Neurobiology (Budapest, Hungary)最新文献_第7页

Neuroprotective and neuronal rescue effects of selegiline: review. 斯来吉兰的神经保护和神经救援作用综述。

Neurobiology (Budapest, Hungary) Pub Date : 1999-01-01

K Magyar, D Haberle

引用次数: 0

The correlation between platelet MAO activity and personality--the effect of smoking and possible mechanisms behind the correlation.

Neurobiology (Budapest, Hungary) Pub Date : 1999-01-01

L Oreland, H Garpenstrand, M Damberg, P O Alm, L H Thorell, B af Klinteberg, J Ekblom

引用次数: 0

Antidepressive and antihypertensive effects of MAO-A inhibition: role of N-acetylserotonin. A review. 复习一下。

Neurobiology (Budapest, Hungary) Pub Date : 1999-01-01

G F Oxenkrug

引用次数: 0

Effects of mobile GSM radiotelephone exposure on the auditory brainstem response (ABR). 移动GSM无线电话暴露对听觉脑干反应(ABR)的影响。

Neurobiology (Budapest, Hungary) Pub Date : 1999-01-01

L Kellényi, G Thuróczy, B Faludy, L Lénárd

引用次数: 0

Preferential inhibition of acetylcholinesterase molecular forms in normal human brain. 正常人脑中乙酰胆碱酯酶分子形态的优先抑制。

Neurobiology (Budapest, Hungary) Pub Date : 1999-01-01

Z Rakonczay, L Török, P Kása

引用次数: 0

Determination of monoamine oxidase activity by HPLC with fluorimetric detection. HPLC -荧光法测定单胺氧化酶活性。

Neurobiology (Budapest, Hungary) Pub Date : 1999-01-01

B Bartolini, K F Tipton, L Bianchi, D Stephenson, C Cunningham, L Della Corte

{"title":"Determination of monoamine oxidase activity by HPLC with fluorimetric detection.","authors":"B Bartolini, K F Tipton, L Bianchi, D Stephenson, C Cunningham, L Della Corte","doi":"","DOIUrl":"","url":null,"abstract":"The aldehyde produced from the oxidative deamination of primary and secondary amines by the monoamine oxidases (EC 1.4.3.4; MAO) or the semicarbazide-sensitive amine oxidases (EC 1.4.3.6; SSAO) may be determined followed reaction at elevated temperatures with 2-diphenylacetyl-1,3-indandione-1-hydrazone (DIH), separation by high-performance chromatography liquid (C-8 column, eluting isocratically with acetonitrile, ammonium acetate, water) and fluorimetric detection (excitation and emission wavelengths 430 and 525 nm). The detection limits for benzaldehyde, p-hydroxybenzaldehyde and 2-phenylacetaldehyde were 125 nM, 150 and 62.3 nM, respectively. Thus the assay is appropriate for determination of amine oxidase activities towards benzylamine, 2-phenylethylamine and tyramine. The fluorescence of the DIH adduct with indole-3-aldehyde was strongly quenched, giving a relatively high detection limit (17.5 microM). The detection limit was lower (3.8 microM) when the absorbance at 430 nm was monitored. Enzyme activities determined by this procedure were shown to be linear with enzyme-protein concentration (rat liver mitochondria). The presence of 1-2 mM semicarbazide, necessary for determining MAO activities in samples also containing SSAO, did not adversely affect the derivatization reaction. The DIH-aldehyde adducts were sufficiently stable to permit their storage at low temperatures prior to assay. The product produced by reaction of 5-hydroxyindole acetaldehyde with DIH had no significant fluorescence and too low an absorbance at 430 nm to allow its determination for assay of activities towards 5-HT. This procedure can also measure succinic semialdehyde (detection limit 240 nM) and thus would be applicable to the determination of GABA transaminase activity.","PeriodicalId":79356,"journal":{"name":"Neurobiology (Budapest, Hungary)","volume":"7 2","pages":"109-21"},"PeriodicalIF":0.0,"publicationDate":"1999-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21448876","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Involvement of monooxygenases and amine oxidases in hydroxyl radical generation in vivo. 单加氧酶和胺氧化酶参与体内羟基自由基的生成。

