发布求助
文献互助 智能选刊 最新文献

Neurobiology (Budapest, Hungary)最新文献

筛选
英文 中文
Response variability and stimulus discrimination capacity of neurons in monkey inferior temporal cortex. 猴下颞叶皮层神经元的反应变异性和刺激辨别能力。
Neurobiology (Budapest, Hungary) Pub Date : 1999-01-01
G Kovács, G Benedek, G Sáry
{"title":"Response variability and stimulus discrimination capacity of neurons in monkey inferior temporal cortex.","authors":"G Kovács,&nbsp;G Benedek,&nbsp;G Sáry","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Single neurons (n = 73) were recorded from the inferior temporal cortex (IT) of an awake macaque monkey, while performing a visual fixation task. Shape stimuli that elicited different responses of the IT neurons, were found to result in different response variances. The response variance vs. mean response relationship of the IT neurons could be described by an analogous function to those found in previous studies of A17 in cats and of V1 in macaques. A comparison of the stimulus discrimination capacities of the individual neurons revealed that neurons which exhibit lower variances can discriminate their preferred and non-preferred shape stimuli more reliably than neurons with higher variances.</p>","PeriodicalId":79356,"journal":{"name":"Neurobiology (Budapest, Hungary)","volume":"7 2","pages":"93-102"},"PeriodicalIF":0.0,"publicationDate":"1999-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21448875","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Alzheimer's Disease Research Laboratory. 阿尔茨海默病研究实验室。
Neurobiology (Budapest, Hungary) Pub Date : 1999-01-01
P Kása
{"title":"Alzheimer's Disease Research Laboratory.","authors":"P Kása","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":79356,"journal":{"name":"Neurobiology (Budapest, Hungary)","volume":"7 2","pages":"255"},"PeriodicalIF":0.0,"publicationDate":"1999-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21483239","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Behavioural effects of selective PDE4 inhibitors in relation to inhibition of catalytic activity and competition for [3H]rolipram binding. 选择性PDE4抑制剂对抑制催化活性和竞争[3H]罗利普兰结合的行为影响。
Neurobiology (Budapest, Hungary) Pub Date : 1999-01-01
Z Kapui, J Bence, E Boronkay, E Mikus, K Urbán Szabó, A Baranyi, P Arányi
{"title":"Behavioural effects of selective PDE4 inhibitors in relation to inhibition of catalytic activity and competition for [3H]rolipram binding.","authors":"Z Kapui,&nbsp;J Bence,&nbsp;E Boronkay,&nbsp;E Mikus,&nbsp;K Urbán Szabó,&nbsp;A Baranyi,&nbsp;P Arányi","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":79356,"journal":{"name":"Neurobiology (Budapest, Hungary)","volume":"7 1","pages":"71-3"},"PeriodicalIF":0.0,"publicationDate":"1999-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21597325","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Changes in cell adhesion and cell motility during induced neurogenesis, in vitro. 体外诱导神经发生过程中细胞粘附和细胞运动的变化。
Neurobiology (Budapest, Hungary) Pub Date : 1999-01-01
K Schlett, A Czirok, K Tárnok, O Haiman, T Vicsek, E Madarász
{"title":"Changes in cell adhesion and cell motility during induced neurogenesis, in vitro.","authors":"K Schlett,&nbsp;A Czirok,&nbsp;K Tárnok,&nbsp;O Haiman,&nbsp;T Vicsek,&nbsp;E Madarász","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":79356,"journal":{"name":"Neurobiology (Budapest, Hungary)","volume":"7 1","pages":"85-6"},"PeriodicalIF":0.0,"publicationDate":"1999-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21597329","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Long-term portocaval shunt and changes in rat brain amine systems. 长期门静脉分流与大鼠脑胺系统的改变。
Neurobiology (Budapest, Hungary) Pub Date : 1999-01-01
W A Fogel, W Andrzejewski, K Sasiak
