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Semicarbazide-sensitive amine oxidases in heart and bovine serum. 心脏和牛血清中对半肼敏感的胺氧化酶
Neurobiology (Budapest, Hungary) Pub Date : 2000-01-01
F Buffoni, G Ignesti, R Pino, L Sartiani, G Dini
{"title":"Semicarbazide-sensitive amine oxidases in heart and bovine serum.","authors":"F Buffoni, G Ignesti, R Pino, L Sartiani, G Dini","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>In guinea pig dorsal skin the semicarbazide-sensitive amine oxidase (SSAO) is localised in fibroblasts. Fibroblasts in culture lose the ability to express this enzymatic activity with doublings, thus suggesting that the SSAO expression needs some factors which are not present in the 10% bovine serum culture medium. Fresh bovine serum of adult animals contains two SSAO activities, one with high affinity for benzylamine and one with lower affinity. The enzyme with lower affinity for benzylamine was identified as spermine oxidase, the oxidation of [14C]-benzylamine was inhibited by semicarbazide, alpha-aminoguanidine and B24, a specific inhibitor of benzylamine oxidase and spermine oxidase, both SSAO enzymes. The enzymatic activity of bovine serum was partially purified, the kinetic properties and sensitivity to inhibitors studied. A mathematical procedure for the analysis of the kinetics resulting from the activity of two enzymes acting on the same substrate seems to give better results than the methods previously described.</p>","PeriodicalId":79356,"journal":{"name":"Neurobiology (Budapest, Hungary)","volume":"8 1","pages":"17-35"},"PeriodicalIF":0.0,"publicationDate":"2000-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21842407","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Molecular interaction between reversible MAO-A inhibitors and the enzyme. Application to aryloxazolidinone, a prototype series. 应用于芳基唑烷酮系列样机。
Neurobiology (Budapest, Hungary) Pub Date : 2000-01-01
F Ooms, S Jegham, P George, F Durant, J Wouters
{"title":"Molecular interaction between reversible MAO-A inhibitors and the enzyme. Application to aryloxazolidinone, a prototype series.","authors":"F Ooms,&nbsp;S Jegham,&nbsp;P George,&nbsp;F Durant,&nbsp;J Wouters","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Among the various chemical classes of monoamine oxidase A inhibitors, phenyloxazolidinone represent one of the major series. The purpose of this paper is to review the experimental (X-ray diffraction, NMR, electronic absorption spectroscopy, lipophilicity studies) and theoretical (quantum chemistry, molecular mechanics, molecular dynamics) studies which have led to the description of the mode of interaction between phenyloxazolidinone inhibitors and the MAO-A enzyme.</p>","PeriodicalId":79356,"journal":{"name":"Neurobiology (Budapest, Hungary)","volume":"8 1","pages":"81-98"},"PeriodicalIF":0.0,"publicationDate":"2000-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21843062","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Age-related changes of MAO-A and -B distribution in human and mouse brain.
Neurobiology (Budapest, Hungary) Pub Date : 2000-01-01
N Mahy, N Andrés, C Andrade, J Saura
{"title":"Age-related changes of MAO-A and -B distribution in human and mouse brain.","authors":"N Mahy,&nbsp;N Andrés,&nbsp;C Andrade,&nbsp;J Saura","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Age-related changes of MAO-A and -B were studied in human and BL/C57 mouse brain areas (substantia nigra, putamen and cerebellum). [3H]Ro41-1049 and [3H]lazabemide were used as selective radioligands to image and quantify MAO-A and MAO-B respectively by enzyme autoradiography. MAO-A binding was higher in mouse, whereas MAO-B binding was higher in human. With aging, mouse MAO-A was significantly reduced between 4 and 8 weeks and remained unchanged until 19 months followed by a slight increase between 19 and 25 months. In contrast, no clear variation was observed in humans between the age of 17-93 years. In most of the structures studied a clear age-related increase in MAO-B was observed beginning in mouse brain at 4 weeks, whereas in human tissue this increase started at the age of 50-60 years. These results show marked differences in the levels and variations of mouse and human MAO-A and -B associated with aging and should be taken into account when extrapolating experimental data from mouse to human.</p>","PeriodicalId":79356,"journal":{"name":"Neurobiology (Budapest, Hungary)","volume":"8 1","pages":"47-54"},"PeriodicalIF":0.0,"publicationDate":"2000-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21842409","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Modification of dopamine release by selective inhibitors of MAO-B.