Neurobiology (Budapest, Hungary) Pub Date : 1999-01-01

M Benedetti Strolin, K F Tipton

{"title":"Involvement of monooxygenases and amine oxidases in hydroxyl radical generation in vivo.","authors":"M Benedetti Strolin, K F Tipton","doi":"","DOIUrl":"","url":null,"abstract":"The levels of hydroxyl radicals in vivo were measured in rat blood plasma by determining the formation of 2,3-dihydroxybenzoate (2,3-DHB) resulting from the attack of hydroxyl radicals on injected salicylate. This approach was used to study the effects of alterations in the activities of cytochrome P-540 (CYP)-dependent hydroxylases (monooxygenases) and monoamine oxidase (MAO), two groups of enzymes that can produce reactive oxygen species in the reactions they catalyse. Pretreatment with inducers of the cytochrome P540 (CYP) hydroxylases, such as phenobarbital and dexamethasone, resulted in substantial increases in the plasma oxygen radical formation, suggesting that the action of these enzymes on endogenous substrates, or on exogenous substrates such as salicylate, may contribute to oxygen radical formation in vivo. In contrast, pretreatment with the monoamine oxidase (MAO) inhibitors clorgyline and deprenyl did not have any significant effect on the plasma 2,3-DHB levels, perhaps reflecting the different intracellular locations of MAO and the CYP-dependent hydroxylases. Injection of pentylamine, a substrate of MAO-B and semicarbazide-sensitive amine oxidase (SSAO) was also without significant effect.","PeriodicalId":79356,"journal":{"name":"Neurobiology (Budapest, Hungary)","volume":"7 2","pages":"123-34"},"PeriodicalIF":0.0,"publicationDate":"1999-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21448877","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Some peculiar aspects of monoamine oxidase inhibition. 单胺氧化酶抑制的一些特殊方面。

Neurobiology (Budapest, Hungary) Pub Date : 1999-01-01

Z B Ramadan, P Dostert, K F Tipton

引用次数: 0

Direct connections between dendritic terminals of tectal ganglion cells and glutamate-positive terminals of presumed optic fibres in layers 4-5 of the optic tectum of Gallus domesticus. A light- and electron microscopic study. 家鸡视神经顶盖4-5层树突末梢细胞与假定的光纤谷氨酸阳性末梢之间的直接连接。光镜和电子显微镜研究。

Neurobiology (Budapest, Hungary) Pub Date : 1999-01-01

T Tömböl, A Németh

{"title":"Direct connections between dendritic terminals of tectal ganglion cells and glutamate-positive terminals of presumed optic fibres in layers 4-5 of the optic tectum of Gallus domesticus. A light- and electron microscopic study.","authors":"T Tömböl, A Németh","doi":"","DOIUrl":"","url":null,"abstract":"The principal afferent fibres of the avian optic tectum are the optic fibres of retinal origin. They terminate on the contralateral side, in the external layers (2-7) of the optic tectum (called optic layers) turning into these layers from the external surface. The terminal branchings of the optic fibres develop four densely innervated areas in layers 2, 3, 4-5 and 7. Their terminals are large and of various appearance in the different areas. In the middle third of the optic layer (in layers 4-5), thin dendritic terminal sections of tectal ganglion cells (according to Ramòn y Cajal) of layer 13 terminate into bunches. Phaseolus vulgaris lectin immunotracer corroborates these dendritic endings (further: dendritic terminals) of tectal ganglion cells. The direct connections between these dendritic terminals and the supposed optic fibres were studied under electron microscope and it was found that the large terminals of optic fibres containing round synaptic vesicles establish asymmetrical synapses with several dendritic profiles, among them Phaseolus lectin labelled dendritic terminals of ganglion cells. This result morphologically supports the former physiological observation of a direct synaptic transmission between optic fibres and ganglion cells of layer 13. In addition, on the dendritic terminals of ganglion cells, symmetrical synapses established by GABA-positive terminals were found. The optic terminals, the GABA-immunopositive terminals and the dendritic terminals of ganglion cells form complex synaptic units surrounded with glial sheath, and thus they establish glomerulus-like synaptic units. The size of the dendritic tree and the branching pattern of the dendrites of ganglion cells point to divergence and convergence in visual transmission.","PeriodicalId":79356,"journal":{"name":"Neurobiology (Budapest, Hungary)","volume":"7 1","pages":"45-67"},"PeriodicalIF":0.0,"publicationDate":"1999-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21597323","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Incorporation of ubiquitin into the rat brain mitochondria is accompanied by increased proteolytic digestibility of MAO.

Neurobiology (Budapest, Hungary) Pub Date : 1999-01-01

O A Buneeva, M V Medvedeva, A E Medvedev

引用次数: 0