{"title":"Long-term portocaval shunt and changes in rat brain amine systems.","authors":"W A Fogel,&nbsp;W Andrzejewski,&nbsp;K Sasiak","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Brain amine system parameters were investigated in Wistar rats sacrificed 7 months following portocaval shunt or sham operation. After removal of the cerebellum and pons, the hypothalamus and remaining parts of the brain were examined. Histamine was assayed radioenzymatically; indoles and catechols by HPLC with electrochemical detection; spermidine and spermine by HPLC with fluorometry. MAO-A and MAO-B activities were estimated with radioassays employing serotonin and beta-phenylethylamine, respectively and specific inhibitors, clorgyline and deprenyl. Long-term portocaval shunt did not significantly alter cerebral catecholamines, serotonin, spermidine or spermine concentrations. However, brain histamine and 5-hydroxyindoleactic acid were significantly raised. Of the MAO enzymes only MAO-B activity was elevated (ca. 25%, p < 0.05) in the hypothalamus but not in the rest of the brain. The kinetic measurements suggest an adaptive change in MAO-B protein synthesis. The data suggest changes evoked by portocaval shunt in brain amine systems are permanent and there are species differences in MAO enzymes' response to higher substrate supply.</p>","PeriodicalId":79356,"journal":{"name":"Neurobiology (Budapest, Hungary)","volume":"7 4","pages":"413-20"},"PeriodicalIF":0.0,"publicationDate":"1999-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21738813","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
L-alpha-glycerylphosphorylcholine enhances the amplitude of the pattern electroretinogram in rhesus monkeys. A pilot study. l - α -甘油酰磷胆碱能增强恒河猴视网膜电图的振幅。一项初步研究。
Neurobiology (Budapest, Hungary) Pub Date : 1999-01-01
A Antal, S Kéri, I Bodis-Wollner
{"title":"L-alpha-glycerylphosphorylcholine enhances the amplitude of the pattern electroretinogram in rhesus monkeys. A pilot study.","authors":"A Antal,&nbsp;S Kéri,&nbsp;I Bodis-Wollner","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The effects of L-alpha-glyceryl-phosphorylcholine (LGPC), a putative acetylcholine precursor, were studied on the pattern electroretinogram (PERG) in two rhesus monkeys. In the time interval 10-30 min after LGPC administration (85 mg/kg i.m.), the amplitude of the PERG increased significantly. In both monkeys the amplitude enhancement was more pronounced for low spatial frequency stimuli (1 cycle/degree) than for medium spatial frequency gratings (5 cycles/degree). This result suggests that besides the general facilitatory properties, LGPC may have specific spatial frequency tuning effects at the level of retinal information processing.</p>","PeriodicalId":79356,"journal":{"name":"Neurobiology (Budapest, Hungary)","volume":"7 4","pages":"407-12"},"PeriodicalIF":0.0,"publicationDate":"1999-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21738812","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Substance P radioimmunoassay for quantitative characterization of sensory neurotransmitter release. P物质放射免疫法定量表征感觉神经递质释放。
Neurobiology (Budapest, Hungary) Pub Date : 1999-01-01
J Németh, G Oroszi, M Thán, Z S Helyes, E Pintér, B Farkas, J Szolcsányi
{"title":"Substance P radioimmunoassay for quantitative characterization of sensory neurotransmitter release.","authors":"J Németh,&nbsp;G Oroszi,&nbsp;M Thán,&nbsp;Z S Helyes,&nbsp;E Pintér,&nbsp;B Farkas,&nbsp;J Szolcsányi","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>In the present work we report the development of a new radioimmunoassay method for measuring the substance P content liberated from isolated rat tracheae in response to electrical or chemical (capsaicin, resiniferatoxin, piperine) stimulation. The amount of substance P released by electrical stimulation has been found to be dependent on the number of pulses and chemically elicited substance P release also proved to be dose-dependent. Our findings reinforce previous data that resiniferatoxin is approximately 100 times more potent than capsaicin and the potency ratio between piperine and capsaicin is 1/50.</p>","PeriodicalId":79356,"journal":{"name":"Neurobiology (Budapest, Hungary)","volume":"7 4","pages":"437-44"},"PeriodicalIF":0.0,"publicationDate":"1999-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21738816","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Distribution of pituitary adenylate cyclase activating polypeptide (PACAP) immunoreactive elements in the brain stem of rats studied by immunohistochemistry. 免疫组织化学方法研究垂体腺苷酸环化酶激活多肽(PACAP)免疫反应因子在大鼠脑干中的分布。
Neurobiology (Budapest, Hungary) Pub Date : 1999-01-01
M Kausz, Z Murai, A Arimura, K Köves