Neurobiology (Budapest, Hungary) Pub Date : 2000-01-01
J P Finberg, I Lamensdorf, T Armoni
{"title":"Modification of dopamine release by selective inhibitors of MAO-B.","authors":"J P Finberg,&nbsp;I Lamensdorf,&nbsp;T Armoni","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Chronic low dose deprenyl treatment in rats causes an increase in striatal extracellular dopamine level, without significant reduction in deaminated metabolite formation. This effect could be the result of increased endogenous levels of the MAO-B substrate beta-phenylethylamine, which is both a releaser of dopamine as well as an inhibitor of the neuronal membrane active dopamine uptake. In guinea pigs, however, striatal extracellular dopamine was not increased either by deprenyl or by clorgyline. Local infusion of the dopamine uptake inhibitor GBR-12909 caused a greater increase in striatal dopamine in microdialysate in rats than in guinea pigs. Intra-species differences in synaptic architecture or in density of dopamine transporter expression may account for these differences.</p>","PeriodicalId":79356,"journal":{"name":"Neurobiology (Budapest, Hungary)","volume":"8 2","pages":"137-42"},"PeriodicalIF":0.0,"publicationDate":"2000-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21889394","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Selective inhibitors and computer modelling of the active site of monoamine oxidase. 单胺氧化酶活性位点的选择性抑制剂和计算机模拟。
Neurobiology (Budapest, Hungary) Pub Date : 2000-01-01
A E Medvedev, A S Ivanov, A V Veselovsky
{"title":"Selective inhibitors and computer modelling of the active site of monoamine oxidase.","authors":"A E Medvedev,&nbsp;A S Ivanov,&nbsp;A V Veselovsky","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>MAO inhibitors can be employed for computer modelling of the active site of MAO A and B. Competitive fully reversible MAO inhibitors with rigid structure and limited number of conformers are preferential compounds for these studies. Among various isatin analogues with nearllanar structure selective MAO B inhibitors fit to 3D box of 8.5x5.1x1.8 A, whereas 3D box of 14.2x5.6x1.8 A accommodates selective MAO A inhibitors. Validity of these data was tested using a series of pyrazinocarbazoles, analogues of short-acting antidepressant pirlindole. Rigid analogues exhibiting potent and selective inhibition of MAO A have 3D size limits of 13x7x4.4 A. Flexible analogues also demonstrated potent inhibition of MAO B and in contrast to rigid analogues their inhibitory activity did not show any dependence on 3D sizes. 3D-QSAR with CoMFA of isatin and pirlindole analogues of MAO A and B revealed differences in the models of MAO A and B.</p>","PeriodicalId":79356,"journal":{"name":"Neurobiology (Budapest, Hungary)","volume":"8 2","pages":"201-14"},"PeriodicalIF":0.0,"publicationDate":"2000-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21889398","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Electrophysiological characteristics and morphological properties of dentate granule--and CA3 pyramidal cells in slices cut from neonatally irradiated rats. 初生辐照大鼠齿状颗粒细胞和CA3锥体细胞电生理特征和形态特征。
Neurobiology (Budapest, Hungary) Pub Date : 1999-01-01
B Czéh, L Seress, G Czéh
{"title":"Electrophysiological characteristics and morphological properties of dentate granule--and CA3 pyramidal cells in slices cut from neonatally irradiated rats.","authors":"B Czéh,&nbsp;L Seress,&nbsp;G Czéh","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Neonatal irradiation reduces the dentate granule cells by 60-80%, and consequently the mossy fiber projection toward the CA3 and hilar areas decreases. The number of hilar cells diminishes. Thorny excrescences on the dendrites of the CA3 pyramidal cells get smaller both in number (from 20-30 per neuron in normal to 1-6 per neuron after irradiation) and in size. In spite of these morphological changes functional efficacy of the mossy-fiber projection to CA3 pyramidal cells remains sufficient to generate monosynaptic action potentials when stimulated electrically. Inhibitory circuits activated by mossy fiber volleys seem to be unaffected by irradiation. Main biophysical properties of CA3 pyramidal and surviving granule cells remain within the normal range. Further work should determine if efficacy of the mossy fiber projection increases to compensate for the substantial decrease of presynaptic input, or the power of transmission far exceeds the level needed to fire postsynaptic cells in normal rats.</p>","PeriodicalId":79356,"journal":{"name":"Neurobiology (Budapest, Hungary)","volume":"7 1","pages":"1-17"},"PeriodicalIF":0.0,"publicationDate":"1999-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21597320","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Receptor components of glutamate-evoked increase in intracellular Ca2+ concentration of neurons in culture. 谷氨酸受体成分诱发培养神经元细胞内Ca2+浓度升高。
