contractility and the histopathological alterations in the ileal tissues. The histopathology of tissues was investigated by using light microscopy. Isolated ileum contractility was measured by using the conventional organ bath system with standard and Ca-free Tyrode perfusion solutions. Ileum preparations were initially contracted with ACh maximally and these contraction amplitudes were given as% values. The average amplitude of these contractions of all experimental groups were found to be increased significantly with respect to control group, in both perfusion solutions. Under light microscopy, in the preparations treated with 1000 IU/kg/day heparin, we have observed edema in the ileal mucosa and neutrophil infiltration in the villi. In addition, the glandular tissue degeneration was also seen in 2000 IU/kg@day group. We can suggest that most probably, the binding of heparin to the receptor on the cell membrane results Ca-release.</p>","PeriodicalId":79356,"journal":{"name":"Neurobiology (Budapest, Hungary)","volume":"7 1","pages":"33-43"},"PeriodicalIF":0.0,"publicationDate":"1999-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21597322","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Duration of action of GYKI 52466 and its analogues in antiepileptic, anti-ischaemic and muscle relaxant tests. GYKI 52466及其类似物在抗癫痫、抗缺血和肌肉松弛试验中的作用时间。
Neurobiology (Budapest, Hungary) Pub Date : 1999-01-01
T Szabados, G Gigler, I Gyertyán, I Gacsályi, G Lévay
{"title":"Duration of action of GYKI 52466 and its analogues in antiepileptic, anti-ischaemic and muscle relaxant tests.","authors":"T Szabados,&nbsp;G Gigler,&nbsp;I Gyertyán,&nbsp;I Gacsályi,&nbsp;G Lévay","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":79356,"journal":{"name":"Neurobiology (Budapest, Hungary)","volume":"7 1","pages":"87-8"},"PeriodicalIF":0.0,"publicationDate":"1999-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21597330","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
beta-Amyloid[1-40]-induced early hyperpolarization in M26-1F cells, an immortalized rat striatal cell line. β -淀粉样蛋白[1-40]诱导永生化大鼠纹状体细胞系M26-1F细胞早期超极化。
Neurobiology (Budapest, Hungary) Pub Date : 1999-01-01
G Laskay, M Zarándi, K Jost, B Penke, E Bálint, I Ocsovszki, M Tarcsa, S Várszegi, K Gulya
{"title":"beta-Amyloid[1-40]-induced early hyperpolarization in M26-1F cells, an immortalized rat striatal cell line.","authors":"G Laskay,&nbsp;M Zarándi,&nbsp;K Jost,&nbsp;B Penke,&nbsp;E Bálint,&nbsp;I Ocsovszki,&nbsp;M Tarcsa,&nbsp;S Várszegi,&nbsp;K Gulya","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The short-term (20-minute) action of beta[1-40]-amyloid on the resting transmembrane potential was investigated by means of flow-cytofluorimetric studies in M26-1F cells, an immortalized rat striatal cell line, using the potential-sensitive fluorescent probe bis-oxonol. The distribution of the individual cell-associated probe fluorescence was found to be shifted to lower levels in cells treated with beta-amyloid[1-40] for 20 minutes as compared with that of their untreated counterparts. A change in the same direction was caused by valinomycin, a hyperpolarizing ionophore, whereas gramicidin, a depolarizing ionophore, induced a shift to higher fluorescence intensities. These findings, together with the reported behaviour of this particular fluorescent probe at different transmembrane potential levels, indicate that beta-amyloid[1-40] is capable of inducing early hyperpolarization in M26-1F cells. This is one of the earliest cell physiological effect of beta-amyloid peptides that has been reported so far. Moreover, our findings indicate an ionophore-like action of amyloid peptides.</p>","PeriodicalId":79356,"journal":{"name":"Neurobiology (Budapest, Hungary)","volume":"7 4","pages":"431-6"},"PeriodicalIF":0.0,"publicationDate":"1999-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21738815","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Neural tissue transplant in the lateral hypothalamic lesioned rats: functional recovery pattern. 外侧下丘脑损伤大鼠神经组织移植:功能恢复模式。
Neurobiology (Budapest, Hungary) Pub Date : 1999-01-01
S Jain, R Mathur, R Sharma, U Nayar
{"title":"Neural tissue transplant in the lateral hypothalamic lesioned rats: functional recovery pattern.","authors":"S Jain,&nbsp;R Mathur,&nbsp;R Sharma,&nbsp;U Nayar","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Transplantation has come of age as an important investigative tool for studying normal growth and development of the brain tissue. The present study reports the effect of lateral hypothalamic (LHA) lesion and foetal hypothalamic tissue transplantation on the feeding behaviour. In a group of rats, LHA was lesioned bilaterally by passing direct current. Subsequently, in a separate group of rats, foetal hypothalamic tissue was transplanted at the lesioned site. Following LHA lesion, all the rats died of aphagia and adipsia within 7 days, whereas, the rats in whom foetal hypothalamus was transplanted, started taking food and water in small quantities from the first day of transplantation itself. Later, they were able to attain their preoperative values. This recovery of the feeding behaviour following foetal tissue transplantation may be due to the formation of synaptic connections or due to the release of neurotrophic factors.</p>","PeriodicalId":79356,"journal":{"name":"Neurobiology (Budapest, Hungary)","volume":"7 4","pages":"421-30"},"PeriodicalIF":0.0,"publicationDate":"1999-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21738814","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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