{"title":"Distribution of pituitary adenylate cyclase activating polypeptide (PACAP) immunoreactive elements in the brain stem of rats studied by immunohistochemistry.","authors":"M Kausz,&nbsp;Z Murai,&nbsp;A Arimura,&nbsp;K Köves","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>In the present work the distribution of pituitary adenylate cyclase activating polypeptide (PACAP) immunoreactive elements in rat brain stem were described using immunohistochemistry. The following structures were PACAP immunoreactive: 1. The dorsomedial and ventrolateral cell columns of the motor nuclei of cranial nerves. 2. Primary somatosensory cells in the mesencephalic nucleus of the trigeminal nerve and central axons of the branchial cranial nerves in the spinal trigeminal tract. 3. Visceral afferent fibers in the solitary tract and cell bodies in the dorsal motor nucleus of the vagus. 4. Second and third order sensory neurons of the cochlear and vestibular systems. 5. Scattered fibers in various regions of the brain stem and well-defined fiber bundles in the interpeduncular area. 6. Cell bodies in the red nucleus, substantia niga, in some cell groups of the reticular formation and in the raphe nuclei, as well as in the pontine dorsolateral tegmentum.</p>","PeriodicalId":79356,"journal":{"name":"Neurobiology (Budapest, Hungary)","volume":"7 1","pages":"19-31"},"PeriodicalIF":0.0,"publicationDate":"1999-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21597321","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Metabolic transformation of deprenyl enantiomers in rats. 去戊烯基对映体在大鼠体内的代谢转化。
Neurobiology (Budapest, Hungary) Pub Date : 1999-01-01
E Szökö, H Kalász, K Magyar
{"title":"Metabolic transformation of deprenyl enantiomers in rats.","authors":"E Szökö,&nbsp;H Kalász,&nbsp;K Magyar","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The optical isomers of deprenyl have different pharmacological activities and potency. Selegiline, an (-)-isomer, is the more potent monoamine oxidase B enzyme inhibitor, and this substance is used in the therapy of Parkinson's disease. The neuroprotective and neuronal rescue effects of deprenyl, as well as the psychostimulant action of its metabolites, methamphetamine and amphetamine are also different for the enantiomers. In this study the biotransformation of deprenyl enantiomers was compared. Stereoselective dealkylation of both optical isomers was found as major metabolic alteration. The difference in the ratio of the formed metabolites suggests the existence of preferred metabolic pathways for the enantiomers.</p>","PeriodicalId":79356,"journal":{"name":"Neurobiology (Budapest, Hungary)","volume":"7 2","pages":"247-54"},"PeriodicalIF":0.0,"publicationDate":"1999-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21448113","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Topical acetylsalicylic acid versus lidocaine for postherpetic neuralgia: results of a double-blind comparative clinical trial. 局部乙酰水杨酸与利多卡因治疗疱疹后神经痛:一项双盲比较临床试验的结果。
Neurobiology (Budapest, Hungary) Pub Date : 1999-01-01
J Tajti, D Szok, L Vécsei
{"title":"Topical acetylsalicylic acid versus lidocaine for postherpetic neuralgia: results of a double-blind comparative clinical trial.","authors":"J Tajti,&nbsp;D Szok,&nbsp;L Vécsei","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>A double-blind comparative clinical trial was performed with topical aspirin versus lidocaine for the treatment of 40 patients with postherpetic neuralgia. The percentage improvement following topical aspirin application was 72.2 +/- 19.9 S.D., while with lidocaine it was 72.8 +/- 25.3 S.D. These results suggest that the effect of topical treatment with aspirin is as good as that with lidocaine, since there was no significant difference (P = 0.778) between the two drugs in respect of pain reduction and accordingly the topical application of acetylsalicylic acid can be equally recommended.</p>","PeriodicalId":79356,"journal":{"name":"Neurobiology (Budapest, Hungary)","volume":"7 2","pages":"103-8"},"PeriodicalIF":0.0,"publicationDate":"1999-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21448874","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
首页 上一页 下一页 尾页
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整，为了账户安全，请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
请完成安全验证×
相关产品
×
本文献相关产品
联系我们：info@booksci.cn Book学术提供免费学术资源搜索服务，方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号：481959085
Book学术官方微信