Neurobiology (Budapest, Hungary) Pub Date : 1999-01-01
C Horváth, S Farkas, J Nagy
{"title":"Receptor components of glutamate-evoked increase in intracellular Ca2+ concentration of neurons in culture.","authors":"C Horváth,&nbsp;S Farkas,&nbsp;J Nagy","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":79356,"journal":{"name":"Neurobiology (Budapest, Hungary)","volume":"7 1","pages":"69-70"},"PeriodicalIF":0.0,"publicationDate":"1999-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21597324","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Columnar organization of nitric oxide synthase (NOS) in the prefrontal cortex of primates. 灵长类动物前额皮质一氧化氮合酶(NOS)的柱状组织。
Neurobiology (Budapest, Hungary) Pub Date : 1999-01-01
E Knyihár-Csillik, L Vécsei, P S Goldman-Rakic, B Csillik
{"title":"Columnar organization of nitric oxide synthase (NOS) in the prefrontal cortex of primates.","authors":"E Knyihár-Csillik,&nbsp;L Vécsei,&nbsp;P S Goldman-Rakic,&nbsp;B Csillik","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":79356,"journal":{"name":"Neurobiology (Budapest, Hungary)","volume":"7 4","pages":"479-80"},"PeriodicalIF":0.0,"publicationDate":"1999-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21777987","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Neuroprotection by (R)-deprenyl and 7-nitroindazole in the MPTP C57BL/6 mouse model of neurotoxicity. (R)-去戊烯基和7-硝基茚唑对MPTP C57BL/6小鼠神经毒性模型的保护作用。
Neurobiology (Budapest, Hungary) Pub Date : 1999-01-01
K Castagnoli, S Palmer, N Castagnoli
{"title":"Neuroprotection by (R)-deprenyl and 7-nitroindazole in the MPTP C57BL/6 mouse model of neurotoxicity.","authors":"K Castagnoli,&nbsp;S Palmer,&nbsp;N Castagnoli","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The neurodegenerative properties of the parkinsonian inducing agent 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) are thought to result from inhibition of complex I of the mitochondrial respiratory chain by the monoamine oxidase-B (MAO-B) generated 1-methyl-4-phenylpyridinium metabolite MPP+. 7-Nitroindazole (7-NI) both a reversible MAO-B inhibitor and a neuronal nitric oxide synthase (nNOS) inhibitor, and (R)-deprenyl a potent MAO-B inactivator, provide neuroprotection in the C57BL/6 mouse model of MPTP neurotoxicity. The results reported here demonstrate the complexities of the effects of 7-NI in this model and examine the possibility of other mechanisms of neuroprotection by (R)-deprenyl.</p>","PeriodicalId":79356,"journal":{"name":"Neurobiology (Budapest, Hungary)","volume":"7 2","pages":"135-49"},"PeriodicalIF":0.0,"publicationDate":"1999-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21448878","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Inhibition of monoamine oxidase by pirlindole analogues: 3D-QSAR analysis. 吡哚类似物对单胺氧化酶的抑制作用:3D-QSAR分析。
Neurobiology (Budapest, Hungary) Pub Date : 1999-01-01
A E Medvedev, R R Ramsay, A S Ivanov, A V Veselovsky, V I Shvedov, O V Tikhonova, A P Barradas, C K Davidson, T A Moskvitina, O A Fedotova, L N Axenova
{"title":"Inhibition of monoamine oxidase by pirlindole analogues: 3D-QSAR analysis.","authors":"A E Medvedev,&nbsp;R R Ramsay,&nbsp;A S Ivanov,&nbsp;A V Veselovsky,&nbsp;V I Shvedov,&nbsp;O V Tikhonova,&nbsp;A P Barradas,&nbsp;C K Davidson,&nbsp;T A Moskvitina,&nbsp;O A Fedotova,&nbsp;L N Axenova","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>A series of pirlindole analogues were tested as inhibitors of monoamine oxidase A and B. Although we did not find strict dependence between 3D-size of molecules and their inhibitory potency, rigid analogues exhibited potent and selective inhibition of MAO-A. They have 3D size limits of 13 angstroms (length) x 7 angstroms (height) x 4.4 angstroms (widths). Besides MAO-A inhibition flexible analogues also demonstrated potent inhibition of MAO-B. Five compounds were studied as inhibitors of purified human liver MAO-A. Their inhibitory potencies coincided with those obtained using rat liver mitochondrial MAO-A. Each compound induced changes in the spectrum of MAO-A but these did not correlate with the flexibility of the derivative. It is also possible that the oxygen bridge introduced with the flexibility might influence spectral patterns.</p>","PeriodicalId":79356,"journal":{"name":"Neurobiology (Budapest, Hungary)","volume":"7 2","pages":"151-8"},"PeriodicalIF":0.0,"publicationDate":"1999-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21448879","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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